T J Schnitzer

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. doi request reprint A 4-week randomized study of acetaminophen extended-release vs rofecoxib in knee osteoarthritis
    T J Schnitzer
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Osteoarthritis Cartilage 17:1-7. 2009
  2. pmc Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study
    Javeria A Hashmi
    Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Mol Pain 8:29. 2012
  3. doi request reprint Calcaneal quantitative ultrasound compared with hip and femoral neck dual-energy x-ray absorptiometry in people with a spinal cord injury
    Thomas J Schnitzer
    Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, 710 N Lake Shore Drive, Room 1020, Chicago, IL 60611, USA
    PM R 4:748-55. 2012
  4. pmc A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis
    Marwan N Baliki
    Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave, Chicago IL 60611, USA
    Mol Pain 4:47. 2008
  5. ncbi request reprint Efficacy and safety of four doses of lumiracoxib versus diclofenac in patients with knee or hip primary osteoarthritis: a phase II, four-week, multicenter, randomized, double-blind, placebo-controlled trial
    Thomas J Schnitzer
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Arthritis Rheum 51:549-57. 2004
  6. ncbi request reprint Update on guidelines for the treatment of chronic musculoskeletal pain
    Thomas J Schnitzer
    Department of Medicine, Northwestern University Feinberg School of Medicine, 710 North Lake Shore, 10th Floor, Chicago, IL 60611, USA
    Clin Rheumatol 25:S22-9. 2006
  7. ncbi request reprint Efficacy of rofecoxib, celecoxib, and acetaminophen in patients with osteoarthritis of the knee. A combined analysis of the VACT studies
    Thomas J Schnitzer
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Rheumatol 32:1093-105. 2005
  8. doi request reprint Efficacy and safety of naproxcinod in the treatment of patients with osteoarthritis of the knee: a 13-week prospective, randomized, multicenter study
    T J Schnitzer
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Osteoarthritis Cartilage 18:629-39. 2010
  9. doi request reprint Long-term open-label study of tanezumab for moderate to severe osteoarthritic knee pain
    T J Schnitzer
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Osteoarthritis Cartilage 19:639-46. 2011
  10. doi request reprint A 13-week, multicenter, randomized, double-blind study of lumiracoxib in hip osteoarthritis
    Thomas J Schnitzer
    Northwestern University Feinberg School of Medicine, 710 N Lake Shore Drive, Chicago, IL 60611, USA
    Clin Rheumatol 30:1433-46. 2011

Detail Information

Publications40

  1. doi request reprint A 4-week randomized study of acetaminophen extended-release vs rofecoxib in knee osteoarthritis
    T J Schnitzer
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Osteoarthritis Cartilage 17:1-7. 2009
    ..To compare the safety and efficacy of acetaminophen extended-release (APAP ER) with rofecoxib for the management of pain associated with knee osteoarthritis (OA)...
  2. pmc Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study
    Javeria A Hashmi
    Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Mol Pain 8:29. 2012
    ..Functional MRI was used to identify brain activity for fluctuations of spontaneous pain, at baseline and at two time points after start of treatment (6 hours and 2 weeks)...
  3. doi request reprint Calcaneal quantitative ultrasound compared with hip and femoral neck dual-energy x-ray absorptiometry in people with a spinal cord injury
    Thomas J Schnitzer
    Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, 710 N Lake Shore Drive, Room 1020, Chicago, IL 60611, USA
    PM R 4:748-55. 2012
    ..To evaluate the sensitivity and specificity of calcaneal quantitative ultrasound (QUS) measurements for identifying osteoporosis determined by dual-energy x-ray absorptiometry (DXA) at the hip in a spinal cord injury (SCI) population...
  4. pmc A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis
    Marwan N Baliki
    Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave, Chicago IL 60611, USA
    Mol Pain 4:47. 2008
    ..Moreover, lidocaine patch treatment modulates distinct brain circuitry in each condition, yet in OA we observe divergent results with fMRI and with questionnaire based instruments...
  5. ncbi request reprint Efficacy and safety of four doses of lumiracoxib versus diclofenac in patients with knee or hip primary osteoarthritis: a phase II, four-week, multicenter, randomized, double-blind, placebo-controlled trial
    Thomas J Schnitzer
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Arthritis Rheum 51:549-57. 2004
    ..To compare the efficacy and tolerability of the novel cyclooxygenase 2-selective inhibitor lumiracoxib with placebo and diclofenac in osteoarthritis (OA)...
