Hemant K Roy

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Spectral markers in preneoplastic intestinal mucosa: an accurate predictor of tumor risk in the MIN mouse
    Hemant K Roy
    Feinberg School of Medicine at Northwestern University, Department of Internal Medicine, Evanston Northwestern Healthcare, 2650 Ridge Avenue, Evanston, IL 60201, USA
    Cancer Epidemiol Biomarkers Prev 14:1639-45. 2005
  2. pmc Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis
    Hemant K Roy
    Department of Medicine, Feinberg School of Medicine at Northwestern University, Section of Gastroenterology, Evanston Northwestern Healthcare, G208 Evanston Hospital, 2650 Ridge Avenue, Evanston, IL 60201, USA
    FEBS Lett 581:3857-62. 2007
  3. pmc Spectral slope from the endoscopically-normal mucosa predicts concurrent colonic neoplasia: a pilot ex-vivo clinical study
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 2650 Ridge Avenue, G208, Evanston, Illinois 60201, USA
    Dis Colon Rectum 51:1381-6. 2008
  4. pmc Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Gastroenterology 135:1069-78. 2008
  5. ncbi request reprint The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Evanston, IL 60201, USA
    Cancer Lett 217:161-9. 2005
  6. ncbi request reprint Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosa
    Hemant K Roy
    Department of Medicine, Evanston Northwestern Healthcare Research Institute, Feinberg School of Medicine at Northwestern University, Evanston, Illinois 60201, USA
    Clin Cancer Res 12:961-8. 2006
  7. pmc Association between rectal optical signatures and colonic neoplasia: potential applications for screening
    Hemant K Roy
    Department of Medicine, Evanston Northwestern Healthcare, Northwestern University, Evanston, IL 60201, USA
    Cancer Res 69:4476-83. 2009
  8. ncbi request reprint Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Evanston, IL 60201, USA
    Mol Cancer Ther 3:1159-65. 2004
  9. ncbi request reprint The transcriptional repressor SNAIL is overexpressed in human colon cancer
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Dig Dis Sci 50:42-6. 2005
  10. pmc Optical measurement of rectal microvasculature as an adjunct to flexible sigmoidosocopy: gender-specific implications
    Hemant K Roy
    Department of Medicine, NorthShore University Health System, Evanston, IL 60201, USA
    Cancer Prev Res (Phila) 3:844-51. 2010

Collaborators

Detail Information

Publications79

  1. ncbi request reprint Spectral markers in preneoplastic intestinal mucosa: an accurate predictor of tumor risk in the MIN mouse
    Hemant K Roy
    Feinberg School of Medicine at Northwestern University, Department of Internal Medicine, Evanston Northwestern Healthcare, 2650 Ridge Avenue, Evanston, IL 60201, USA
    Cancer Epidemiol Biomarkers Prev 14:1639-45. 2005
    ..In the present study, we explored the ability of four-dimensional ELF to identify an inherited predisposition to colorectal cancer, an issue of considerable importance for optimizing population screening strategies...
  2. pmc Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis
    Hemant K Roy
    Department of Medicine, Feinberg School of Medicine at Northwestern University, Section of Gastroenterology, Evanston Northwestern Healthcare, G208 Evanston Hospital, 2650 Ridge Avenue, Evanston, IL 60201, USA
    FEBS Lett 581:3857-62. 2007
    ..These data indicate that iNOS induction may have a critical role in augmenting the predysplastic mucosal blood supply and thereby fostering colon carcinogenesis...
  3. pmc Spectral slope from the endoscopically-normal mucosa predicts concurrent colonic neoplasia: a pilot ex-vivo clinical study
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 2650 Ridge Avenue, G208, Evanston, Illinois 60201, USA
    Dis Colon Rectum 51:1381-6. 2008
    ..In this study, we assessed the translatability of spectral slope analysis to human colorectal cancer screening...
  4. pmc Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Gastroenterology 135:1069-78. 2008
    ..To assess the potential clinical translatability of this putative field effect marker, we characterized the early increase in blood supply (EIBS) in human beings in vivo...
  5. ncbi request reprint The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Evanston, IL 60201, USA
    Cancer Lett 217:161-9. 2005
    ..In conclusion, we demonstrate that the differential mechanisms for beta-catenin suppression may be determined, at least partly, by GSK-3beta...
