John Pandolfino

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Do endoscopic antireflux procedures fit in the current treatment paradigm of gastroesophageal reflux disease?
    John E Pandolfino
    Department of Medicine, Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, Illinois Electronic address
    Clin Gastroenterol Hepatol 12:544-54. 2014
  2. pmc Distensibility of the esophagogastric junction assessed with the functional lumen imaging probe (FLIP™) in achalasia patients
    J E Pandolfino
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Neurogastroenterol Motil 25:496-501. 2013
  3. pmc Evaluation of esophageal contractile propagation using esophageal pressure topography
    J E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    Neurogastroenterol Motil 24:20-6. 2012
  4. doi request reprint Use and utility of the Bravo pH capsule
    John E Pandolfino
    Department of Medicine, Division of Gastroenterology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Clin Gastroenterol 42:571-8. 2008
  5. ncbi request reprint Does the Bravo pH capsule affect esophageal motor function?
    J E Pandolfino
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Dis Esophagus 20:406-10. 2007
  6. ncbi request reprint Prolonged pH monitoring: Bravo capsule
    John E Pandolfino
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Gastrointest Endosc Clin N Am 15:307-18. 2005
  7. ncbi request reprint Measuring EGJ opening patterns using high resolution intraluminal impedance
    J E Pandolfino
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Neurogastroenterol Motil 17:200-6. 2005
  8. pmc Acid reflux event detection using the Bravo wireless versus the Slimline catheter pH systems: why are the numbers so different?
    J E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Suite 1400, Chicago, Illinois 60611, USA
    Gut 54:1687-92. 2005
  9. ncbi request reprint Upper sphincter function during transient lower oesophageal sphincter relaxation (tLOSR); it is mainly about microburps
    J E Pandolfino
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neurogastroenterol Motil 19:203-10. 2007
  10. ncbi request reprint Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Gastroenterology 131:1725-33. 2006

Research Grants

  1. Anatomic and Mechanical Variables of the EGJ in GERD
    John Pandolfino; Fiscal Year: 2006
  2. The mechanics of symptom generation in dysphagia
    John Pandolfino; Fiscal Year: 2009
  3. The mechanics of symptom generation in dysphagia
    John E Pandolfino; Fiscal Year: 2010

Detail Information

Publications62

  1. pmc Do endoscopic antireflux procedures fit in the current treatment paradigm of gastroesophageal reflux disease?
    John E Pandolfino
    Department of Medicine, Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, Illinois Electronic address
    Clin Gastroenterol Hepatol 12:544-54. 2014
    ..At present, we have the luxury of time to wait for such a device to become available. ..
  2. pmc Distensibility of the esophagogastric junction assessed with the functional lumen imaging probe (FLIP™) in achalasia patients
    J E Pandolfino
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Neurogastroenterol Motil 25:496-501. 2013
    ..The aim of this study is to apply this tool to the assessment of the EGJ in untreated and treated achalasia patients and to compare EGJ distensibility with other diagnostic tools utilized in managing achalasia...
  3. pmc Evaluation of esophageal contractile propagation using esophageal pressure topography
    J E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    Neurogastroenterol Motil 24:20-6. 2012
    ....
  4. doi request reprint Use and utility of the Bravo pH capsule
    John E Pandolfino
    Department of Medicine, Division of Gastroenterology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Clin Gastroenterol 42:571-8. 2008
    ..This review will highlight the advantages of the Bravo system and how it should be used...
  5. ncbi request reprint Does the Bravo pH capsule affect esophageal motor function?
    J E Pandolfino
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Dis Esophagus 20:406-10. 2007
    ..However, capsule presence was associated with a locus of augmented peristalsis and this phenomenon was most evident in subjects who perceived the presence of the Bravo capsule...
  6. ncbi request reprint Prolonged pH monitoring: Bravo capsule
    John E Pandolfino
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Gastrointest Endosc Clin N Am 15:307-18. 2005
    ..Further refinements in methodology and recording protocol are likely to be made, which will improve diagnostic accuracy and lower cost...
  7. ncbi request reprint Measuring EGJ opening patterns using high resolution intraluminal impedance
    J E Pandolfino
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Neurogastroenterol Motil 17:200-6. 2005
    ..These results support that impedance monitoring can be adapted to identify sphincter opening, to distinguish sphincter opening from sphincter relaxation, and to determine luminal contents during the opening period...
  8. pmc Acid reflux event detection using the Bravo wireless versus the Slimline catheter pH systems: why are the numbers so different?
