Research Topics
Species | Janardan ReddySummaryAffiliation: Northwestern University Country: USA Publications
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Publications
Sustained activation of PPARĪ± by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob miceJiansheng Huang
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
FASEB J 26:628-38. 2012....
Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic systemJ K Reddy
Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
Annu Rev Nutr 21:193-230. 2001....- Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitisJ K Reddy
Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
Am J Physiol Gastrointest Liver Physiol 281:G1333-9. 2001.... - Peroxisome proliferators and peroxisome proliferator-activated receptor alpha: biotic and xenobiotic sensingJanardan K Reddy
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
Am J Pathol 164:2305-21. 2004 - Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidationJanardan K Reddy
Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611 3008, USA
Am J Physiol Gastrointest Liver Physiol 290:G852-8. 2006..Delineation of the pathogenetic aspects of FLD is necessary for developing novel therapeutic strategies for this disease... - Protein profiling of mouse livers with peroxisome proliferator-activated receptor alpha activationRuiyin Chu
Department of Functional Genomics, Aventis Pharmaceuticals, Inc, Bridgewater, New Jersey 08807, USA
Mol Cell Biol 24:6288-97. 2004..We conclude that livers with PPARalpha activation are transcriptionally geared towards fatty acid combustion... - PPARalpha in the pathogenesis of fatty liver diseaseM Sambasiva Rao
Hepatology 40:783-6. 2004 - Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liverSongtao Yu
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
Biochimie 86:743-61. 2004..The identification of these and other novel PPARgamma-target genes should provide a basis for understanding the molecular mechanisms underlying energy storage and lipid homeostasis... - Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicityYuzhi Jia
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 102:12531-6. 2005..We conclude that transcription coactivator PBP/TRAP220/MED1 is involved in the regulation of hepatic CAR function and that PBP deficiency in liver abrogates acetaminophen hepatotoxicity... - Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liverDongsheng Guo
The Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
Biochem Biophys Res Commun 347:485-95. 2006.... - Transcription coactivator PRIP, the peroxisome proliferator-activated receptor (PPAR)-interacting protein, is redundant for the function of nuclear receptors PParalpha and CAR, the constitutive androstane receptor, in mouse liverJoy Sarkar
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Gene Expr 13:255-69. 2007..The dependence of PPARalpha- and CAR-regulated gene transcription on coactivator PBP but not on PRIP attests to the existence of coactivator selectivity in nuclear receptor function... - Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family membersJun Xia
Department of Cell and Development Biology, University of Illinois at Urbana Champaign, Urbana, IL 60801, USA
Arch Biochem Biophys 468:49-57. 2007..SRC-3 alone of the p160 coactivators enhanced CAR transactivation in hepatic cells without PB treatment... - Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liverDongsheng Guo
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
J Biol Chem 282:36766-76. 2007..These observations, therefore, provide information for the first time to indicate that PPARalpha ligands not only serve as PPARalpha agonists but possibly act as CAR antagonists... - Pancreatic stem cells: differentiation optionsM Sambasiva Rao
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Stem Cell Rev 1:265-71. 2005 - Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liverYuzhi Jia
Department of Pathology, Northwestern University, Feinberg School of Medicine, Illinois 60611 3008, USA
J Biol Chem 279:24427-34. 2004..In essence, the absence of PBP in hepatocytes in vivo appears to mimic the absence of PPARalpha, indicating that coactivator PBP is essential for PPARalpha-regulated gene expression in liver parenchymal cells... - Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferatorsIvan Rusyn
Laboratory of Environmental Genomics, Department of Environmental Sciences and Engineering, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599, USA
Cancer Res 64:1050-7. 2004.... - Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesisSongtao Yu
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Curr Mol Med 3:561-72. 2003..In addition, mice lacking AOX developed steatohepatitis and provided clues regarding the molecular mechanism responsible for steatosis and steatohepatitis and the role of unmetabolized AOX substrates in the activation of PPAR alpha... - Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivatorSailesh Surapureddi
