Research Topics
| John PandolfinoSummaryAffiliation: Northwestern University Country: USA Publications
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Publications
Evaluation of esophageal contractile propagation using esophageal pressure topographyJ E Pandolfino
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
Neurogastroenterol Motil 24:20-6. 2012..Additionally, this review will also be utilized to complement the description of the Chicago Classification of Esophageal Motor Disorders, which is presented in this supplement issue...
Does the Bravo pH capsule affect esophageal motor function?J E Pandolfino
Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois 60611, USA
Dis Esophagus 20:406-10. 2007..However, capsule presence was associated with a locus of augmented peristalsis and this phenomenon was most evident in subjects who perceived the presence of the Bravo capsule...- Slimline vs. glass pH electrodes: what degree of accuracy should we expect?J E Pandolfino
Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
Aliment Pharmacol Ther 23:331-40. 2006..Ambulatory pH monitoring is considered the gold standard for measuring oesophageal acid exposure, however, data comparing antimony and glass electrodes are limited... - Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteersJohn E Pandolfino
Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
Am J Physiol Gastrointest Liver Physiol 290:G1033-40. 2006..In addition to providing conventional EGJ relaxation parameters, this technology also creates opportunities to quantify more precise measures of EGJ relaxation and morphology... - Comparison of esophageal acid exposure at 1 cm and 6 cm above the squamocolumnar junction using the Bravo pH monitoring systemJ E Pandolfino
Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
Dis Esophagus 19:177-82. 2006..These findings suggest that measurement of acid exposure 1 cm above the SCJ may improve accuracy of pH monitoring by detecting acid reflux events confined to the distal esophagus... - A new confusing model of GERD: a spectrum of phenotypic progressionJ E Pandolfino
Department of Medicine, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, 676 N. St. Clair Street, Suite 1400, Chicago, IL 60611, USA
Dig Liver Dis 38:648-51. 2006 - Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometryJohn E Pandolfino
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Gastroenterology 131:1725-33. 2006.... - Upper sphincter function during transient lower oesophageal sphincter relaxation (tLOSR); it is mainly about microburpsJ E Pandolfino
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Neurogastroenterol Motil 19:203-10. 2007..Whether or not GORD patients with extra-oesophageal symptoms exhibit an exaggeration of the UOS relaxation response during reflux is yet to be determined... - Use and utility of the Bravo pH capsuleJohn E Pandolfino
Department of Medicine, Division of Gastroenterology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Clin Gastroenterol 42:571-8. 2008..This review will highlight the advantages of the Bravo system and how it should be used... - High-resolution manometry: an atlas of esophageal motility disorders and findings of GERD using esophageal pressure topographyJohn E Pandolfino
Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 St Clair Street, Suite 1400, Chicago, IL 60611 2951, USA
Thorac Surg Clin 21:465-75. 2011..A section on impaired bolus transit is also included to highlight the important aspect of impaired clearance in the pathogenesis of GERD... 
