Leonidas C Platanias

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi Mechanisms of type-I- and type-II-interferon-mediated signalling
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, 710 North Fairbanks Court, Olson 8250, Chicago, Illinois 60611, USA
    Nat Rev Immunol 5:375-86. 2005
  2. doi An overview of the mTOR pathway as a target in cancer therapy
    Ryan D Gentzler
    Northwestern University, Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, 303 East Superior Street, Lurie 3 107, Chicago, IL 60611, USA 1 312 5034267 1 312 9081372
    Expert Opin Ther Targets 16:481-9. 2012
  3. doi Next generation of mammalian target of rapamycin inhibitors for the treatment of cancer
    Valerie Nelson
    Northwestern University Medical School, Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, 303 East Superior Street, Lurie 3 107, Chicago, IL 60611, USA
    Expert Opin Investig Drugs 22:715-22. 2013
  4. ncbi Vitamin D and acute promyelocytic leukemia
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Leuk Lymphoma 47:581. 2006
  5. ncbi Introduction: interferon signals: what is classical and what is nonclassical?
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Interferon Cytokine Res 25:732. 2005
  6. pmc Biological responses to arsenic compounds
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 284:18583-7. 2009
  7. ncbi The p38 mitogen-activated protein kinase pathway and its role in interferon signaling
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, 303 East Chicago Avenue, Olson Pavilion, Room 8250, Chicago, IL 60611, USA
    Pharmacol Ther 98:129-42. 2003
  8. ncbi Map kinase signaling pathways and hematologic malignancies
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago IL 60611, USA
    Blood 101:4667-79. 2003
  9. ncbi Activation of protein kinase C delta by IFN-gamma
    Dilip K Deb
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Immunol 171:267-73. 2003
  10. ncbi Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons
    Yongzhong Li
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, 710 North Fairbanks St, Chicago, Illinois 60611, USA
    J Biol Chem 280:10001-10. 2005

Collaborators

Detail Information

Publications98

  1. ncbi Mechanisms of type-I- and type-II-interferon-mediated signalling
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, 710 North Fairbanks Court, Olson 8250, Chicago, Illinois 60611, USA
    Nat Rev Immunol 5:375-86. 2005
    ..It is anticipated that an increased understanding of the contributions of these recently identified pathways will advance our current thinking about how interferons work...
  2. doi An overview of the mTOR pathway as a target in cancer therapy
    Ryan D Gentzler
    Northwestern University, Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, 303 East Superior Street, Lurie 3 107, Chicago, IL 60611, USA 1 312 5034267 1 312 9081372
    Expert Opin Ther Targets 16:481-9. 2012
    ....
  3. doi Next generation of mammalian target of rapamycin inhibitors for the treatment of cancer
    Valerie Nelson
    Northwestern University Medical School, Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, 303 East Superior Street, Lurie 3 107, Chicago, IL 60611, USA
    Expert Opin Investig Drugs 22:715-22. 2013
    ....
  4. ncbi Vitamin D and acute promyelocytic leukemia
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Leuk Lymphoma 47:581. 2006
  5. ncbi Introduction: interferon signals: what is classical and what is nonclassical?
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Interferon Cytokine Res 25:732. 2005
  6. pmc Biological responses to arsenic compounds
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 284:18583-7. 2009
    ..Such an approach may ultimately provide the means to selectively enhance the suppressive effects of this agent on malignant cells and render normally resistant tumors sensitive to its antineoplastic properties...
  7. ncbi The p38 mitogen-activated protein kinase pathway and its role in interferon signaling
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, 303 East Chicago Avenue, Olson Pavilion, Room 8250, Chicago, IL 60611, USA
    Pharmacol Ther 98:129-42. 2003
    ..Such activation is required for IFNalpha-dependent suppression of leukemic cell progenitor growth, indicating that this pathway plays a critical role in the induction of the antileukemic effects of IFNalpha...
  8. ncbi Map kinase signaling pathways and hematologic malignancies
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago IL 60611, USA
    Blood 101:4667-79. 2003
    ..In this review, the involvement of various Map kinase pathways in the pathophysiology of hematologic malignances is summarized and the clinical implications of the recent advances in the field are discussed...