  6. ncbi request reprint Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosa
    Hemant K Roy
    Department of Medicine, Evanston Northwestern Healthcare Research Institute, Feinberg School of Medicine at Northwestern University, Evanston, Illinois 60201, USA
    Clin Cancer Res 12:961-8. 2006
    ..In the present study, we investigated the ability of enhanced backscattering analysis of the preneoplastic mucosa to predict risk of colon carcinogenesis...
  7. pmc Association between rectal optical signatures and colonic neoplasia: potential applications for screening
    Hemant K Roy
    Department of Medicine, Evanston Northwestern Healthcare, Northwestern University, Evanston, IL 60201, USA
    Cancer Res 69:4476-83. 2009
    ..Further studies with an endoscopically compatible fiber optic probe are under way for multicenter clinical validation...
  8. ncbi request reprint Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Evanston, IL 60201, USA
    Mol Cancer Ther 3:1159-65. 2004
    ..To investigate the importance of SNAIL in colorectal carcinogenesis, we examined the phenotypic and cellular consequences of SNAIL down-regulation in the MIN mouse...
  9. ncbi request reprint The transcriptional repressor SNAIL is overexpressed in human colon cancer
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Dig Dis Sci 50:42-6. 2005
    ..11). In conclusion, we demonstrate, for the first time, that SNAIL is upregulated in human colon cancer, which potentially may have significance in control of metastasis and possibly serve as a target for chemopreventive agents...
  10. pmc Optical measurement of rectal microvasculature as an adjunct to flexible sigmoidosocopy: gender-specific implications
    Hemant K Roy
    Department of Medicine, NorthShore University Health System, Evanston, IL 60201, USA
    Cancer Prev Res (Phila) 3:844-51. 2010
    ..Therefore, using rectal EIBS in combination with flexible sigmoidoscopy mitigated the gender gap and may allow flexible sigmoidoscopy to be considered as a viable colorectal cancer screening test in women...
  11. pmc Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening
    Hemant K Roy
    Department of Medicine, NorthShore University HealthSystem Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
    Cancer Res 70:7748-54. 2010
    ..Our results offer proof of concept that buccal PWS may potentially herald a minimally intrusive prescreening test that could be integral to the success of lung cancer population screening programs...
  12. doi request reprint Involvement of p21cip1/waf1 in the anti-proliferative effects of polyethylene glycol in colon carcinogenesis
    Hemant K Roy
    Department of Medicine, NorthShore University Healthcare System, Evanston, IL 60201, USA
    Int J Oncol 38:529-36. 2011
    ..These results demonstrate for the first time that PEG is involved in p21 regulation concomitant with G1S phase cell cycle arrest and it is through these effects that it can exert its anti-proliferative and hence chemopreventive role...
  13. ncbi request reprint Four-dimensional elastic light-scattering fingerprints as preneoplastic markers in the rat model of colon carcinogenesis
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwest Healthcare, Northwestern Univerity, IL 60201, USA
    Gastroenterology 126:1071-81; discussion 948. 2004
    ..We therefore investigated whether 4D-ELF would be able to identify preneoplastic changes in the colonocytes of the azoxymethane (AOM)-treated rat model of colon carcinogenesis...
  14. ncbi request reprint Ethanol promotes intestinal tumorigenesis in the MIN mouse. Multiple intestinal neoplasia
    Hemant K Roy
    Department of Internal Medicine, University of Nebraska Medical Center and Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA
    Cancer Epidemiol Biomarkers Prev 11:1499-502. 2002
    ..Furthermore, whereas mechanisms remain incompletely elucidated, our data implicate formation of MAA adducts. This report provides further support that ethanol consumption is a risk factor for colorectal cancer...
  15. ncbi request reprint Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/beta-catenin signaling
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare, 2650 Ridge Avenue, IL, USA
    Mol Cancer Ther 5:2060-9. 2006
    ..In conclusion, we show, for the first time, a molecular mechanism through which PEG imparts its antiproliferative and hence profound chemopreventive effect...
  16. pmc Rectal mucosal microvascular blood supply increase is associated with colonic neoplasia
    Andrew J Gomes
    Biomedical Engineering Department, Northwestern University, IL, USA
    Clin Cancer Res 15:3110-7. 2009
    ..We now investigate whether in situ detection of EIBS in the rectum can predict neoplasia elsewhere in the colon...
