Research Topics
Species | Amy PallerSummaryAffiliation: Northwestern University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Perceptions of physicians and pediatric patients about atopic dermatitis, its impact, and its treatmentAmy S Paller
Northwestern University Medical School and Children's Memorial Hospital, Chicago, Illinois 60614, USA
Clin Pediatr (Phila) 41:323-32. 2002..Atopic dermatitis significantly impacts QOL in children, particularly in those with moderate-to-severe disease. New treatments should offer enhanced efficacy, less frequent application, and fewer adverse effects...- Molecular genetics of the inherited disorders of cornification: an updateAlan D Irvine
Our Lady's Hospital for Sick Children, Dublin
Adv Dermatol 18:111-49. 2002 - Association of pediatric psoriasis severity with excess and central adiposity: an international cross-sectional studyAmy S Paller
Department of Dermatology, Northwestern University, 676 N St Clair, Ste 1600, Chicago, IL 60611, USA
JAMA Dermatol 149:166-76. 2013..To investigate the relationship of excess and central adiposity with pediatric psoriasis severity... 
Oral glycopyrrolate as second-line treatment for primary pediatric hyperhidrosisAmy S Paller
Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 2941, USA
J Am Acad Dermatol 67:918-23. 2012..Primary focal hyperhidrosis not uncommonly begins during the first two decades of life, and can have a profound effect on quality of life. Few treatment options have been studied in children...- Latest approaches to treating atopic dermatitisAmy S Paller
Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 2941, USA
Chem Immunol Allergy 96:132-40. 2012.... - Genetic disorders of skin: a decade of progressAmy S Paller
Division of Dermatology, Children's Memorial Hospital, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
Arch Dermatol 139:74-7. 2003 - Tacrolimus ointment is more effective than pimecrolimus cream with a similar safety profile in the treatment of atopic dermatitis: results from 3 randomized, comparative studiesAmy S Paller
Northwestern University Medical School Children s Memorial Hospital, Chicago, Illinois 60611 2923, USA
J Am Acad Dermatol 52:810-22. 2005..To compare the efficacy and safety of tacrolimus ointment and pimecrolimus cream in adult and pediatric patients with mild to very severe atopic dermatitis (AD)... 
Piecing together the puzzle of cutaneous mosaicismAmy S Paller
Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
J Clin Invest 114:1407-9. 2004..Rarely, an individual shows skin lesions that follow the pattern of type 1 mosaicism, but the rest of the skin shows a milder form of the disorder (type 2 mosaicism). A new study provides the molecular basis for type 2 mosaicism...- Genetic immunodeficiency disordersAmy S Paller
Department of Pediatrics, Children s Memorial Hospital, Northwestern University s Feinberg School of Medicine, Chicago, IL 60614, USA
Clin Dermatol 23:68-77. 2005..The underlying molecular basis for most genetic immunodeficiencies is now understood, allowing improved genetic counseling and prenatal diagnosis... - Fluocinolone acetonide 0.01% in peanut oil: therapy for childhood atopic dermatitis, even in patients who are peanut sensitiveAmy S Paller
Department of Pediatrics, Children s Memorial Hospital, Northwestern University Medical Center, USA
J Am Acad Dermatol 48:569-77. 2003..Fluocinolone acetonide 0.01% in a blend of refined peanut and mineral oils has been used as treatment for scalp psoriasis for several years, but only more recently for atopic dermatitis... - Three times weekly tacrolimus ointment reduces relapse in stabilized atopic dermatitis: a new paradigm for useAmy S Paller
Department of Dermatology, Northwestern University s Feinberg Medical School Children s Memorial Hospital, 676 North St Clair St, Suite 1600, Chicago, IL 60611, USA
Pediatrics 122:e1210-8. 2008.... - Etanercept treatment for children and adolescents with plaque psoriasisAmy S Paller
Children s Memorial Hospital and Department of Dermatology, Northwestern University Medical School, Chicago, IL 60611 2941, USA
N Engl J Med 358:241-51. 2008..We assessed the efficacy and safety of etanercept in children and adolescents with moderate-to-severe plaque psoriasis... - Long-term etanercept in pediatric patients with plaque psoriasisAmy S Paller