  6. ncbi request reprint Update on guidelines for the treatment of chronic musculoskeletal pain
    Thomas J Schnitzer
    Department of Medicine, Northwestern University Feinberg School of Medicine, 710 North Lake Shore, 10th Floor, Chicago, IL 60611, USA
    Clin Rheumatol 25:S22-9. 2006
    ....
  7. ncbi request reprint Efficacy of rofecoxib, celecoxib, and acetaminophen in patients with osteoarthritis of the knee. A combined analysis of the VACT studies
    Thomas J Schnitzer
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Rheumatol 32:1093-105. 2005
    ..5 mg (n=259), or rofecoxib 25 mg (n=527) in a double blind trial [Vioxx, Acetaminophen, Celecoxib Trial (VACT2)]. Results were also pooled with the similarly designed VACT1 trial...
  8. doi request reprint Efficacy and safety of naproxcinod in the treatment of patients with osteoarthritis of the knee: a 13-week prospective, randomized, multicenter study
    T J Schnitzer
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Osteoarthritis Cartilage 18:629-39. 2010
    ..To evaluate the efficacy and safety of the cyclooxygenase-inhibiting nitric-oxide donator, naproxcinod, compared with naproxen and placebo in patients with osteoarthritis (OA) of the knee...
  9. doi request reprint Long-term open-label study of tanezumab for moderate to severe osteoarthritic knee pain
    T J Schnitzer
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Osteoarthritis Cartilage 19:639-46. 2011
    ..This study was designed to evaluate the long-term safety and effectiveness of repeated doses of the humanized anti-nerve growth factor antibody, tanezumab, during open-label treatment of patients with OA knee pain...
  10. doi request reprint A 13-week, multicenter, randomized, double-blind study of lumiracoxib in hip osteoarthritis
    Thomas J Schnitzer
    Northwestern University Feinberg School of Medicine, 710 N Lake Shore Drive, Chicago, IL 60611, USA
    Clin Rheumatol 30:1433-46. 2011
    ..Lumiracoxib was similar to celecoxib for all three co-primary endpoints. All treatments were well tolerated. In conclusion, lumiracoxib is effective in reducing pain and improving function in hip OA patients...
  11. ncbi request reprint Comparison of the COX-inhibiting nitric oxide donator AZD3582 and rofecoxib in treating the signs and symptoms of Osteoarthritis of the knee
    Thomas J Schnitzer
    Northwestern Center for Clinical Research, Chicago, Illinois 60611, USA
    Arthritis Rheum 53:827-37. 2005
    ....
  12. ncbi request reprint An observational, retrospective, cohort study of dosing patterns for rofecoxib and celecoxib in the treatment of arthritis
    Thomas J Schnitzer
    Northwestern Center for Clinical Research, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Clin Ther 25:3162-72. 2003
    ..This study assessed prescribing patterns for rofecoxib and celecoxib in the treatment of osteoarthritis (OA) and rheumatoid arthritis (RA), as well as differences in prescribing patterns across physician specialties...
  13. ncbi request reprint Efficacy of tramadol in treatment of chronic low back pain
    T J Schnitzer
    Office of Clinical Research and Training, Northwestern University, Chicago, IL 60611, USA
    J Rheumatol 27:772-8. 2000
    ..To evaluate the efficacy and safety of tramadol in the treatment of chronic low back pain...
  14. ncbi request reprint Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial
    Thomas J Schnitzer
    Office of Clinical Research and Training, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Lancet 364:665-74. 2004
    ....
  15. doi request reprint Bone mineral loss at the proximal femur in acute spinal cord injury
    W B Edwards
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 W Taylor Street, 650 AHSB, m c 517, Chicago, IL 60612, USA
    Osteoporos Int 24:2461-9. 2013
    ..Individuals with acute SCI experienced a marked loss of bone mineral from a combination of trabecular and endocortical resorption. Targeted therapeutic interventions are thus warranted in this population...
  16. ncbi request reprint Need for common internal controls when assessing the relative efficacy of pharmacologic agents using a meta-analytic approach: case study of cyclooxygenase 2-selective inhibitors for the treatment of osteoarthritis
    Chin Lee
    Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Arthritis Rheum 53:510-8. 2005
    ..To evaluate the role of common internal controls in a meta-analysis of the relative efficacy of cyclooxygenase 2-selective inhibitors (coxibs) in the treatment of osteoarthritis (OA)...
