L Sharma

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. doi request reprint The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study
    Leena Sharma
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, 240 East Huron, McGaw M300, Chicago, IL 60611, USA
    Ann Rheum Dis 72:235-40. 2013
  2. doi request reprint Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees
    Leena Sharma
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 58:1716-26. 2008
  3. ncbi request reprint The role of proprioceptive deficits, ligamentous laxity, and malalignment in development and progression of knee osteoarthritis
    Leena Sharma
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Ward 3 315, Chicago, IL 60611, USA
    J Rheumatol Suppl 70:87-92. 2004
  4. ncbi request reprint Physical functioning over three years in knee osteoarthritis: role of psychosocial, local mechanical, and neuromuscular factors
    Leena Sharma
    Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 48:3359-70. 2003
  5. ncbi request reprint Examination of exercise effects on knee osteoarthritis outcomes: why should the local mechanical environment be considered?
    Leena Sharma
    Division of Rheumatology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Arthritis Rheum 49:255-60. 2003
  6. pmc Varus and valgus alignment and incident and progressive knee osteoarthritis
    Leena Sharma
    Northwestern University, Chicago, IL 60611, USA
    Ann Rheum Dis 69:1940-5. 2010
  7. ncbi request reprint Nonpharmacologic management of osteoarthritis
    Leena Sharma
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Curr Opin Rheumatol 14:603-7. 2002
  8. ncbi request reprint The role of knee alignment in disease progression and functional decline in knee osteoarthritis
    L Sharma
    Northwestern University Medical School, 303 E Chicago Ave, Ward Bldg 3 315, Chicago, IL 60611, USA
    JAMA 286:188-95. 2001
  9. ncbi request reprint Epidemiology of osteoarthritis: an update
    Leena Sharma
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Curr Opin Rheumatol 18:147-56. 2006
  10. ncbi request reprint Local factors in osteoarthritis
    L Sharma
    Division of Rheumatology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Curr Opin Rheumatol 13:441-6. 2001

Detail Information

Publications51

  1. doi request reprint The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study
    Leena Sharma
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, 240 East Huron, McGaw M300, Chicago, IL 60611, USA
    Ann Rheum Dis 72:235-40. 2013
    ..The authors tested the hypothesis: in knees with normal cartilage morphology by MRI, varus is associated with incident medial cartilage damage and valgus with incident lateral damage...
  2. doi request reprint Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees
    Leena Sharma
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 58:1716-26. 2008
    ..The aim of this study was to test whether meniscal damage, meniscal extrusion, malalignment, and laxity each predicted tibiofemoral cartilage loss after controlling for the other factors...
  3. ncbi request reprint The role of proprioceptive deficits, ligamentous laxity, and malalignment in development and progression of knee osteoarthritis
    Leena Sharma
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Ward 3 315, Chicago, IL 60611, USA
    J Rheumatol Suppl 70:87-92. 2004
  4. ncbi request reprint Physical functioning over three years in knee osteoarthritis: role of psychosocial, local mechanical, and neuromuscular factors
    Leena Sharma
    Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 48:3359-70. 2003
    ....
  5. ncbi request reprint Examination of exercise effects on knee osteoarthritis outcomes: why should the local mechanical environment be considered?
    Leena Sharma
    Division of Rheumatology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Arthritis Rheum 49:255-60. 2003
  6. pmc Varus and valgus alignment and incident and progressive knee osteoarthritis
    Leena Sharma
    Northwestern University, Chicago, IL 60611, USA
    Ann Rheum Dis 69:1940-5. 2010
    ..This study tested whether alignment influences the risk of incident and progressive radiographic tibiofemoral osteoarthritis...
  7. ncbi request reprint Nonpharmacologic management of osteoarthritis
    Leena Sharma
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Curr Opin Rheumatol 14:603-7. 2002
    ..For many of these interventions, further investigation will be necessary to define their place in the management of osteoarthritis...