    J E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Suite 1400, Chicago, Illinois 60611, USA
    Gut 54:1687-92. 2005
    ..This study analysed the relative accuracy of the Bravo wireless and the Slimline catheter-Mark III Digitrapper pH systems in the detection of acid reflux events...
  9. ncbi request reprint Upper sphincter function during transient lower oesophageal sphincter relaxation (tLOSR); it is mainly about microburps
    J E Pandolfino
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neurogastroenterol Motil 19:203-10. 2007
    ..Whether or not GORD patients with extra-oesophageal symptoms exhibit an exaggeration of the UOS relaxation response during reflux is yet to be determined...
  10. ncbi request reprint Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Gastroenterology 131:1725-33. 2006
    ....
  11. ncbi request reprint Comparison of esophageal acid exposure at 1 cm and 6 cm above the squamocolumnar junction using the Bravo pH monitoring system
    J E Pandolfino
    Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Dis Esophagus 19:177-82. 2006
    ..These findings suggest that measurement of acid exposure 1 cm above the SCJ may improve accuracy of pH monitoring by detecting acid reflux events confined to the distal esophagus...
  12. ncbi request reprint A new confusing model of GERD: a spectrum of phenotypic progression
    J E Pandolfino
    Department of Medicine, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Dig Liver Dis 38:648-51. 2006
  13. ncbi request reprint Slimline vs. glass pH electrodes: what degree of accuracy should we expect?
    J E Pandolfino
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
    Aliment Pharmacol Ther 23:331-40. 2006
    ..Ambulatory pH monitoring is considered the gold standard for measuring oesophageal acid exposure, however, data comparing antimony and glass electrodes are limited...
  14. pmc High-resolution manometry: an atlas of esophageal motility disorders and findings of GERD using esophageal pressure topography
    John E Pandolfino
    Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 St Clair Street, Suite 1400, Chicago, IL 60611 2951, USA
    Thorac Surg Clin 21:465-75. 2011
    ..A section on impaired bolus transit is also included to highlight the important aspect of impaired clearance in the pathogenesis of GERD...
  15. ncbi request reprint Absence of a deglutitive inhibition equivalent with secondary peristalsis
    John E Pandolfino
    Division of Gastroenterology, Dept of Medicine, Northwestern Univ Feinberg School of Medicine, Suite 1400, 676 N St Clair St, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 288:G671-6. 2005
    ..Being that the elicitation of SP in the smooth muscle esophagus is intramurally mediated, this suggests that deglutitive inhibition is a centrally mediated phenomenon rather than an intrinsic property of peristalsis...
  16. pmc The time course and persistence of "concurrent contraction" during normal peristalsis
    John E Pandolfino
    Northwestern Univ, Feinberg School of Medicine, Dept of Medicine, Division of Gastroenterology and Hepatology, Chicago, Illinois 60611 2951, USA
    Am J Physiol Gastrointest Liver Physiol 301:G679-83. 2011
    ..How abnormalities of the extent or timing of concurrent contraction relate to clinical syndromes requires further investigation...
  17. pmc Distal esophageal spasm in high-resolution esophageal pressure topography: defining clinical phenotypes
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Gastroenterology 141:469-75. 2011
    ..Our aim was to apply standardized metrics of contraction velocity and latency to high-resolution esophageal pressure topography (EPT) studies to refine the diagnosis of DES...
  18. pmc The contractile deceleration point: an important physiologic landmark on oesophageal pressure topography
    J E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
    Neurogastroenterol Motil 22:395-400, e90. 2010
    ..This study aimed to correlate oesophageal bolus transit with features of oesophageal pressure topography (OPT) plots and establish OPT metrics for accurately measuring peristaltic velocity...
  19. ncbi request reprint Evaluation of esophageal motor disorders in the era of high-resolution manometry and intraluminal impedance
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Gastroenterol Rep 11:182-9. 2009
    ..This article provides an update on these technologies in clinical practice and how they may be helpful in the future...
  20. pmc Unique features of esophagogastric junction pressure topography in hiatus hernia patients with dysphagia
    John E Pandolfino
    Department of Medicine, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Surgery 147:57-64. 2010
    ....
  21. pmc High-resolution manometry in clinical practice: utilizing pressure topography to classify oesophageal motility abnormalities
    J E Pandolfino
    Department of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    Neurogastroenterol Motil 21:796-806. 2009
    ..It is our expectation that modification of this classification scheme will continue to occur and this should further clarify the utility of pressure topography plotting in assessing oesophageal motility disorders...
