Research Topics
| Matthew R ParsekSummaryAffiliation: Northwestern University Country: USA Publications
| Collaborators
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Detail Information
Publications
Mucin-Pseudomonas aeruginosa interactions promote biofilm formation and antibiotic resistanceRebecca M Landry
Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
Mol Microbiol 59:142-51. 2006..Together, these experiments suggest that mucin, which may serve as an attachment surface in CF airways, impacts P. aeruginosa biofilm development and function...- Bacterial biofilms: an emerging link to disease pathogenesisMatthew R Parsek
Department of Civil and Environmental Engineering, Northwestern University, Evanston, Illinois 60208 3109, USA
Annu Rev Microbiol 57:677-701. 2003..The consequences of pathogens living in environmental biofilms and an analysis of some specific environmental biofilm systems are presented... 
Survival and growth in the presence of elevated copper: transcriptional profiling of copper-stressed Pseudomonas aeruginosaGail M Teitzel
Department of Civil and Environmental Engineering, Northwestern University, Evanston, Illinois 60208, USA
J Bacteriol 188:7242-56. 2006..These studies suggest that two resistance nodulation division efflux systems, a P-type ATPase, and a two-component regulator were particularly important for copper tolerance in P. aeruginosa...- Heavy metal resistance of biofilm and planktonic Pseudomonas aeruginosaGail M Teitzel
Department of Civil and Environmental Engineering, Northwestern University, Evanston, Illinois 60208, USA
Appl Environ Microbiol 69:2313-20. 2003.... - Characterization of colony morphology variants isolated from Pseudomonas aeruginosa biofilmsMary Jo Kirisits
University of Iowa, Department of Microbiology, 540E EMRB, Iowa City, IA 52242
Appl Environ Microbiol 71:4809-21. 2005..These variants displayed many of the same characteristics as the laboratory variants, suggesting a link between laboratory and cystic fibrosis biofilms... - Does Pseudomonas aeruginosa use intercellular signalling to build biofilm communities?Mary Jo Kirisits
Department of Civil, Architectural, and Environmental Engineering, The University of Texas at Austin, Austin, TX 78712, USA
Cell Microbiol 8:1841-9. 2006..This review will discuss quorum sensing and biofilm formation and studies that link these two processes... - The effect of the chemical, biological, and physical environment on quorum sensing in structured microbial communitiesAlexander R Horswill
Department of Microbiology, University of Iowa, Iowa, IA 52242, USA
Anal Bioanal Chem 387:371-80. 2007..As these studies continue to refine our understanding of these mechanisms, an emerging challenge is to identify if and when the local environment can affect signaling... - The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditionalJoshua D Shrout
Department of Microbiology, University of Iowa, Iowa City, IA, USA
Mol Microbiol 62:1264-77. 2006..These data led to a model proposing that the prevailing nutritional conditions dictate the contributions of quorum sensing and swarming motility at a key juncture early in biofilm development... - The promise and peril of transcriptional profiling in biofilm communitiesDingding An
Department of Microbiology, University of Washington, School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 7242, USA
Curr Opin Microbiol 10:292-6. 2007..Thus, an emerging challenge is to use transcriptional profiling in combination with techniques that can identify and separate relevant subpopulations within a biofilm... - Influence of the hydrodynamic environment on quorum sensing in Pseudomonas aeruginosa biofilmsMary Jo Kirisits
Department of Civil, Architectural, and Environmental Engineering, The University of Texas at Austin, 1 University Station C1786, Austin, TX 78712, USA
J Bacteriol 189:8357-60. 2007..The amount of biofilm biomass required for full QS induction of the population increased as the flow rate increased... - Subinhibitory concentrations of azithromycin decrease nontypeable Haemophilus influenzae biofilm formation and Diminish established biofilmsTimothy D Starner
Department of Pediatrics, University of Iowa, 2080H Medical Laboratories, 200 Hawkins Drive, Iowa City, IA 52242, USA
Antimicrob Agents Chemother 52:137-45. 2008..influenzae... - Microbiology: bilingual bacteriaMatthew R Parsek