  8. ncbi request reprint The role of knee alignment in disease progression and functional decline in knee osteoarthritis
    L Sharma
    Northwestern University Medical School, 303 E Chicago Ave, Ward Bldg 3 315, Chicago, IL 60611, USA
    JAMA 286:188-95. 2001
    ..Few risk factors for disease progression or functional decline have been identified. Hip-knee-ankle alignment influences load distribution at the knee; varus and valgus alignment increase medial and lateral load, respectively...
  9. ncbi request reprint Epidemiology of osteoarthritis: an update
    Leena Sharma
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Curr Opin Rheumatol 18:147-56. 2006
    ..Epidemiologic studies have supplied, in addition to incidence, prevalence and risk factor data, much of what is known about the natural history of osteoarthritis...
  10. ncbi request reprint Local factors in osteoarthritis
    L Sharma
    Division of Rheumatology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Curr Opin Rheumatol 13:441-6. 2001
    ..Such strategies may be especially powerful for local factors, given the vicious cycles set in motion by these factors and the effect of these factors on neighboring joint-organ structures...
  11. ncbi request reprint The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis
    L Torres
    Department of Medicine, Feinberg School of Medicine, Northwestern University, USA
    Osteoarthritis Cartilage 14:1033-40. 2006
    ..Pain severity in knee OA is variable, ranging from barely perceptible to immobilizing. The knee lesions that contribute to pain severity have received little attention...
  12. ncbi request reprint Quadriceps strength and osteoarthritis progression in malaligned and lax knees
    Leena Sharma
    Department of Medicine, Feinberg School of Medicine, Northwestern University Medical School, 300 East Superior Avenue, Tarry Building 3 715, Chicago, Illinois 60611, USA
    Ann Intern Med 138:613-9. 2003
    ..The relationship between quadriceps strength and progression of knee osteoarthritis may differ according to these factors...
  13. ncbi request reprint Knee pain and joint loading in subjects with osteoarthritis of the knee
    D E Hurwitz
    Department of Orthopedic Surgery, Section of Rheumatology, Rush Presbyterian St Luke s Medical Cente, Chicago, Illinois 60612, USA
    J Orthop Res 18:572-9. 2000
    ..Additional long-term prospective studies are needed to determine whether increased loading during walking actually results in accelerated progression of the disease...
  14. ncbi request reprint The mechanism of the effect of obesity in knee osteoarthritis: the mediating role of malalignment
    L Sharma
    Division of Rheumatology, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 43:568-75. 2000
    ....
  15. ncbi request reprint Leg symptoms in peripheral arterial disease: associated clinical characteristics and functional impairment
    M M McDermott
    Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
    JAMA 286:1599-606. 2001
    ..Persons with lower-extremity peripheral arterial disease (PAD) are often asymptomatic or have leg symptoms other than intermittent claudication (IC)...
  16. pmc Lower extremity nerve function in patients with lower extremity ischemia
    Mary M McDermott
    Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair, Suite 200, Chicago, IL 60611, USA
    Arch Intern Med 166:1986-92. 2006
    ..We determined whether lower extremity ischemia, as measured by the ankle brachial index (ABI), is associated with impaired lower extremity nerve function...
  17. ncbi request reprint Epidemiology of osteoarthritis: an update
    Sakeba N Issa
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, 240 E Huron Street, McGaw M 300, Chicago, IL 60611, USA
    Curr Rheumatol Rep 8:7-15. 2006
    ..Predictors of function decline in osteoarthritis include lower self-efficacy, knee laxity, less aerobic exercise, worse joint proprioception, and greater knee pain...
  18. pmc Lower extremity ischemia, calf skeletal muscle characteristics, and functional impairment in peripheral arterial disease
    Mary M McDermott
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Am Geriatr Soc 55:400-6. 2007
    ..To determine whether lower ankle brachial index (ABI) levels are associated with lower calf skeletal muscle area and higher calf muscle percentage fat in persons with and without lower extremity peripheral arterial disease (PAD)...
  19. pmc Associations of borderline and low normal ankle-brachial index values with functional decline at 5-year follow-up: the WALCS (Walking and Leg Circulation Study)
    Mary M McDermott
    Department of Medicine, Northwestern University s Feinberg School of Medicine, 750 North Lake Shore Drive, Chicago, IL 60611, USA
    J Am Coll Cardiol 53:1056-62. 2009
    ..We studied associations of borderline and low normal ankle-brachial index (ABI) values with functional decline over a 5-year follow-up...