  17. pmc Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy
    Hariharan Subramanian
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
    Cancer Res 69:5357-63. 2009
    ..These results have important implications in that PWS can be used as a new method to identify patients harboring malignant or premalignant tumors by interrogating easily accessible tissue sites distant from the location of the lesion...
  18. pmc Measuring mucosal blood supply in vivo with a polarization-gating probe
    Vladimir M Turzhitsky
    Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60201, USA
    Appl Opt 47:6046-57. 2008
    ..This effect was primarily limited to the mucosal microcirculation and was not present in the larger blood vessels located deeper in colonic tissue...
  19. pmc Biological mechanisms underlying structural changes induced by colorectal field carcinogenesis measured with low-coherence enhanced backscattering (LEBS) spectroscopy
    Nikhil N Mutyal
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 8:e57206. 2013
    ....
  20. pmc Dysregulation of microRNAs in colonic field carcinogenesis: implications for screening
    Dhananjay P Kunte
    Department of Medicine, NorthShore University Healthsystem, Evanston, Illinois, USA
    PLoS ONE 7:e45591. 2012
    ..Based on our results, we propose an accurate, inexpensive, non-invasive miRNA test for CRC risk stratification based on rectal brushings or from abraded fecal colonocytes...
  21. ncbi request reprint Optical markers in duodenal mucosa predict the presence of pancreatic cancer
    Yang Liu
    Biomedical Engineering Department, Northwestern University, Illinois, USA
    Clin Cancer Res 13:4392-9. 2007
    ..We propose a novel approach to predict pancreatic cancer through the assessment of the adjacent periampullary duodenal mucosa without any interrogation of the pancreatic duct or imaging of the pancreas...
  22. pmc Polyethylene glycol-mediated colorectal cancer chemoprevention: roles of epidermal growth factor receptor and Snail
    Ramesh K Wali
    Feinberg School of Medicine at Northwestern University, Department of Internal Medicine, Evanston Northwestern Healthcare, 1001 University Place, Suite 314, Evanston, IL 60201, USA
    Mol Cancer Ther 7:3103-11. 2008
    ..In conclusion, we show that EGFR is the proximate membrane signaling molecule through which PEG initiates antiproliferative activity with Snail/beta-catenin pathway playing the central intermediary function...
  23. ncbi request reprint Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking
    Rhonda M Brand
    Division of Emergency Medicine, Department of Internal Medicine, Evanston Northwestern Healthcare and Feinberg School of Medicine at Northwestern University, Evanston, IL 60201, USA
    World J Gastroenterol 12:4485-91. 2006
    ..To investigate whether a fuzzy logic model could predict colorectal cancer (CRC) risk engendered by smoking in hereditary non-polyposis colorectal cancer (HNPCC) patients...
  24. pmc Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor response
    Ramesh K Wali
    Department of Medicine, NorthShore University Healthsystem, Evanston, Illinois, United States of America
    PLoS ONE 7:e38047. 2012
    ..In conclusion, we demonstrate, for the first time, that PEG has promising efficacy and safety as a chemopreventive efficacy against oral carcinogenesis...
  25. ncbi request reprint Depth-resolved low-coherence enhanced backscattering
    Young L Kim
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Opt Lett 30:741-3. 2005
    ..We further demonstrate that depth-resolved LEBS spectroscopy has the potential to identify the origin of precancerous transformations in the colon at an early, previously undetectable stage...
  26. ncbi request reprint Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation
    Dhananjay P Kunte
    Department of Internal Medicine, Evanston Northwestern Healthcare, 2650 Ridge Avenue, Evanston, IL 60201, USA
    FEBS Lett 579:3497-502. 2005
    ..Thus, we demonstrate, for the first time, that Csk suppression is an important early event in colorectal cancer pathogenesis...
  27. pmc Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization
    Dhwanil Damania
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
    Cancer Res 72:2720-7. 2012
    ..Therefore, our findings suggest that PWS-measured L(d) is an accurate marker of field carcinogenesis. This approach provides a potential prescreening strategy for risk stratification before colonoscopy...
  28. pmc Association of stem-like cells in gender-specific chemoprevention against intestinal neoplasia in MIN mouse
    Seema R Gandhi
    Department of Internal Medicine, NorthShore University Healthsystem, Evanston, IL 60201, USA
    Oncol Rep 26:1127-32. 2011
    ..4% in females to 10.7% in males). We conclude that a higher number of stem-like cells in the uninvolved mucosa paralleled tumorigenesis and mirrored greater chemopreventive responsiveness of female MIN mice compared to males...
