John E Pandolfino

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Effects of large hiatal hernias on esophageal peristalsis
    Sabine Roman
    Northwestern University, Feinberg School of Medicine, Department of Medicine, Chicago, IL 60611 2951, USA
    Arch Surg 147:352-7. 2012
  2. pmc Esophageal pressure topography criteria indicative of incomplete bolus clearance: a study using high-resolution impedance manometry
    William J Bulsiewicz
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 104:2721-8. 2009
  3. ncbi Absence of a deglutitive inhibition equivalent with secondary peristalsis
    John E Pandolfino
    Division of Gastroenterology, Dept of Medicine, Northwestern Univ Feinberg School of Medicine, Suite 1400, 676 N St Clair St, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 288:G671-6. 2005
  4. pmc Distal contraction latency: a measure of propagation velocity optimized for esophageal pressure topography studies
    Sabine Roman
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 106:443-51. 2011
  5. pmc Achalasia: a new clinically relevant classification by high-resolution manometry
    John E Pandolfino
    Northwestern University, The Feinberg School of Medicine, Department of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1526-33. 2008
  6. pmc Utilizing intraluminal pressure gradients to predict esophageal clearance: a validation study
    John E Pandolfino
    Departments of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 103:1898-905. 2008
  7. ncbi Classifying esophageal motility by pressure topography characteristics: a study of 400 patients and 75 controls
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 103:27-37. 2008
  8. ncbi Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteers
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1033-40. 2006
  9. pmc Restoration of normal distensive characteristics of the esophagogastric junction after fundoplication
    John E Pandolfino
    Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
    Ann Surg 242:43-8. 2005
  10. pmc High-resolution manometry: an atlas of esophageal motility disorders and findings of GERD using esophageal pressure topography
    John E Pandolfino
    Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 St Clair Street, Suite 1400, Chicago, IL 60611 2951, USA
    Thorac Surg Clin 21:465-75. 2011

Collaborators

Detail Information

Publications50

  1. pmc Effects of large hiatal hernias on esophageal peristalsis
    Sabine Roman
    Northwestern University, Feinberg School of Medicine, Department of Medicine, Chicago, IL 60611 2951, USA
    Arch Surg 147:352-7. 2012
    ..Anatomic changes induced by large hiatal hernia may alter esophageal pressure topography measurements made during high-resolution manometry...
  2. pmc Esophageal pressure topography criteria indicative of incomplete bolus clearance: a study using high-resolution impedance manometry
    William J Bulsiewicz
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 104:2721-8. 2009
    ..This study used high-resolution impedance manometry (HRIM) to determine pressure topography thresholds of peristaltic integrity predictive of incomplete esophageal bolus clearance...
  3. ncbi Absence of a deglutitive inhibition equivalent with secondary peristalsis
    John E Pandolfino
    Division of Gastroenterology, Dept of Medicine, Northwestern Univ Feinberg School of Medicine, Suite 1400, 676 N St Clair St, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 288:G671-6. 2005
    ..Being that the elicitation of SP in the smooth muscle esophagus is intramurally mediated, this suggests that deglutitive inhibition is a centrally mediated phenomenon rather than an intrinsic property of peristalsis...
  4. pmc Distal contraction latency: a measure of propagation velocity optimized for esophageal pressure topography studies
    Sabine Roman
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 106:443-51. 2011
    ..This study aimed to exploit a coordinate-based strategy to quantify the normal latency of the distal esophageal contraction as a measure of propagation velocity optimized for high-resolution esophageal pressure topography (EPT) studies...
  5. pmc Achalasia: a new clinically relevant classification by high-resolution manometry
    John E Pandolfino
    Northwestern University, The Feinberg School of Medicine, Department of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1526-33. 2008
    ..This study aimed to compare the clinical characteristics and treatment response of these 3 subtypes...
  6. pmc Utilizing intraluminal pressure gradients to predict esophageal clearance: a validation study
    John E Pandolfino
    Departments of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 103:1898-905. 2008
    ..Esophageal bolus clearance requires a preferential esophagogastric pressure gradient sustained for a sufficient period. We aimed to validate a high-resolution manometry (HRM) paradigm for predicting bolus clearance...
