Amy S Paller

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. doi request reprint Treatment strategies for atopic dermatitis: optimizing the available therapeutic options
    Amy S Paller
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Attending Physician, Ann and Robert Lurie Children s Hospital of Chicago, Chicago, IL, USA
    Semin Cutan Med Surg 31:S10-7. 2012
  2. pmc GLI1 genotypes do not predict basal cell carcinoma risk: a case control study
    Andrea Watson
    1Department of Pediatrics, University of Minnesota Duluth, Minnesota, USA
    Mol Cancer 8:113. 2009
  3. ncbi request reprint Three times weekly tacrolimus ointment reduces relapse in stabilized atopic dermatitis: a new paradigm for use
    Amy S Paller
    Department of Dermatology, Northwestern University s Feinberg Medical School Children s Memorial Hospital, 676 North St Clair St, Suite 1600, Chicago, IL 60611, USA
    Pediatrics 122:e1210-8. 2008
  4. doi request reprint Long-term etanercept in pediatric patients with plaque psoriasis
    Amy S Paller
    Children s Memorial Hospital and Northwestern University Medical School, Chicago, Illinois, USA
    J Am Acad Dermatol 63:762-8. 2010
  5. doi request reprint Current issues in atopic comorbidities and preventing the atopic march
    Eric L Simpson
    Department of Dermatology, Oregon Health and Science University, Portland, OR 97239 4501, USA
    Semin Cutan Med Surg 31:S6-9. 2012
  6. doi request reprint Deacetylated GM3 promotes uPAR-associated membrane molecular complex to activate p38 MAPK in metastatic melanoma
    Qiu Yan
    Department of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Cancer Res 11:665-75. 2013
  7. pmc Clinical manifestations of pediatric psoriasis: results of a multicenter study in the United States
    Katherine Mercy
    Department of Dermatology, Northwestern University, Chicago, Illinois 60611, USA
    Pediatr Dermatol 30:424-8. 2013
  8. ncbi request reprint Suppression of epidermal growth factor receptor signaling by protein kinase C-alpha activation requires CD82, caveolin-1, and ganglioside
    Xiao Qi Wang
    Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA, and Department of Biochemistry, The First Affiliated Hospital, Dalian, Liaoning, China
    Cancer Res 67:9986-95. 2007
  9. doi request reprint Understanding and managing atopic dermatitis in adult patients
    Charles N Ellis
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109 5314, USA
    Semin Cutan Med Surg 31:S18-22. 2012
  10. doi request reprint Improving the patient-clinician and parent-clinician partnership in atopic dermatitis management
    Anthony J Mancini
    Northwestern University Feinberg School of Medicine, and Head, Division of Pediatric Dermatology, Ann and Robert H Lurie Children s Hospital of Chicago, Chicago, IL 60611 2605, USA
    Semin Cutan Med Surg 31:S23-8. 2012

Detail Information

Publications49

  1. doi request reprint Treatment strategies for atopic dermatitis: optimizing the available therapeutic options
    Amy S Paller
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Attending Physician, Ann and Robert Lurie Children s Hospital of Chicago, Chicago, IL, USA
    Semin Cutan Med Surg 31:S10-7. 2012
    ..The value of adjuvant therapy with wet wraps to "cool down" particularly erythematous and pruritic flares is becoming increasingly recognized...
  2. pmc GLI1 genotypes do not predict basal cell carcinoma risk: a case control study
    Andrea Watson
    1Department of Pediatrics, University of Minnesota Duluth, Minnesota, USA
    Mol Cancer 8:113. 2009
    ....
  3. ncbi request reprint Three times weekly tacrolimus ointment reduces relapse in stabilized atopic dermatitis: a new paradigm for use
    Amy S Paller
    Department of Dermatology, Northwestern University s Feinberg Medical School Children s Memorial Hospital, 676 North St Clair St, Suite 1600, Chicago, IL 60611, USA
    Pediatrics 122:e1210-8. 2008
    ....
  4. doi request reprint Long-term etanercept in pediatric patients with plaque psoriasis
    Amy S Paller
    Children s Memorial Hospital and Northwestern University Medical School, Chicago, Illinois, USA
    J Am Acad Dermatol 63:762-8. 2010
    ..No systemic therapies are approved by the US Food and Drug Administration for the treatment of psoriasis in children and adolescents...
