NELSON P SPRUSTON

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum
    Donald C Cooper
    Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, Evanston, Illinois, USA
    PLoS Biol 3:e175. 2005
  2. doi Pyramidal neurons: dendritic structure and synaptic integration
    Nelson Spruston
    Northwestern University, Department of Neurobiology and Physiology, 2205 Tech Drive, Evanston, Illinois 60208, USA
    Nat Rev Neurosci 9:206-21. 2008
  3. pmc Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions
    Catherine Cook Kaczorowski
    Department of Neurobiology and Physiology, 2205 Tech Drive, Evanston, IL 60208, USA
    J Physiol 578:799-818. 2007
  4. ncbi R-type calcium channels contribute to afterdepolarization and bursting in hippocampal CA1 pyramidal neurons
    Alexia E Metz
    Northwestern University Institute for Neuroscience, Evanston, Illinois 60208, USA
    J Neurosci 25:5763-73. 2005
  5. ncbi Intracellular correlate of EPSP-spike potentiation in CA1 pyramidal neurons is controlled by GABAergic modulation
    Nathan P Staff
    Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208, USA
    Hippocampus 13:801-5. 2003
  6. pmc Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites
    Nace L Golding
    Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, 2205 Tech Dr, Evanston, IL 60208 3520, USA
    J Physiol 568:69-82. 2005
  7. ncbi Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons
    Tim Jarsky
    Institute for Neuroscience, Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, Illinois 60208, USA
    Nat Neurosci 8:1667-76. 2005
  8. ncbi Distribution of bursting neurons in the CA1 region and the subiculum of the rat hippocampus
    Tim Jarsky
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Comp Neurol 506:535-47. 2008
  9. ncbi Psychostimulant-induced plasticity of intrinsic neuronal excitability in ventral subiculum
    Donald C Cooper
    Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 23:9937-46. 2003
  10. pmc Synaptic depolarization is more effective than back-propagating action potentials during induction of associative long-term potentiation in hippocampal pyramidal neurons
    Jason Hardie
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 29:3233-41. 2009

Collaborators

Detail Information

Publications19

  1. pmc Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum
    Donald C Cooper
    Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, Evanston, Illinois, USA
    PLoS Biol 3:e175. 2005
    ..Prolonged inactivation of sodium channels is responsible for an activity-dependent switch from bursting to single spiking, constituting a novel mechanism through which network dynamics are controlled by ion channel gating...
  2. doi Pyramidal neurons: dendritic structure and synaptic integration
    Nelson Spruston
    Northwestern University, Department of Neurobiology and Physiology, 2205 Tech Drive, Evanston, Illinois 60208, USA
    Nat Rev Neurosci 9:206-21. 2008
    ..These properties support a variety of coincidence-detection mechanisms, which are likely to be crucial for synaptic integration and plasticity...
  3. pmc Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions
    Catherine Cook Kaczorowski
    Department of Neurobiology and Physiology, 2205 Tech Drive, Evanston, IL 60208, USA
    J Physiol 578:799-818. 2007
    ..In whole-cell recordings using KGluc, repetitive theta-burst firing induced AHP plasticity that mimics learning-related reduction in the AHP...
  4. ncbi R-type calcium channels contribute to afterdepolarization and bursting in hippocampal CA1 pyramidal neurons
    Alexia E Metz
    Northwestern University Institute for Neuroscience, Evanston, Illinois 60208, USA
    J Neurosci 25:5763-73. 2005
    ..Because the ADP correlates directly with burst firing in CA1 neurons, R-type calcium channels are crucial to this important cellular behavior, which is known to encode hippocampal place fields and enhance synaptic plasticity...
  5. ncbi Intracellular correlate of EPSP-spike potentiation in CA1 pyramidal neurons is controlled by GABAergic modulation
    Nathan P Staff
    Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208, USA
    Hippocampus 13:801-5. 2003
    ..Our findings do not rule out, however, the possibility that modulation of voltage-gated conductances also contributes to E-S potentiation...
  6. pmc Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites
    Nace L Golding
    Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, 2205 Tech Dr, Evanston, IL 60208 3520, USA
    J Physiol 568:69-82. 2005
    ..A prediction of this powerful EPSP attenuation is that distal synaptic inputs are likely only to be effective in the presence of conductance scaling, dendritic excitability, or both...
  7. ncbi Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons
    Tim Jarsky
    Institute for Neuroscience, Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, Illinois 60208, USA
    Nat Neurosci 8:1667-76. 2005
    ....
  8. ncbi Distribution of bursting neurons in the CA1 region and the subiculum of the rat hippocampus
    Tim Jarsky
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Comp Neurol 506:535-47. 2008
    ..Taken together with the known organization of connections from CA3 to CA1 and CA1 to subiculum, our results indicate that bursting neurons are most likely to be connected to regular spiking neurons and vice versa...
  9. ncbi Psychostimulant-induced plasticity of intrinsic neuronal excitability in ventral subiculum
    Donald C Cooper
    Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 23:9937-46. 2003
    ....
  10. pmc Synaptic depolarization is more effective than back-propagating action potentials during induction of associative long-term potentiation in hippocampal pyramidal neurons
    Jason Hardie
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 29:3233-41. 2009
    ..Thus, back-propagating action potentials may contribute to modest LTP, but local synaptic depolarization and/or dendritic spikes mediate a stronger form of LTP that requires spatial proximity of the associated synaptic inputs...
  11. pmc Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors
    Shannon J Moore
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Neuron 61:287-300. 2009
    ..These results indicate that the output of subiculum can be strongly and bidirectionally regulated by activation of glutamatergic inputs within the hippocampus and cholinergic afferents from the medial septum...
  12. pmc Compartmental neural simulations with spatial adaptivity
    Michael J Rempe
    Department of Applied Mathematics, Northwestern University, Evanston, IL 60208, USA
    J Comput Neurosci 25:465-80. 2008
    ..For certain problems spatial adaptivity reduces the computation time by up to 80%...
  13. ncbi Dendritic spikes as a mechanism for cooperative long-term potentiation
    Nace L Golding
    Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, Evanston, IL 60208 3520, USA
    Nature 418:326-31. 2002
    ..We find that this mechanism can also function at proximal synapses, suggesting that dendritic spikes participate generally in a form of synaptic potentiation that does not require postsynaptic action potential firing in the axon...
  14. pmc Dendritic spikes induce single-burst long-term potentiation
    Stefan Remy
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 104:17192-7. 2007
    ..Thus, dendritic spikes are a critical trigger for a form of LTP that is consistent with the function of the hippocampus in episodic memory...
  15. pmc Synapse distribution suggests a two-stage model of dendritic integration in CA1 pyramidal neurons
    Yael Katz
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Neuron 63:171-7. 2009
    ..Computational modeling suggests that the observed synapse distribution enhances the contribution of each dendritic branch to neuronal output...
  16. ncbi Serotonin receptor activation inhibits sodium current and dendritic excitability in prefrontal cortex via a protein kinase C-dependent mechanism
    David B Carr
    Department of Physiology, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 22:6846-55. 2002
    ..These findings show that 5-HT2a,c receptor activation reduces dendritic excitability and may negatively modulate activity-dependent dendritic synaptic plasticity...
  17. ncbi Distance-dependent differences in synapse number and AMPA receptor expression in hippocampal CA1 pyramidal neurons
    Daniel A Nicholson
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Neuron 50:431-42. 2006
    ....
  18. pmc Coincidence detection of place and temporal context in a network model of spiking hippocampal neurons
    Yael Katz
    Interdepartmental Biological Sciences Program, Northwestern University, Evanston, Illinois, United States of America
    PLoS Comput Biol 3:e234. 2007
    ..The model leads to a number of experimentally testable predictions that may lead to a better understanding of the biophysical basis of information processing in the hippocampus...
  19. ncbi Peering into the dendritic machinery of striatal medium spiny neurons
    D James Surmeier
    Institute for Neuroscience, Northwestern University, Chicago, IL 60611, USA
    Neuron 44:401-2. 2004
    ..The results offer new insights into the workings of these clinically important yet mysterious neurons...

