Paul Schumacker

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel
    Gilles Lebuffe
    Department of Medicine, Emergency Resuscitation Center, University of Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 284:H299-308. 2003
  2. ncbi request reprint Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction
    Gregory B Waypa
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Novartis Found Symp 272:176-92; discussion 192-5, 214-7. 2006
  3. pmc ROS-mediated PARP activity undermines mitochondrial function after permeability transition pore opening during myocardial ischemia-reperfusion
    Jacqueline M Schriewer
    Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Am Heart Assoc 2:e000159. 2013
  4. pmc Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation
    Gregory B Waypa
    Department of Pediatrics, Division of Neonatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Am J Respir Crit Care Med 187:424-32. 2013
  5. pmc Lung cell hypoxia: role of mitochondrial reactive oxygen species signaling in triggering responses
    Paul T Schumacker
    Department of Pediatrics, Division of Neonatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Am Thorac Soc 8:477-84. 2011
  6. pmc SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF
    Paul T Schumacker
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, 310 E Superior St Searle Bldg 4 685, Chicago, IL 60611, USA
    Cancer Cell 19:299-300. 2011
  7. ncbi request reprint Reactive oxygen species in cancer cells: live by the sword, die by the sword
    Paul T Schumacker
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Cell 10:175-6. 2006
  8. doi request reprint A tumor suppressor SIRTainty
    Paul T Schumacker
    Department of Pediatrics, Robert F Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cancer Cell 17:5-6. 2010
  9. pmc Is enough oxygen too much?
    Paul T Schumacker
    Division of Neonatology, Department of Pediatrics, Northwestern University, Feinberg School of Medicine, 310 E, Superior St, Morton Bldg 4 685, Chicago, IL 60611, USA
    Crit Care 14:191. 2010
  10. pmc Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis
    Robert D Guzy
    Department of Pediatrics, Northwestern University, 303 East Chicago Ave, Ward Bldg 12 191, Chicago, IL 60611
    Mol Cell Biol 28:718-31. 2008

Research Grants

  1. Respiratory and Metabolic Adaptation to Hypoxia
    Paul T Schumacker; Fiscal Year: 2010
  2. OXYGEN SENSING AND CELL SIGNALING IN HYPOXIA
    Paul Schumacker; Fiscal Year: 2001
  3. O2 Sensing in Hypoxic Pulmonary Vasoconstriction
    Paul Schumacker; Fiscal Year: 2009
  4. RESPIRATORY AND METABOLIC ADAPTATION TO CELLULAR HYPOXIA
    Paul Schumacker; Fiscal Year: 2006
  5. O2 SENSING BY MITOCHONDRIA DURING INTERMITTENT HYPOXIA
    Paul Schumacker; Fiscal Year: 2003
  6. RESPIRATORY AND METABOLIC ADAPTATION TO CELLULAR HYPOXIA
    Paul Schumacker; Fiscal Year: 2000
  7. MICROVASCULAR CONTROL OF 02 EXTRACTION IN HYPOXIA
    Paul Schumacker; Fiscal Year: 1993
  8. MECHANISMS FOR A DEPENDENCE OF 02 UPTAKE ON DELIVERY
    Paul Schumacker; Fiscal Year: 1993

