Peter Penzes

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurochem 126:165-82. 2013
  2. pmc Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Cytoskeleton (Hoboken) 69:426-41. 2012
  3. pmc Regulation of the actin cytoskeleton in dendritic spines
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Adv Exp Med Biol 970:81-95. 2012
  4. pmc Epac2-mediated dendritic spine remodeling: implications for disease
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Cell Neurosci 46:368-80. 2011
  5. pmc Dendritic spine pathology in neuropsychiatric disorders
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 14:285-93. 2011
  6. pmc Kalirin signaling: implications for synaptic pathology
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Mol Neurobiol 45:109-18. 2012
  7. pmc Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Ward 7 174, Chicago, IL 60611, USA
    Brain Res Rev 67:184-92. 2011
  8. doi request reprint Not just actin? A role for dynamic microtubules in dendritic spines
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Neuron 61:3-5. 2009
  9. doi request reprint Convergent CaMK and RacGEF signals control dendritic structure and function
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Trends Cell Biol 18:405-13. 2008
  10. doi request reprint Dendritic spine dynamics--a key role for kalirin-7
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Trends Neurosci 31:419-27. 2008

Research Grants

Collaborators

Detail Information

Publications34

  1. pmc Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurochem 126:165-82. 2013
    ..Here, we discuss recent genetic, neuropathological, and molecular studies that implicate alterations in excitatory and inhibitory synaptic circuits in the pathogenesis of psychiatric disorders across the lifespan...
  2. pmc Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Cytoskeleton (Hoboken) 69:426-41. 2012
    ..Finally, we discuss the importance of these actin regulatory pathways in neuropsychiatric disorders...
  3. pmc Regulation of the actin cytoskeleton in dendritic spines
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Adv Exp Med Biol 970:81-95. 2012
    ..We will place special emphasis on small GTPase pathways, as they have an established importance in dendritic spine plasticity and pathology. Finally, we will discuss some epigenetic mechanisms that control spine morphogenesis...
  4. pmc Epac2-mediated dendritic spine remodeling: implications for disease
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Cell Neurosci 46:368-80. 2011
    ....
  5. pmc Dendritic spine pathology in neuropsychiatric disorders
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 14:285-93. 2011
    ....
  6. pmc Kalirin signaling: implications for synaptic pathology
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Mol Neurobiol 45:109-18. 2012
    ..Here, we review recent studies that have genetically and functionally linked kalirin signaling to a number of human disorders. Kalirin signaling may thus represent a disease mechanism and provide a novel therapeutic target...
  7. pmc Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Ward 7 174, Chicago, IL 60611, USA
    Brain Res Rev 67:184-92. 2011
    ..Spine stabilizing pathways may thus represent efficacious therapeutic targets for combating AD pathology...
  8. doi request reprint Not just actin? A role for dynamic microtubules in dendritic spines
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Neuron 61:3-5. 2009
    ..Microtubules, long thought to be absent from dendritic spines, are capable of controlling spine morphology, opening up a new line of investigation into mechanisms of spine plasticity and maintenance...
  9. doi request reprint Convergent CaMK and RacGEF signals control dendritic structure and function
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Trends Cell Biol 18:405-13. 2008
    ..Through this pathway, CaMKs and RacGEFs amplify calcium signals and translate them into spatially and temporally regulated structural remodeling of dendritic spines...
  10. doi request reprint Dendritic spine dynamics--a key role for kalirin-7
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Trends Neurosci 31:419-27. 2008
    ....
  11. ncbi request reprint Pumping up the synapse
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 56:942-4. 2007
    ....
  12. pmc Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines
    Kevin M Woolfrey
    Department of Physiology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 12:1275-84. 2009
    ..Thus, we identify a previously unknown mechanism that promotes dynamic remodeling and depression of spiny synapses, disruption of which may contribute to some aspects of disease...
  13. pmc Coordination of synaptic adhesion with dendritic spine remodeling by AF-6 and kalirin-7
    Zhong Xie
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 28:6079-91. 2008
    ....
  14. pmc Neuregulin1 signaling promotes dendritic spine growth through kalirin
    Michael E Cahill
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Neurochem 126:625-35. 2013
    ..Finally, we show that environmental enrichment, known to promote spine growth, robustly enhances the levels of erbB4 protein in the forebrain. These findings provide a mechanistic link between NRG1 signaling and spine morphogenesis..
  15. pmc Afadin is required for maintenance of dendritic structure and excitatory tone
    Deepak P Srivastava
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 287:35964-74. 2012
    ..Collectively, these data suggest that afadin is required for the maintenance of dendritic structure and excitatory tone...
  16. pmc Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity
    Deepak P Srivastava
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 105:14650-5. 2008
    ..This work describes a form of two-step wiring plasticity relevant for cortical memory and identifies targets that may facilitate recovery from brain injuries...
  17. pmc Hippocampal phenotypes in kalirin-deficient mice
    Zhong Xie
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Cell Neurosci 46:45-54. 2011
    ..These studies allow the comparison of the phenotypes of different kalirin mutant mice and shed light on the brain region-specific functions of small GTPase signaling...
  18. pmc Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines
    Zhong Xie
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 56:640-56. 2007
    ....
