Kristina R Patterson

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport
    Kristina R Patterson
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States
    Biochemistry 50:10300-10. 2011
  2. pmc Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease
    Kristina R Patterson
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 286:23063-76. 2011
  3. pmc Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases
    Nicholas M Kanaan
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 31:9858-68. 2011
  4. pmc Tau as a therapeutic target in neurodegenerative disease
    Diana S Himmelstein
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Tarry 8 754, 300 E Superior St, Chicago, IL 60611, USA
    Pharmacol Ther 136:8-22. 2012
  5. ncbi request reprint Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease
    Peleg M Horowitz
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 24:7895-902. 2004

Detail Information

Publications5

  1. pmc Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport
    Kristina R Patterson
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States
    Biochemistry 50:10300-10. 2011
    ..Taken together, our data provide a novel molecular basis for the protective effect of Hsp70 in tauopathies...
  2. pmc Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease
    Kristina R Patterson
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 286:23063-76. 2011
    ....
  3. pmc Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases
    Nicholas M Kanaan
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 31:9858-68. 2011
    ..Results from these studies reveal a novel role for tau in modulating axonal phosphotransferases and provide a molecular basis for a toxic gain-of-function associated with pathogenic forms of tau...
  4. pmc Tau as a therapeutic target in neurodegenerative disease
    Diana S Himmelstein
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Tarry 8 754, 300 E Superior St, Chicago, IL 60611, USA
    Pharmacol Ther 136:8-22. 2012
    ..Although the evidence for tau-based treatments is encouraging, additional work is undoubtedly needed to optimize each treatment strategy for the successful development of safe and effective therapeutics...
  5. ncbi request reprint Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease
    Peleg M Horowitz
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 24:7895-902. 2004
    ..Collectively, these results suggest a role for caspase-6 and N-terminal truncation of tau during neurofibrillary tangle evolution and the progression of Alzheimer's disease...