Collaborators

Detail Information

Publications53

  1. ncbi request reprint ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel
    Gilles Lebuffe
    Department of Medicine, Emergency Resuscitation Center, University of Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 284:H299-308. 2003
    ..We conclude that ROS can trigger preconditioning by causing activation of the K(ATP) channel, which then induces generation of ROS and NO that are both required for preconditioning protection...
  2. ncbi request reprint Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction
    Gregory B Waypa
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Novartis Found Symp 272:176-92; discussion 192-5, 214-7. 2006
    ..Below we will discuss the aspects of this novel model of O2 sensing and its applicability to the HPV response...
  3. pmc ROS-mediated PARP activity undermines mitochondrial function after permeability transition pore opening during myocardial ischemia-reperfusion
    Jacqueline M Schriewer
    Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Am Heart Assoc 2:e000159. 2013
    ..We therefore wanted to determine whether oxidant stress, mPTP opening, and PARP activity contribute to the same death pathway after myocardial I/R...
  4. pmc Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation
    Gregory B Waypa
    Department of Pediatrics, Division of Neonatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Am J Respir Crit Care Med 187:424-32. 2013
    ..Hence, genetic animal models are required to test mechanistic hypotheses...
  5. pmc Lung cell hypoxia: role of mitochondrial reactive oxygen species signaling in triggering responses
    Paul T Schumacker
    Department of Pediatrics, Division of Neonatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Am Thorac Soc 8:477-84. 2011
    ..Although the specific targets of reactive oxygen species signals are not fully understood, this signaling pathway is critical for development and for normal lung responses in the newborn and the mature lung...
  6. pmc SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF
    Paul T Schumacker
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, 310 E Superior St Searle Bldg 4 685, Chicago, IL 60611, USA
    Cancer Cell 19:299-300. 2011
    ..This shift is mediated by an increase in cellular reactive oxygen species (ROS) generation that amplifies HIF-α stabilization and HIF-dependent gene expression, thereby driving the tumor phenotype...
  7. ncbi request reprint Reactive oxygen species in cancer cells: live by the sword, die by the sword
    Paul T Schumacker
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Cell 10:175-6. 2006
    ..In this respect, it appears that tumor cells may die by the same systems they require...
  8. doi request reprint A tumor suppressor SIRTainty
    Paul T Schumacker
    Department of Pediatrics, Robert F Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cancer Cell 17:5-6. 2010
    ..show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth...
  9. pmc Is enough oxygen too much?
    Paul T Schumacker
    Division of Neonatology, Department of Pediatrics, Northwestern University, Feinberg School of Medicine, 310 E, Superior St, Morton Bldg 4 685, Chicago, IL 60611, USA
    Crit Care 14:191. 2010
    ..They suggest that 'permissive hypoxia' represents a therapeutic possibility. But before we turn down the inspired O2 levels we should consider the broader effects of hypoxia on tissue repair in critical illness...
  10. pmc Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis
    Robert D Guzy
    Department of Pediatrics, Northwestern University, 303 East Chicago Ave, Ward Bldg 12 191, Chicago, IL 60611
    Mol Cell Biol 28:718-31. 2008
    ..Therefore, differences in ROS production, HIF proliferation, and cell proliferation contribute to the differences in tumor phenotype in cells lacking SdhB as opposed to those lacking SdhA...
  11. pmc Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells
    Gregory B Waypa
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Circ Res 106:526-35. 2010
    ..Recent studies have implicated mitochondrial reactive oxygen species (ROS) in regulating hypoxic pulmonary vasoconstriction (HPV), but controversy exists regarding whether hypoxia increases or decreases ROS generation...
  12. pmc Hyperoxia increases phosphodiesterase 5 expression and activity in ovine fetal pulmonary artery smooth muscle cells
    Kathryn N Farrow
    Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Circ Res 102:226-33. 2008
    ..These data suggest that PDE5 expression and activity play a critical role in modulating neonatal pulmonary vascular tone in response to common clinical treatments for PPHN, such as oxygen and inhaled NO...
  13. pmc Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia
    Eric L Bell
    The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Cell Biol 27:5737-45. 2007
    ..These findings provide genetic evidence that hypoxia utilizes mitochondrial ROS as signaling molecules to activate HIF-dependent extension of replicative life span...
  14. pmc Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family
    Andrew M Evens
    Lymphoma Program, Division of Hematology Oncology, and Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA
    Br J Haematol 141:676-80. 2008
    ..g. 44% DLBCL vs. 11% of FL cases with moderate-to-high expression of HIF-1alpha and HIF-2alpha, P = 0.0017). These data demonstrate that HIF and the thioredoxin family are abnormally activated in lymphoma...
  15. pmc Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-aminoadenosine
    Mala Shanmugam
    Robert H Lurie Comprehensive Cancer Center, MD Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    J Biol Chem 284:26816-30. 2009
    ..This study establishes the potential of metabolic targeting as a broader means to kill and sensitize myeloma and identifies a compound that can achieve this goal...
  16. pmc Hypoxia increases ROS signaling and cytosolic Ca(2+) in pulmonary artery smooth muscle cells of mouse lungs slices
    Jennifer R Desireddi
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60611, USA
    Antioxid Redox Signal 12:595-602. 2010
    ..Collectively, these results indicate that an increase in cytosolic ROS signaling is required for the increase in [Ca(2+)](i) in PASMCs in precision-cut mouse lung slices during the acute HPV response...
  17. ncbi request reprint Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells
    Gregory B Waypa
    Department of Pediatrics, Division of Neonatology, Northwestern University, Chicago, IL 60611, USA
    Circ Res 99:970-8. 2006
