Marc H Scheetz

..Despite the well-documented increase in fluoroquinolone resistance to Pseudomonas aeruginosa, the effect on pathogenicity is unknown. This paper will explore the clinical effect...

..A relationship was found (r(2) = 0.73, P = 0.03) and predicts increasing resistance with current trends of linezolid use...

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..We sought to determine the cost-effectiveness of Antimicrobial Stewardship Teams (ASTs) on the reduction of morbidity and mortality associated with nosocomial bacteraemia...

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..To report a sieving coefficient for peramivir in a patient receiving continuous venovenous hemofiltration (CVVH)...

..Future studies should evaluate these findings in vivo...

..To describe the peritoneal fluid penetration of tigecycline...

..006). Therefore, inaccurate detection and reporting of LIRVRE by disk diffusion and Etest is associated with increased patient morbidity and resource use...

..Guided antibiotic adjustment for the treatment of multidrug-resistant, gram-negative pathogens is explored...

..The possibility of increased serum vancomycin concentrations as a method to optimize current treatment outcomes is also explored...

..Inactive therapy was more important than carbapenem susceptibility with respect to outcomes, was a strong predictor of death, and is potentially modifiable...

..Agar and broth dilution methods were in concordance with PCR detection of the mutation, and disk diffusion was somewhat less sensitive but equally specific...

..To better define the utility of surrogate markers for doripenem susceptibility relative to gold standard microbiology tests...

..Inactive antimicrobial therapy in the first 24 h did not significantly impact average outcomes for GNBI among hospitalized patients but may have caused harm to specific individuals...

..We recommend additional clinical studies to better understand the susceptibility breakpoint for carbapenems...

..In vitro susceptibility classifications of fluoroquinolones for the treatment of bloodstream infections caused by gram-negative organisms require further study...

..Analysis of carbapenemases by PCR revealed that imipenem resistance but not meropenem resistance was associated with the presence of bla(OXA-23) and bla(OXA-40) genes...

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..2 times more likely to have closely related isolates obtained for all subsequent cultures than patients with initial carbapenem-intermediate or carbapenem-susceptible isolates...

..Because neither of these factors are modifiable, efforts to minimize the negative impact of PABSI should focus on appropriate prevention and infection control efforts...

..We sought to quantify the impact of the warning on healthcare institutions...

..The most common bacterial pathogens and empiric antibiotic recommendations for immunocompetent adults will be discussed. In addition, circumstances that may influence the selection of certain antibiotics are reviewed...

..To describe cerebral spinal fluid (CSF) penetration of tigecycline...

..No difference existed in liver abnormalities for high-dose voriconazole; however, higher mg/kg doses and a longer duration of therapy may be associated with hepatotoxicity...

..The optimal treatment for bloodstream infections (BSIs) with vancomycin-resistant enterococci (VRE) is unknown...

..Here we describe the scope of recent anti-infective shortages in the United States and explore the reasons for inadequate drug supply...

..This suggests that ongoing therapeutic drug monitoring and dose adjustment may be beneficial in patients requiring prolonged voriconazole therapy...

..We describe the incidence of hepatotoxicity with short- versus long-course nevirapine-containing regimens in these groups...

..To report pharmacokinetic alterations and optimal dosing of piperacillin/tazobactam in an obese patient...

..To determine the amount of time between which isolates could be considered genetically similar by pulsed-field gel electrophoresis, isolate change over time within single patients was studied...

..To summarize the published clinical data on posaconazole, critically review the New Drug Application data submitted to the Food and Drug Administration, and provide information critical for evaluation and formulary positioning...

..We evaluated targeted antimicrobial prophylaxis in men undergoing transrectal ultrasound guided prostate biopsy based on rectal swab culture results...

..By utilizing a preemptive therapeutic strategy with VGCV targeted only toward patients at risk for developing CMV disease, the rate and extent of leukopenia may be reduced...

..Report of neutropenia associated with piperacillin usage prior to 15 days of therapy is a novel finding that requires further evaluation. Current reporting methods poorly characterise patient groups at risk...

..VAN as the sole etiologic factor for nephrotoxic acute tubular necrosis (ATN) has not been described. Here, we report a case of biopsy-proven ATN resulting from VAN...