  5. doi request reprint Current issues in atopic comorbidities and preventing the atopic march
    Eric L Simpson
    Department of Dermatology, Oregon Health and Science University, Portland, OR 97239 4501, USA
    Semin Cutan Med Surg 31:S6-9. 2012
    ..The skin barrier represents a potential new target for novel atopic prevention strategies...
  6. doi request reprint Deacetylated GM3 promotes uPAR-associated membrane molecular complex to activate p38 MAPK in metastatic melanoma
    Qiu Yan
    Department of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Cancer Res 11:665-75. 2013
    ....
  7. pmc Clinical manifestations of pediatric psoriasis: results of a multicenter study in the United States
    Katherine Mercy
    Department of Dermatology, Northwestern University, Chicago, Illinois 60611, USA
    Pediatr Dermatol 30:424-8. 2013
    ..More aggressive monitoring and management should be considered for guttate psoriasis, given its later association with more severe disease...
  8. ncbi request reprint Suppression of epidermal growth factor receptor signaling by protein kinase C-alpha activation requires CD82, caveolin-1, and ganglioside
    Xiao Qi Wang
    Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA, and Department of Biochemistry, The First Affiliated Hospital, Dalian, Liaoning, China
    Cancer Res 67:9986-95. 2007
    ..Given the role of these membrane molecules in suppressing EGFR signaling, up-regulation of GM3, caveolin-1, and CD82 function may be an effective adjunctive therapy for treating epithelial cell malignancies...
  9. doi request reprint Understanding and managing atopic dermatitis in adult patients
    Charles N Ellis
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109 5314, USA
    Semin Cutan Med Surg 31:S18-22. 2012
    ..The treatment options for AD in adults are the same as those for children with AD, with some modifications...
  10. doi request reprint Improving the patient-clinician and parent-clinician partnership in atopic dermatitis management
    Anthony J Mancini
    Northwestern University Feinberg School of Medicine, and Head, Division of Pediatric Dermatology, Ann and Robert H Lurie Children s Hospital of Chicago, Chicago, IL 60611 2605, USA
    Semin Cutan Med Surg 31:S23-8. 2012
    ....
  11. pmc Ganglioside GM3 Depletion Reverses Impaired Wound Healing in Diabetic Mice by Activating IGF-1 and Insulin Receptors
    Xiao Qi Wang
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Invest Dermatol 134:1446-55. 2014
    ..GM3 supplementation or inhibition of IGF-1R or PI3K reverses the increased migration of GM3S(-/-) KCs, whereas IR knockdown only partially suppresses migration. ..
  12. ncbi request reprint Tacrolimus ointment promotes repigmentation of vitiligo in children: a review of 57 cases
    Nanette B Silverberg
    Department of Dermatology, Division of Pediatric Dermatology, St Luke s Roosevelt Hospital Center, New York, NY, USA
    J Am Acad Dermatol 51:760-6. 2004
    ..However, these therapies are often not effective and use of corticosteroids on the face may lead to cutaneous atrophy, telangiectasia, and ocular complications...
  13. doi request reprint Kawasaki disease: part II. Complications and treatment
    Stephanie Bayers
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
    J Am Acad Dermatol 69:513.e1-8; quiz 521-2. 2013
    ..Some patients do not respond to intravenous immunoglobulin and require additional therapy. Part II of this continuing medical education article will focus on the complications of Kawasaki disease and potential treatment options. ..
  14. doi request reprint Kawasaki disease: part I. Diagnosis, clinical features, and pathogenesis
    Stephanie Bayers
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
    J Am Acad Dermatol 69:501.e1-11; quiz 511-2. 2013
    ..A particular focus is given to the various dermatologic manifestations that may occur. ..
  15. ncbi request reprint Ganglioside GM3 promotes carcinoma cell proliferation via urokinase plasminogen activator-induced extracellular signal-regulated kinase-independent p70S6 kinase signaling
    Xiao Qi Wang
    Department of Dermatology, Northwestern University s Feinberg School of Medicine, Chicago, Illinois, USA
    J Invest Dermatol 126:2687-96. 2006
    ..Therapeutic modalities that target or supplement gangliosides may require concomitant treatment that suppresses EGFR or uPAR signaling, respectively, to control neoplastic cell proliferation...