  29. ncbi request reprint Low-coherence enhanced backscattering: review of principles and applications for colon cancer screening
    Young L Kim
    Northwestern University, Biomedical Engineering Department, Evanston, Illinois 60208, USA
    J Biomed Opt 11:041125. 2006
    ..Then, we demonstrate the potential of LEBS spectroscopy for predicting the risk of colon carcinogenesis and colonoscopy-free screening for colorectal cancer (CRC)...
  30. pmc Investigating population risk factors of pancreatic cancer by evaluation of optical markers in the duodenal mucosa
    Vladimir Turzhitsky
    Biomedical Engineering Department, Northwestern University, Evanston, IL, USA
    Dis Markers 25:313-21. 2008
    ....
  31. ncbi request reprint Polyethylene glycol inhibits intestinal neoplasia and induces epithelial apoptosis in Apc(min) mice
    Hemant K Roy
    Department of Medicine, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Evanston, IL 60201, USA
    Cancer Lett 215:35-42. 2004
    ..The correlation between pro-apoptotic actions and chemopreventive efficacy of PEG in these models strongly implicates induction of apoptosis as one of the impending mechanisms of chemoprevention...
  32. pmc Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis
    Ashish K Tiwari
    Department of Medicine, NorthShore University Healthsystem, Evanston, IL, USA
    Cancer Lett 306:205-13. 2011
    ..This finding has potential implications as a biomarker for risk-stratification and target for chemoprevention...
  33. pmc FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density
    Wentao Qi
    Department of Medicine, Division of Gastroenterology, NorthShore University HealthSystem Research Institute, Evanston, Illinois 60201, USA
    J Biol Chem 288:16274-81. 2013
    ..Taken together, FOXO3 and LDs might serve as new targets for therapeutic intervention of colon cancer...
  34. pmc In vivo measurement of the shape of the tissue-refractive-index correlation function and its application to detection of colorectal field carcinogenesis
    Andrew J Gomes
    Northwestern University, Department of Biomedical Engineering, Evanston, Illinois 60218, USA
    J Biomed Opt 17:047005. 2012
    ..These results suggest that noninvasive measurement of the shape of the refractive-index correlation function could be a promising marker of early cancer development...
  35. doi request reprint Detecting alterations in cell ultrastructure with optical imaging
    Vadim Backman
    Northwestern University, Evanston, IL 60208, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6325-6. 2009
    ..e. microarchitecture)...
  36. pmc Partial-wave microscopic spectroscopy detects subwavelength refractive index fluctuations: an application to cancer diagnosis
    Hariharan Subramanian
    Biomedical Engineering Department, Northwestern University, Evanston, Ilinois 60208, USA
    Opt Lett 34:518-20. 2009
    ..We also demonstrate the potential of this technique to detect nanoscale alterations in cells from patients with pancreatic cancer who are otherwise classified as normal by conventional microscopic histopathology...
  37. pmc Quantification of nanoscale density fluctuations by electron microscopy: probing cellular alterations in early carcinogenesis
    Prabhakar Pradhan
    Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA
    Phys Biol 8:026012. 2011
    ..Potential applications of the technique for early cancer screening and detection are also discussed...
  38. pmc Antiproliferative effect of sulindac in colonic neoplasia prevention: role of COOH-terminal Src kinase
    Dhananjay P Kunte
    Feinberg School of Medicine at Northwestern University, Department of Internal Medicine, Evanston Northwestern Healthcare, 2650 Ridge Avenue, Suite G208, Evanston, IL 60201, USA
    Mol Cancer Ther 7:1797-806. 2008
    ..01). Thus, this is the first demonstration that the antiproliferative activity of NSAID is modulated, at least partly, through the Csk/Src axis...
  39. ncbi request reprint Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy
    Michael P Siegel
    Department of Biomedical Engineering, E310, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    Appl Opt 45:335-42. 2006
    ..To the best of our knowledge, this study represents the first evidence that polarization gating can be used as a spectroscopic tool to quantify hemoglobin concentration as well as oxygen saturation in the uppermost tissue layer...
  40. ncbi request reprint Low-coherent backscattering spectroscopy for tissue characterization
    Young L Kim
    Department of Biomedical Engineering, Northwestern University, E310, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    Appl Opt 44:366-77. 2005
    ....