Children s Memorial Hospital and Northwestern University Medical School, Chicago, Illinois, USA
J Am Acad Dermatol 63:762-8. 2010..No systemic therapies are approved by the US Food and Drug Administration for the treatment of psoriasis in children and adolescents... - New insights about infant and toddler skin: implications for sun protectionAmy S Paller
Department of Dermatology, Feinberg School of Medicine, Northwestern University, 676 N St Clair St, Suite 1600, Chicago, IL 60611, USA
Pediatrics 128:92-102. 2011..In this article we review recent studies in which differences between the skin properties of infants and young children and those of adults were compared, and we discuss the implications of these differences for sun-protection practices... - Pathogenesis-based therapy reverses cutaneous abnormalities in an inherited disorder of distal cholesterol metabolismAmy S Paller
Department of Dermatology and Pediatrics, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Invest Dermatol 131:2242-8. 2011..These findings validate pathogenesis-based therapy that provides the deficient end product and prevents accumulation of toxic metabolites, an approach of potential utility for other syndromic lipid metabolic disorders... - Cost-effectiveness analysis of tacrolimus ointment versus high-potency topical corticosteroids in adults with moderate to severe atopic dermatitisCharles N Ellis
Department of Dermatology, University of Michigan Medical School, Ann Arbor 48109-0314, USA
J Am Acad Dermatol 48:553-63. 2003..CONCLUSION: In the base case analyses, tacrolimus ointment was more cost-effective than HPTCs administered in 2-week treatment cycles, and similar in cost-effectiveness to 4-week cycles of HPTCs... - Adhesion and migration, the diverse functions of the laminin alpha3 subunitKevin J Hamill
Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 8 746, Chicago, IL 60611, USA
Dermatol Clin 28:79-87. 2010..This article provides an overview of the gene, transcripts, and protein structures of laminin alpha3. Also discussed are the proposed functions for the alpha3 subunit-containing laminins... - Ganglioside loss promotes survival primarily by activating integrin-linked kinase/Akt without phosphoinositide 3-OH kinase signalingPing Sun
Department of Pediatrics, Children s Memorial Institute for Education and Research, North Western University Medical School, 2300 Children s Plaza, Chicago, IL 60614, U S A
J Invest Dermatol 119:107-17. 2002..These data suggest that ganglioside depletion modulates cell survival primarily through protein kinase B/Akt stimulation by a pathway that does not require phosphoinositide 3-OH kinase and epidermal growth factor receptor signaling... - Gangliosides inhibit urokinase-type plasminogen activator (uPA)-dependent squamous carcinoma cell migration by preventing uPA receptor/alphabeta integrin/epidermal growth factor receptor interactionsXiao Qi Wang
Departments of Dermatology and Pediatrics, Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Invest Dermatol 124:839-48. 2005.... - Ganglioside modulation regulates epithelial cell adhesion and spreading via ganglioside-specific effects on signalingXiao-Qi Wang
Departments of Pediatrics and Dermatology, Children's Memorial Institute for Education and Research, Northwestern University Medical School, Chicago, IL 60614, USA
J Biol Chem 277:40410-9. 2002.... - The epidemiology of molluscum contagiosum in childrenMagdalene A Dohil
Division of Pediatric and Adolescent Dermatology, Children's Hospital, Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, California, USA
J Am Acad Dermatol 54:47-54. 2006..Limitations include that this was a retrospective study with a population limited to tertiary pediatric dermatology referral centers... - "Free-floating" desmosomes in lipoid proteinosis: an inherent defect in keratinocyte adhesion?Jon A Dyer
Department of Dermatology, Northwestern University s Feinberg School of Medicine, Chicago, Illinois, USA
Pediatr Dermatol 23:1-6. 2006.... - Tacrolimus ointment is effective for psoriasis on the face and intertriginous areas in pediatric patientsAdriana Brune