  7. ncbi Classifying esophageal motility by pressure topography characteristics: a study of 400 patients and 75 controls
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 103:27-37. 2008
    ..This study aimed to devise a scheme for the systematic analysis of esophageal high-resolution manometry (HRM) studies displayed using topographic plotting...
  8. ncbi Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteers
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1033-40. 2006
    ..In addition to providing conventional EGJ relaxation parameters, this technology also creates opportunities to quantify more precise measures of EGJ relaxation and morphology...
  9. pmc Restoration of normal distensive characteristics of the esophagogastric junction after fundoplication
    John E Pandolfino
    Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
    Ann Surg 242:43-8. 2005
    ..To study the mechanical characteristics of the esophagogastric junction (EGJ) of postfundoplication patients and compare them with previously reported data on normal subjects and GERD patients...
  10. pmc High-resolution manometry: an atlas of esophageal motility disorders and findings of GERD using esophageal pressure topography
    John E Pandolfino
    Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 St Clair Street, Suite 1400, Chicago, IL 60611 2951, USA
    Thorac Surg Clin 21:465-75. 2011
    ..A section on impaired bolus transit is also included to highlight the important aspect of impaired clearance in the pathogenesis of GERD...
  11. pmc Functional esophagogastric junction obstruction with intact peristalsis: a heterogeneous syndrome sometimes akin to achalasia
    John R Scherer
    Department of Medicine, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    J Gastrointest Surg 13:2219-25. 2009
    ..Some patients with suspected achalasia are found on manometry to have preserved peristalsis, thereby excluding that diagnosis. This study evaluated a series of such patients with functional esophagogastric junction (EGJ) obstruction...
  12. ncbi Deglutitive upper esophageal sphincter relaxation: a study of 75 volunteer subjects using solid-state high-resolution manometry
    Sudip K Ghosh
    Northwestern University, Feinberg School of Medicine, Div of Gastroenterology, Dept of Medicine, 676 N St Clair St, Suite 1400, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 291:G525-31. 2006
    ..Normative values were established to aid in future clinical and investigative studies...
  13. ncbi Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Gastroenterology 131:1725-33. 2006
    ....
  14. pmc Weak peristalsis in esophageal pressure topography: classification and association with Dysphagia
    Sabine Roman
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 106:349-56. 2011
    ..This study aimed to develop a classification of weak peristalsis in EPT based on a comparative analysis of control subjects and patients with unexplained non-obstructive dysphagia...
  15. pmc Pressure morphology of the relaxed lower esophageal sphincter: the formation and collapse of the phrenic ampulla
    Monika A Kwiatek
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Physiol Gastrointest Liver Physiol 302:G389-96. 2012
    ....
  16. pmc Esophageal motility disorders in terms of pressure topography: the Chicago Classification
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    J Clin Gastroenterol 42:627-35. 2008
    ....
  17. ncbi Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteers
    Sudip K Ghosh
    Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 290:G988-97. 2006
    ....
  18. ncbi High-resolution manometry of the EGJ: an analysis of crural diaphragm function in GERD
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Gastroenterol 102:1056-63. 2007
    ..This study compared CD function of subjects with and without gastroesophageal reflux disease (GERD)...
  19. pmc Esophagogastric junction distensibility assessed with an endoscopic functional luminal imaging probe (EndoFLIP)
    Monika A Kwiatek
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 2951, USA
    Gastrointest Endosc 72:272-8. 2010
    ..Increased esophagogastric junction (EGJ) compliance is a key abnormality in GERD leading to increased volumes of reflux. To date, EGJ distensibility has been measured only with investigational barostat-based prototype devices...
  20. pmc Phenotypes and clinical context of hypercontractility in high-resolution esophageal pressure topography (EPT)
    Sabine Roman
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 107:37-45. 2012
    ..This study aimed to refine the criteria for esophageal hypercontractility in high-resolution esophageal pressure topography (EPT) and to examine the clinical context in which it occurs...
  21. pmc Distal esophageal spasm in high-resolution esophageal pressure topography: defining clinical phenotypes
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Gastroenterology 141:469-75. 2011
    ..Our aim was to apply standardized metrics of contraction velocity and latency to high-resolution esophageal pressure topography (EPT) studies to refine the diagnosis of DES...