  41. pmc HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure
    Yolanda Stypula-Cyrus
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 8:e64600. 2013
    ..Together, these results demonstrate the importance of HDAC activity in early carcinogenic events and the unique role of higher-order chromatin structure in determining cell tumorigenicity...
  42. pmc Role of cytoskeleton in controlling the disorder strength of cellular nanoscale architecture
    Dhwanil Damania
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
    Biophys J 99:989-96. 2010
    ..We therefore demonstrate that cytoskeleton plays a role in the control of cellular nanoscale disorder...
  43. pmc Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cells
    Hariharan Subramanian
    Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 105:20118-23. 2008
    ..These data indicate that this advance in single-cell optics represented by PWS may have significant biomedical applications...
  44. pmc Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cells
    Dhwanil Damania
    Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA
    Int J Cancer 133:1143-52. 2013
    ..We further show independent validation of the presence of cervical field carcinogenesis with micro-RNA expression data. ..
  45. ncbi request reprint Coherent backscattering spectroscopy
    Young L Kim
    Department of Biomedical Engineering, Department of Gastroenterology, Northwestern University, Evanston, Illinois 60208, USA
    Opt Lett 29:1906-8. 2004
    ..CBS spectroscopy may find important applications in probing random media such as biological tissue in which depth-selective measurements are crucial...
  46. doi request reprint Accuracy of the Born approximation in calculating the scattering coefficient of biological continuous random media
    Ilker R Capoglu
    Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    Opt Lett 34:2679-81. 2009
    ..The validity ranges for the correlation length and the refractive index fluctuation strength of the medium are clearly identified. These 2-D results show promise for future 3-D investigations...
  47. pmc Ultrastructural alterations in field carcinogenesis measured by enhanced backscattering spectroscopy
    Andrew J Radosevich
    Northwestern University, Department of Biomedical Engineering, Tech E310, 2145 Sheridan Road, Evanston, Illinois 60208
    J Biomed Opt 18:097002. 2013
    ..Second, these changes are predominantly attributable to a reduction in the presence of subdiffractional structures. Third, similar trends are seen for both cancer types, suggesting a common progression of structural alterations in each...
  48. pmc Polyethylene glycol diminishes pathological effects of Citrobacter rodentium infection by blocking bacterial attachment to the colonic epithelia
    Wentao Qi
    Department of Medicine, Division of Gastroenterology, NorthShore University Research Institute, Evanston, IL USA
    Gut Microbes 2:267-73. 2011
    ..Finally, PEG efficiently reduced C. rodentium shedding from the colon during infection. In conclusion, PEG can be an efficient and safe preventive agent against EPEC and EHEC infections...
  49. pmc Generation of an incident focused light pulse in FDTD
    Ilker R Capoglu
    Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA
    Opt Express 16:19208-20. 2008
    ..The accuracy of our results is demonstrated by comparison with exact theoretical formulas...
  50. ncbi request reprint Penetration depth of low-coherence enhanced backscattered light in subdiffusion regime
    Hariharan Subramanian
    Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 75:041914. 2007
    ..e., [l{s}pil{s}{2}]1/3) ...
  51. doi request reprint Decreased colorectal cancer and adenoma risk in patients with microscopic colitis
    Eugene F Yen
    Division of Gastroenterology, Pritzker School of Medicine, University of Chicago, NorthShore University Healthsystem, 2650 Ridge Avenue, Suite G221, Evanston, IL 60201, USA
    Dig Dis Sci 57:161-9. 2012
    ..Our aim was to identify patients with microscopic colitis, and to compare long-term rates of colorectal cancer or adenoma to a control group of patients without microscopic colitis...
  52. ncbi request reprint Associations between the age at diagnosis and location of colorectal cancer and the use of alcohol and tobacco: implications for screening
    Anna L Zisman
    Department of Internal Medicine, Evanston Northwestern Healthcare, Feinberg School of Medicine, Northwestern University, Evanston, IL 60201, USA
    Arch Intern Med 166:629-34. 2006
    ..Although hereditary predisposition is commonly used, the effect of exogenous risk factors has remained largely unexplored. To address this, we analyzed the age at presentation and location of CRC in relation to alcohol and tobacco use...
