Research Topics
| Tanya SimuniSummaryAffiliation: Northwestern University Country: USA Publications
Research Grants
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Detail Information
Publications
Tolerability of isradipine in early Parkinson's disease: a pilot dose escalation studyTanya Simuni
Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Mov Disord 25:2863-6. 2010..The two most common reasons for dose reduction were leg edema (7) and dizziness (3). There was no difference in isradipine tolerability between subjects with and without dopaminergic treatment, or with and without hypertension...
Somnolence and other sleep disorders in Parkinson's disease: the challenge for the practicing neurologistTanya Simuni
Parkinson's Disease and Movement Disorders Center, Department of Neurology, Feinberg School of Medicine, Northwestern University, 675 North St. Clair Street, Suite 20-100, Chicago, IL 60611, USA
Neurol Clin 22:S107-26. 2004- Treatment of early Parkinson's disease. Part 2Tanya Simuni
Department of Neurology, Northwestern University, Parkinson s Disease and Movement Disorders Center, Chicago, Ill, USA
Eur Neurol 61:206-15. 2009..Part 2 of the article, presented here, reviews key data relevant to the assessment of potential neuroprotective therapies and the treatment of non-motor symptoms... - Treatment of early Parkinson's disease. Part 1Tanya Simuni
Department of Neurology, Northwestern University, Parkinson s Disease and Movement Disorders Center, Chicago, Ill 60611, USA
Eur Neurol 61:193-205. 2009..Safety and tolerability data are also reviewed. Part 2 of the article reviews key findings relevant to the assessment of potential neuroprotective therapies and the treatment of non-motor symptoms... - Nonmotor manifestations of Parkinson's diseaseTanya Simuni
Department of Neurology, Northwestern University, Chicago, IL, USA
Ann Neurol 64:S65-80. 2008..This article reviews depression, sleep, and autonomic dysfunction in PD... - Perturbations of ground support alter posture and locomotion coupling during step initiation in Parkinson's diseaseMark W Rogers
Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Exp Brain Res 208:557-67. 2011..Moreover, impaired step initiation in PD may at least acutely be enhanced by augmenting the coupling between posture and locomotion... 
Effect of movement frequency on repetitive finger movements in patients with Parkinson's diseaseElizabeth L Stegemoller
Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Mov Disord 24:1162-9. 2009....- Short-term effects of posture-assisted step training on rapid step initiation in Parkinson's diseaseMarie Laure Mille
Department of Physical Therapy, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
J Neurol Phys Ther 33:88-95. 2009..Ground reaction forces and step kinematics were recorded... - Rate-dependent impairments in repetitive finger movements in patients with Parkinson's disease are not due to peripheral fatigueElizabeth L Stegemoller
Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Neurosci Lett 482:1-6. 2010.... - Brain donation--what do patients with movement disorders know and how do they feel about it?Teresa Kuhta
Parkinson s Disease and Movement Disorders Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Parkinsonism Relat Disord 17:204-7. 2011..We advocate proactive education of patients with various movement disorders about the purpose and benefits of brain donation... - Cancer incidence in a trial of an antiapoptotic agent for Parkinson's diseaseSteven R Schwid
Department of Neurology, University of Rochester, Rochester, New York, USA
Mov Disord 25:1801-8. 2010..Melanoma occurrence in our PD patients was greater than predicted compared with the general population and was unrelated to dopaminergic therapy. Clinical surveillance of PD patients for melanoma may be warranted... - A recommended scale for cognitive screening in clinical trials of Parkinson's diseaseKelvin L Chou
Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 5316, USA
Mov Disord 25:2501-7. 2010..Widespread adoption of a single instrument such as the MoCA in clinical trials can improve comparability between research studies on PD... - Long-term effects of bilateral subthalamic nucleus stimulation on health-related quality of life in advanced Parkinson's diseaseAndrew Siderowf
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
Mov Disord 21:746-53. 2006..01). In this selected group of patients, many of the short-term gains in HRQL persist beyond 18 months after STN implantation. Benefits in nonmotor aspects of HRQL such as bodily discomfort and stigma appear to be among the most durable... - Amantadine for freezing of gait in patients with Parkinson diseaseRoneil Malkani