  22. pmc New technologies in the gastrointestinal clinic and research: impedance and high-resolution manometry
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, Illinois 60611, USA
    World J Gastroenterol 15:131-8. 2009
    ..This review describes the potential benefits that these new technologies may have over conventional techniques for the evaluation of dysphagia...
  23. doi request reprint The pathophysiologic basis for epidemiologic trends in gastroesophageal reflux disease
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University s Feinberg School of Medicine, 676 North St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Gastroenterol Clin North Am 37:827-43, viii. 2008
    ..This article explores the interplay between pathophysiology and epidemiology by focusing on these risk factors and their potential effect on GERD pathogenesis...
  24. pmc Achalasia: a new clinically relevant classification by high-resolution manometry
    John E Pandolfino
    Northwestern University, The Feinberg School of Medicine, Department of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1526-33. 2008
    ..This study aimed to compare the clinical characteristics and treatment response of these 3 subtypes...
  25. ncbi request reprint Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteers
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1033-40. 2006
    ..In addition to providing conventional EGJ relaxation parameters, this technology also creates opportunities to quantify more precise measures of EGJ relaxation and morphology...
  26. ncbi request reprint New technologies for the evaluation of esophageal motility disorders: impedance, high-resolution manometry, and intraluminal ultrasound
    Ikuo Hirano
    Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Gastroenterol Clin North Am 36:531-51, viii. 2007
    ..This article describes the technical aspects of each of these technologies and the potential benefits they offer over conventional techniques for the evaluation of esophageal motor diseases...
  27. ncbi request reprint Review article: oesophageal pH monitoring--technologies, interpretation and correlation with clinical outcomes
    P J Kahrilas
    Division of Gastroeneterology, Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
    Aliment Pharmacol Ther 22:2-9. 2005
    ..More research is needed to determine whether the detection of reflux events with Bravo will provide a good correlation with symptom episodes...
  28. pmc Oesophageal peristaltic transition zone defects: real but few and far between
    S K Ghosh
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Neurogastroenterol Motil 20:1283-90. 2008
    ..8%). Although far less common than distal peristaltic or OGJ abnormailites, TZ defects may be related to dysphagia in a minority of patients (<4% in this series) and should be considered a distinct oesophageal motility disorder...
  29. ncbi request reprint Distinct patterns of oesophageal shortening during primary peristalsis, secondary peristalsis and transient lower oesophageal sphincter relaxation
    G Shi
    Department of Medicine, North Western University Medical School, Chicago, IL 60611, USA
    Neurogastroenterol Motil 14:505-12. 2002
    ..During TLOSR, significant elevation of the SCJ occurred only after LOS opening, suggesting that this was a consequence of oesophageal distension induced by gas reflux rather than a component of the opening mechanism...
  30. pmc Transient lower oesophageal sphincter relaxation in achalasia: everything but LOS relaxation
    M A Kwiatek
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 2951, USA
    Neurogastroenterol Motil 21:1294-e123. 2009
    ....
  31. ncbi request reprint The effect of glucagon-induced gastric relaxation on TLOSR frequency
    H Y Chang
    Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Neurogastroenterol Motil 15:3-8. 2003
    ..Despite causing substantial proximal stomach relaxation, glucagon did not increase TLOSR frequency. This suggests that the relevant gastric mechanoreceptors responsible for triggering TLOSRs do not respond to passive elongation...
  32. ncbi request reprint The Bravo pH capsule system
    M A Kwiatek
    Northwestern University, The Feinberg School of Medicine, Division of Gastroenterology, Department of Medicine, Chicago, IL 60611, United States
    Dig Liver Dis 40:156-60. 2008
    ..In addition, we will also focus on the technical aspects related to its safety, tolerability and diagnostic accuracy...
  33. ncbi request reprint Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteers
    Sudip K Ghosh
    Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 290:G988-97. 2006
    ....
  34. doi request reprint The relationship between obesity and GERD: "big or overblown"
    John E Pandolfino
    Am J Gastroenterol 103:1355-7. 2008
    ..These results highlight the complexity of this relationship and once more support the concept that GERD is a multifactorial disease that cannot be defined by a single anatomical or functional abnormality...
  35. pmc Utilizing intraluminal pressure gradients to predict esophageal clearance: a validation study
    John E Pandolfino
    Departments of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 103:1898-905. 2008
    ..Esophageal bolus clearance requires a preferential esophagogastric pressure gradient sustained for a sufficient period. We aimed to validate a high-resolution manometry (HRM) paradigm for predicting bolus clearance...