  9. ncbi Activation of protein kinase C delta by IFN-gamma
    Dilip K Deb
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Immunol 171:267-73. 2003
    ..Thus, PKCdelta is activated during engagement of the IFN-gamma receptor and plays an important role in IFN-gamma signaling by mediating serine phosphorylation of Stat1 and facilitating transcription of IFN-gamma-stimulated genes...
  10. ncbi Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons
    Yongzhong Li
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, 710 North Fairbanks St, Chicago, Illinois 60611, USA
    J Biol Chem 280:10001-10. 2005
    ..Altogether, our findings demonstrate that MKK3 and MKK6 are rapidly activated during engagement of the Type I IFN receptor and play important roles in Type I IFN signaling and the generation of IFN responses...
  11. pmc Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells
    Simrit Parmar
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Lakeside Veterans Administration Medical Center, Section of Hematology Oncology, University of Chicago, IL, USA
    Blood 106:2436-43. 2005
    ..They also support the concept that combined use of imatinib mesylate with mTOR inhibitors may be an appropriate future therapeutic strategy for the treatment of CML...
  12. ncbi Role of p38alpha Map kinase in Type I interferon signaling
    Yongzhong Li
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 279:970-9. 2004
    ..Altogether, our data establish that the p38alpha Map kinase pathway regulates activation of downstream effectors that participate in the induction of IFN-dependent gene transcription, to mediate IFN-responses...
  13. ncbi Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells
    Lakhvir Lal
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Blood 105:1669-77. 2005
    ....
  14. pmc Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling
    Surinder Kaur
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Immunol 181:7316-23. 2008
    ..Thus, integration of signals via PI3K is a critical event during engagement of the IFN receptors that complements both the transcriptional activity of Jak-STAT pathways and controls initiation of mRNA translation...
  15. pmc Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2
    Blazej Dolniak
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Department of Medicine, Northwestern University Medical School, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 283:12034-42. 2008
    ..Taken together, these findings indicate an important role for Mnk kinases, acting as negative regulators for signals that control generation of arsenic trioxide-dependent apoptosis and antileukemic responses...
  16. ncbi Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide
    Amit Verma
    Robert H Lurie Comprehensive Cancer Center and Section of Hematology Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:44988-95. 2002
    ..Altogether, these data provide evidence for a novel function of the p38 MAP kinase pathway, acting as a negative regulator of arsenic trioxide-induced apoptosis and inhibition of malignant cell growth...
  17. ncbi Engagement of protein kinase C-theta in interferon signaling in T-cells
    Kishore K Srivastava
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 279:29911-20. 2004
    ..Altogether, these findings demonstrate that PKC-theta is an interferon-inducible kinase and strongly suggest that it plays an important role in the generation of interferon-responses in T-cells...
  18. pmc Role of the Akt pathway in mRNA translation of interferon-stimulated genes
    Surinder Kaur
    Division of Hematology Oncology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School and Lakeside Veterans Affairs Medical Center, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 105:4808-13. 2008
    ..Thus, activation of the Akt pathway by the IFN receptors complements the function of IFN-activated JAK-STAT pathways, by allowing mRNA translation of IFN-stimulated genes and, ultimately, the induction of the biological effects of IFNs...
  19. ncbi Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons
    Fatima Lekmine
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 278:27772-80. 2003
    ..Altogether, our data establish that the Type I IFN receptor-activated PI 3'-kinase pathway mediates activation of the p70 S6 kinase and inactivation of 4E-BP1, to regulate mRNA translation and induction of Type I IFN responses...
  20. ncbi Activation of protein kinase C delta by all-trans-retinoic acid
    Suman Kambhampati
    Robert H Lurie Comprehensive Cancer Center and the Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and Lakeside Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 278:32544-51. 2003
    ..Altogether, our data provide strong evidence that PKC delta is activated in an RA-dependent manner and plays a critical role in the generation of the biological effects of RA in malignant cells...