Department of Neurology, Northwestern University, Chicago, IL
Clin Neuropharmacol 35:266-8. 2012..Treatment studies of levodopa and selegiline have shown limited benefit for FOG. Limited data suggest that amantadine, an N-methyl-D-aspartate receptor antagonist, may be beneficial for FOG in PD... - The effects of Parkinson's disease and age on syncopated finger movementsElizabeth L Stegemoller
Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Brain Res 1290:12-20. 2009.... - A computerized survey of pain in Parkinson's disease patients: A pilot feasibility studyDavid B Page
Northwestern University Feinberg School of Medicine, Department of Neurology, Chicago, IL, USA
Parkinsonism Relat Disord 16:139-41. 2010..PAINReportIt was feasible as a data-collection modality among our PD cohort, and with modifications may be used as both an investigative instrument and clinical tool for the evaluation of PD-related pain syndromes... - A longitudinal program for biomarker development in Parkinson's disease: a feasibility studyBernard Ravina
Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Mov Disord 24:2081-90. 2009..The PostCEPT cohort and associated studies strongly support the feasibility of the LABS-PD approach of retaining and repurposing clinical trial cohorts to collect longitudinal clinical and biomarker data... - Piloting the NPF data-driven quality improvement initiativeMichael S Okun
National Parkinson Foundation Center of Excellence, University of Florida, Movement Disorders Center, McKnight Brain Institute, Department of Neurology, Gainesville, FL 32611, USA
Parkinsonism Relat Disord 16:517-21. 2010..To pilot a data-driven quality care program in National Parkinson Foundation (NPF) Centers of Excellence... - Acute effects of a lateral postural assist on voluntary step initiation in patients with Parkinson's diseaseMarie Laure Mille
Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Mov Disord 22:20-7. 2007..001), and the speed of the first step became faster for PD subjects. Postural assistance affecting the interaction between posture and locomotion may have therapeutic potential for improving movement function in patients with PD... - Parkinson's disease medication use and costs following deep brain stimulationFrances M Weaver
Hines VA Hospital, Center for Management of Complex Chronic Care, Hines, Illinois 60141, USA
Mov Disord 27:1398-403. 2012..However, cumulative medication costs over 36 months were lower for the STN than for GPi patients. PD medication use and costs decreased following DBS in either target over 36 months, but cumulative costs were less for STN than for GPi... - Pathways mediating abnormal intracortical inhibition in Parkinson's diseaseColum D MacKinnon
Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Ann Neurol 58:516-24. 2005..These findings show that the low threshold inhibitory pathways mediating SICI are normal in PD. The suppression of SICI observed at higher CSIs suggests that the threshold of intracortical facilitatory pathways is decreased in PD... - Bilateral stimulation of the subthalamic nucleus in patients with Parkinson disease: a study of efficacy and safetyTanya Simuni
Parkinson's Disease and Movement Disorders Center, Pennsylvania Hospital, Philadelphia, USA
J Neurosurg 96:666-72. 2002..Serious adverse events were common in this cohort; however, only two patients suffered permanent sequelae... - Serum urate as a predictor of clinical and radiographic progression in Parkinson diseaseMichael A Schwarzschild
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, USA
Arch Neurol 65:716-23. 2008..To determine whether concentration of serum urate, a purine metabolite and potent antioxidant that has been linked to a reduced risk of Parkinson disease (PD), predicts prognosis in PD... - Long-term outcomes of bilateral subthalamic nucleus stimulation in patients with advanced Parkinson's diseaseGrace S Liang
The Parkinson's Institute, Sunnyvale, CA, USA
Stereotact Funct Neurosurg 84:221-7. 2006..We conclude that STN DBS is an effective long-term therapy for selected patients with advanced PD... - Bilateral subthalamic nucleus deep brain stimulation for advanced PD: correlation of intraoperative MER and postoperative MRI with neuropathological findingsGeorge J Counelis
Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Mov Disord 18:1062-5. 2003....
Research Grants
- Parkinson's Disease Neuroprotection TrialTanya Simuni; Fiscal Year: 2007....