Achalasia: a new clinically relevant classification by high-resolution manometryJohn E Pandolfino
Northwestern University, The Feinberg School of Medicine, Department of Medicine, Chicago, Illinois, USA
Gastroenterology 135:1526-33. 2008..This study aimed to compare the clinical characteristics and treatment response of these 3 subtypes...- The pathophysiologic basis for epidemiologic trends in gastroesophageal reflux diseaseJohn E Pandolfino
Division of Gastroenterology, Department of Medicine, Northwestern University s Feinberg School of Medicine, 676 North St Clair Street, Suite 1400, Chicago, IL 60611, USA
Gastroenterol Clin North Am 37:827-43, viii. 2008..This article explores the interplay between pathophysiology and epidemiology by focusing on these risk factors and their potential effect on GERD pathogenesis... - New technologies in the gastrointestinal clinic and research: impedance and high-resolution manometryJohn E Pandolfino
Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, Illinois 60611, USA
World J Gastroenterol 15:131-8. 2009..This review describes the potential benefits that these new technologies may have over conventional techniques for the evaluation of dysphagia... - High-resolution manometry in clinical practice: utilizing pressure topography to classify oesophageal motility abnormalitiesJ E Pandolfino
Department of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
Neurogastroenterol Motil 21:796-806. 2009..It is our expectation that modification of this classification scheme will continue to occur and this should further clarify the utility of pressure topography plotting in assessing oesophageal motility disorders... - Unique features of esophagogastric junction pressure topography in hiatus hernia patients with dysphagiaJohn E Pandolfino
Department of Medicine, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Surgery 147:57-64. 2010.... - The contractile deceleration point: an important physiologic landmark on oesophageal pressure topographyJ E Pandolfino
Division of Gastroenterology, Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
Neurogastroenterol Motil 22:395-400, e90. 2010..This study aimed to correlate oesophageal bolus transit with features of oesophageal pressure topography (OPT) plots and establish OPT metrics for accurately measuring peristaltic velocity... - Distal esophageal spasm in high-resolution esophageal pressure topography: defining clinical phenotypesJohn E Pandolfino
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
Gastroenterology 141:469-75. 2011..Our aim was to apply standardized metrics of contraction velocity and latency to high-resolution esophageal pressure topography (EPT) studies to refine the diagnosis of DES... - The time course and persistence of "concurrent contraction" during normal peristalsisJohn E Pandolfino
Northwestern Univ, Feinberg School of Medicine, Dept of Medicine, Division of Gastroenterology and Hepatology, Chicago, Illinois 60611 2951, USA
Am J Physiol Gastrointest Liver Physiol 301:G679-83. 2011..How abnormalities of the extent or timing of concurrent contraction relate to clinical syndromes requires further investigation... - Acid reflux event detection using the Bravo wireless versus the Slimline catheter pH systems: why are the numbers so different?J E Pandolfino
Division of Gastroenterology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Suite 1400, Chicago, Illinois 60611, USA
Gut 54:1687-92. 2005..This study analysed the relative accuracy of the Bravo wireless and the Slimline catheter-Mark III Digitrapper pH systems in the detection of acid reflux events... - Measuring EGJ opening patterns using high resolution intraluminal impedanceJ E Pandolfino
Department of Medicine, Northwestern University, The Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
Neurogastroenterol Motil 17:200-6. 2005..These results support that impedance monitoring can be adapted to identify sphincter opening, to distinguish sphincter opening from sphincter relaxation, and to determine luminal contents during the opening period... - Absence of a deglutitive inhibition equivalent with secondary peristalsisJohn E Pandolfino
Division of Gastroenterology, Dept of Medicine, Northwestern Univ Feinberg School of Medicine, Suite 1400, 676 N St Clair St, Chicago, IL 60611, USA
Am J Physiol Gastrointest Liver Physiol 288:G671-6. 2005..Being that the elicitation of SP in the smooth muscle esophagus is intramurally mediated, this suggests that deglutitive inhibition is a centrally mediated phenomenon rather than an intrinsic property of peristalsis... - Evaluation of esophageal motor disorders in the era of high-resolution manometry and intraluminal impedanceJohn E Pandolfino