  21. pmc Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses
    Surinder Kaur
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 109:7723-8. 2012
    ..Together, our data provide evidence for unique functions of mTORC2 complexes in the induction of type I IFN responses and suggest a critical role for mTORC2-mediated signals in IFN signaling...
  22. ncbi Role of protein kinase C-delta (PKC-delta) in the generation of the effects of IFN-alpha in chronic myelogenous leukemia cells
    Surinder Kaur
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Affairs Medical Center, Chicago, Ill 60611, USA
    Exp Hematol 33:550-7. 2005
    ..We examined whether a member of the protein kinase C (PKC) family of proteins, PKC-delta, is activated during treatment of BCR-ABL cells with IFN-alpha and participates in the induction of interferon responses...
  23. pmc Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses
    Sonali Joshi
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, and Jesse Brown Veterans Administration Medical Center, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:12097-102. 2009
    ..Together, our findings establish that the Mnk/eIF4E kinase pathway is activated in an IFN-inducible manner and plays important roles in mRNA translation for ISGs and generation of IFN-inducible anti-proliferative responses...
  24. pmc Role of Schlafen 2 (SLFN2) in the generation of interferon alpha-induced growth inhibitory responses
    Efstratios Katsoulidis
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 284:25051-64. 2009
    ....
  25. pmc Arsenic trioxide-dependent activation of thousand-and-one amino acid kinase 2 and transforming growth factor-beta-activated kinase 1
    Jennifer L McNeer
    Division of Hematology Oncology, Department of Pediatrics, Northwestern University Medical School, Chicago, Illinois, USA
    Mol Pharmacol 77:828-35. 2010
    ..Thus, molecular or pharmacological targeting of these kinases may provide a novel approach to enhance the generation of arsenic-dependent antileukemic responses...
  26. ncbi Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses
    Jessica K Altman
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Lakeside Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 283:1992-2001. 2008
    ....
  27. pmc Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors
    Jessica K Altman
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Jesse Brown VA Medical Center, Chicago, Illinois, USA
    Clin Cancer Res 17:4378-88. 2011
    ..To determine whether mTORC2 and rapamycin-insensitive (RI)-mTORC1 complexes are present in acute myeloid leukemia (AML) cells and to examine the effects of dual mTORC2/mTORC1 inhibition on primitive AML leukemic progenitors...
  28. ncbi Activation of mammalian target of rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL-expressing cells
    Patrick Yoon
    Robert H Lurie Comprehensive Cancer Center, 303 East Superior Street, Lurie 3 107, Chicago, IL 60611, USA
    Mol Cancer Ther 5:2815-23. 2006
    ....
  29. pmc Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells
    Efstratios Katsoulidis
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 283:10793-803. 2008
    ..Altogether, our data provide evidence for a novel mechanism by which BCR-ABL impairs host defenses and promotes malignant transformation, involving dual suppression of IFN-activated signaling pathways...
  30. ncbi Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysis
    Hidayatullah G Munshi
    Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 279:39042-50. 2004
    ....
  31. pmc Negative regulatory effects of Mnk kinases in the generation of chemotherapy-induced antileukemic responses
    Jessica K Altman
    Robert H Lurie Comprehensive Cancer Center, Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    Mol Pharmacol 78:778-84. 2010
    ..They also identify this pathway as a novel target for the design of new approaches to enhance the antileukemic effects of chemotherapy or mTOR inhibitors in AML...
  32. pmc Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription
    Weiqi Huang
    Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA
    Mol Cell Biol 30:4575-94. 2010
    ..Therefore, these studies have identified a Gas2/calpain-dependent mechanism by which ICSBP influences beta-catenin activity in myeloid leukemia...
  33. ncbi Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein
    Fatima Lekmine
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, IL 60611, USA
    Exp Cell Res 295:173-82. 2004
    ....
  34. ncbi Role of the p38 mitogen-activated protein kinase pathway in cytokine-mediated hematopoietic suppression in myelodysplastic syndromes
    Efstratios Katsoulidis
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    Cancer Res 65:9029-37. 2005
    ..Taken altogether, our data implicate the p38 MAPK in the pathophysiology of myelodysplasias and suggest that p38 pharmacologic inhibitors may have therapeutic applications in the treatment of MDS...