  53. ncbi request reprint AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis
    Hemant K Roy
    Department of Internal Medicine, University of Nebraska Medical Center Eppley Cancer Institute, 982000 Nebraska Medical Center, Omaha, NE 68198 2000, USA
    Carcinogenesis 23:201-5. 2002
    ..The early inhibition of apoptosis during sporadic colon carcinogenesis may be related, at least partly, to the overexpression of AKT...
  54. ncbi request reprint Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome)
    Patrice Watson
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Neb, USA
    Arch Intern Med 164:2429-31. 2004
    ..Environmental factors governing the phenotypic variability of cancer-associated syndromes such as HNPCC have not been elucidated...
  55. ncbi request reprint Exact solution of Maxwell's equations for optical interactions with a macroscopic random medium: addendum
    Snow H Tseng
    Department of Electrical and Computer Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Opt Lett 30:56-7. 2005
    ..This is an important point that we hereby report to future users of PSTD simulations in electrodynamics and optics. Note that all our original conclusions remain valid...
  56. pmc Quasi one-dimensional light beam generated by a graded-index microsphere
    Soon Cheol Kong
    Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL 60208, USA
    Opt Express 17:3722-31. 2009
    ..Of particular interest in this regard is a potential application to visible-light detection of nanometer-scale anomalies within biological cells indicative of early-stage cancer...
  57. ncbi request reprint Backscattering enhancement of light by nanoparticles positioned in localized optical intensity peaks
    Zhigang Chen
    Department of Electrical and Computer Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Appl Opt 45:633-8. 2006
    ..Potential applications include visible-light detection, characterization, and manipulation of nanoparticles...
  58. ncbi request reprint Superenhanced backscattering of light by nanoparticles
    Zhigang Chen
    Department of Electrical and Computer Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Opt Lett 31:196-8. 2006
    ..Potential applications of this phenomenon include visible-light detection, characterization, and manipulation of particles as small as a few nanometers...
  59. ncbi request reprint Elastic backscattering spectroscopic microscopy
    Yang Liu
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Opt Lett 30:2445-7. 2005
    ..We also demonstrate that the spectroscopic data can provide nanoscale structural information beyond what conventional microscopy reveals...
  60. ncbi request reprint Exact solution of Maxwell's equations for optical interactions with a macroscopic random medium
    Snow H Tseng
    Department of Electrical and Computer Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Opt Lett 29:1393-5. 2004
    ..More generally, our results have a wider implication: Namely, the study of electromagnetic wave propagation within random media is moving toward exact rather than approximate solutions of Maxwell's equations...
  61. ncbi request reprint Circular polarization memory effect in low-coherence enhanced backscattering of light
    Young L Kim
    Department of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA
    Opt Lett 31:2744-6. 2006
    ....
  62. ncbi request reprint Development of a bioengineered tissue model and its application in the investigation of the depth selectivity of polarization gating
    Yang Liu
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Appl Opt 44:2288-99. 2005
    ..As an example, we report the utilization of this model to study the effect of epithelium and the underlying connective tissue on the depth selectivity of polarization gating...
  63. ncbi request reprint Origin of low-coherence enhanced backscattering
    Young L Kim
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208, USA
    Opt Lett 31:1459-61. 2006
    ..Moreover, we show the first experimental evidence that the minimal number of scattering events in EBS is double scattering, which has been hypothesized since the first observation of EBS...
  64. ncbi request reprint Analytical techniques for addressing forward and inverse problems of light scattering by irregularly shaped particles
    Xu Li
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Opt Lett 29:1239-41. 2004
    ..We also demonstrate that these approaches have the potential to address the inverse-scattering problem by means of a spectral analysis of the total scattering cross section of arbitrarily shaped particles...
  65. ncbi request reprint Modeling low-coherence enhanced backscattering using Monte Carlo simulation
    Hariharan Subramanian
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Appl Opt 45:6292-300. 2006
    ..We show that small exit angles are highly sensitive to low-order scattering, which is crucial for accurate modeling of LEBS. Our results show that the predictions of the model are in excellent agreement with the experimental data...
  66. ncbi request reprint Anomalous oscillations in the spectra of light backscattered by inhomogeneous microparticles
    Xu Li
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 75:037601. 2007
    ..We explain this anomalous behavior by examining the path-length distributions of the backscattered photons in the cross polarization...