    ..These results demonstrate that hypoxia triggers increases in PASMC [Ca(2+)](i) by augmenting ROS signaling from the mitochondria...
  18. ncbi request reprint Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes
    Gregory B Waypa
    Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, Ill 60637, USA
    Circ Res 91:719-26. 2002
    ....
  19. pmc Interdependence of HIF-1α and TGF-β/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression
    Rajit K Basu
    Divisions of Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Am J Physiol Renal Physiol 300:F898-905. 2011
    ..Taken together, our data demonstrate cooperation in signaling between Smad3 and HIF-1α and suggest a new paradigm in which HIF-1α is necessary for normoxic, TGF-β1-stimulated renal cell fibrogenesis...
  20. pmc Mitochondrial oxidant stress increases PDE5 activity in persistent pulmonary hypertension of the newborn
    Kathryn N Farrow
    Department of Pediatrics, Northwestern University, Chicago, IL 60611, United States
    Respir Physiol Neurobiol 174:272-81. 2010
    ..We conclude that baseline PDE5 activity and oxidative stress is increased in PPHN PASMC, and scavenging H2O2 is sufficient to block oxidant-mediated increases in PDE5 activity in PPHN...
  21. pmc Hypoxia-induced changes in pulmonary and systemic vascular resistance: where is the O2 sensor?
    Gregory B Waypa
    Department of Pediatrics, Division of Neonatology, Northwestern University, Morton Building 4 685, 310 East Superior St, Chicago, IL 60611, USA
    Respir Physiol Neurobiol 174:201-11. 2010
    ....
  22. pmc Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP
    Andrew M Evens
    DO, Division of Hematology Oncology, 676 N St Clair St, Suite 850, Chicago, IL 60611, USA
    J Clin Oncol 28:1017-24. 2010
    ..CONCLUSION The expression of HIF-1alpha protein is an important independent favorable prognostic factor for survival in patients with DLBCL treated with R-CHOP...
  23. pmc Epithelial cell death is an important contributor to oxidant-mediated acute lung injury
    G R Scott Budinger
    Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 240 East Huron Street, Chicago, IL 60611, USA
    Am J Respir Crit Care Med 183:1043-54. 2011
    ..Acute lung injury and the acute respiratory distress syndrome are characterized by increased lung oxidant stress and apoptotic cell death. The contribution of epithelial cell apoptosis to the development of lung injury is unknown...
  24. pmc Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS
    Tatyana A Klimova
    Department of Medicine, Northwestern University, Chicago, Illinois, USA
    FASEB J 23:783-94. 2009
    ..Collectively, these results indicate a ROS-independent but p53/pRb-dependent senescence mechanism during hyperoxia...
  25. pmc Prolonged hypoxia increases ROS signaling and RhoA activation in pulmonary artery smooth muscle and endothelial cells
    Annie Y Chi
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60611, USA
    Antioxid Redox Signal 12:603-10. 2010
    ..Thus, the ROS signal is sustained during prolonged hypoxia in PASMCs and PAECs, and this is sufficient but not required for RhoA activation...
  26. ncbi request reprint Current paradigms in cellular oxygen sensing
    Paul T Schumacker
    Department of Medicine, MC6026, Chicago, IL 60637, USA
    Adv Exp Med Biol 543:57-71. 2003
    ..The sources of these oxidant signals are thought to include members of the NAD(P)H oxidase system and/or mitochondria. This article reviews evidence for and against the involvement of these systems in the O2 sensing pathway...
  27. ncbi request reprint Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia
    Daryl P Pearlstein
    Departments of Medicine and Surgery, The University of Chicago, Chicago, Illinois, USA
    Arterioscler Thromb Vasc Biol 22:566-73. 2002
    ....
  28. ncbi request reprint Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes
    Zuo Hui Shao
    Tang Center for Herbal Medicine Research, Emergency Resuscitation Research Center, and Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Cardiovasc Toxicol 3:331-9. 2003
    ..Consumers may take higher doses of dietary supplements in the belief that natural herbs have no major side effects. This study demonstrates that dosages of GSPE should be optimized to avoid potential harmful pro-oxidant effects...
  29. ncbi request reprint Oxygen sensing in hypoxic pulmonary vasoconstriction: using new tools to answer an age-old question
    Gregory B Waypa
    Department of Pediatrics, North Western University, Ward Building 12 191, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Exp Physiol 93:133-8. 2008
    ..However, recent developments in genetic techniques and redox-sensitive probes may allow us eventually to reach a consensus concerning the O(2) sensing mechanism underlying HPV...
  30. ncbi request reprint Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing
    Gregory B Waypa
    Dept of Medicine MC6026, The University of Chicago, 5841 South Maryland Ave, Chicago, IL 60637, USA
    J Appl Physiol 98:404-14. 2005
    ..This article summarizes the potential involvement of a mitochondria-induced ROS signal in these two very different models...
  31. ncbi request reprint Mitochondrial complex III is required for hypoxia-induced ROS production and gene transcription in yeast
    Robert D Guzy
    Pulmonary and Critical Care, Department of Medicine, The University of Chicago, Chicago, Illinois 60611, USA
    Antioxid Redox Signal 9:1317-28. 2007
    ..These findings indicate that the mitochondrial O2 sensing mechanism is highly conserved throughout evolution...
  32. ncbi request reprint Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
    Robert D Guzy
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Cell Metab 1:401-8. 2005
    ..These results demonstrate that mitochondria function as O(2) sensors and signal hypoxic HIF-1 alpha and HIF-2 alpha stabilization by releasing ROS to the cytosol...
  33. ncbi request reprint Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes
    Zuo Hui Shao
    Department of Medicine, Section of Emergency Medicine, University of Chicago, 5841 S Maryland Avenue, MC 5068, Chicago, IL 60637, USA
    Pharmacol Res 47:463-9. 2003
    ..Its effect does not require PKC, mito K(ATP) channel, or NO synthase, presumably because it acts by reactive oxygen species scavenging and iron chelating directly...
  34. ncbi request reprint O(2) sensing in hypoxic pulmonary vasoconstriction: the mitochondrial door re-opens
    Gregory B Waypa
    Department of Medicine MC6026, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Respir Physiol Neurobiol 132:81-91. 2002
