Research Topics
Genomes and Genes | Hemant K RoySummaryAffiliation: Northwestern University Country: USA Publications
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Publications
Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimensionHemant K Roy
Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Evanston, IL 60201, USA
Mol Cancer Ther 3:1159-65. 2004..To investigate the importance of SNAIL in colorectal carcinogenesis, we examined the phenotypic and cellular consequences of SNAIL down-regulation in the MIN mouse...
Association between rectal optical signatures and colonic neoplasia: potential applications for screeningHemant K Roy
Department of Medicine, Evanston Northwestern Healthcare, Northwestern University, Evanston, IL 60201, USA
Cancer Res 69:4476-83. 2009..Further studies with an endoscopically compatible fiber optic probe are under way for multicenter clinical validation...- Optical measurement of rectal microvasculature as an adjunct to flexible sigmoidosocopy: gender-specific implicationsHemant K Roy
Department of Medicine, NorthShore University Health System, Evanston, IL 60201, USA
Cancer Prev Res (Phila) 3:844-51. 2010..Therefore, using rectal EIBS in combination with flexible sigmoidoscopy mitigated the gender gap and may allow flexible sigmoidoscopy to be considered as a viable colorectal cancer screening test in women... 
Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screeningHemant K Roy
Department of Medicine, NorthShore University HealthSystem Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
Cancer Res 70:7748-54. 2010..Our results offer proof of concept that buccal PWS may potentially herald a minimally intrusive prescreening test that could be integral to the success of lung cancer population screening programs...- Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesisHemant K Roy
Department of Medicine, Feinberg School of Medicine at Northwestern University, Section of Gastroenterology, Evanston Northwestern Healthcare, G208 Evanston Hospital, 2650 Ridge Avenue, Evanston, IL 60201, USA
FEBS Lett 581:3857-62. 2007..These data indicate that iNOS induction may have a critical role in augmenting the predysplastic mucosal blood supply and thereby fostering colon carcinogenesis... - The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesisHemant K Roy
Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Evanston, IL 60201, USA
Cancer Lett 217:161-9. 2005..In conclusion, we demonstrate that the differential mechanisms for beta-catenin suppression may be determined, at least partly, by GSK-3beta... - The transcriptional repressor SNAIL is overexpressed in human colon cancerHemant K Roy
Department of Internal Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
Dig Dis Sci 50:42-6. 2005..11). In conclusion, we demonstrate, for the first time, that SNAIL is upregulated in human colon cancer, which potentially may have significance in control of metastasis and possibly serve as a target for chemopreventive agents... - Spectral slope from the endoscopically-normal mucosa predicts concurrent colonic neoplasia: a pilot ex-vivo clinical studyHemant K Roy
Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 2650 Ridge Avenue, G208, Evanston, Illinois 60201, USA
Dis Colon Rectum 51:1381-6. 2008..In this study, we assessed the translatability of spectral slope analysis to human colorectal cancer screening... - Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia riskHemant K Roy
Department of Internal Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
Gastroenterology 135:1069-78. 2008..To assess the potential clinical translatability of this putative field effect marker, we characterized the early increase in blood supply (EIBS) in human beings in vivo... - Ethanol promotes intestinal tumorigenesis in the MIN mouse. Multiple intestinal neoplasiaHemant K Roy
Department of Internal Medicine, University of Nebraska Medical Center and Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA
Cancer Epidemiol Biomarkers Prev 11:1499-502. 2002..Furthermore, whereas mechanisms remain incompletely elucidated, our data implicate formation of MAA adducts. This report provides further support that ethanol consumption is a risk factor for colorectal cancer... - Involvement of p21cip1/waf1 in the anti-proliferative effects of polyethylene glycol in colon carcinogenesisHemant K Roy
Department of Medicine, NorthShore University Healthcare System, Evanston, IL 60201, USA
Int J Oncol 38:529-36. 2011..These results demonstrate for the first time that PEG is involved in p21 regulation concomitant with G1S phase cell cycle arrest and it is through these effects that it can exert its anti-proliferative and hence chemopreventive role... - Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosaHemant K Roy