  17. ncbi request reprint A comparison of the efficacy and safety of nonsteroidal antiinflammatory agents versus acetaminophen in the treatment of osteoarthritis: a meta-analysis
    Chin Lee
    Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
    Arthritis Rheum 51:746-54. 2004
    ....
  18. ncbi request reprint Osteoarthritis management: the role of cyclooxygenase-2-selective inhibitors
    T J Schnitzer
    Office of Clinical Research and Training, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Clin Ther 23:313-326; discussion 311-2. 2001
    ..The most recent OA guidelines from the American College of Rheumatology were published in 2000 because new therapies such as the COX-2-selective inhibitors had been introduced for the management of OA...
  19. ncbi request reprint Lumiracoxib in the treatment of osteoarthritis, rheumatoid arthritis and acute postoperative dental pain: results of three dose-response studies
    Thomas J Schnitzer
    Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Curr Med Res Opin 21:151-61. 2005
    ....
  20. doi request reprint Bone mineral and stiffness loss at the distal femur and proximal tibia in acute spinal cord injury
    W B Edwards
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 W Taylor Street, 650 AHSB, m c 517, Chicago, IL, 60621, USA
    Osteoporos Int 25:1005-15. 2014
    ..Marked bone mineral loss was observed from a combination of trabecular and endocortical resorption. Reductions in stiffness were 2-fold greater than reductions in integral bone mineral...
  21. ncbi request reprint Update on alendronate for osteoporosis: once-weekly dosing
    T J Schnitzer
    Northwestern University, Clinical Research and Training, Chicago, Illinois 60611, USA
    Expert Opin Pharmacother 2:1461-72. 2001
    ..Sales data several months after introduction of once-weekly alendronate into the marketplace demonstrate rapid and extensive acceptance of this new regimen...
  22. ncbi request reprint Knee pain and joint loading in subjects with osteoarthritis of the knee
    D E Hurwitz
    Department of Orthopedic Surgery, Section of Rheumatology, Rush Presbyterian St Luke s Medical Cente, Chicago, Illinois 60612, USA
    J Orthop Res 18:572-9. 2000
    ..Additional long-term prospective studies are needed to determine whether increased loading during walking actually results in accelerated progression of the disease...
  23. ncbi request reprint Severity of joint pain and Kellgren-Lawrence grade at baseline are better predictors of joint space narrowing than bone scintigraphy in obese women with knee osteoarthritis
    Steven A Mazzuca
    Department of Medicine, Indiana University School of Medicine IUSM, Indianapolis, 46202, USA
    J Rheumatol 32:1540-6. 2005
    ....
  24. doi request reprint Tanezumab for the treatment of pain from osteoarthritis of the knee
    Nancy E Lane
    Department of Medicine, University of California at Davis Medical School, Sacramento, CA 95817, USA
    N Engl J Med 363:1521-31. 2010
    ..This proof-of-concept study was designed to investigate the safety and analgesic efficacy of tanezumab, a humanized monoclonal antibody that binds and inhibits nerve growth factor...
  25. ncbi request reprint Update of ACR guidelines for osteoarthritis: role of the coxibs
    Thomas J Schnitzer
    Office of Clinical Research and Training, Northwestern University Medical School, Evanston, IL 60611, USA
    J Pain Symptom Manage 23:S24-30; discussion S31-4. 2002
    ..It is anticipated that the guidelines for the management of OA will continue to evolve as new therapies become available...
  26. ncbi request reprint The patient with a fragility fracture: an evolving role for the orthopaedic surgeon
    T J Schnitzer
    Department of Medicine, Northwestern University, Chicago, IL, USA
    QJM 97:101-4. 2004
    ....
  27. ncbi request reprint Use of nonsteroidal anti-inflammatory drugs and gastroprotective agents before the advent of cyclooxygenase-2-selective inhibitors: analysis of a large United States claims database
    T J Schnitzer
    Office of Clinical Research and Training, Northwestern University, Chicago, Illinois, USA
    Clin Ther 23:1984-98. 2001
    ..Prior GPA use was the strongest predictor of subsequent concomitant GPA/ NSAID use. Differences in GPA use were observed among patients using different NSAIDs...