  35. pmc Antileukemic effects of AMPK activators on BCR-ABL-expressing cells
    Eliza Vakana
    Robert H Lurie Comprehensive Cancer Center, Chicago, IL, USA
    Blood 118:6399-402. 2011
    ....
  36. ncbi Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling
    Surinder Kaur
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 282:1757-68. 2007
    ..Taken altogether, our data suggest an important role for mTOR-dependent pathways in IFN signaling and identify 4E-BP1 and TSC1-TSC2 as key components in the generation of IFN-dependent biological responses...
  37. pmc Activation of protein kinase C{eta} by type I interferons
    Amanda J Redig
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 284:10301-14. 2009
    ..Altogether, our studies establish PKCeta as a unique element in IFN signaling that plays a key and essential role in the generation of the regulatory effects of type I IFNs on normal and leukemic hematopoiesis...
  38. ncbi Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses
    Nick Giafis
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Department of Medicine, Northwestern University Medical School, 303 East Superior Street, Chicago, IL 60611, USA
    Cancer Res 66:6763-71. 2006
    ..Altogether, our data indicate that the Mkk3/6-p38 signaling cascade is activated in a negative regulatory feedback manner to control induction of As(2)O(3)-mediated antileukemic effects...
  39. pmc Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins
    Antonella Sassano
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, 303 East Superior Street, Lurie 3 107, Chicago, IL 60611, USA
    Mol Cancer Ther 8:615-25. 2009
    ....
  40. ncbi 8-Amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, and Akt kinase: role in induction of apoptosis in multiple myeloma
    Kulsoom Ghias
    Robert H Lurie Comprehensive Cancer Center, Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Olson 8340, Chicago, Illinois 60611, USA n
    Mol Cancer Ther 4:569-77. 2005
    ....
  41. ncbi Role of the p38 mitogen-activated protein kinase pathway in the generation of the effects of imatinib mesylate (STI571) in BCR-ABL-expressing cells
    Simrit Parmar
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 279:25345-52. 2004
    ..They also suggest that, in addition to activation of mitogenic pathways, BCR-ABL promotes leukemogenesis by suppressing the function of growth inhibitory signaling cascades...
  42. ncbi Suppressive effects of statins on acute promyelocytic leukemia cells
    Antonella Sassano
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside VA Medical Center, Chicago, Illinois 60611, USA
    Cancer Res 67:4524-32. 2007
    ....
  43. ncbi Cutting edge: activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia
    Amit Verma
    Section of Hematology Oncology, Department of Medicine, University of Illinois and West Side Veterans Administration Medical Center, Chicago, IL 60607, USA
    J Immunol 168:5984-8. 2002
    ....
  44. pmc Statin-dependent activation of protein kinase Cδ in acute promyelocytic leukemia cells and induction of leukemic cell differentiation
    Antonella Sassano
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology and Northwestern University Medical School, Chicago, IL 60611, USA
    Leuk Lymphoma 53:1779-84. 2012
    ..Altogether, our data establish a novel function for PKCδ as a mediator of statin-induced differentiation of APL cells and antileukemic effects...
  45. pmc Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
    Nathalie Carayol
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Jesse Brown VA Medical Center, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 107:12469-74. 2010
    ....
  46. ncbi p38 MAP kinase modulates Smad-dependent changes in human prostate cell adhesion
    Steven A Hayes
    Division of Hematology Oncology, Department of Medicine Northwestern University Medical School and the Robert H Lurie Cancer Center of Northwestern University, Olson 8524, 710 N Fairbanks, Chicago, IL 60611 3008, USA
    Oncogene 22:4841-50. 2003
    ..This represents a mechanism by which the pleiotropic effects of TGFbeta may be channeled to modulate cell adhesion...
  47. pmc Role of the translational repressor 4E-BP1 in the regulation of p21(Waf1/Cip1) expression by retinoids
    Padma Kannan-Thulasiraman
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Jesse Brown VA Medical Center, 303 East Superior, Chicago, IL, USA
    Biochem Biophys Res Commun 368:983-9. 2008
    ..Altogether, these findings strongly suggest a key regulatory role for the translational repressor 4E-BP1 in the generation of retinoid-dependent functional responses...