Department of Medicine, Evanston Northwestern Healthcare Research Institute, Feinberg School of Medicine at Northwestern University, Evanston, Illinois 60201, USA
Clin Cancer Res 12:961-8. 2006..In the present study, we investigated the ability of enhanced backscattering analysis of the preneoplastic mucosa to predict risk of colon carcinogenesis... - Four-dimensional elastic light-scattering fingerprints as preneoplastic markers in the rat model of colon carcinogenesisHemant K Roy
Department of Internal Medicine, Evanston Northwest Healthcare, Northwestern Univerity, IL 60201, USA
Gastroenterology 126:1071-81; discussion 948. 2004..We therefore investigated whether 4D-ELF would be able to identify preneoplastic changes in the colonocytes of the azoxymethane (AOM)-treated rat model of colon carcinogenesis... - Spectral markers in preneoplastic intestinal mucosa: an accurate predictor of tumor risk in the MIN mouseHemant K Roy
Feinberg School of Medicine at Northwestern University, Department of Internal Medicine, Evanston Northwestern Healthcare, 2650 Ridge Avenue, Evanston, IL 60201, USA
Cancer Epidemiol Biomarkers Prev 14:1639-45. 2005..In the present study, we explored the ability of four-dimensional ELF to identify an inherited predisposition to colorectal cancer, an issue of considerable importance for optimizing population screening strategies... - Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/beta-catenin signalingHemant K Roy
Department of Internal Medicine, Evanston Northwestern Healthcare, 2650 Ridge Avenue, IL, USA
Mol Cancer Ther 5:2060-9. 2006..In conclusion, we show, for the first time, a molecular mechanism through which PEG imparts its antiproliferative and hence profound chemopreventive effect... - Rectal mucosal microvascular blood supply increase is associated with colonic neoplasiaAndrew J Gomes
Biomedical Engineering Department, Northwestern University, IL, USA
Clin Cancer Res 15:3110-7. 2009..We now investigate whether in situ detection of EIBS in the rectum can predict neoplasia elsewhere in the colon... - Measuring mucosal blood supply in vivo with a polarization-gating probeVladimir M Turzhitsky
Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60201, USA
Appl Opt 47:6046-57. 2008..This effect was primarily limited to the mucosal microcirculation and was not present in the larger blood vessels located deeper in colonic tissue... - Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopyHariharan Subramanian
Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
Cancer Res 69:5357-63. 2009..These results have important implications in that PWS can be used as a new method to identify patients harboring malignant or premalignant tumors by interrogating easily accessible tissue sites distant from the location of the lesion... - Dysregulation of MicroRNAs in colonic field carcinogenesis: implications for screeningDhananjay P Kunte
Department of Medicine, NorthShore University Healthsystem, Evanston, Illinois, USA
PLoS ONE 7:e45591. 2012..Based on our results, we propose an accurate, inexpensive, non-invasive miRNA test for CRC risk stratification based on rectal brushings or from abraded fecal colonocytes... - Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smokingRhonda M Brand
Division of Emergency Medicine, Department of Internal Medicine, Evanston Northwestern Healthcare and Feinberg School of Medicine at Northwestern University, Evanston, IL 60201, USA
World J Gastroenterol 12:4485-91. 2006..To investigate whether a fuzzy logic model could predict colorectal cancer (CRC) risk engendered by smoking in hereditary non-polyposis colorectal cancer (HNPCC) patients... - Optical markers in duodenal mucosa predict the presence of pancreatic cancerYang Liu
Biomedical Engineering Department, Northwestern University, Illinois, USA
Clin Cancer Res 13:4392-9. 2007..We propose a novel approach to predict pancreatic cancer through the assessment of the adjacent periampullary duodenal mucosa without any interrogation of the pancreatic duct or imaging of the pancreas... - Polyethylene glycol-mediated colorectal cancer chemoprevention: roles of epidermal growth factor receptor and SnailRamesh K Wali
Feinberg School of Medicine at Northwestern University, Department of Internal Medicine, Evanston Northwestern Healthcare, 1001 University Place, Suite 314, Evanston, IL 60201, USA
Mol Cancer Ther 7:3103-11. 2008..In conclusion, we show that EGFR is the proximate membrane signaling molecule through which PEG initiates antiproliferative activity with Snail/beta-catenin pathway playing the central intermediary function... - Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor responseRamesh K Wali
