Affiliation: Northwestern University
- Degradation of tau protein by puromycin-sensitive aminopeptidase in vitroSoma Sengupta
Department of Cell and Molecular Biology, Feinberg School of Medicine at Northwestern University
Biochemistry 45:15111-9. 2006..These results are consistent with observations that PSA modulates tau levels in vivo and suggest that this enzyme may be involved in tau degradation in human brain...
- Prestin-based outer hair cell motility is necessary for mammalian cochlear amplificationPeter Dallos
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
Neuron 58:333-9. 2008..These animals have knockout-like behavior, demonstrating that prestin-based electromotility is required for cochlear amplification...
- A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegenerationStanislav L Karsten
Program in Neurogenetics, Department of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Neuron 51:549-60. 2006..Further investigation is warranted in defining the role of PSA and other genes identified here as potential therapeutic targets in tauopathy...