L Sharma

..The authors tested the hypothesis: in knees with normal cartilage morphology by MRI, varus is associated with incident medial cartilage damage and valgus with incident lateral damage...

..For many of these interventions, further investigation will be necessary to define their place in the management of osteoarthritis...

..The aim of this study was to test whether meniscal damage, meniscal extrusion, malalignment, and laxity each predicted tibiofemoral cartilage loss after controlling for the other factors...

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..This study tested whether alignment influences the risk of incident and progressive radiographic tibiofemoral osteoarthritis...

..Epidemiologic studies have supplied, in addition to incidence, prevalence and risk factor data, much of what is known about the natural history of osteoarthritis...

..Such strategies may be especially powerful for local factors, given the vicious cycles set in motion by these factors and the effect of these factors on neighboring joint-organ structures...

..Few risk factors for disease progression or functional decline have been identified. Hip-knee-ankle alignment influences load distribution at the knee; varus and valgus alignment increase medial and lateral load, respectively...

..The contribution of bone marrow lesions to pain severity appeared to require the presence of bone attrition...

..Subset-specific approaches beyond strengthening exercises should be developed to enhance joint-protective muscle activity...

..Additional long-term prospective studies are needed to determine whether increased loading during walking actually results in accelerated progression of the disease...

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..Persons with lower-extremity peripheral arterial disease (PAD) are often asymptomatic or have leg symptoms other than intermittent claudication (IC)...

..To determine whether lower ankle brachial index (ABI) levels are associated with lower calf skeletal muscle area and higher calf muscle percentage fat in persons with and without lower extremity peripheral arterial disease (PAD)...

..Predictors of function decline in osteoarthritis include lower self-efficacy, knee laxity, less aerobic exercise, worse joint proprioception, and greater knee pain...

..We determined whether lower extremity ischemia, as measured by the ankle brachial index (ABI), is associated with impaired lower extremity nerve function...

..We studied associations of borderline and low normal ankle-brachial index (ABI) values with functional decline over a 5-year follow-up...

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..To investigate the association between baseline physical activity and 1-year functional performance in adults with knee osteoarthritis (OA)...

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..This study was undertaken to examine the cross-sectional and longitudinal relationship between self-reported physical activity and observed functional performance in adults with knee osteoarthritis (OA)...

..This study assessed functional performance, calf muscle characteristics, peripheral nerve function, and quality of life in asymptomatic persons with peripheral arterial disease (PAD)...

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..To determine whether persons with poorer lower extremity functioning have reduced physical activity levels...

..We determined whether statin use (versus nonuse) is associated with superior lower-extremity functioning independently of cholesterol levels and other confounders in patients with and without peripheral arterial disease...

..The purpose of this study was to determine the relationship between depressive symptoms and objective measures of lower extremity functioning in persons with PAD...

..This study assessed the impact of a low cost, multicomponent physical activity intervention for older adults with lower extremity osteoarthritis...

..Knees in which AP laxity decreased had less medial joint space loss than did knees without a decrease in AP laxity. The knee joint may successfully compensate for AP laxity; the absence of such compensation may have a deleterious effect...

..Varus thrust increased the odds of progression among varus-aligned knees considered separately, suggesting that knees with a thrust are a subset of varus-aligned knees at particularly high risk for progression of OA...

..We undertook this study to determine the frequency of varus and valgus thrust in African Americans and Caucasians and to identify factors associated with thrust presence...

..Interventions that address the stress imposed by alignment on the PF compartments may delay PF OA progression and should be developed...

..The present study was designed to test whether greater toe-out is associated with lower likelihood of medial OA progression...

..The aim of this study was to investigate whether the percent of denuded bone is associated with moderate-to-severe knee pain or frequent knee pain and longitudinally with frequent knee pain 2 years after the baseline evaluation...

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..We present final outcomes from the multiple-component Fit and Strong! intervention for older adults with lower extremity osteoarthritis...

..The likelihood of medial tibiofemoral OA progression was reduced 50% per 1 unit of hip abduction moment...

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..This study examined the association between a tear within a specific meniscal segment and subsequent 2-year cartilage loss in subregions that the torn segment overlies...

..To confirm preclinical data suggesting that doxycycline can slow the progression of osteoarthritis (OA). The primary outcome measure was joint space narrowing (JSN) in the medial tibiofemoral compartment...

..To examine whether the effects of 12 weeks of quadriceps strengthening on the knee adduction moment, pain, and function in people with medial knee osteoarthritis (OA) differ in those with and without varus malalignment...

..Overall, these results suggest the need for further research into the biochemical changes seen during disease progression and the effects of therapeutic interventions...

..To determine whether reducing walking speed is a strategy used by patients with knee osteoarthritis (OA) of varying disease severity to reduce the maximum knee adduction moment...

..43, P = 0.02). CONCLUSION: The biochemical information provided by dGEMRIC scans may augment radiography by improving the differentiation of disease status within a given radiographic grade, especially in early OA...

..To describe the methods by which remarkable levels of subject retention and adherence were achieved in a 30-month multicenter randomized placebo-controlled trial (RCT) of a disease-modifying osteoarthritis drug (DMOAD)...

..I He proposed study will provide important information regarding these factors that will be directly applicable to the development of strategies to prevent disease progression and disability. ..

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..The results of the proposed study will inform therapy of knee OA that takes advantage of the hip musculature. ..

..Adjustment will be made for potential confounders, which, in specific analyses, may include disease severity, disease progression, age, gender, BMI, physical activity, and injury. ..

..The results of the proposed study will inform therapy of knee OA that takes advantage of the hip musculature. ..

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..This is a key, modifiable component of the knee joint environment that has received little attention in knee OA, despite a potentially large role for stability in the preservation of knee joint integrity and person-level functioning. ..