  16. doi request reprint Etanercept treatment for children and adolescents with plaque psoriasis
    Amy S Paller
    Children s Memorial Hospital and Department of Dermatology, Northwestern University Medical School, Chicago, IL 60611 2941, USA
    N Engl J Med 358:241-51. 2008
    ..We assessed the efficacy and safety of etanercept in children and adolescents with moderate-to-severe plaque psoriasis...
  17. ncbi request reprint "Free-floating" desmosomes in lipoid proteinosis: an inherent defect in keratinocyte adhesion?
    Jon A Dyer
    Department of Dermatology, Northwestern University s Feinberg School of Medicine, Chicago, Illinois, USA
    Pediatr Dermatol 23:1-6. 2006
    ....
  18. ncbi request reprint Tacrolimus ointment is effective for psoriasis on the face and intertriginous areas in pediatric patients
    Adriana Brune
    Department of Dermatology, Northwestern University s Feinberg School of Medicine, 676 N St Clair Street, Chicago, IL 60611, USA
    Pediatr Dermatol 24:76-80. 2007
    ..The only adverse event reported in 6 months of observation was significant pruritus in one patient. We therefore conclude that tacrolimus ointment is an effective treatment for psoriasis on the face or intertriginous areas in children...
  19. ncbi request reprint Pachyonychia congenita in pediatric patients: natural history, features, and impact
    Sonal Shah
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
    JAMA Dermatol 150:146-53. 2014
    ..The highly visible nail changes and painful plantar thickening exert a psychosocial effect on most affected adolescents. Phenotype-genotype correlations in children with PC validate the new classification based on the affected gene. ..
  20. ncbi request reprint Pediatric morphea (localized scleroderma): review of 136 patients
    Stephanie Christen-Zaech
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 2997, USA
    J Am Acad Dermatol 59:385-96. 2008
    ..Morphea is an autoimmune inflammatory sclerosing disorder that may cause permanent functional disability and disfigurement...
  21. ncbi request reprint Pityriasis lichenoides in childhood: a retrospective review of 124 patients
    Sibel Ersoy-Evans
    Department of Dermatology, Northwestern University s Feinberg School of Medicine, Chicago, IL 60611 2941, USA
    J Am Acad Dermatol 56:205-10. 2007
    ..Pityriasis lichenoides (PL) occurs in all age groups, although predominantly in younger individuals...
  22. ncbi request reprint Tacrolimus ointment is more effective than pimecrolimus cream with a similar safety profile in the treatment of atopic dermatitis: results from 3 randomized, comparative studies
    Amy S Paller
    Northwestern University Medical School Children s Memorial Hospital, Chicago, Illinois 60611 2923, USA
    J Am Acad Dermatol 52:810-22. 2005
    ..To compare the efficacy and safety of tacrolimus ointment and pimecrolimus cream in adult and pediatric patients with mild to very severe atopic dermatitis (AD)...
  23. pmc Association of pediatric psoriasis severity with excess and central adiposity: an international cross-sectional study
    Amy S Paller
    Department of Dermatology, Northwestern University, 676 N St Clair, Ste 1600, Chicago, IL 60611, USA
    JAMA Dermatol 149:166-76. 2013
    ..To investigate the relationship of excess and central adiposity with pediatric psoriasis severity...
  24. pmc Pathogenesis-based therapy reverses cutaneous abnormalities in an inherited disorder of distal cholesterol metabolism
    Amy S Paller
    Department of Dermatology and Pediatrics, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Invest Dermatol 131:2242-8. 2011
    ..These findings validate pathogenesis-based therapy that provides the deficient end product and prevents accumulation of toxic metabolites, an approach of potential utility for other syndromic lipid metabolic disorders...
  25. doi request reprint Oral glycopyrrolate as second-line treatment for primary pediatric hyperhidrosis
    Amy S Paller
    Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 2941, USA
    J Am Acad Dermatol 67:918-23. 2012
    ..Primary focal hyperhidrosis not uncommonly begins during the first two decades of life, and can have a profound effect on quality of life. Few treatment options have been studied in children...
