TIMOTHY SEARL

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc A1 Adenosine Receptor-Mediated Inhibition of Parasympathetic Neuromuscular Transmission in Human and Murine Urinary Bladder
    Timothy J Searl
    Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois T J S, E M S and Division of Urology, Southern Illinois University School of Medicine, Springfield, Illinois D I D, S R A, A M E Z, K T M
    J Pharmacol Exp Ther 356:116-22. 2016
  2. pmc Modulation of purinergic neuromuscular transmission by phorbol dibutyrate is independent of protein kinase C in murine urinary bladder
    T J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Pharmacol Exp Ther 342:312-7. 2012
  3. pmc Evidence for constitutively-active adenosine receptors at mammalian motor nerve endings
    Timothy J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Eur J Pharmacol 685:38-41. 2012
  4. ncbi request reprint Modulation of calcium-dependent and -independent acetylcholine release from motor nerve endings
    Timothy J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern Feinberg School of Medicine, Chicago IL 60611, USA
    J Mol Neurosci 30:215-8. 2006
  5. pmc Mechanisms of neuromodulation as dissected using Sr2+ at motor nerve endings
    Timothy J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL 60611, USA
    J Neurophysiol 99:2779-88. 2008
  6. pmc The mechanism for prejunctional enhancement of neuromuscular transmission by ethanol in the mouse
    T J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Pharmacol Exp Ther 335:465-71. 2010
  7. pmc Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction
    T J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL, USA
    Br J Pharmacol 161:659-67. 2010
  8. pmc Regulation by Rab3A of an endogenous modulator of neurotransmitter release at mouse motor nerve endings
    Jody K Hirsh
    Department of Molecular Pharmacology and Biological Chemistry S 215, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Physiol 545:337-43. 2002
  9. pmc Phorbol esters and neurotransmitter release: more than just protein kinase C?
    Eugene M Silinsky
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, U S A
    Br J Pharmacol 138:1191-201. 2003
  10. pmc Modulation of Ca(2+)-dependent and Ca(2+)-independent miniature endplate potentials by phorbol ester and adenosine in frog
    Timothy J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Br J Pharmacol 145:954-62. 2005

Research Grants

Collaborators

Detail Information

Publications10

  1. pmc A1 Adenosine Receptor-Mediated Inhibition of Parasympathetic Neuromuscular Transmission in Human and Murine Urinary Bladder
    Timothy J Searl
    Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois T J S, E M S and Division of Urology, Southern Illinois University School of Medicine, Springfield, Illinois D I D, S R A, A M E Z, K T M
    J Pharmacol Exp Ther 356:116-22. 2016
    ..8-Cyclopentyltheophylline, a selective A1 receptor antagonist, reversed the effects of CPA on EJP amplitudes with no effect of spontaneous EJPs, confirming the role of A1 receptors in mediating these effects. ..
  2. pmc Modulation of purinergic neuromuscular transmission by phorbol dibutyrate is independent of protein kinase C in murine urinary bladder
    T J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Pharmacol Exp Ther 342:312-7. 2012
    ..These results suggest that PDBu increases the purinergic component of detrusor transmission through increasing neurogenic ATP release via a PKC-independent mechanism...
  3. pmc Evidence for constitutively-active adenosine receptors at mammalian motor nerve endings
    Timothy J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Eur J Pharmacol 685:38-41. 2012
    ....
  4. ncbi request reprint Modulation of calcium-dependent and -independent acetylcholine release from motor nerve endings
    Timothy J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern Feinberg School of Medicine, Chicago IL 60611, USA
    J Mol Neurosci 30:215-8. 2006
    ..However, each of these core components of the release machinery is individually essential for the neurotransmitter release process. Therefore, we decided to approach this problem by alternative means...
  5. pmc Mechanisms of neuromodulation as dissected using Sr2+ at motor nerve endings
    Timothy J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL 60611, USA
    J Neurophysiol 99:2779-88. 2008
    ..The results demonstrate both the utility of the binomial distribution in Sr2+ solutions and the dual effects of cyclic AMP on both PKA-dependent and PKA-independent processes at the amphibian neuromuscular junction...
  6. pmc The mechanism for prejunctional enhancement of neuromuscular transmission by ethanol in the mouse
    T J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Pharmacol Exp Ther 335:465-71. 2010
    ..Identifying the mechanism through which ethanol enhances neurotransmitter release at the neuromuscular junction may be useful in determining the processes underlying the enhancement of neurotransmitter release at other synapses...
  7. pmc Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction
    T J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL, USA
    Br J Pharmacol 161:659-67. 2010
    ..Here, we report on the effects of ethanol on evoked neuromuscular transmission and the interaction of ethanol with non-depolarizing blocking drugs...
  8. pmc Regulation by Rab3A of an endogenous modulator of neurotransmitter release at mouse motor nerve endings
    Jody K Hirsh
    Department of Molecular Pharmacology and Biological Chemistry S 215, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Physiol 545:337-43. 2002
    ..CPT had no effect on the pattern of responses recorded during repetitive stimulation in either strain. The results suggest that Rab3A reduces the potency of adenosine as an endogenous mediator of neuromuscular depression...
  9. pmc Phorbol esters and neurotransmitter release: more than just protein kinase C?
    Eugene M Silinsky
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, U S A
    Br J Pharmacol 138:1191-201. 2003
    ..Indeed, Munc13 and its invertebrate homologues are the main players in priming the secretory apparatus for its critical function in the exocytosis process...
  10. pmc Modulation of Ca(2+)-dependent and Ca(2+)-independent miniature endplate potentials by phorbol ester and adenosine in frog
    Timothy J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Br J Pharmacol 145:954-62. 2005
    ....

Research Grants1

  1. Dissection of Ethanol Actions on Cholinergic Nerve Endings
    TIMOTHY SEARL; Fiscal Year: 2008
    ..Our preliminary data with botulinums toxins demonstrate that the synaptic vesicle protein synaptobrevin is an important target for the effects of ethanol. [unreadable] [unreadable] [unreadable] [unreadable]..