  48. pmc Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis
    Sonali Joshi
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 286:6017-26. 2011
    ..These findings establish a key role for the Mnk/eIF4E pathway in the regulatory effects of IFNγ on normal hematopoiesis and identify Mnk kinases as important elements in the control of IFNγ-inducible ISG mRNA translation...
  49. pmc Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signals
    Barbara Kroczynska
    Robert H Lurie Comprehensive Cancer Center and and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    Mol Cell Biol 29:2865-75. 2009
    ....
  50. ncbi Role of Stat5 in type I interferon-signaling and transcriptional regulation
    Shahab Uddin
    Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, USA
    Biochem Biophys Res Commun 308:325-30. 2003
    ..Furthermore, our results strongly suggest that, in addition to phosphorylation on tyrosine residues, phosphorylation on serine residues exhibits regulatory effects on the transcriptional capacity of Stat5...
  51. pmc Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursors
    Swarna Mehrotra
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 288:23814-22. 2013
    ..Altogether, these findings provide evidence for key and essential roles of the Mnk kinase pathway in the generation of the antineoplastic effects of type I IFNs in Jak2V617F-dependent MPNs. ..
  52. ncbi Mitogen-activated protein kinase pathways in interferon signaling
    Antonella Sassano
    Robert H Lurie Comprehensive Cancer Center, Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL, USA
    Methods Mol Med 116:135-50. 2005
    ..Also, the methodological approaches used to examine the role of this pathway on the regulation of hematopoiesis are discussed...
  53. ncbi Activation of the mitogen- and stress-activated kinase 1 by arsenic trioxide
    Padma Kannan-Thulasiraman
    Robert H Lurie Comprehensive Cancer Center and the Division of Hematology Oncology, Department of Medicine, Northwestern University Medical School, and Lakeside VA Hospital Chicago, Illinois 60611, USA
    J Biol Chem 281:22446-52. 2006
    ..Altogether, these findings indicate an important role for MSK1 downstream of p38 in the regulation of As2O3 responses...
  54. pmc Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses
    Bhumika Sharma
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 287:42352-60. 2012
    ..Altogether, our findings demonstrate that Spry proteins are potent regulators of Type I IFN signaling and negatively control induction of Type I IFN-mediated biological responses...
  55. ncbi Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727
    Shahab Uddin
    Section of Hematology Oncology, Department of Medicine, University of Illinois at Chicago and West Side Veterans Administration Medical Center, Chicago, Illinois 60607, USA
    J Biol Chem 277:14408-16. 2002
    ..Altogether, these findings indicate that PKC-delta functions as a serine kinase for Stat1 and an upstream regulator of the p38 MAP kinase and plays an important role in the induction of Type I IFN-biological responses...
  56. pmc Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide
    Dennis J Goussetis
    Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA
    Blood 120:3555-62. 2012
    ....
  57. pmc HoxA10 protein regulates transcription of gene encoding fibroblast growth factor 2 (FGF2) in myeloid cells
    Chirag A Shah
    Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 287:18230-48. 2012
    ..Therapeutic targeting of Fgf2-stimulated signaling pathways might be a rational approach to this poor prognosis subset of AML...
  58. pmc Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses
    Barbara Kroczynska
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
    Mol Cell Biol 32:2809-22. 2012
    ..Altogether, these findings provide evidence for a unique function of PDCD4 in the type I IFN system and indicate a key regulatory role for this protein in mRNA translation of ISGs and control of IFN responses...
  59. pmc Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling
    Brooke M Emerling
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Mol Cell Biol 25:4853-62. 2005
    ..These results provide genetic evidence that p38 mitogen-activated protein kinase signaling is essential for HIF-1 activation...
  60. pmc Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway
    Nathalie Carayol
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60611, USA
    J Biol Chem 283:8601-10. 2008
    ..Altogether, our studies identify a novel mechanism by which BCR-ABL may promote leukemic cell growth, involving sequential engagement of the mTOR/p70 S6K pathway and downstream suppression of PDCD4 expression...