Department of Dermatology, Northwestern University s Feinberg School of Medicine, 676 N St Clair Street, Chicago, IL 60611, USA
Pediatr Dermatol 24:76-80. 2007..The only adverse event reported in 6 months of observation was significant pruritus in one patient. We therefore conclude that tacrolimus ointment is an effective treatment for psoriasis on the face or intertriginous areas in children... - MAS063DP is effective monotherapy for mild to moderate atopic dermatitis in infants and children: a multicenter, randomized, vehicle-controlled studyMark Boguniewicz
Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado School of Medicine, Denver, CO 80206, USA
J Pediatr 152:854-9. 2008..To examine the efficacy and safety of MAS063DP (Atopiclair) cream in the management of mild to moderate atopic dermatitis in infants and children... - Tacrolimus ointment promotes repigmentation of vitiligo in children: a review of 57 casesNanette B Silverberg
Department of Dermatology, Division of Pediatric Dermatology, St Luke's-Roosevelt Hospital Center, New York, NY, USA
J Am Acad Dermatol 51:760-6. 2004..Two patients initially experienced burning on application. CONCLUSIONS: Topical tacrolimus ointment is an effective alternative therapy for childhood vitiligo, particularly involving the head and neck... - Suppression of epidermal growth factor receptor signaling by protein kinase C-alpha activation requires CD82, caveolin-1, and gangliosideXiao Qi Wang
Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA, and Department of Biochemistry, The First Affiliated Hospital, Dalian, Liaoning, China
Cancer Res 67:9986-95. 2007..Given the role of these membrane molecules in suppressing EGFR signaling, up-regulation of GM3, caveolin-1, and CD82 function may be an effective adjunctive therapy for treating epithelial cell malignancies... - Pediatric morphea (localized scleroderma): review of 136 patientsStephanie Christen-Zaech
Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 2997, USA
J Am Acad Dermatol 59:385-96. 2008..Morphea is an autoimmune inflammatory sclerosing disorder that may cause permanent functional disability and disfigurement... - Effectiveness of imiquimod cream 5% for treating childhood molluscum contagiosum in a double-blind, randomized pilot trialAmy U Theos
Department of Dermatology, University of Alabama Medical School, Birmingham, USA
Cutis 74:134-8, 141-2. 2004..9% in the vehicle group. Imiquimod was well tolerated and appears to be a promising therapeutic option in the treatment of MC in children. Larger studies are needed to confirm the results of this small pilot study... - Ganglioside GM3 inhibits matrix metalloproteinase-9 activation and disrupts its association with integrinXiao Qi Wang
Department of Pediatrics, Children s Memorial Institute for Education and Research, Northwestern University Medical School, Chicago, Illinois 60614, USA
J Biol Chem 278:25591-9. 2003..These data suggest modulation of epidermal growth factor receptor signaling and dissociation of integrin/matrix metalloproteinase-9 as mechanisms for the GM3-induced effects on matrix metalloproteinase-9 function... - Pustular miliaria rubra: a specific cutaneous finding of type I pseudohypoaldosteronismAmy Urbatsch
Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Pediatr Dermatol 19:317-9. 2002..Inflammation of and around the damaged eccrine glands has been attributed to the deleterious effects of excessive eccrine gland salt exposure... - Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor receptorXiao Qi Wang
Department of Pediatrics, Children s Memorial Institute for Education and Research, Northwestern University Medical School, Chicago, Illinois 60614, USA
J Biol Chem 277:47028-34. 2002..These studies suggest that GM3 modulates the caveolin-1/EGFR association and is critical for the EGF-induced tyrosine phosphorylation of caveolin-1 that is associated with its inhibition of EGFR activation... - From the Medical Board of the National Psoriasis Foundation: monitoring and vaccinations in patients treated with biologics for psoriasisMark Lebwohl
Department of Dermatology, Mount Sinai School of Medicine, New York, New York, USA
J Am Acad Dermatol 58:94-105. 2008..Biologics are widely used in the treatment of psoriasis and psoriatic arthritis... - Incontinentia pigmenti in male patientsTheresa R Pacheco