  20. pmc Within-subregion relationship between bone marrow lesions and subsequent cartilage loss in knee osteoarthritis
    Ami Kothari
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Arthritis Care Res (Hoboken) 62:198-203. 2010
    ....
  21. pmc Moving to maintain function in knee osteoarthritis: evidence from the osteoarthritis initiative
    Dorothy D Dunlop
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Arch Phys Med Rehabil 91:714-21. 2010
    ..To investigate the association between baseline physical activity and 1-year functional performance in adults with knee osteoarthritis (OA)...
  22. pmc Assessing physical activity in persons with knee osteoarthritis using accelerometers: data from the osteoarthritis initiative
    Jing Song
    Northwestern University Feinberg School of Medicine, Institute for Healthcare Studies, Chicago, Illinois 60611, USA
    Arthritis Care Res (Hoboken) 62:1724-32. 2010
    ....
  23. pmc Physical activity levels and functional performance in the osteoarthritis initiative: a graded relationship
    Dorothy D Dunlop
    Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Arthritis Rheum 63:127-36. 2011
    ..This study was undertaken to examine the cross-sectional and longitudinal relationship between self-reported physical activity and observed functional performance in adults with knee osteoarthritis (OA)...
  24. doi request reprint Asymptomatic peripheral arterial disease is associated with more adverse lower extremity characteristics than intermittent claudication
    Mary M McDermott
    Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
    Circulation 117:2484-91. 2008
    ..This study assessed functional performance, calf muscle characteristics, peripheral nerve function, and quality of life in asymptomatic persons with peripheral arterial disease (PAD)...
  25. ncbi request reprint Severity of joint pain and Kellgren-Lawrence grade at baseline are better predictors of joint space narrowing than bone scintigraphy in obese women with knee osteoarthritis
    Steven A Mazzuca
    Department of Medicine, Indiana University School of Medicine IUSM, Indianapolis, 46202, USA
    J Rheumatol 32:1540-6. 2005
    ....
  26. ncbi request reprint The natural history of anteroposterior laxity and its role in knee osteoarthritis progression
    Nimesh Dayal
    Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Arthritis Rheum 52:2343-9. 2005
    ....
  27. ncbi request reprint Lower extremity performance is associated with daily life physical activity in individuals with and without peripheral arterial disease
    Mary Mcgrae McDermott
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois, USA
    J Am Geriatr Soc 50:247-55. 2002
    ..To determine whether persons with poorer lower extremity functioning have reduced physical activity levels...
  28. ncbi request reprint Statin use and leg functioning in patients with and without lower-extremity peripheral arterial disease
    Mary Mcgrae McDermott
    Feinberg School of Medicine at Northwestern University, Chicago, Ill, USA
    Circulation 107:757-61. 2003
    ..We determined whether statin use (versus nonuse) is associated with superior lower-extremity functioning independently of cholesterol levels and other confounders in patients with and without peripheral arterial disease...
  29. pmc Depressive symptoms and lower extremity functioning in men and women with peripheral arterial disease
    Mary Mcgrae McDermott
    Department of Medicine, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA
    J Gen Intern Med 18:461-7. 2003
    ..The purpose of this study was to determine the relationship between depressive symptoms and objective measures of lower extremity functioning in persons with PAD...
  30. ncbi request reprint Impact of the fit and strong intervention on older adults with osteoarthritis
    Susan L Hughes
    Health Research and Policy Centers, University of Illinois at Chicago, 850 W Jackson Boulevard, Suite 400, Chicago, IL 60607, USA
    Gerontologist 44:217-28. 2004
    ..This study assessed the impact of a low cost, multicomponent physical activity intervention for older adults with lower extremity osteoarthritis...
  31. pmc The ratio of type II collagen breakdown to synthesis and its relationship with the progression of knee osteoarthritis
    S Cahue
    Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Osteoarthritis Cartilage 15:819-23. 2007
    ....