  61. ncbi Signalling pathways activated by all-trans-retinoic acid in acute promyelocytic leukemia cells
    Suman Kambhampati
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    Leuk Lymphoma 45:2175-85. 2004
    ..The clinical implications and potential translational applications from the accumulating knowledge in the field are also discussed...
  62. pmc Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors
    Jessica K Altman
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Blood 121:3675-81. 2013
    ....
  63. ncbi The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1
    Chunliu Zhu
    Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University and Chicago Lakeside Veterans Affairs Hospital, Chicago, Illinois 60611, USA
    J Biol Chem 279:50874-85. 2004
    ..This novel ICSBP function provides insight into regulation of myelopoiesis under normal conditions and in myeloproliferative disorders...
  64. doi Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma
    Jennifer Woodard
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, Illinois, USA
    Clin Cancer Res 14:4640-9. 2008
    ....
  65. pmc All trans retinoic acid nanodisks enhance retinoic acid receptor mediated apoptosis and cell cycle arrest in mantle cell lymphoma
    Amareshwar T K Singh
    Division of Haematology Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Br J Haematol 150:158-69. 2010
    ..In summary, incorporation of ATRA into ND enhanced the biological activity of this retinoid in cell culture models of MCL...
  66. pmc Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide
    Dennis J Goussetis
    Division of Hematology Oncology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 285:29989-97. 2010
    ....
  67. ncbi The PI3' kinase pathway in interferon signaling
    Surinder Kaur
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, 303 East Superior Street, Chicago, IL 60611, USA
    J Interferon Cytokine Res 25:780-7. 2005
    ..This pathway is activated distinctively from the Stat pathway but plays important roles in the regulation of IFN-dependent gene transcription and initiation of mRNA translation...
  68. pmc Protein kinase R as mediator of the effects of interferon (IFN) gamma and tumor necrosis factor (TNF) alpha on normal and dysplastic hematopoiesis
    Bhumika Sharma
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 286:27506-14. 2011
    ....
  69. ncbi Mechanisms of type I interferon signaling in normal and malignant cells
    Yongzhong Li
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans, Administration Medical Center, Chicago, IL 60611, USA
    Arch Immunol Ther Exp (Warsz) 52:156-63. 2004
    ..In this review, the regulation of various signaling cascades by the type I IFN receptor is summarized and an update on recent advances in the field is provided...
  70. ncbi Calcium-induced matrix metalloproteinase 9 gene expression is differentially regulated by ERK1/2 and p38 MAPK in oral keratinocytes and oral squamous cell carcinoma
    Subhendu Mukhopadhyay
    Department of Cell and Molecular Biology, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 279:33139-46. 2004
    ....
  71. ncbi EVI1 abrogates interferon-alpha response by selectively blocking PML induction
    Silvia Buonamici
    Department of Pathology and Cancer Center, University of Illinois, Chicago, Illinois 60607, USA
    J Biol Chem 280:428-36. 2005
    ..These results point to a novel mechanism utilized by an oncogene to escape normal cell response to growth-controlling cytokines...
  72. doi Mechanisms of mRNA translation of interferon stimulated genes
    Sonali Joshi
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, and Jesse Brown VA Medical Center, Chicago, IL, USA
    Cytokine 52:123-7. 2010
    ..The emerging roles of microRNAs in mRNA translation of ISGs are also discussed...
  73. pmc Regulatory effects of ribosomal S6 kinase 1 (RSK1) in IFNλ signaling
    Barbara Kroczynska
    Division of Hematology Oncology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 286:1147-56. 2011
    ..Altogether, our data provide evidence for a critical role for the activated RSK1 in IFNλ signaling...
  74. ncbi Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis
    Amit Verma
    Section of Hematology Oncology, Department of Medicine, University of Illinois at Chicago and West Side Veterans Affairs Medical Center, Chicago, Illinois 60607, USA
    J Biol Chem 277:7726-35. 2002
    ....
  75. ncbi Interferons: mechanisms of action and clinical applications
    Simrit Parmar
    Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
    Curr Opin Oncol 15:431-9. 2003
    ..These cytokines have found important applications in clinical medicine, including the treatment of certain malignancies. The purpose of this review is to provide an update on basic and clinical research in the interferon field...