  36. ncbi request reprint Esophagogastric junction morphology predicts susceptibility to exercise-induced reflux
    John E Pandolfino
    Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Gastroenterol 99:1430-6. 2004
    ..The aim of this study was to use vigorous exercise as a provocation for strain-induced reflux and examine the correlation between endoscopically assessed EGJ integrity and exercise-induced reflux...
  37. ncbi request reprint Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects
    John E Pandolfino
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Gastroenterology 125:1018-24. 2003
    ..Flow across the esophagogastric junction (EGJ) is strongly related to opening dimensions. This study aimed to determine whether opening of the relaxed EGJ was altered in patients with gastroesophageal reflux disease (GERD)...
  38. ncbi request reprint Ambulatory esophageal pH monitoring using a wireless system
    John E Pandolfino
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
    Am J Gastroenterol 98:740-9. 2003
    ..An alternative to conventional pH monitoring is the wireless Medtronic Bravo pH System. The aim of this study was to evaluate the safety, performance, and tolerability of this system...
  39. ncbi request reprint The target of therapies: pathophysiology of gastroesophageal reflux disease
    Peter J Kahrilas
    Department of Medicine, Northwestern University s Feinberg School of Medicine, Division of Gastroenterology, Searle Bldg, 10th Floor, Suite 541, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Gastrointest Endosc Clin N Am 13:1-17. 2003
    ....
  40. ncbi request reprint Deglutitive inhibition affects both esophageal peristaltic amplitude and shortening
    Guoxiang Shi
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Physiol Gastrointest Liver Physiol 284:G575-82. 2003
    ..Deglutitive inhibition affects both the longitudinal and circular muscle layers of the esophageal wall, and the occurrence of inhibition evident in one layer is strongly correlated with the other...
  41. ncbi request reprint Comparison of inter- and intraobserver consistency for grading of esophagitis by expert and trainee endoscopists
    John E Pandolfino
    Northwestern University Medical School, Chicago, Illinois 60611, USA
    Gastrointest Endosc 56:639-43. 2002
    ..This study evaluated intra- and interobserver variability in the endoscopic scoring of esophagitis by using two grading schemes, the Los Angeles and Hetzel-Dent scales...
  42. ncbi request reprint Esophagogastric junction distensibility: a factor contributing to sphincter incompetence
    John E Pandolfino
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    Am J Physiol Gastrointest Liver Physiol 282:G1052-8. 2002
    ....
  43. pmc Esophageal motility disorders in terms of pressure topography: the Chicago Classification
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    J Clin Gastroenterol 42:627-35. 2008
    ....
  44. pmc Challenging the limits of esophageal manometry
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Gastroenterology 134:16-8. 2008
  45. ncbi request reprint Obesity: a challenge to esophagogastric junction integrity
    John E Pandolfino
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 130:639-49. 2006
    ..The aim of the current study was to analyze the relationship between obesity and the morphology of the esophagogastric junction (EGJ) pressure segment using high-resolution manometry...
  46. ncbi request reprint Deglutitive upper esophageal sphincter relaxation: a study of 75 volunteer subjects using solid-state high-resolution manometry
    Sudip K Ghosh
    Northwestern University, Feinberg School of Medicine, Div of Gastroenterology, Dept of Medicine, 676 N St Clair St, Suite 1400, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 291:G525-31. 2006
    ..Normative values were established to aid in future clinical and investigative studies...
  47. ncbi request reprint Four-day Bravo pH capsule monitoring with and without proton pump inhibitor therapy
    Ikuo Hirano
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Chicago, IL 60611 2951, USA
    Clin Gastroenterol Hepatol 3:1083-8. 2005
    ..The aim of the present study was to determine the feasibility of 4-day pH recordings using a pH system that would encompass time periods both before and during PPI therapy...
  48. ncbi request reprint Bravo capsule placement in the gastric cardia: a novel method for analysis of proximal stomach acid environment
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Gastroenterol 100:1721-7. 2005
    ..Intragastric pH monitoring is currently done using catheter-based pH systems. This study assessed the feasibility of proximal intragastric pH recording with the Bravo wireless pH monitoring system using novel methodology...
  49. ncbi request reprint Comparison of the Bravo wireless and Digitrapper catheter-based pH monitoring systems for measuring esophageal acid exposure
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 100:1466-76. 2005
    ..We compared esophageal acid exposure data obtained during simultaneous esophageal pH studies using the Bravo wireless and the Slimline catheter-Mark III Digitrapper pH systems...