  19. pmc Kalirin loss results in cortical morphological alterations
    Zhong Xie
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Cell Neurosci 43:81-9. 2010
    ..These data demonstrate important roles for kalirin in the regulation of cortical structure, ultrastructure, and spine structural plasticity...
  20. pmc Social, communication, and cortical structural impairments in Epac2-deficient mice
    Deepak P Srivastava
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 32:11864-78. 2012
    ..Together, these findings provide novel insight into the molecular and cellular substrates of social and communication behavior...
  21. pmc Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling
    Kelly A Jones
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:19575-80. 2009
    ..These results suggest a potential role for serotonin signaling in modulating spine morphology and kalirin-7's function at cortical synapses...
  22. pmc Estrogen receptor ß activity modulates synaptic signaling and structure
    Deepak P Srivastava
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 30:13454-60. 2010
    ..These results implicate ERβ signaling in controlling dendritic spine morphology, in part via a PAK/ERK1/2-dependent pathway, and provide mechanistic insight into the rapid cellular effects of estrogen on brain function...
  23. pmc Segregated populations of hippocampal principal CA1 neurons mediating conditioning and extinction of contextual fear
    Natalie C Tronson
    Department of Psychiatry and Behavioral Sciences, The Asher Center for the Study, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 29:3387-94. 2009
    ..These results demonstrate that extinction mechanisms based on Erk signaling involve a specific population of CA1 principal neurons distinctively regulated by afferent cholinergic input from the medial septum...
  24. pmc Long-term perturbation of spine plasticity results in distinct impairments of cognitive function
    Jon Eric VanLeeuwen
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Neurochem 123:781-9. 2012
    ..Our data support spines as neuronal structures important for cognition and suggest interplay between brain regions is critical for complex cognitive processing...
  25. pmc Spatially restricted actin-regulatory signaling contributes to synapse morphology
    Daniel A Nicholson
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA
    J Neurochem 121:852-60. 2012
    ..Overall, our findings indicate that kalirin-7 is differentially compartmentalized in spines as a function of both synapse morphology and spine size...
  26. pmc Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes
    Michael E Cahill
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:13058-63. 2009
    ..Several of these deficits are delayed and age-dependent. Our study thus links spine morphogenic signaling with age-dependent, delayed, disease-related phenotypes, including cognitive dysfunction...
  27. pmc Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein
    Maria V Barbolina
    Department of Biopharmaceutical Sciences, University of Illinois, Chicago, Illinois 60622, USA
    J Biol Chem 288:141-51. 2013
    ..Similar results were obtained in other tissue-invasive cells such as vascular endothelial cells, suggesting a novel mechanism for functional coupling of matrix adhesion with Wnt signaling...
  28. pmc An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice
    Deepak P Srivastava
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS Biol 10:e1001350. 2012
    ....
  29. pmc N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation
    Christina Schrick
    Department of Psychiatry and Behavioral Sciences, The Asher Center for Depressive Disorders, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 55:786-98. 2007
    ..The data suggest that the newly identified role of hippocampal N-cadherin in memory consolidation may be mediated, at least in part, by cytoskeletal IQGAP1/Erk signaling...
  30. ncbi request reprint Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6
    Zhong Xie
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611
    Neuron 48:605-18. 2005
    ..These results identify a signaling pathway that regulates activity-dependent synaptic structural plasticity and coordinates it with functional plasticity...
  31. pmc Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization
    Xiaoting Wang
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 33:11012-22. 2013
    ....
  32. pmc Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion
    Maria V Barbolina
    Department of Chemical and Biological Engineering, Northwestern University, Chicago, IL, USA
    Int J Cancer 125:816-25. 2009
    ..Together these data suggest that downregulation of CTGF in EOC cells may be important for cell invasion through modulation of cell-matrix adhesion...
  33. pmc Rapid estradiol modulation of neuronal connectivity and its implications for disease
    Deepak P Srivastava
    Department of Physiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA
    Front Endocrinol (Lausanne) 2:77. 2011
    ..We will then go on to discuss the potential role of 17 β-estradiol modulation of neural circuits and its potential relevance for the treatment of psychiatric and neurodevelopmental disorders...
  34. ncbi request reprint Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin
    Peter Penzes
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Neuron 37:263-74. 2003
    ..This novel signal transduction pathway may be critical for the regulation of the actin cytoskeleton controlling spine morphogenesis during development and plasticity...

Research Grants8

  1. Regulation of the Actin Cytoskeleton in Dendric Spines
    Peter Penzes; Fiscal Year: 2002
    ..serine/threonine phosphorylation, and generate initial information about the types of protein kinases involved. Together, these experiments will provide a basis for future studies of regulation of kalirin-7 and spine morphogenesis. ..
  2. Role of kalirin-7 and Rac1 in synaptic plasticity
    Peter Penzes; Fiscal Year: 2009
    ..These studies will use primary cultures of cortical and hippocampal neurons. ..
  3. Role of kalirin signaling in synaptic plasticity
    Peter Penzes; Fiscal Year: 2010
    ..As both spine density and kalirin expression are reduced in schizophrenic patients'brains, these studies are expected to provide important insight into the mechanisms of spine pathology in mental disorders. 1 ..