Department of Medicine, NorthShore University Healthsystem, Evanston, Illinois, United States of America
PLoS ONE 7:e38047. 2012..In conclusion, we demonstrate, for the first time, that PEG has promising efficacy and safety as a chemopreventive efficacy against oral carcinogenesis... - Depth-resolved low-coherence enhanced backscatteringYoung L Kim
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
Opt Lett 30:741-3. 2005..We further demonstrate that depth-resolved LEBS spectroscopy has the potential to identify the origin of precancerous transformations in the colon at an early, previously undetectable stage... - Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferationDhananjay P Kunte
Department of Internal Medicine, Evanston Northwestern Healthcare, 2650 Ridge Avenue, Evanston, IL 60201, USA
FEBS Lett 579:3497-502. 2005..Thus, we demonstrate, for the first time, that Csk suppression is an important early event in colorectal cancer pathogenesis... - Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerizationDhwanil Damania
Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
Cancer Res 72:2720-7. 2012..Therefore, our findings suggest that PWS-measured L(d) is an accurate marker of field carcinogenesis. This approach provides a potential prescreening strategy for risk stratification before colonoscopy... - Association of stem-like cells in gender-specific chemoprevention against intestinal neoplasia in MIN mouseSeema R Gandhi
Department of Internal Medicine, NorthShore University Healthsystem, Evanston, IL 60201, USA
Oncol Rep 26:1127-32. 2011..4% in females to 10.7% in males). We conclude that a higher number of stem-like cells in the uninvolved mucosa paralleled tumorigenesis and mirrored greater chemopreventive responsiveness of female MIN mice compared to males... - Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesisAshish K Tiwari
Department of Medicine, NorthShore University Healthsystem, Evanston, IL, USA
Cancer Lett 306:205-13. 2011..This finding has potential implications as a biomarker for risk-stratification and target for chemoprevention... - Polyethylene glycol inhibits intestinal neoplasia and induces epithelial apoptosis in Apc(min) miceHemant K Roy
Department of Medicine, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Evanston, IL 60201, USA
Cancer Lett 215:35-42. 2004..The correlation between pro-apoptotic actions and chemopreventive efficacy of PEG in these models strongly implicates induction of apoptosis as one of the impending mechanisms of chemoprevention... - Low-coherence enhanced backscattering: review of principles and applications for colon cancer screeningYoung L Kim
Northwestern University, Biomedical Engineering Department, Evanston, Illinois 60208, USA
J Biomed Opt 11:041125. 2006..Then, we demonstrate the potential of LEBS spectroscopy for predicting the risk of colon carcinogenesis and colonoscopy-free screening for colorectal cancer (CRC)... - Investigating population risk factors of pancreatic cancer by evaluation of optical markers in the duodenal mucosaVladimir Turzhitsky
Biomedical Engineering Department, Northwestern University, Evanston, IL, USA
Dis Markers 25:313-21. 2008.... - In vivo measurement of the shape of the tissue-refractive-index correlation function and its application to detection of colorectal field carcinogenesisAndrew J Gomes
Northwestern University, Department of Biomedical Engineering, Evanston, Illinois 60218, USA
J Biomed Opt 17:047005. 2012..These results suggest that noninvasive measurement of the shape of the refractive-index correlation function could be a promising marker of early cancer development... - Detecting alterations in cell ultrastructure with optical imagingVadim Backman
Northwestern University, Evanston, IL 60208, USA
Conf Proc IEEE Eng Med Biol Soc 2009:6325-6. 2009..e. microarchitecture)... - Quantification of nanoscale density fluctuations by electron microscopy: probing cellular alterations in early carcinogenesisPrabhakar Pradhan
Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA
Phys Biol 8:026012. 2011..Potential applications of the technique for early cancer screening and detection are also discussed... - Partial-wave microscopic spectroscopy detects subwavelength refractive index fluctuations: an application to cancer diagnosisHariharan Subramanian
Biomedical Engineering Department, Northwestern University, Evanston, Ilinois 60208, USA