    ..This increase would then lead to the activation of an oxidant-sensitive signaling transduction pathway leading to HPV. This article summarizes the potential involvement of mitochondria in these two very different models...
  35. ncbi request reprint Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes
    Andre Kulisz
    Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1324-9. 2002
    ....
  36. ncbi request reprint Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro
    Zuo Hui Shao
    Tang Center for Herbal Medicine Research, Emergency Medicine and Emergency Resuscitation Center, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Am J Chin Med 32:89-95. 2004
    ..This has the advantage of avoiding possible side effects that may arise when higher doses of a single herb are used in an attempt to achieve a maximum degree of antioxidant activity...
  37. ncbi request reprint Hypoxic conformance of metabolism in primary rat hepatocytes: a model of hepatic hibernation
    Ram M Subramanian
    Section of Gastroenterology and Hepatology, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Hepatology 45:455-64. 2007
    ....
  38. pmc Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution
    Saul Soberanes
    Division of Pulmonary and Critical Care Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 284:2176-86. 2009
    ..We conclude that particulate matter air pollution induces the generation of ROS primarily from site III of the mitochondrial electron transport chain and that these ROS activate the intrinsic apoptotic pathway through ASK1, JNK, and p53...
  39. ncbi request reprint Nitric oxide during ischemia attenuates oxidant stress and cell death during ischemia and reperfusion in cardiomyocytes
    Hirotaro Iwase
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Free Radic Biol Med 43:590-9. 2007
    ..This response is associated with a remarkable attenuation of cell death, suggesting that ischemic cell death may be a regulated event...
  40. pmc Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide
    Olesya A Ulanovskaya
    Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    Nat Chem Biol 4:418-24. 2008
    ..This result provided the molecular basis for the potent antiproliferative activity of this class of marine macrolides, thus identifying them as new biochemical tools for investigation of eukaryotic energy metabolism...
  41. ncbi request reprint Oxidant stress during simulated ischemia primes cardiomyocytes for cell death during reperfusion
    Emmanuel Robin
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:19133-43. 2007
    ..These findings reveal that, in isolated cardiomyocytes, sublethal H(2)O(2) generation during simulated ischemia regulates cell death during simulated reperfusion, which is mediated by the reperfusion oxidant burst...
  42. ncbi request reprint Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia
    Robert D Guzy
    Department of Pediatrics, North Western University, Chicago, IL 60611, USA
    Exp Physiol 91:807-19. 2006
    ....
  43. pmc Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels
    Paul T Mungai
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Mol Cell Biol 31:3531-45. 2011
    ....
  44. ncbi request reprint Hypoxia-inducible factor-1 (HIF-1)
    Paul T Schumacker
    Department of Pediatrics, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
    Crit Care Med 33:S423-5. 2005
  45. pmc AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis
    István Vadász
    Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Invest 118:752-62. 2008
    ....
  46. ncbi request reprint Physiological hypoxia promotes survival of cultured cortical neurons
    Dongdong Li
    Department of Neurology MC2030, The University of Chicago, 5841S Maryland Avenue, Chicago, IL 60637, USA
    Eur J Neurosci 22:1319-26. 2005
    ..These data point to the dynamic role played by hypoxia, associated with HIF-1 up-regulation, in promoting survival of cortical neurons, in part through stimulation of VEGF expression and release...
  47. ncbi request reprint Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants
    Mir H Ali
    Department of Medicine, Section of Pulmonary and Critical Care, University of Chicago, Illinois, USA
    Am J Physiol Lung Cell Mol Physiol 291:L38-45. 2006
    ..These findings indicate that mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves PKC...
  48. pmc Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation
    Kyle D Mansfield
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cell Metab 1:393-9. 2005
    ..These results provide genetic evidence indicating that mtROS act upstream of prolyl hydroxylases in regulating HIF-1 alpha and HIF-2 alpha in this O(2)-sensing pathway...
  49. ncbi request reprint Cell death during ischemia: relationship to mitochondrial depolarization and ROS generation
    Jacques Levraut
    Pulmonary and Critical Care Medicine, University of Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 284:H549-58. 2003
    ..Collectively, these studies identify a central role for mitochondrial ROS generation during ischemia in the mitochondrial depolarization and subsequent cell death induced by ischemia and reperfusion in this model...
  50. ncbi request reprint Angiotensin II signaling in the brain: compartmentalization of redox signaling?
    Paul T Schumacker
    Circ Res 91:982-4. 2002
  51. ncbi request reprint Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stress
    Zuo Hui Shao
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago, IL 60637, USA
    Biochim Biophys Acta 1670:165-71. 2004
    ..We conclude that AGBE is a potent antioxidant that protects cardiomyocytes against oxidant-mediated injury and this protection is partly mediated by its free radical scavenging properties...
  52. ncbi request reprint Mitochondrial requirement for endothelial responses to cyclic strain: implications for mechanotransduction
    Mir H Ali
    Am J Physiol Lung Cell Mol Physiol 287:L486-96. 2004
    ..These findings demonstrate that mitochondria function as mechanotransducers in endothelium by increasing ROS signaling, which is required for strain-induced increase in VCAM-1 expression via NF-kappaB...
  53. ncbi request reprint Baicalein attenuates oxidant stress in cardiomyocytes
    Zuo Hui Shao
    Section of Emergency Medicine, Department of Medicine, University of Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 282:H999-H1006. 2002
    ..We conclude that baicalein can scavenge ROS generation in cardiomyocytes and that it protects against cell death in an ischemia-reperfusion model when given only at reperfusion...

