Hemant K Roy
Affiliation: Northwestern University
Roy H, Subramanian H, Damania D, Hensing T, Rom W, Pass H, et al
. Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening. Cancer Res. 2010;70:7748-54 pubmed publisher
..Our results offer proof of concept that buccal PWS may potentially herald a minimally intrusive prescreening test that could be integral to the success of lung cancer population screening programs. ..
Roy H, Koetsier J, Tiwari A, Joshi S, Kunte D, Ward T, et al
. Involvement of p21cip1/waf1 in the anti-proliferative effects of polyethylene glycol in colon carcinogenesis. Int J Oncol. 2011;38:529-36 pubmed publisher
..These results demonstrate for the first time that PEG is involved in p21 regulation concomitant with G1S phase cell cycle arrest and it is through these effects that it can exert its anti-proliferative and hence chemopreventive role. ..
Roy H, Smyrk T, Koetsier J, Victor T, Wali R. The transcriptional repressor SNAIL is overexpressed in human colon cancer. Dig Dis Sci. 2005;50:42-6 pubmed
..11). In conclusion, we demonstrate, for the first time, that SNAIL is upregulated in human colon cancer, which potentially may have significance in control of metastasis and possibly serve as a target for chemopreventive agents. ..
Roy H, Karolski W, Wali R, Ratashak A, Hart J, Smyrk T. The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis. Cancer Lett. 2005;217:161-9 pubmed
..In conclusion, we demonstrate that the differential mechanisms for beta-catenin suppression may be determined, at least partly, by GSK-3beta...
Roy H, Kim Y, Wali R, Liu Y, Koetsier J, Kunte D, et al
. Spectral markers in preneoplastic intestinal mucosa: an accurate predictor of tumor risk in the MIN mouse. Cancer Epidemiol Biomarkers Prev. 2005;14:1639-45 pubmed
..Moreover, the reversal of spectral markers by celecoxib treatment supports the neoplastic relevance. ..
Roy H, Iversen P, Hart J, Liu Y, Koetsier J, Kim Y, et al
. Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension. Mol Cancer Ther. 2004;3:1159-65 pubmed
..While this PMO regimen afforded modest SNAIL suppression and hence tumor reduction, this provides compelling evidence for the role of SNAIL overexpression in colonic neoplasia. ..
Roy H, Wali R, Kim Y, Liu Y, Hart J, Kunte D, et al
. Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis. FEBS Lett. 2007;581:3857-62 pubmed
..These data indicate that iNOS induction may have a critical role in augmenting the predysplastic mucosal blood supply and thereby fostering colon carcinogenesis. ..