Opt Lett 34:518-20. 2009..We also demonstrate the potential of this technique to detect nanoscale alterations in cells from patients with pancreatic cancer who are otherwise classified as normal by conventional microscopic histopathology... - Antiproliferative effect of sulindac in colonic neoplasia prevention: role of COOH-terminal Src kinaseDhananjay P Kunte
Feinberg School of Medicine at Northwestern University, Department of Internal Medicine, Evanston Northwestern Healthcare, 2650 Ridge Avenue, Suite G208, Evanston, IL 60201, USA
Mol Cancer Ther 7:1797-806. 2008..01). Thus, this is the first demonstration that the antiproliferative activity of NSAID is modulated, at least partly, through the Csk/Src axis... - Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopyMichael P Siegel
Department of Biomedical Engineering, E310, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
Appl Opt 45:335-42. 2006..To the best of our knowledge, this study represents the first evidence that polarization gating can be used as a spectroscopic tool to quantify hemoglobin concentration as well as oxygen saturation in the uppermost tissue layer... - Low-coherent backscattering spectroscopy for tissue characterizationYoung L Kim
Department of Biomedical Engineering, Northwestern University, E310, 2145 Sheridan Road, Evanston, Illinois 60208, USA
Appl Opt 44:366-77. 2005.... - Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cellsHariharan Subramanian
Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
Proc Natl Acad Sci U S A 105:20118-23. 2008..These data indicate that this advance in single-cell optics represented by PWS may have significant biomedical applications... - Role of cytoskeleton in controlling the disorder strength of cellular nanoscale architectureDhwanil Damania
Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
Biophys J 99:989-96. 2010..We therefore demonstrate that cytoskeleton plays a role in the control of cellular nanoscale disorder... - Coherent backscattering spectroscopyYoung L Kim
Department of Biomedical Engineering, Department of Gastroenterology, Northwestern University, Evanston, Illinois 60208, USA
Opt Lett 29:1906-8. 2004..CBS spectroscopy may find important applications in probing random media such as biological tissue in which depth-selective measurements are crucial... - Accuracy of the Born approximation in calculating the scattering coefficient of biological continuous random mediaIlker R Capoglu
Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
Opt Lett 34:2679-81. 2009..The validity ranges for the correlation length and the refractive index fluctuation strength of the medium are clearly identified. These 2-D results show promise for future 3-D investigations... - Polyethylene glycol diminishes pathological effects of Citrobacter rodentium infection by blocking bacterial attachment to the colonic epitheliaWentao Qi
Department of Medicine, Division of Gastroenterology, NorthShore University Research Institute, Evanston, IL USA
Gut Microbes 2:267-73. 2011..Finally, PEG efficiently reduced C. rodentium shedding from the colon during infection. In conclusion, PEG can be an efficient and safe preventive agent against EPEC and EHEC infections... - Penetration depth of low-coherence enhanced backscattered light in subdiffusion regimeHariharan Subramanian
Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA
Phys Rev E Stat Nonlin Soft Matter Phys 75:041914. 2007..e., [l{s}pil{s}{2}]1/3) ... - Generation of an incident focused light pulse in FDTDIlker R Capoglu
Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA
Opt Express 16:19208-20. 2008..The accuracy of our results is demonstrated by comparison with exact theoretical formulas... - Biological mechanisms underlying structural changes induced by colorectal field carcinogenesis measured with low-coherence enhanced backscattering (LEBS) spectroscopyNikhil N Mutyal
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America
PLoS ONE 8:e57206. 2013.... - Decreased colorectal cancer and adenoma risk in patients with microscopic colitisEugene F Yen
Division of Gastroenterology, Pritzker School of Medicine, University of Chicago, NorthShore University Healthsystem, 2650 Ridge Avenue, Suite G221, Evanston, IL 60201, USA
Dig Dis Sci 57:161-9. 2012..Our aim was to identify patients with microscopic colitis, and to compare long-term rates of colorectal cancer or adenoma to a control group of patients without microscopic colitis... - Associations between the age at diagnosis and location of colorectal cancer and the use of alcohol and tobacco: implications for screeningAnna L Zisman
Department of Internal Medicine, Evanston-Northwestern Healthcare, Feinberg School of Medicine, Northwestern University, Evanston, IL 60201, USA