  32. ncbi request reprint Varus-valgus alignment in the progression of patellofemoral osteoarthritis
    September Cahue
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 50:2184-90. 2004
    ....
  33. ncbi request reprint Thrust during ambulation and the progression of knee osteoarthritis
    Alison Chang
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 50:3897-903. 2004
    ....
  34. pmc Denuded subchondral bone and knee pain in persons with knee osteoarthritis
    Kirsten Moisio
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 60:3703-10. 2009
    ..The aim of this study was to investigate whether the percent of denuded bone is associated with moderate-to-severe knee pain or frequent knee pain and longitudinally with frequent knee pain 2 years after the baseline evaluation...
  35. pmc Frequency of varus and valgus thrust and factors associated with thrust presence in persons with or at higher risk of developing knee osteoarthritis
    Alison Chang
    Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 62:1403-11. 2010
    ..We undertook this study to determine the frequency of varus and valgus thrust in African Americans and Caucasians and to identify factors associated with thrust presence...
  36. pmc The relationship between toe-out angle during gait and progression of medial tibiofemoral osteoarthritis
    Alison Chang
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Ann Rheum Dis 66:1271-5. 2007
    ..The present study was designed to test whether greater toe-out is associated with lower likelihood of medial OA progression...
  37. ncbi request reprint Long-term impact of Fit and Strong! on older adults with osteoarthritis
    Susan L Hughes
    Institute for Health Research and Policy, University of Illinois at Chicago, 1747 W Roosevelt Road, Room 558, Chicago, IL 60608, USA
    Gerontologist 46:801-14. 2006
    ..We present final outcomes from the multiple-component Fit and Strong! intervention for older adults with lower extremity osteoarthritis...
  38. ncbi request reprint The influence of alignment on risk of knee osteoarthritis progression according to baseline stage of disease
    Rui Cerejo
    Division of Rheumatology, Northwestern University Medical School, 303 East Chicago Avenue, Ward Building 3 315, Chicago, IL 60611, USA
    Arthritis Rheum 46:2632-6. 2002
    ..Our goal was to explore the impact of alignment on subsequent progression of knee OA according to the baseline stage of disease...
  39. ncbi request reprint Hip abduction moment and protection against medial tibiofemoral osteoarthritis progression
    Alison Chang
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, 240 East Huron, Chicago, IL 60611, USA
    Arthritis Rheum 52:3515-9. 2005
    ..To test the hypothesis that a greater peak internal hip abduction moment is associated with a reduced likelihood of ipsilateral medial tibiofemoral osteoarthritis (OA) progression...
  40. ncbi request reprint Full-limb and knee radiography assessments of varus-valgus alignment and their relationship to osteoarthritis disease features by magnetic resonance imaging
    Sakeba N Issa
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 57:398-406. 2007
    ....
  41. pmc Subregional effects of meniscal tears on cartilage loss over 2 years in knee osteoarthritis
    Alison Chang
    Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Ann Rheum Dis 70:74-9. 2011
    ..This study examined the association between a tear within a specific meniscal segment and subsequent 2-year cartilage loss in subregions that the torn segment overlies...
  42. ncbi request reprint Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial
    Kenneth D Brandt
    Indiana University School of Medicine, Rheumatology Division, Indianapolis, IN 46202 5100, USA
    Arthritis Rheum 52:2015-25. 2005
    ..To confirm preclinical data suggesting that doxycycline can slow the progression of osteoarthritis (OA). The primary outcome measure was joint space narrowing (JSN) in the medial tibiofemoral compartment...
  43. doi request reprint Does knee malalignment mediate the effects of quadriceps strengthening on knee adduction moment, pain, and function in medial knee osteoarthritis? A randomized controlled trial
    Boon Whatt Lim
    Center for Health, Exercise, and Sports Medicine, School of Physiotherapy, The University of Melbourne, Victoria, Australia
    Arthritis Rheum 59:943-51. 2008
    ..To examine whether the effects of 12 weeks of quadriceps strengthening on the knee adduction moment, pain, and function in people with medial knee osteoarthritis (OA) differ in those with and without varus malalignment...