Department of Dermatology, University of Colorado Health Sciences Center, USA
J Am Acad Dermatol 55:251-5. 2006..Postzygotic mutation/somatic mosaicism is the likely mechanism. Given the potential sequelae associated with this condition, continuing follow-up of these patients is recommended... - Venous malformations in blue rubber bleb nevus syndrome: variable onset of presentationWalter K Nahm
Division of Dermatology, University of California-San Diego School of Medicine, San Diego, CA 92113, USA
J Am Acad Dermatol 50:S101-6. 2004..Subcutaneous venous malformations may occasionally be the sole presenting finding in patients with this unusual syndrome, and may be evident even in the prenatal period... - Pityriasis lichenoides in childhood: a retrospective review of 124 patientsSibel Ersoy Evans
Department of Dermatology, Northwestern University s Feinberg School of Medicine, Chicago, IL 60611 2941, USA
J Am Acad Dermatol 56:205-10. 2007..Pityriasis lichenoides (PL) occurs in all age groups, although predominantly in younger individuals... - Ganglioside GM3 blocks the activation of epidermal growth factor receptor induced by integrin at specific tyrosine sitesXiao Qi Wang
Departments of Pediatrics and Dermatology, Children s Memorial Institute for Education and Research, Northwestern University Medical School, Chicago, Illinois 60614, USA
J Biol Chem 278:48770-8. 2003.... - Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severityJennifer T Huang
Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Pediatrics 123:e808-14. 2009.... - Persistent association of nailfold capillaroscopy changes and skin involvement over thirty-six months with duration of untreated disease in patients with juvenile dermatomyositisStephanie Christen-Zaech
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
Arthritis Rheum 58:571-6. 2008..To determine the association of changes on nailfold capillaroscopy with clinical findings and genotype in children with juvenile dermatomyositis (DM), in order to identify potential differences in disease course over 36 months... - Ganglioside GM3 promotes carcinoma cell proliferation via urokinase plasminogen activator-induced extracellular signal-regulated kinase-independent p70S6 kinase signalingXiao Qi Wang
Department of Dermatology, Northwestern University s Feinberg School of Medicine, Chicago, Illinois, USA
J Invest Dermatol 126:2687-96. 2006..Therapeutic modalities that target or supplement gangliosides may require concomitant treatment that suppresses EGFR or uPAR signaling, respectively, to control neoplastic cell proliferation... - Subcutaneous panniculitic T-cell lymphoma in children: response to combination therapy with cyclosporine and chemotherapyAyelet Shani-Adir
Division of Dermatology, Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614, USA
J Am Acad Dermatol 50:S18-22. 2004..A clinicopathologic review of 8 described pediatric cases of subcutaneous panniculitic T-cell lymphoma is also presented... - Phenotype of atopic dermatitis subjects with a history of eczema herpeticumLisa A Beck
Department of Dermatology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Allergy Clin Immunol 124:260-9, 269.e1-7. 2009..A subset of subjects with atopic dermatitis (AD) are susceptible to serious infections with herpes simplex virus, called eczema herpeticum, or vaccina virus, called eczema vaccinatum... - Incontinentia pigmenti: a review and update on the molecular basis of pathophysiologyAlexander L Berlin
Department of Dermatology, University of Illinois College of Medicine, 60612, USA
J Am Acad Dermatol 47:169-87; quiz 188-90. 2002..Additionally, participants will gain the most current knowledge of the genetic and molecular basis of cutaneous pathomechanism... - Topically applied imiquimod inhibits vascular tumor growth in vivoRobert Sidbury
Department of Pediatrics, Children's Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614, USA
J Invest Dermatol 121:1205-9. 2003.... - Intertriginous pustular psoriasisJane S Bellet