Department of Pathology, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 99:11836-41. 2002..The composition of this complex may provide insight into the basis of tissue and species sensitivity to peroxisome proliferators... - Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpressionSongtao Yu
Department of Pathology, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
J Biol Chem 278:498-505. 2003..We conclude that excess PPARgamma activity can lead to the development of a novel type of adipogenic hepatic steatosis... - Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic developmentYi Jun Zhu
Department of Pathology, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
J Biol Chem 278:1986-90. 2003..These observations indicate that PRIP like PBP, CBP, and p300 is an essential and nonredundant coactivator... - Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factorsSusan E Crawford
Department of Pathology, Northwestern University School of Medicine, Chicago, Illinois 60611 3008, USA
J Biol Chem 277:3585-92. 2002..These observations identify the GATA family of transcription factors as a new interacting partner of PBP and demonstrate that PBP is essential for normal development of vital organ systems... - Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damageDouglas E Hughes
University of Illinois at Chicago, College of Medicine, Department of Molecular Genetics, Chicago, IL 60607 7170, USA
Hepatology 37:1414-24. 2003.... - Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogenKirstin Meyer
Department of Pathology, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611 3008, USA
Carcinogenesis 24:975-84. 2003.... - Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal beta-oxYuzhi Jia
Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611 3008, USA
J Biol Chem 278:47232-9. 2003.... - Profiling of acyl-CoA oxidase-deficient and peroxisome proliferator Wy14,643-treated mouse liver protein by surface-enhanced laser desorption/ionization ProteinChip Biology SystemRuiyin Chu
Department of Functional Genomics, Aventis Pharmaceuticals, Inc, Bridgewater, NJ 08807, USA
Gene Expr 10:165-77. 2002..This SELDI method offers several technical advantages for detection of differentially expressed proteins, including ease and speed of screening, no need for chromatographic processing, and small sample size... - Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulationParimal Misra
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 3008, USA
J Biol Chem 277:20011-9. 2002.... - Biochemical characterization of two functional human liver acyl-CoA oxidase isoforms 1a and 1b encoded by a single geneDavid Oaxaca-Castillo
INSERM, U866, Dijon F 21000, France
Biochem Biophys Res Commun 360:314-9. 2007..ACOX1a seems to be more labile and exhibits only 50% specific activity toward palmitoyl-CoA as compared to ACOX1b... - The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gammaHui Li
Department of Microbiology and Immunology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 283:13077-86. 2008..Last, an ERK-regulated site in Med1 protein is also essential for up-regulating IFN-induced transcription although not critical for binding to C/EBP-beta... 
Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alphaSailesh Surapureddi
Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Mol Pharmacol 74:913-23. 2008..We conclude that the coactivator NCOA6 mediates the mechanism of the synergistic activation of the CYP2C9 gene by CAR and HNF4alpha...- Transcriptional regulation of Cidea, mitochondrial cell death-inducing DNA fragmentation factor alpha-like effector A, in mouse liver by peroxisome proliferator-activated receptor alpha and gammaNavin Viswakarma
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
J Biol Chem 282:18613-24. 2007..The induction of Cidea in liver with these PPARalpha and -gamma agonists suggests a possible role for Cidea in energy metabolism and a less likely role in hepatocyte apoptosis... - Critical role for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARalpha ligand-induced liver tumor developmentKojiro Matsumoto
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 3008, USA
J Biol Chem 282:17053-60. 2007..These studies provide direct evidence in support of a critical role of PBP/TRAP220 in liver regeneration, induction of hepatotoxicity, and hepatocarcinogenesis... - Transcription coactivators for peroxisome proliferator-activated receptorsSongtao Yu
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Biochim Biophys Acta 1771:936-51. 2007..Identification of PPAR specific coactivators should further our understanding of the complexities of metabolic diseases associated with energy metabolism... - Phosphorylation of transcriptional coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP). Stimulation of transcriptional regulation by mitogen-activated protein kinaseParimal Misra
Department of Pathology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 3008, USA