  44. pmc Overweight: advancing our understanding of its impact on the knee and the hip
    Leena Sharma
    Ann Rheum Dis 66:141-2. 2007
  45. ncbi request reprint Is a strong quadriceps muscle bad for a patient with knee osteoarthritis?
    Leena Sharma
    Ann Intern Med 140:150. 2004
  46. ncbi request reprint Glycosaminoglycan distribution in cartilage as determined by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): potential clinical applications
    Ashley Williams
    Department of Radiology, Beth Israel Deaconess Medical Center, 4 Blackfan Cir, Rm 147, Boston, MA 02115, USA
    AJR Am J Roentgenol 182:167-72. 2004
    ..We sought to describe a range of in vivo observations of glycosaminoglycan distribution in knee cartilage using the delayed gadolinium-enhanced MRI of cartilage technique...
  47. ncbi request reprint Work Group recommendations: 2002 Exercise and Physical Activity Conference, St Louis, Missouri
    David Krebs
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Arthritis Rheum 49:261-2. 2003
  48. ncbi request reprint Subject retention and adherence in a randomized placebo-controlled trial of a disease-modifying osteoarthritis drug
    Steven A Mazzuca
    Indiana University School of Medicine, Indianapolis, 46202 5100, USA
    Arthritis Rheum 51:933-40. 2004
    ..To describe the methods by which remarkable levels of subject retention and adherence were achieved in a 30-month multicenter randomized placebo-controlled trial (RCT) of a disease-modifying osteoarthritis drug (DMOAD)...
  49. ncbi request reprint The role of varus and valgus alignment in knee osteoarthritis
    Leena Sharma
    Arthritis Rheum 56:1044-7. 2007
  50. ncbi request reprint Delayed gadolinium-enhanced magnetic resonance imaging of cartilage in knee osteoarthritis: findings at different radiographic stages of disease and relationship to malalignment
    Ashley Williams
    Beth Israel Deaconess Medical Center and Harvard Medical School, 4 Blackfan Circle, Boston, MA 02115, USA
    Arthritis Rheum 52:3528-35. 2005
    ....
  51. ncbi request reprint Potential strategies to reduce medial compartment loading in patients with knee osteoarthritis of varying severity: reduced walking speed
    Anne M√ľndermann
    Stanford University, Stanford, California 94305 3030, USA
    Arthritis Rheum 50:1172-8. 2004
    ..To determine whether reducing walking speed is a strategy used by patients with knee osteoarthritis (OA) of varying disease severity to reduce the maximum knee adduction moment...

Research Grants27

  1. Strength, Laxity, and Position Sense in OA Progression
    Leena Sharma; Fiscal Year: 2006
    ..I He proposed study will provide important information regarding these factors that will be directly applicable to the development of strategies to prevent disease progression and disability. ..
  2. Laxity and Malalignment in a Large Cohort Study of OA
    Leena Sharma; Fiscal Year: 2006
    ..abstract_text> ..
  3. Relationship of Hip Muscle Group Weakness to Deterioration of the OA Knee by MRI
    Leena Sharma; Fiscal Year: 2009
    ..The results of the proposed study will inform therapy of knee OA that takes advantage of the hip musculature. ..
  4. Thrust and Meniscal Lesions in Knee OA in the OAI
    Leena Sharma; Fiscal Year: 2009
    ..Adjustment will be made for potential confounders, which, in specific analyses, may include disease severity, disease progression, age, gender, BMI, physical activity, and injury. ..
  5. Relationship of Hip Muscle Group Weakness to Deterioration of the OA Knee by MRI
    Leena Sharma; Fiscal Year: 2010
    ..The results of the proposed study will inform therapy of knee OA that takes advantage of the hip musculature. ..
  6. Progression of knee OA: The role of local factors
    Leena Sharma; Fiscal Year: 2006
    ....
  7. Dynamic Instability in Persons with Knee Osteoarthritis
    Leena Sharma; Fiscal Year: 2010
    ..This is a key, modifiable component of the knee joint environment that has received little attention in knee OA, despite a potentially large role for stability in the preservation of knee joint integrity and person-level functioning. ..