Arch Intern Med 166:629-34. 2006..If confirmed, these factors should guide recommendations regarding initiation of CRC screening and, possibly, choice of techniques... - AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesisHemant K Roy
Department of Internal Medicine, University of Nebraska Medical Center Eppley Cancer Institute, 982000 Nebraska Medical Center, Omaha, NE 68198 2000, USA
Carcinogenesis 23:201-5. 2002..The early inhibition of apoptosis during sporadic colon carcinogenesis may be related, at least partly, to the overexpression of AKT... - Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome)Patrice Watson
Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Neb, USA
Arch Intern Med 164:2429-31. 2004..Environmental factors governing the phenotypic variability of cancer-associated syndromes such as HNPCC have not been elucidated... - Anomalous oscillations in the spectra of light backscattered by inhomogeneous microparticlesXu Li
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
Phys Rev E Stat Nonlin Soft Matter Phys 75:037601. 2007..We explain this anomalous behavior by examining the path-length distributions of the backscattered photons in the cross polarization... - Modeling low-coherence enhanced backscattering using Monte Carlo simulationHariharan Subramanian
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
Appl Opt 45:6292-300. 2006..We show that small exit angles are highly sensitive to low-order scattering, which is crucial for accurate modeling of LEBS. Our results show that the predictions of the model are in excellent agreement with the experimental data... - Origin of low-coherence enhanced backscatteringYoung L Kim
Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208, USA
Opt Lett 31:1459-61. 2006..Moreover, we show the first experimental evidence that the minimal number of scattering events in EBS is double scattering, which has been hypothesized since the first observation of EBS... - Development of a bioengineered tissue model and its application in the investigation of the depth selectivity of polarization gatingYang Liu
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
Appl Opt 44:2288-99. 2005..As an example, we report the utilization of this model to study the effect of epithelium and the underlying connective tissue on the depth selectivity of polarization gating... - Exact solution of Maxwell's equations for optical interactions with a macroscopic random medium: addendumSnow H Tseng
Department of Electrical and Computer Engineering, Northwestern University, Evanston, Illinois 60208, USA
Opt Lett 30:56-7. 2005..This is an important point that we hereby report to future users of PSTD simulations in electrodynamics and optics. Note that all our original conclusions remain valid... - Nonscalar elastic light scattering from continuous random media in the Born approximationJeremy D Rogers
Biomedical Engineering, Northwestern University, 2145 Sheridan Avenue, Evanston, Illinois 60208, USA
Opt Lett 34:1891-3. 2009..Parameters such as scattering coefficient, anisotropy factor, and spectral dependence are derived from the differential scattering cross section for this general class of functions... - Quasi one-dimensional light beam generated by a graded-index microsphereSoon Cheol Kong
Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL 60208, USA
Opt Express 17:3722-31. 2009..Of particular interest in this regard is a potential application to visible-light detection of nanometer-scale anomalies within biological cells indicative of early-stage cancer... - Superenhanced backscattering of light by nanoparticlesZhigang Chen
Department of Electrical and Computer Engineering, Northwestern University, Evanston, Illinois 60208, USA
Opt Lett 31:196-8. 2006..Potential applications of this phenomenon include visible-light detection, characterization, and manipulation of particles as small as a few nanometers... - Analytical techniques for addressing forward and inverse problems of light scattering by irregularly shaped particlesXu Li
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
Opt Lett 29:1239-41. 2004..We also demonstrate that these approaches have the potential to address the inverse-scattering problem by means of a spectral analysis of the total scattering cross section of arbitrarily shaped particles... - Elastic backscattering spectroscopic microscopyYang Liu
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
Opt Lett 30:2445-7. 2005..We also demonstrate that the spectroscopic data can provide nanoscale structural information beyond what conventional microscopy reveals... - Circular polarization memory effect in low-coherence enhanced backscattering of lightYoung L Kim
Department of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA
Opt Lett 31:2744-6. 2006.... - Exact solution of Maxwell's equations for optical interactions with a macroscopic random mediumSnow H Tseng
Department of Electrical and Computer Engineering, Northwestern University, Evanston, Illinois 60208, USA
Opt Lett 29:1393-5. 2004..More generally, our results have a wider implication: Namely, the study of electromagnetic wave propagation within random media is moving toward exact rather than approximate solutions of Maxwell's equations... - Backscattering enhancement of light by nanoparticles positioned in localized optical intensity peaksZhigang Chen
Department of Electrical and Computer Engineering, Northwestern University, Evanston, Illinois 60208, USA
Appl Opt 45:633-8. 2006..Potential applications include visible-light detection, characterization, and manipulation of nanoparticles... - Increased cumulative incidence of prostate malignancies in colorectal cancer patientsNuri Ozden
Department of Internal Medicine, Omaha Veteran's Administration Medical Center, Nebraska, USA
Int J Gastrointest Cancer 34:49-54. 2003..CONCLUSION: This preliminary report suggests that there is an association between CRC and prostate cancer. If replicated in other populations, this may have important implications for cancer screening strategies... - Optimal design of structured nanospheres for ultrasharp light-scattering resonances as molecular imaging multilabelsKun Chen
Northwestern University, Department of Biomedical Engineering, Evanston, Illinois 60208, USA
J Biomed Opt 10:024005. 2005..Our theoretical study demonstrates that dozens of molecular targets can potentially be imaged simultaneously using this approach... - Spectroscopic applications in gastrointestinal endoscopyHemant K Roy
Department of Medicine, Boston University Medical Center, Boston, MA, USA
Clin Gastroenterol Hepatol 10:1335-41. 2012..Future studies need to focus on efficacy, cost, practicality (time required, etc), and particularly developing the paradigms that will impact upon clinical decision making... - The MUC gene family: their role in the diagnosis and prognosis of gastric cancerShantibhusan Senapati
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
Histol Histopathol 23:1541-52. 2008..Furthermore, the role of mucins and their related carbohydrate epitope is discussed in the normal stomach and in the diagnosis and prognosis of gastric adenocarcinomas... - Advances in biophotonics detection of field carcinogenesis for colon cancer risk stratificationVadim Backman
1 Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
J Cancer 4:251-61. 2013..On the other hand, the colonic mucosa represents the end product of the complex interplay between these multiple factors. The power of field carcinogenesis is that it reflects this interplay between genetics and environment... - Spectroscopic translation of cell-material interactionsJosephine Allen
Northwestern University, Biomedical Engineering Department, 2145 Sheridan Rd, Room E310, Evanston, IL 60208, USA
Biomaterials 28:162-74. 2007.... - Photonic nanojet-enabled optical data storageSoon Cheol Kong
Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL 60208, USA
Opt Express 16:13713-9. 2008.... - Colorectal cancer risk: black, white, or shades of gray?Hemant K Roy
JAMA 300:1459-61. 2008 - Purging the colon while preserving the kidneysHemant K Roy
Arch Intern Med 168:565-7. 2008 - Workshop on imaging science development for cancer prevention and preemptionGary J Kelloff
NIH NCI DCTD, Cancer Imaging Program, Bethesda, MD, USA
Cancer Biomark 3:1-33. 2007..Imaging devices, alone or in combination with anticancer drugs, may also provide novel interventions to treat or prevent precancer... - Colon cancer screening: the good, the bad, and the uglyHemant K Roy
Arch Intern Med 166:2177-9. 2006 - Biomarkers for the early detection of cancer: an inflammatory conceptHemant K Roy
Arch Intern Med 167:1822-4. 2007
Research Grants
- Spectral Markers for Early Detection of Colon NeoplasiaHemant Roy; Fiscal Year: 2007..In the future these spectral markers may be assayed with a 4D-ELF probe during rectal examination, thus providing a practical and accurate means of determining the optimal CRC screening regimen. ..
- Improving colonoscopic miss rate by real time microvascular blood analysisHemant Roy; Fiscal Year: 2007..This could have major importance for colon cancer prevention efforts in the United States. ..
- Transforming Colorectal Cancer Screening through Multimodal Spectral MarkersVadim Backman; Fiscal Year: 2011..Our approach is to develop a minimally intrusive, highly accurate pre-screen that would allow tailoring timing/intensity of screening and surveillance. ..