Division of Gastroenterology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Curr Gastroenterol Rep 11:182-9. 2009..This article provides an update on these technologies in clinical practice and how they may be helpful in the future... - Prolonged pH monitoring: Bravo capsuleJohn E Pandolfino
Department of Medicine, Northwestern University, The Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
Gastrointest Endosc Clin N Am 15:307-18. 2005..Further refinements in methodology and recording protocol are likely to be made, which will improve diagnostic accuracy and lower cost... - New technologies for the evaluation of esophageal motility disorders: impedance, high-resolution manometry, and intraluminal ultrasoundIkuo Hirano
Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 1400, Chicago, IL 60611, USA
Gastroenterol Clin North Am 36:531-51, viii. 2007..This article describes the technical aspects of each of these technologies and the potential benefits they offer over conventional techniques for the evaluation of esophageal motor diseases... - Review article: oesophageal pH monitoring--technologies, interpretation and correlation with clinical outcomesP J Kahrilas
Division of Gastroeneterology, Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
Aliment Pharmacol Ther 22:2-9. 2005..More research is needed to determine whether the detection of reflux events with Bravo will provide a good correlation with symptom episodes... - Transient lower oesophageal sphincter relaxation in achalasia: everything but LOS relaxationM A Kwiatek
Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 2951, USA
Neurogastroenterol Motil 21:1294-e123. 2009.... - Distinct patterns of oesophageal shortening during primary peristalsis, secondary peristalsis and transient lower oesophageal sphincter relaxationG Shi
Department of Medicine, North-western University Medical School, Chicago, IL 60611, USA
Neurogastroenterol Motil 14:505-12. 2002..During TLOSR, significant elevation of the SCJ occurred only after LOS opening, suggesting that this was a consequence of oesophageal distension induced by gas reflux rather than a component of the opening mechanism... - Oesophageal peristaltic transition zone defects: real but few and far betweenS K Ghosh
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Neurogastroenterol Motil 20:1283-90. 2008..8%). Although far less common than distal peristaltic or OGJ abnormailites, TZ defects may be related to dysphagia in a minority of patients (<4% in this series) and should be considered a distinct oesophageal motility disorder... - The effect of glucagon-induced gastric relaxation on TLOSR frequencyH Y Chang
Northwestern University, Feinberg School of Medicine, Chicago, IL 60611-3008, USA
Neurogastroenterol Motil 15:3-8. 2003..Despite causing substantial proximal stomach relaxation, glucagon did not increase TLOSR frequency. This suggests that the relevant gastric mechanoreceptors responsible for triggering TLOSRs do not respond to passive elongation... - The Bravo pH capsule systemM A Kwiatek
Northwestern University, The Feinberg School of Medicine, Division of Gastroenterology, Department of Medicine, Chicago, IL 60611, United States
Dig Liver Dis 40:156-60. 2008..In addition, we will also focus on the technical aspects related to its safety, tolerability and diagnostic accuracy... - Challenging the limits of esophageal manometryPeter J Kahrilas
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Gastroenterology 134:16-8. 2008 - Esophageal motility disorders in terms of pressure topography: the Chicago ClassificationPeter J Kahrilas
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
J Clin Gastroenterol 42:627-35. 2008.... - Utilizing intraluminal pressure gradients to predict esophageal clearance: a validation studyJohn E Pandolfino
Departments of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Am J Gastroenterol 103:1898-905. 2008..Esophageal bolus clearance requires a preferential esophagogastric pressure gradient sustained for a sufficient period. We aimed to validate a high-resolution manometry (HRM) paradigm for predicting bolus clearance... - Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjectsJohn E Pandolfino
Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Gastroenterology 125:1018-24. 2003..Therapy focused on EGJ compliance may benefit GERD patients... - The relationship between obesity and GERD: "big or overblown"John E Pandolfino