  22. pmc Unique features of esophagogastric junction pressure topography in hiatus hernia patients with dysphagia
    John E Pandolfino
    Department of Medicine, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Surgery 147:57-64. 2010
    ....
  23. pmc Esophagogastric junction distensibility after fundoplication assessed with a novel functional luminal imaging probe
    Monika A Kwiatek
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    J Gastrointest Surg 14:268-76. 2010
    ..The aim of the study was to compare the esophagogastric junction (EGJ) compliance in response to controlled distension in fundoplication (FP) patients and controls using the functional luminal imaging probe (FLIP)...
  24. ncbi Utilizing intraluminal pressure differences to predict esophageal bolus flow dynamics
    Sudip K Ghosh
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Division of Gastroenterology, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1023-8. 2007
    ..This may help predict abnormal bolus transit and the underlying mechanical properties of the EGJ...
  25. ncbi Evaluation of esophageal motor disorders in the era of high-resolution manometry and intraluminal impedance
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Gastroenterol Rep 11:182-9. 2009
    ..This article provides an update on these technologies in clinical practice and how they may be helpful in the future...
  26. pmc Mechanical properties of the esophagus in eosinophilic esophagitis
    Monika A Kwiatek
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Gastroenterology 140:82-90. 2011
    ..This study aimed to analyze the mechanical properties of the esophagus in eosinophilic esophagitis (EoE) using the functional luminal imaging probe (EndoFLIP; Crospon Medical Devices, Galway, Ireland)...
  27. pmc Hyperdynamic upper esophageal sphincter pressure: a manometric observation in patients reporting globus sensation
    Monika A Kwiatek
    Division of Gastroenterology, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Gastroenterol 104:289-98. 2009
    ....
  28. ncbi Comparison of the Bravo wireless and Digitrapper catheter-based pH monitoring systems for measuring esophageal acid exposure
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 100:1466-76. 2005
    ..We compared esophageal acid exposure data obtained during simultaneous esophageal pH studies using the Bravo wireless and the Slimline catheter-Mark III Digitrapper pH systems...
  29. ncbi Bravo capsule placement in the gastric cardia: a novel method for analysis of proximal stomach acid environment
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Gastroenterol 100:1721-7. 2005
    ..Intragastric pH monitoring is currently done using catheter-based pH systems. This study assessed the feasibility of proximal intragastric pH recording with the Bravo wireless pH monitoring system using novel methodology...
  30. ncbi Obesity: a challenge to esophagogastric junction integrity
    John E Pandolfino
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 130:639-49. 2006
    ..The aim of the current study was to analyze the relationship between obesity and the morphology of the esophagogastric junction (EGJ) pressure segment using high-resolution manometry...
  31. ncbi Impaired deglutitive EGJ relaxation in clinical esophageal manometry: a quantitative analysis of 400 patients and 75 controls
    Sudip K Ghosh
    Dept of Medicine, Feinberg School of Medicine, Northwestern Univ, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 293:G878-85. 2007
    ....
  32. pmc Approaches to the diagnosis and grading of hiatal hernia
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    Best Pract Res Clin Gastroenterol 22:601-16. 2008
    ....
  33. ncbi Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects
    John E Pandolfino
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Gastroenterology 125:1018-24. 2003
    ..Flow across the esophagogastric junction (EGJ) is strongly related to opening dimensions. This study aimed to determine whether opening of the relaxed EGJ was altered in patients with gastroesophageal reflux disease (GERD)...
  34. pmc The time course and persistence of "concurrent contraction" during normal peristalsis
    John E Pandolfino
    Northwestern Univ, Feinberg School of Medicine, Dept of Medicine, Division of Gastroenterology and Hepatology, Chicago, Illinois 60611 2951, USA
    Am J Physiol Gastrointest Liver Physiol 301:G679-83. 2011
    ..How abnormalities of the extent or timing of concurrent contraction relate to clinical syndromes requires further investigation...
  35. pmc High-resolution manometry studies are frequently imperfect but usually still interpretable
    Sabine Roman
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Clin Gastroenterol Hepatol 9:1050-5. 2011
    ..Clinical esophageal manometry can be technically challenging. We investigated the prevalence and causes of technically imperfect, high-resolution esophageal pressure topography (EPT) studies at a tertiary referral hospital...