Nature 450:805-7. 2007 - Analysis of Pseudomonas aeruginosa conditional psl variants reveals roles for the psl polysaccharide in adhesion and maintaining biofilm structure postattachmentLuyan Ma
Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
J Bacteriol 188:8213-21. 2006..aeruginosa. This translated into significant changes in the architecture of the biofilm. We propose that Psl has an important role in P. aeruginosa adhesion, which is critical for initiation and maintenance of the biofilm structure... - Quorum sensing and motility mediate interactions between Pseudomonas aeruginosa and Agrobacterium tumefaciens in biofilm coculturesDingding An
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 103:3828-33. 2006..a. and that the outcome of competition and the relative contribution of different factors to competition are strongly influenced by the environment in which they occur... - Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compoundMorten Hentzer
Department of Molecular Microbiology, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark
Microbiology 148:87-102. 2002..It does, however, affect the architecture of the biofilm and enhances the process of bacterial detachment, leading to a loss of bacterial biomass from the substratum... - Statistical analysis of Pseudomonas aeruginosa biofilm development: impact of mutations in genes involved in twitching motility, cell-to-cell signaling, and stationary-phase sigma factor expressionArne Heydorn
Section of Molecular Microbiology, The Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark
Appl Environ Microbiol 68:2008-17. 2002..The results are discussed in relation to the current model of P. aeruginosa biofilm development... - A component of innate immunity prevents bacterial biofilm developmentPradeep K Singh
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Nature 417:552-5. 2002..These findings reveal a specific anti-biofilm defence mechanism acting at a critical juncture in biofilm development, the time bacteria stop roaming as individuals and aggregate into durable communities... - Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesisSang Sun Yoon
Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Dev Cell 3:593-603. 2002..Thus, future investigations of CF pathogenesis and therapy should include a better understanding of anaerobic metabolism and biofilm development by P. aeruginosa... - Biofilms 2003: emerging themes and challenges in studies of surface-associated microbial lifeMatthew R Parsek
The University of Iowa, Department of Microbiology, 540E EMRB, Iowa City, IA 52242-1109, USA
J Bacteriol 186:4427-40. 2004 - Identification of psl, a locus encoding a potential exopolysaccharide that is essential for Pseudomonas aeruginosa PAO1 biofilm formationKara D Jackson
Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1064, USA
J Bacteriol 186:4466-75. 2004..Understanding psl-encoded exopolysaccharide expression and protection in biofilms will provide insight into the pathogenesis of P. aeruginosa in cystic fibrosis and other infections involving biofilms... - Phosphorus limitation enhances biofilm formation of the plant pathogen Agrobacterium tumefaciens through the PhoR-PhoB regulatory systemThomas Danhorn
Department of Biology, 1001 E 3rd St, Jordan Hall 142, Indiana University, Bloomington, IN 47405 1847, USA
J Bacteriol 186:4492-501. 2004..tumefaciens surface interactions... - Sociomicrobiology: the connections between quorum sensing and biofilmsMatthew R Parsek
Department of Microbiology, The University of Iowa, 540 EMRB, Iowa City, IA 52242-1109, USA
Trends Microbiol 13:27-33. 2005..Bacteria exhibit many social activities and they represent a model for dissecting social behavior at the genetic level. Therefore, we introduce the term 'sociomicrobiology'... - The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-gamma-mediated macrophage killingJeff G Leid
Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA
J Immunol 175:7512-8. 2005..aeruginosa biofilm bacteria from the human immune system... - Growing and analyzing biofilms in fermentersBronwyn E Ramey
University of Iowa, Iowa City, Iowa, USA
Curr Protoc Microbiol . 2005..These methods also utilize continuous culture, or chemostat, conditions to maintain a quasi-steady state...