  26. pmc Adhesion and migration, the diverse functions of the laminin alpha3 subunit
    Kevin J Hamill
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 8 746, Chicago, IL 60611, USA
    Dermatol Clin 28:79-87. 2010
    ..This article provides an overview of the gene, transcripts, and protein structures of laminin alpha3. Also discussed are the proposed functions for the alpha3 subunit-containing laminins...
  27. doi request reprint Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity
    Jennifer T Huang
    Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Pediatrics 123:e808-14. 2009
    ....
  28. ncbi request reprint Gangliosides inhibit urokinase-type plasminogen activator (uPA)-dependent squamous carcinoma cell migration by preventing uPA receptor/alphabeta integrin/epidermal growth factor receptor interactions
    Xiao Qi Wang
    Departments of Dermatology and Pediatrics, Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Invest Dermatol 124:839-48. 2005
    ....
  29. pmc Persistent association of nailfold capillaroscopy changes and skin involvement over thirty-six months with duration of untreated disease in patients with juvenile dermatomyositis
    Stephanie Christen-Zaech
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Arthritis Rheum 58:571-6. 2008
    ..To determine the association of changes on nailfold capillaroscopy with clinical findings and genotype in children with juvenile dermatomyositis (DM), in order to identify potential differences in disease course over 36 months...
  30. pmc Unexpected occurrence of xeroderma pigmentosum in an uncle and nephew
    Stephanie Christen-Zaech
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Arch Dermatol 145:1285-91. 2009
    ..Approximately 20% of patients with XP also develop progressive neurologic degeneration...
  31. ncbi request reprint Cost-effectiveness analysis of tacrolimus ointment versus high-potency topical corticosteroids in adults with moderate to severe atopic dermatitis
    Charles N Ellis
    Department of Dermatology, University of Michigan Medical School, Ann Arbor 48109 0314, USA
    J Am Acad Dermatol 48:553-63. 2003
    ..Few cost-effectiveness analyses have been conducted on topical therapies for atopic dermatitis...
  32. ncbi request reprint Effectiveness of imiquimod cream 5% for treating childhood molluscum contagiosum in a double-blind, randomized pilot trial
    Amy U Theos
    Department of Dermatology, University of Alabama Medical School, Birmingham, USA
    Cutis 74:134-8, 141-2. 2004
    ..9% in the vehicle group. Imiquimod was well tolerated and appears to be a promising therapeutic option in the treatment of MC in children. Larger studies are needed to confirm the results of this small pilot study...
  33. doi request reprint Out of the skin of babes: measuring the full impact of atopic dermatitis in infants and young children
    Amy S Paller
    Department of Dermatology, Northwestern University Feinberg School of Medicine, 676 N Street Clair, Suite 1600, Chicago, Illinois 60611, USA
    J Invest Dermatol 132:2494-6. 2012
    ..The work emphasizes that psychometric measurement continues to develop and reminds us that optimal care of children with atopic dermatitis requires considering its multidimensional effects on both the children and their families...
  34. ncbi request reprint Lipid rafts: membrane triage centers
    Xiao Qi Wang
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, 645 N Michigan Avenue, Chicago, IL 60611, USA
    J Invest Dermatol 126:951-3. 2006
    ..The mechanism(s) by which trafficking into or out of lipid rafts affects signaling remains unclear...
  35. ncbi request reprint The relationship between family medical history and childhood vitiligo
    Urvi Pajvani
    Department of Dermatology, Children s Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Am Acad Dermatol 55:238-44. 2006
    ....
  36. ncbi request reprint Incontinentia pigmenti in male patients
    Theresa R Pacheco
    Department of Dermatology, University of Colorado Health Sciences Center, USA
    J Am Acad Dermatol 55:251-5. 2006
    ..The condition is generally considered to be lethal in utero in male fetuses, suggesting that having some normal gene expression is critical for survival...
  37. pmc Phenotype of atopic dermatitis subjects with a history of eczema herpeticum
    Lisa A Beck
    Department of Dermatology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Allergy Clin Immunol 124:260-9, 269.e1-7. 2009
    ..A subset of subjects with atopic dermatitis (AD) are susceptible to serious infections with herpes simplex virus, called eczema herpeticum, or vaccina virus, called eczema vaccinatum...