  28. ncbi request reprint COX-2-selective inhibitors in the treatment of arthritis
    Thomas J Schnitzer
    Office of Clinical Research and Training, Northwestern University School of Medicine, Chicago, IL 60611, USA
    Cleve Clin J Med 69:SI20-30. 2002
    ..The use of coxibs to treat OA and RA is recommended as first-line therapy when symptoms of pain and inflammation are present in patients vulnerable to potential NSAID-associated GI toxicity...
  29. ncbi request reprint A comprehensive review of clinical trials on the efficacy and safety of drugs for the treatment of low back pain
    Thomas J Schnitzer
    Office of Clinical Research and Training, Northwestern University, Chicago, Illinois, USA
    J Pain Symptom Manage 28:72-95. 2004
    ..More rigorously designed trials should be implemented to establish comparative efficacy and safety of drugs used to treat chronic and acute LBP...
  30. ncbi request reprint Pain management today - optimising the benefit/risk ratio: defining the role of weak opioids and combination analgesics
    Thomas J Schnitzer
    Clin Rheumatol 25:S1. 2006
  31. ncbi request reprint Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial
    Michael E Farkouh
    Cardiovascular Clinical Research Center, New York University School of Medicine, 530 First Avenue, New York, NY 10016, USA
    Lancet 364:675-84. 2004
    ....
  32. ncbi request reprint Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial
    Kenneth D Brandt
    Indiana University School of Medicine, Rheumatology Division, Indianapolis, IN 46202 5100, USA
    Arthritis Rheum 52:2015-25. 2005
    ..To confirm preclinical data suggesting that doxycycline can slow the progression of osteoarthritis (OA). The primary outcome measure was joint space narrowing (JSN) in the medial tibiofemoral compartment...
  33. ncbi request reprint Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial
    Gregory P Geba
    Merck and Co Inc, US Human Health, PO Box 4, West Point, PA 19486 0004, USA
    JAMA 287:64-71. 2002
    ..Osteoarthritis (OA) is often treated with nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, or specific inhibitors of cyclooxygenase 2 (COX-2)...
  34. ncbi request reprint Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use
    Loren Laine
    University of Southern California School of Medicine, Los Angeles 90033, USA
    Gastroenterology 124:288-92. 2003
    ..We performed a post hoc analysis of serious lower GI clinical events with a nonselective NSAID and a COX-2-selective agent in a prospective, double-blind, randomized GI outcomes trial...
  35. ncbi request reprint Response to expression of concern regarding VIGOR study
    Claire Bombardier
    N Engl J Med 354:1196-9. 2006
  36. ncbi request reprint Rofecoxib 12.5 mg, rofecoxib 25 mg, and celecoxib 200 mg in the treatment of symptomatic osteoarthritis: results of two similarly designed studies
    Steven S Smugar
    Merck and Co, Inc, West Point, PA 19486 0004, USA
    Curr Med Res Opin 22:1353-67. 2006
    ..To compare the efficacy of rofecoxib and celecoxib for the treatment of knee or hip OA over 6 weeks...
  37. ncbi request reprint Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
    Daniel O Clegg
    Division of Rheumatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    N Engl J Med 354:795-808. 2006
    ..The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee pain from osteoarthritis...
  38. ncbi request reprint Alendronate improves bone mineral density in elderly women with osteoporosis residing in long-term care facilities. A randomized, double-blind, placebo-controlled trial
    Susan L Greenspan
    University of Pittsburgh Osteoporosis Prevention and Treatment Center, 1110 Kaufmann Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Ann Intern Med 136:742-6. 2002
    ..Many elderly female residents of long-term care facilities have osteoporosis and could benefit from intervention to increase bone density...
  39. ncbi request reprint Means, responders, and meaning: evaluation of clinical trials in osteoarthritis
    Thomas J Schnitzer
    Arthritis Rheum 48:3001-3. 2003
  40. ncbi request reprint Subject retention and adherence in a randomized placebo-controlled trial of a disease-modifying osteoarthritis drug
    Steven A Mazzuca
    Indiana University School of Medicine, Indianapolis, 46202 5100, USA
    Arthritis Rheum 51:933-40. 2004
    ..To describe the methods by which remarkable levels of subject retention and adherence were achieved in a 30-month multicenter randomized placebo-controlled trial (RCT) of a disease-modifying osteoarthritis drug (DMOAD)...