Research Grants24

  1. Modeling microcircuits of realistic hippocampal neurons
    Nelson Spruston; Fiscal Year: 2005
    ..5) Graduate students and postdoctoral researchers, recruited from the ranks of applied mathematicians interested in biological applications, will be trained in computational neuroscience. ..
  2. SYNAPTIC INTEGRATION AND PROPAGATION IN CA1 DENDRITES
    Nelson Spruston; Fiscal Year: 2007
    ....
  3. Modeling microcircuits of realistic hippocampal neurons
    Nelson Spruston; Fiscal Year: 2009
    ..5) Developing advanced computational methods for microcircuit modeling. The proposed work has important implications for several neurological disorders, including Alzheimer's disease, epilepsy, and schizophrenia. ..
  4. Modeling microcircuits of realistic hippocampal neurons
    NELSON P SPRUSTON; Fiscal Year: 2010
    ..5) Developing advanced computational methods for microcircuit modeling. The proposed work has important implications for several neurological disorders, including Alzheimer's disease, epilepsy, and schizophrenia. ..
  5. SYNAPTIC INTEGRATION AND PROPAGATION IN CA1 DENDRITES
    NELSON P SPRUSTON; Fiscal Year: 2010
    ..Such insights will lead to a better understanding of hippocampal function, which is necessary to understand diseases affecting the hippocampus, such as Alzheimer's disease, schizophrenia, and epilepsy. ..
  6. 2006 Dendrites: Molecules, Structure and Function (Gordon Research Conference)
    Nelson Spruston; Fiscal Year: 2007
    ..The conference will bring together researchers working on dendrites using a variety of techniques and approaches, in both health and disease. A heavy emphasis will be placed on involving graduate students and postdocs in the meeting. ..
  7. Modeling microcircuits of realistic hippocampal neurons
    Nelson Spruston; Fiscal Year: 2007
    ..5) Developing advanced computational methods for microcircuit modeling. The proposed work has important implications for several neurological disorders, including Alzheimer's disease, epilepsy, and schizophrenia. ..
  8. SYNAPTIC INTEGRATION AND PROPAGATION IN CA1 DENDRITES
    Nelson Spruston; Fiscal Year: 2009
    ..CA1 neurons are among the most abundant in the hippocampus, and they are affected in diseases such as epilepsy and Alzheimer's disease. ..
  9. SYNAPTIC INTEGRATION AND PROPAGATION IN CA1 DENDRITES
    Nelson Spruston; Fiscal Year: 1999
    ....
  10. SYNAPTIC INTEGRATION AND PROPAGATION IN CA1 DENDRITES
    Nelson Spruston; Fiscal Year: 2004
    ..abstract_text> ..
  11. Modeling microcircuits of realistic hippocampal neurons
    NELSON P SPRUSTON; Fiscal Year: 2010
    ..5) Developing advanced computational methods for microcircuit modeling. The proposed work has important implications for several neurological disorders, including Alzheimer's disease, epilepsy, and schizophrenia. ..