Am J Gastroenterol 103:1355-7. 2008..These results highlight the complexity of this relationship and once more support the concept that GERD is a multifactorial disease that cannot be defined by a single anatomical or functional abnormality... - Esophagogastric junction distensibility: a factor contributing to sphincter incompetenceJohn E Pandolfino
Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611-3008, USA
Am J Physiol Gastrointest Liver Physiol 282:G1052-8. 2002.... - Ambulatory esophageal pH monitoring using a wireless systemJohn E Pandolfino
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611-3008, USA
Am J Gastroenterol 98:740-9. 2003..The 95th percentile for the 2-day recordings in control subjects was 5.3%, slightly higher than observed with conventional systems... - Deglutitive inhibition affects both esophageal peristaltic amplitude and shorteningGuoxiang Shi
Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
Am J Physiol Gastrointest Liver Physiol 284:G575-82. 2003..Deglutitive inhibition affects both the longitudinal and circular muscle layers of the esophageal wall, and the occurrence of inhibition evident in one layer is strongly correlated with the other... - Comparison of inter- and intraobserver consistency for grading of esophagitis by expert and trainee endoscopistsJohn E Pandolfino
Northwestern University Medical School, Chicago, Illinois 60611, USA
Gastrointest Endosc 56:639-43. 2002..2%). CONCLUSIONS: Reproducibility in grading esophagitis was good for both expert endoscopists and fellows, although there was greater consistency among the experts. Both the Los Angeles and Hetzel-Dent scoring systems are reproducible... - The target of therapies: pathophysiology of gastroesophageal reflux diseasePeter J Kahrilas
Department of Medicine, Northwestern University s Feinberg School of Medicine, Division of Gastroenterology, Searle Bldg, 10th Floor, Suite 541, 303 East Chicago Avenue, Chicago, IL 60611, USA
Gastrointest Endosc Clin N Am 13:1-17. 2003.... - Classifying esophageal motility by pressure topography characteristics: a study of 400 patients and 75 controlsJohn E Pandolfino
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Am J Gastroenterol 103:27-37. 2008..This study aimed to devise a scheme for the systematic analysis of esophageal high-resolution manometry (HRM) studies displayed using topographic plotting... - Comparison of the Bravo wireless and Digitrapper catheter-based pH monitoring systems for measuring esophageal acid exposureJohn E Pandolfino
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Am J Gastroenterol 100:1466-76. 2005..Accuracy of pH data sets from both systems can be improved by scrutiny for artifacts and use of an in vivo pH reference... - Bravo capsule placement in the gastric cardia: a novel method for analysis of proximal stomach acid environmentJohn E Pandolfino
Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Am J Gastroenterol 100:1721-7. 2005..Instantaneous cardia pH defines the potential nadir esophageal pH during reflux events... - The mechanical basis of impaired esophageal emptying postfundoplicationSudip K Ghosh
Department of Mechanical Engineering, The Pennsylvania State University, University Park, Pennsylvania, University Park, PA 16802, USA
Am J Physiol Gastrointest Liver Physiol 289:G21-35. 2005..Immobilization of the intrinsic sphincter by the surgical procedure may contribute to this deficiency, impaired emptying, and possibly, dysphagia... - Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteersSudip K Ghosh
Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
Am J Physiol Gastrointest Liver Physiol 290:G988-97. 2006.... - Bravo capsule pH monitoringJohn E Pandolfino
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Am J Gastroenterol 100:8-10. 2005 - Obesity: a challenge to esophagogastric junction integrityJohn E Pandolfino
Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
Gastroenterology 130:639-49. 2006..CONCLUSIONS: Obese subjects are more likely to have EGJ disruption (leading to hiatal hernia) and an augmented GEPG providing a perfect scenario for reflux to occur. Whether or not weight loss can reverse these abnormalities is unknown... - Deglutitive upper esophageal sphincter relaxation: a study of 75 volunteer subjects using solid-state high-resolution manometrySudip K Ghosh
Northwestern University, Feinberg School of Medicine, Div of Gastroenterology, Dept of Medicine, 676 N St Clair St, Suite 1400, Chicago, IL 60611, USA