Research Grants41

  1. Respiratory and Metabolic Adaptation to Hypoxia
    Paul T Schumacker; Fiscal Year: 2010
    ..Collectively, these studies will provide new information regarding the mechanisms of oxygen sensing in cells, which is important in normal tissues and in disease states. ..
  2. OXYGEN SENSING AND CELL SIGNALING IN HYPOXIA
    Paul Schumacker; Fiscal Year: 2001
    ..These studies will identify a novel pathway of cellular O2 detection, and may help clarify understanding of how cells adapt to lowered O2 conditions. ..
  3. O2 Sensing in Hypoxic Pulmonary Vasoconstriction
    Paul Schumacker; Fiscal Year: 2009
    ..Collectively, these studies will test whether a common O2 sensing mechanism functions in PA myocytes and endothelial cells to trigger their diverse responses in HPV. ..
  4. RESPIRATORY AND METABOLIC ADAPTATION TO CELLULAR HYPOXIA
    Paul Schumacker; Fiscal Year: 2006
    ..Collectively, these studies will provide a more conclusive test of the hypothesis that mitochondrial ROS are the site of 02 sensing responsible for HIF-1 activation and gene expression during hypoxia. ..
  5. O2 SENSING BY MITOCHONDRIA DURING INTERMITTENT HYPOXIA
    Paul Schumacker; Fiscal Year: 2003
    ..Collectively, these studies could identify a novel mechanism of O2 sensing in the lung, and provide a mechanistic explanation for the activation of gene transcritpion and cellular proliferation during intermittent hypoxia. ..
  6. RESPIRATORY AND METABOLIC ADAPTATION TO CELLULAR HYPOXIA
    Paul Schumacker; Fiscal Year: 2000
    ....
  7. MICROVASCULAR CONTROL OF 02 EXTRACTION IN HYPOXIA
    Paul Schumacker; Fiscal Year: 1993
    ..This work will clarify and quantify the relationships among capillary surface area, microvascular flow heterogeneity, and the ability of tissues to maintain supply-independent VO2 in the face of limited O2 delivery...
  8. MECHANISMS FOR A DEPENDENCE OF 02 UPTAKE ON DELIVERY
    Paul Schumacker; Fiscal Year: 1993
    ....