  76. ncbi Acute lymphoblastic leukemia in a patient with chronic cyanoacrylate exposure
    Brian T Layden
    Department of Internal Medicine, Northwestern University Medical School, Chicago, Ill, USA
    Acta Haematol 118:242-3. 2007
    ..This case raises the possibility that chronic exposure to cyanoacrylates, the adhesive agents in industrial strength glue, may be associated with the development of acute lymphoblastic leukemia in humans...
  77. doi Growth suppressive cytokines and the AKT/mTOR pathway
    Barbara Kroczynska
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, 303 East Superior Street, Lurie 3 107, Chicago, IL 60611, USA
    Cytokine 48:138-43. 2009
    ..In this review, the regulatory effects of various growth suppressive cytokines on the mTOR pathway are summarized and the emerging new functions of mTOR are discussed...
  78. ncbi The p38 mitogen-activated protein kinase pathway in interferon signal transduction
    Efstratios Katsoulidis
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, 303 East Superior Street, Lurie 3 125, Chicago, IL 60611, USA
    J Interferon Cytokine Res 25:749-56. 2005
    ..We further dissect and discuss the roles of upstream and downstream components of the p38 MAP kinase in the control of cellular responses triggered by IFNs...
  79. ncbi The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1
    Fatima Lekmine
    Section of Hematology Oncology, University of Illinois at Chicago and West Side Veterans Administration Medical Center, Chicago, Illinois 60607, USA
    Biochem Biophys Res Commun 291:744-50. 2002
    ..Taken altogether, these findings indicate that CrkL provides an important link between Jak-kinases and downstream cascades that play critical roles in IFN-dependent transcriptional regulation and induction of growth inhibitory responses...
  80. ncbi Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells
    Dolores L Mahmud
    The University of Illinois Medical Center, Chicago, Illinois, USA
    Oncogene 21:1556-62. 2002
    ..Thus mammalian forkhead transcription factors are involved in Epo and SCF signaling in primary erythroid progenitors and may play a role in the induction of apoptotic and mitogenic signals...
  81. ncbi Jak family of kinases in cancer
    Amit Verma
    Robert H Lurie Comprehensive Cancer Center and Section of Hematology Oncology, Northwestern University Medical School, Chicago, IL, USA
    Cancer Metastasis Rev 22:423-34. 2003
    ..This review summarizes the role of various Jak-kinase dependent pathways in malignancies and discusses the therapeutic implications of the recent advances in the field...
  82. pmc Identification of a novel microRNA cluster miR-193b-365 in multiple myeloma
    Kenji Unno
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Leuk Lymphoma 50:1865-71. 2009
    ..Given that dysregulation of miR-193b-365 cluster has not been identified in other hematological malignancies examined to date, our findings suggest that miR-193b-365 cluster is part of the unique miRNA signature in MM...
  83. ncbi Akt and mRNA translation by interferons
    Surinder Kaur
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Cell Cycle 7:2112-6. 2008
    ..The implications of such studies on the overall perception of the Akt pathway are also discussed...
  84. ncbi Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma
    Shahab Uddin
    King Fahad National Center for Children s Cancer and Research, Riyadh, Saudi Arabia
    Oncogene 24:7022-30. 2005
    ..Therefore, curcumin may have a future therapeutic role in PEL and possibly other malignancies with constitutive activation of STAT3...
  85. ncbi Signaling via the interferon-alpha receptor in chronic myelogenous leukemia cells
    Amit Verma
    Department of Medicine, University of Illinois at Chicago and West Side Veterans Adminstration Medical Center, IL 60607, USA
    Leuk Lymphoma 43:703-9. 2002
    ..This review summarizes the recent advances in the-field of interferon signaling in CML cells and discusses the implications of identifying signaling proteins that mediate IFNalpha-induced growth inhibition...