  38. doi request reprint Latest approaches to treating atopic dermatitis
    Amy S Paller
    Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 2941, USA
    Chem Immunol Allergy 96:132-40. 2012
    ....
  39. doi request reprint Intertriginous pustular psoriasis
    Jane S Bellet
    Departments of Dermatology and Pediatrics at Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Am Acad Dermatol 60:679-83. 2009
    ..Pustular psoriasis presenting in the intertriginous areas, and particularly the neck, seems specific to infants and may portend progressive extension to widespread involvement. A limitation is that this was a retrospective case series...
  40. doi request reprint New insights about infant and toddler skin: implications for sun protection
    Amy S Paller
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, 676 N St Clair St, Suite 1600, Chicago, IL 60611, USA
    Pediatrics 128:92-102. 2011
    ..In this article we review recent studies in which differences between the skin properties of infants and young children and those of adults were compared, and we discuss the implications of these differences for sun-protection practices...
  41. doi request reprint The misnomer "macrocephaly-cutis marmorata telangiectatica congenita syndrome": report of 12 new cases and support for revising the name to macrocephaly-capillary malformations
    Dakara Rucker Wright
    Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA
    Arch Dermatol 145:287-93. 2009
    ....
  42. doi request reprint The role of abnormalities in the distal pathway of cholesterol synthesis in the Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects (CHILD) syndrome
    Mark A Seeger
    Departments of Dermatology and Pediatrics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Biochim Biophys Acta 1841:345-52. 2014
    ..This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias. ..
  43. ncbi request reprint Eruptive xanthomas masquerading as molluscum contagiosum
    Jennifer Sorrell
    Departments of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
    Pediatrics 134:e257-60. 2014
    ..Through medical intervention, including insulin and fenofibrate therapy, and dietary modification with weight loss, the xanthomas cleared during the subsequent months, and his serum triglyceride levels nearly normalized. ..
  44. doi request reprint Making a mountain out of a molehill: NRAS, mosaicism, and large congenital nevi
    Pedram Gerami
    Department of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Invest Dermatol 133:2127-30. 2013
    ..We discuss the link between mosaic NRAS mutations, cellular senescence, and clinical phenotype in these nevi. ..
  45. ncbi request reprint Subcutaneous panniculitic T-cell lymphoma in children: response to combination therapy with cyclosporine and chemotherapy
    Ayelet Shani-Adir
    Division of Dermatology, Children s Memorial Hospital, 2300 Children s Plaza, Chicago, IL 60614, USA
    J Am Acad Dermatol 50:S18-22. 2004
    ..A clinicopathologic review of 8 described pediatric cases of subcutaneous panniculitic T-cell lymphoma is also presented...
  46. ncbi request reprint Topically applied imiquimod inhibits vascular tumor growth in vivo
    Robert Sidbury
    Department of Pediatrics, Children s Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614, USA
    J Invest Dermatol 121:1205-9. 2003
    ....
  47. ncbi request reprint Genetic immunodeficiency disorders
    Amy S Paller
    Department of Pediatrics, Children s Memorial Hospital, Northwestern University s Feinberg School of Medicine, Chicago, IL 60614, USA
    Clin Dermatol 23:68-77. 2005
    ..The underlying molecular basis for most genetic immunodeficiencies is now understood, allowing improved genetic counseling and prenatal diagnosis...
  48. ncbi request reprint Extrafacial and generalized granulomatous periorificial dermatitis
    Amy J Urbatsch
    Department of Dermatology, University of Alabama at Birmingham, 35233, USA
    Arch Dermatol 138:1354-8. 2002
    ..The condition is self-limiting and is not associated with systemic involvement...
  49. ncbi request reprint Livedo reticularis in a child with moyamoya disease
    Kristen A Richards
    Department of Dermatology, Children s Memorial Hospital, Northwestern University Medical School, Chicago, Illinois, USA
    Pediatr Dermatol 20:124-7. 2003
    ..We describe a girl with livedo reticularis and moyamoya disease with extensive cardiovascular malformations, but without a primary coagulopathy...