  67. pmc Nonscalar elastic light scattering from continuous random media in the Born approximation
    Jeremy D Rogers
    Biomedical Engineering, Northwestern University, 2145 Sheridan Avenue, Evanston, Illinois 60208, USA
    Opt Lett 34:1891-3. 2009
    ..Parameters such as scattering coefficient, anisotropy factor, and spectral dependence are derived from the differential scattering cross section for this general class of functions...
  68. ncbi request reprint Increased cumulative incidence of prostate malignancies in colorectal cancer patients
    Nuri Ozden
    Department of Internal Medicine, Omaha Veteran s Administration Medical Center, Nebraska, USA
    Int J Gastrointest Cancer 34:49-54. 2003
    ..CRC and prostate cancer share many similarities with regard to etiological factors. However, the previous reports on associations between these common malignancies are contradictory and confounded by a lack of rigorous controls...
  69. ncbi request reprint Optimal design of structured nanospheres for ultrasharp light-scattering resonances as molecular imaging multilabels
    Kun Chen
    Northwestern University, Department of Biomedical Engineering, Evanston, Illinois 60208, USA
    J Biomed Opt 10:024005. 2005
    ..Our theoretical study demonstrates that dozens of molecular targets can potentially be imaged simultaneously using this approach...
  70. pmc Spectroscopic applications in gastrointestinal endoscopy
    Hemant K Roy
    Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Clin Gastroenterol Hepatol 10:1335-41. 2012
    ..Future studies need to focus on efficacy, cost, practicality (time required, etc), and particularly developing the paradigms that will impact upon clinical decision making...
  71. ncbi request reprint The MUC gene family: their role in the diagnosis and prognosis of gastric cancer
    Shantibhusan Senapati
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Histol Histopathol 23:1541-52. 2008
    ..Furthermore, the role of mucins and their related carbohydrate epitope is discussed in the normal stomach and in the diagnosis and prognosis of gastric adenocarcinomas...
  72. pmc Advances in biophotonics detection of field carcinogenesis for colon cancer risk stratification
    Vadim Backman
    1 Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
    J Cancer 4:251-61. 2013
    ..On the other hand, the colonic mucosa represents the end product of the complex interplay between these multiple factors. The power of field carcinogenesis is that it reflects this interplay between genetics and environment...
  73. ncbi request reprint Photonic nanojet-enabled optical data storage
    Soon Cheol Kong
    Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL 60208, USA
    Opt Express 16:13713-9. 2008
    ....
  74. ncbi request reprint Spectroscopic translation of cell-material interactions
    Josephine Allen
    Northwestern University, Biomedical Engineering Department, 2145 Sheridan Rd, Room E310, Evanston, IL 60208, USA
    Biomaterials 28:162-74. 2007
    ....
  75. pmc Colorectal cancer risk: black, white, or shades of gray?
    Hemant K Roy
    JAMA 300:1459-61. 2008
  76. doi request reprint Purging the colon while preserving the kidneys
    Hemant K Roy
    Arch Intern Med 168:565-7. 2008
  77. ncbi request reprint Workshop on imaging science development for cancer prevention and preemption
    Gary J Kelloff
    NIH NCI DCTD, Cancer Imaging Program, Bethesda, MD, USA
    Cancer Biomark 3:1-33. 2007
    ..Imaging devices, alone or in combination with anticancer drugs, may also provide novel interventions to treat or prevent precancer...
  78. ncbi request reprint Biomarkers for the early detection of cancer: an inflammatory concept
    Hemant K Roy
    Arch Intern Med 167:1822-4. 2007
  79. ncbi request reprint Colon cancer screening: the good, the bad, and the ugly
    Hemant K Roy
    Arch Intern Med 166:2177-9. 2006

Research Grants5

  1. Spectral Markers for Early Detection of Colon Neoplasia
    Hemant Roy; Fiscal Year: 2007
    ..In the future these spectral markers may be assayed with a 4D-ELF probe during rectal examination, thus providing a practical and accurate means of determining the optimal CRC screening regimen. ..
  2. Improving colonoscopic miss rate by real time microvascular blood analysis
    Hemant Roy; Fiscal Year: 2007
    ..This could have major importance for colon cancer prevention efforts in the United States. ..
  3. Transforming Colorectal Cancer Screening through Multimodal Spectral Markers
    Vadim Backman; Fiscal Year: 2011
    ..Our approach is to develop a minimally intrusive, highly accurate pre-screen that would allow tailoring timing/intensity of screening and surveillance. ..