J Biol Chem 277:48745-54. 2002..The functional role of PKA and PKC phosphorylation sites in PBP remains to be elucidated... - Upregulation of calpastatin in regenerating and developing rat liver: role in resistance against hepatotoxicityPallavi B Limaye
Department of Toxicology, College of Pharmacy, The University of Louisiana at Monroe, Monroe, LA 71209 0495, USA
Hepatology 44:379-88. 2006..In conclusion, CAST overexpression could be used as a therapeutic strategy to prevent progression of liver injury where liver regeneration is severely hampered... - PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complexSailesh Surapureddi
The Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Biochem Biophys Res Commun 343:535-43. 2006..We conclude that ciprofibrate, a PPARalpha ligand, binds a multiprotein complex and PRIC320 cloned from this complex functions as a nuclear receptor coactivator... - Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balanceZhiyong Wang
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Cell Metab 3:111-22. 2006..They exhibit increased basal metabolic rates and heightened levels of physical activity. Therefore, p/CIP and SRC-1 play critical roles in energy balance by controlling both energy intake and energy expenditure... - Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesisKeiichirou Morimura
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Carcinogenesis 27:1074-80. 2006..This mouse model will be useful for human cancer risk assessment of PPARalpha ligands... - Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expressionDavid Patsouris
Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, P O Box 8129, 6700 EV, Wageningen, The Netherlands
Endocrinology 147:1508-16. 2006..It is concluded that 1) PPARalpha and PPARalpha-signaling are activated in liver by chronic high-fat feeding; and 2) PPARgamma may compensate for PPARalpha in PPARalpha null mice on HFD... - PAT5A: a partial agonist of peroxisome proliferator-activated receptor gamma is a potent antidiabetic thiazolidinedione yet weakly adipogenicParimal Misra
Discovery Research, Dr Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad, India
J Pharmacol Exp Ther 306:763-71. 2003..These biological effects suggest that PAT5A is a PPARgamma modulator that activates some (insulin sensitization), but not all (adipogenesis), PPARgamma-signaling pathways... - EDGE: a centralized resource for the comparison, analysis, and distribution of toxicogenomic informationKevin R Hayes
McArdle Laboratory for Cancer Research, 1400 University Avenue, Madison, WI 53706, USA
Mol Pharmacol 67:1360-8. 2005..We propose that EDGE can serve as a prototype resource for the sharing of toxicogenomics information and be used to develop algorithms for efficient chemical classification and hazard prediction... - Transcriptional coactivator PRIP, the peroxisome proliferator-activated receptor gamma (PPARgamma)-interacting protein, is required for PPARgamma-mediated adipogenesisChao Qi
Department of Pathology, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
J Biol Chem 278:25281-4. 2003..These data indicate that PRIP, like PBP, is a downstream regulator of PPARgamma-mediated adipogenesis and that both these coactivators are required for the successful completion of adipogenic program...
Research Grants
- Transcriptional Coactivators in Liver FunctionJanardan K Reddy; Fiscal Year: 2010..They should provide a rational basis for testing strategies to regulate gene expression. ..
- IDENTIFICATION OF LIVER STEM CELLS IN PANCREASJanardan Reddy; Fiscal Year: 2002....
- FASEB Conference: Mechanisms of Liver Growth and DiseaseJanardan Reddy; Fiscal Year: 2002..abstract_text> ..
- BIOLOGICAL STUDIES WITH PEROXISOME PROLIFERATORSJanardan Reddy; Fiscal Year: 2000....
- BIOLOGICAL STUDIES WITH PEROXISOME PROLIFERATORSJanardan Reddy; Fiscal Year: 2004..abstract_text> ..
- Transcriptional Coactivators in Liver FunctionJanardan Reddy; Fiscal Year: 2009..They should provide a rational basis for testing strategies to regulate gene expression. ..
- Biologic Studies with Peroxisome Proliferators and PPARsJanardan Reddy; Fiscal Year: 2007..The studies we now propose will generate new information, which can provide insights into the molecular complexity and the functional implications of PPAR regulated gene expression in liver. ..
- Transcriptional Coactivators in Liver FunctionJanardan Reddy; Fiscal Year: 2007..abstract_text> ..
- HEPATOCYTE DIFFERENTIATION IN PANCREASJanardan Reddy; Fiscal Year: 1990
- BIOLOGIC STUDIES WITH LIVER PEROXISOME PROLIFERATORSJanardan Reddy; Fiscal Year: 1980..The information obtained from these studies should further our knowledge of peroxisomes as well as allow us to recognize the implications of the multiplicity of biologic effects of peroxisome proliferators...
- HEPATOCYTE DIFFERENTIATION IN PANCREASJanardan Reddy; Fiscal Year: 1993..We anticipate that the highly reproducible and clearly characterized model of pancreatic hepatocyte differentiation will most likely yield information of a fundamental nature regarding cell commitment and differentiation...