  36. ncbi Deglutitive inhibition affects both esophageal peristaltic amplitude and shortening
    Guoxiang Shi
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Physiol Gastrointest Liver Physiol 284:G575-82. 2003
    ..Deglutitive inhibition affects both the longitudinal and circular muscle layers of the esophageal wall, and the occurrence of inhibition evident in one layer is strongly correlated with the other...
  37. pmc Environmental - lifestyle related factors
    Sabine Roman
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    Best Pract Res Clin Gastroenterol 24:847-59. 2010
    ..The association of GORD and the type of Hp gastritis remains to be confirmed...
  38. ncbi Four-day Bravo pH capsule monitoring with and without proton pump inhibitor therapy
    Ikuo Hirano
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Chicago, IL 60611 2951, USA
    Clin Gastroenterol Hepatol 3:1083-8. 2005
    ..The aim of the present study was to determine the feasibility of 4-day pH recordings using a pH system that would encompass time periods both before and during PPI therapy...
  39. doi The pathophysiologic basis for epidemiologic trends in gastroesophageal reflux disease
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University s Feinberg School of Medicine, 676 North St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Gastroenterol Clin North Am 37:827-43, viii. 2008
    ..This article explores the interplay between pathophysiology and epidemiology by focusing on these risk factors and their potential effect on GERD pathogenesis...
  40. pmc New technologies in the gastrointestinal clinic and research: impedance and high-resolution manometry
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, Illinois 60611, USA
    World J Gastroenterol 15:131-8. 2009
    ..This review describes the potential benefits that these new technologies may have over conventional techniques for the evaluation of dysphagia...
  41. ncbi The target of therapies: pathophysiology of gastroesophageal reflux disease
    Peter J Kahrilas
    Department of Medicine, Northwestern University s Feinberg School of Medicine, Division of Gastroenterology, Searle Bldg, 10th Floor, Suite 541, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Gastrointest Endosc Clin N Am 13:1-17. 2003
    ....
  42. pmc Many patients continue using proton pump inhibitors after negative results from tests for reflux disease
    Andrew J Gawron
    Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Clin Gastroenterol Hepatol 10:620-5; quiz e57. 2012
    ..We investigated the prevalence of PPI use in patients with negative results from Bravo pH or multichannel intraluminal impedance-pH (MII-pH) tests and factors that might predict the use of PPIs...
  43. ncbi American Gastroenterological Association medical position statement: Clinical use of esophageal manometry
    John E Pandolfino
    Northwestern University, Chicago, Illinois, USA
    Gastroenterology 128:207-8. 2005
  44. pmc Challenging the limits of esophageal manometry
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Gastroenterology 134:16-8. 2008
  45. doi Use and utility of the Bravo pH capsule
    John E Pandolfino
    Department of Medicine, Division of Gastroenterology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Clin Gastroenterol 42:571-8. 2008
    ..This review will highlight the advantages of the Bravo system and how it should be used...
  46. ncbi AGA technical review on the clinical use of esophageal manometry
    John E Pandolfino
    Northwestern University, Chicago, Illinois, USA
    Gastroenterology 128:209-24. 2005
  47. doi Testing for gastroesophageal reflux in the 21st century
    Sabine Roman
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Ann N Y Acad Sci 1232:358-64. 2011
    ....
  48. ncbi Prolonged pH monitoring: Bravo capsule
    John E Pandolfino
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Gastrointest Endosc Clin N Am 15:307-18. 2005
    ..Further refinements in methodology and recording protocol are likely to be made, which will improve diagnostic accuracy and lower cost...
  49. ncbi Esophagogastric junction distensibility: a factor contributing to sphincter incompetence
    John E Pandolfino
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    Am J Physiol Gastrointest Liver Physiol 282:G1052-8. 2002
    ....
  50. doi Esophageal motor disorders: how to bridge the gap between advanced diagnostic tools and paucity of therapeutic modalities?
    John O Clarke
    Division of Gastroenterology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Gastroenterol 46:442-8. 2012
    ..This research will require new techniques to assess visceral hypersensitivity and alterations in central modulation of pain and discomfort...