  86. ncbi A role for mixed lineage kinases in regulating transcription factor CCAAT/enhancer-binding protein-{beta}-dependent gene expression in response to interferon-{gamma}
    Sanjit K Roy
    Greenebaum Cancer Center, Department of Microbiology and Immunology, University of Maryland School of Medicine, Balltimore, MD 21201, USA
    J Biol Chem 280:24462-71. 2005
    ..Together these studies provide the first evidence that MLK3 is involved in IFN-gamma signaling and identify a novel mechanism of transcriptional activation by IFN-gamma...
  87. pmc MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma
    Sanjit K Roy
    Department of Microbiology and Immunology, Molecular and Cellular Biology Program, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 99:7945-50. 2002
    ..A dominant negative MEKK1 blocks C/EBP-beta-driven gene expression stimulated by IFN-gamma. These studies describe an IFN-gamma-stimulated pathway that involves MEKK1-MEK1-ERK1/2 kinases to regulate C/EBP-beta-dependent gene expression...
  88. ncbi Mechanisms of type-I interferon signal transduction
    Shahab Uddin
    King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Biochem Mol Biol 37:635-41. 2004
    ..Recent developments in this research area are emphasized and the implications of these new discoveries on our understanding of interferon actions are discussed...
  89. pmc Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors
    Tony A Navas
    Albert Einstein College of Medicine, Bronx, NY, USA
    Blood 108:4170-7. 2006
    ..These data implicate p38 MAPK in the pathobiology of ineffective hematopoiesis in lowrisk MDS and provide a strong rationale for clinical investigation of SCIO-469 in MDS...
  90. ncbi Interferons
    Simrit Parmar
    Robert H Lurie Comprehensive Cancer Center, Division of Hematology Onocology, Northwestern University Medical School, Chicago, IL, USA
    Cancer Treat Res 126:45-68. 2005
  91. doi Sphingosine kinase is an attractive target for novel pharmacological interventions in non-Hodgkin lymphomas
    Shahab Uddin
    Department of Human Cancer Genomic Research, KFNCCC and R, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Leuk Lymphoma 49:850-1. 2008
  92. ncbi Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells
    Xiaoke Huang
    Division of Hematology Oncology, Department of Medicine, Northwestern University Medical School and the Robert H Lurie Cancer Center of Northwestern University, Chicago, IL 60611, USA
    Cancer Res 65:3470-8. 2005
    ..Any potential causal link to epidemiologic findings will require further investigation...
  93. ncbi c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells
    Kaiser M Bijli
    Department of Pediatrics, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 292:L396-404. 2007
    ..These data implicate an important role of c-Src in phosphorylating RelA/p65 to promote the transcriptional activity of NF-kappaB and thereby ICAM-1 expression in endothelial cells...
  94. ncbi Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells
    Azhar R Hussain
    Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, Biological and Medical Research, Riyadh 11211, Saudi Arabia
    Cancer Res 67:3888-97. 2007
    ....
  95. doi Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines
    Azhar R Hussain
    Department of Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    Mol Cancer Ther 7:3318-29. 2008
    ..These findings also raise the possibility that incorporation of curcumin in treatment regimens may provide a novel approach for the treatment of Burkitt's lymphomas and provide the molecular basis for such future translational efforts...
  96. pmc Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS
    Li Zhou
    Albert Einstein College of Medicine, Bronx, NY, USA
    Blood 112:3434-43. 2008
    ..These data directly implicate TGF-beta signaling in the pathobiology of ineffective hematopoiesis and identify TBRI as a potential therapeutic target in low-risk MDS...
  97. pmc CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1
    Thomas T Murooka
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network and Department of Immunology, University of Toronto, Toronto, ON, Canada
    Blood 111:4892-901. 2008
    ..Taken together, we describe a novel mechanism by which CCL5 influences translation of rapamycin-sensitive mRNAs and "primes" CD4(+) T cells for efficient chemotaxis...
  98. ncbi The protein kinase C (PKC) family of proteins in cytokine signaling in hematopoiesis
    Amanda J Redig
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, 300 East Superior Street, Chicago, IL 60611, USA
    J Interferon Cytokine Res 27:623-36. 2007
    ..In this review, both the engagement of the various PKC members in cytokine and growth factor signaling and their role in the regulation of hematopoiesis are discussed...