Am J Physiol Gastrointest Liver Physiol 291:G525-31. 2006..Normative values were established to aid in future clinical and investigative studies... - Restoration of normal distensive characteristics of the esophagogastric junction after fundoplicationJohn E Pandolfino
Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
Ann Surg 242:43-8. 2005..Since trans-EGJ flow is related to EGJ length and EGJ diameter, these findings suggest that retrograde flow through the EGJ would be decreased by both a reduction in diameter and an increase in length of the EGJ... - Esophagogastric junction morphology predicts susceptibility to exercise-induced refluxJohn E Pandolfino
Northwestern University's Feinberg School of Medicine, Chicago, Illinois 60611, USA
Am J Gastroenterol 99:1430-6. 2004..The degree of exercise-induced reflux is strongly correlated with EGJ morphology and this supports the hypothesis that anatomical integrity of the EGJ is of cardinal importance in preventing strain-induced reflux... - Utilizing intraluminal pressure differences to predict esophageal bolus flow dynamicsSudip K Ghosh
Department of Medicine, Northwestern University, Feinberg School of Medicine, Division of Gastroenterology, Chicago, IL 60611, USA
Am J Physiol Gastrointest Liver Physiol 293:G1023-8. 2007..This may help predict abnormal bolus transit and the underlying mechanical properties of the EGJ... - High-resolution manometry of the EGJ: an analysis of crural diaphragm function in GERDJohn E Pandolfino
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Am J Gastroenterol 102:1056-63. 2007..This study compared CD function of subjects with and without gastroesophageal reflux disease (GERD)... - Impaired deglutitive EGJ relaxation in clinical esophageal manometry: a quantitative analysis of 400 patients and 75 controlsSudip K Ghosh
Dept of Medicine, Feinberg School of Medicine, Northwestern Univ, Chicago, IL 60611, USA
Am J Physiol Gastrointest Liver Physiol 293:G878-85. 2007.... - Four-day Bravo pH capsule monitoring with and without proton pump inhibitor therapyIkuo Hirano
Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Chicago, IL 60611 2951, USA
Clin Gastroenterol Hepatol 3:1083-8. 2005..The aim of the present study was to determine the feasibility of 4-day pH recordings using a pH system that would encompass time periods both before and during PPI therapy... - Acidity surrounding the squamocolumnar junction in GERD patients: "acid pocket" versus "acid film"John E Pandolfino
Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
Am J Gastroenterol 102:2633-41. 2007..This study aimed to localize the gastric-to-esophageal pH transition point relative to the squamocolumnar junction (SCJ) and esophagogastric junction (EGJ) high-pressure zone in controls and GERD patients... - American Gastroenterological Association medical position statement: Clinical use of esophageal manometryJohn E Pandolfino
Northwestern University, Chicago, Illinois, USA
Gastroenterology 128:207-8. 2005 - H. pylori and GERD: is less more?John E Pandolfino
Am J Gastroenterol 99:1222-5. 2004..pylori infection and GERD? and (iii) Will the eradication of H. pylori unleash an epidemic of GERD? Each of these questions entails a unique set of consideration. We will consider each in turn... - Achalasia treatment: improved outcome of laparoscopic myotomy with operative manometryJennifer R Chapman
Surgical Service, Veterans Affairs Chicago Health Care System-Lakeside Division, and Department of Surgery, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Arch Surg 139:508-13; discussion 513. 2004..Laparoscopic myotomy improves quality of life and dysphagia symptoms and may be the treatment of choice in most patients with achalasia... - Ineffective esophageal motility does not equate to GERDPeter J Kahrilas
Am J Gastroenterol 98:715-7. 2003 - AGA technical review on the clinical use of esophageal manometryJohn E Pandolfino
Northwestern University, Chicago, Illinois, USA
Gastroenterology 128:209-24. 2005
Research Grants
- Anatomic and Mechanical Variables of the EGJ in GERDJohn Pandolfino; Fiscal Year: 2006..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
- The mechanics of symptom generation in dysphagiaJohn Pandolfino; Fiscal Year: 2009..This proposal will utilize new analysis techniques to understand the cause of symptoms and determine what can be done to improve esophageal function so that symptoms can be reduced. ..
- The mechanics of symptom generation in dysphagiaJohn E Pandolfino; Fiscal Year: 2010..This proposal will utilize new analysis techniques to understand the cause of symptoms and determine what can be done to improve esophageal function so that symptoms can be reduced. ..