  50. pmc Restoration of normal distensive characteristics of the esophagogastric junction after fundoplication
    John E Pandolfino
    Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
    Ann Surg 242:43-8. 2005
    ..To study the mechanical characteristics of the esophagogastric junction (EGJ) of postfundoplication patients and compare them with previously reported data on normal subjects and GERD patients...
  51. ncbi request reprint High-resolution manometry of the EGJ: an analysis of crural diaphragm function in GERD
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Gastroenterol 102:1056-63. 2007
    ..This study compared CD function of subjects with and without gastroesophageal reflux disease (GERD)...
  52. ncbi request reprint Impaired deglutitive EGJ relaxation in clinical esophageal manometry: a quantitative analysis of 400 patients and 75 controls
    Sudip K Ghosh
    Dept of Medicine, Feinberg School of Medicine, Northwestern Univ, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 293:G878-85. 2007
    ....
  53. ncbi request reprint Acidity surrounding the squamocolumnar junction in GERD patients: "acid pocket" versus "acid film"
    John E Pandolfino
    Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Gastroenterol 102:2633-41. 2007
    ..This study aimed to localize the gastric-to-esophageal pH transition point relative to the squamocolumnar junction (SCJ) and esophagogastric junction (EGJ) high-pressure zone in controls and GERD patients...
  54. ncbi request reprint Bravo capsule pH monitoring
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Gastroenterol 100:8-10. 2005
  55. ncbi request reprint Classifying esophageal motility by pressure topography characteristics: a study of 400 patients and 75 controls
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 103:27-37. 2008
    ..This study aimed to devise a scheme for the systematic analysis of esophageal high-resolution manometry (HRM) studies displayed using topographic plotting...
  56. ncbi request reprint Utilizing intraluminal pressure differences to predict esophageal bolus flow dynamics
    Sudip K Ghosh
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Division of Gastroenterology, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1023-8. 2007
    ..This may help predict abnormal bolus transit and the underlying mechanical properties of the EGJ...
  57. ncbi request reprint The mechanical basis of impaired esophageal emptying postfundoplication
    Sudip K Ghosh
    Department of Mechanical Engineering, The Pennsylvania State University, University Park, Pennsylvania, University Park, PA 16802, USA
    Am J Physiol Gastrointest Liver Physiol 289:G21-35. 2005
    ..Immobilization of the intrinsic sphincter by the surgical procedure may contribute to this deficiency, impaired emptying, and possibly, dysphagia...
  58. ncbi request reprint American Gastroenterological Association medical position statement: Clinical use of esophageal manometry
    John E Pandolfino
    Northwestern University, Chicago, Illinois, USA
    Gastroenterology 128:207-8. 2005
  59. ncbi request reprint Ineffective esophageal motility does not equate to GERD
    Peter J Kahrilas
    Am J Gastroenterol 98:715-7. 2003
  60. ncbi request reprint H. pylori and GERD: is less more?
    John E Pandolfino
    Am J Gastroenterol 99:1222-5. 2004
    ..pylori infection and GERD? and (iii) Will the eradication of H. pylori unleash an epidemic of GERD? Each of these questions entails a unique set of consideration. We will consider each in turn...
  61. ncbi request reprint Achalasia treatment: improved outcome of laparoscopic myotomy with operative manometry
    Jennifer R Chapman
    Surgical Service, Veterans Affairs Chicago Health Care System Lakeside Division, and Department of Surgery, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Arch Surg 139:508-13; discussion 513. 2004
    ..Operative manometry detects residual esophagogastric junction (EGJ) high pressure, ensuring complete myotomy...
  62. ncbi request reprint AGA technical review on the clinical use of esophageal manometry
    John E Pandolfino
    Northwestern University, Chicago, Illinois, USA
    Gastroenterology 128:209-24. 2005

Research Grants3

  1. Anatomic and Mechanical Variables of the EGJ in GERD
    John Pandolfino; Fiscal Year: 2006
    ..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
  2. The mechanics of symptom generation in dysphagia
    John Pandolfino; Fiscal Year: 2009
    ..This proposal will utilize new analysis techniques to understand the cause of symptoms and determine what can be done to improve esophageal function so that symptoms can be reduced. ..
  3. The mechanics of symptom generation in dysphagia
    John E Pandolfino; Fiscal Year: 2010
    ..This proposal will utilize new analysis techniques to understand the cause of symptoms and determine what can be done to improve esophageal function so that symptoms can be reduced. ..