Departments of Dermatology and Pediatrics at Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Am Acad Dermatol 60:679-83. 2009..Pustular psoriasis presenting in the intertriginous areas, and particularly the neck, seems specific to infants and may portend progressive extension to widespread involvement. A limitation is that this was a retrospective case series... - The misnomer "macrocephaly-cutis marmorata telangiectatica congenita syndrome": report of 12 new cases and support for revising the name to macrocephaly-capillary malformationsDakara Rucker Wright
Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA
Arch Dermatol 145:287-93. 2009.... - Extrafacial and generalized granulomatous periorificial dermatitisAmy J Urbatsch
Department of Dermatology, University of Alabama at Birmingham, 35233, USA
Arch Dermatol 138:1354-8. 2002..The condition is self-limiting and is not associated with systemic involvement... - Lipid rafts: membrane triage centersXiao-Qi Wang
Department of Dermatology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Chicago, IL 60611, USA
J Invest Dermatol 126:951-3. 2006..The mechanism(s) by which trafficking into or out of lipid rafts affects signaling remains unclear... - Livedo reticularis in a child with moyamoya diseaseKristen A Richards
Department of Dermatology, Children's Memorial Hospital, Northwestern University Medical School, Chicago, Illinois, USA
Pediatr Dermatol 20:124-7. 2003..We describe a girl with livedo reticularis and moyamoya disease with extensive cardiovascular malformations, but without a primary coagulopathy... - Efficacy and safety of tacrolimus ointment treatment for up to 4 years in patients with atopic dermatitisJon M Hanifin
Oregon Health Sciences University, Portland, Oregon 97239, USA
J Am Acad Dermatol 53:S186-94. 2005..This study was designed to evaluate the long-term safety and efficacy of 0.1% tacrolimus ointment in adult and pediatric patients with atopic dermatitis (AD)... - Extracellular matrix protein 1 gene (ECM1) mutations in lipoid proteinosis and genotype-phenotype correlationTakahiro Hamada
Department of Cell and Molecular Pathology Immunofluorescence, St John s Institute of Dermatology, St Thomas Hospital, London, UK
J Invest Dermatol 120:345-50. 2003..Clinically, it appears that mutations outside exon 7 are usually associated with a slightly more severe mucocutaneous lipoid proteinosis phenotype, but neurological features do not show any specific genotype-phenotype correlation... - Intermittent therapy for flare prevention and long-term disease control in stabilized atopic dermatitis: a randomized comparison of 3-times-weekly applications of tacrolimus ointment versus vehicleDebra Breneman
University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Am Acad Dermatol 58:990-9. 2008..Intermittent dosing of a topical calcineurin inhibitor for preventing atopic dermatitis (AD) disease relapse in patients with stabilized AD has not been evaluated... - In this issue: genotype-phenotype correlations: lessons learned from 'milder' genodermatosesAmy S Paller
J Invest Dermatol 120:vi-vii. 2003 - Compound heterozygous mutations in the hairless gene in atrichia with papular lesionsAmy S Paller
J Invest Dermatol 121:430-2. 2003 - New KIT mutations in patients with piebaldismTomoko Murakami
Department of Dermatology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi Abeno ku, Osaka 545 8585, Japan
J Dermatol Sci 35:29-33. 2004..The leukoderma is usually stable throughout life. KIT mutations have been demonstrated in about 75% of patients with piebaldism... - Leukotriene receptor antagonists are ineffective for severe atopic dermatitisNanette B Silverberg
J Am Acad Dermatol 50:485-6. 2004 - In this issue: The complexities of epidermolysis bullosa "simplex"Amy S Paller
J Invest Dermatol 122:vi-vii. 2004 - The economics of topical immunomodulators for the treatment of atopic dermatitisWilliam Abramovits
Baylor University Medical Center and University of Texas Southwestern School of Medicine, Dallas, Texas, USA
Pharmacoeconomics 23:543-66. 2005..TIMs represent an exciting advance in the treatment of atopic dermatitis. Additional research will help determine the proper place of TIMs among the current array of therapeutic options for atopic dermatitis... - Atopic dermatitis and the atopic marchJonathan M Spergel
Division of Allergy and Immunology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Allergy Clin Immunol 112:S118-27. 2003..Animal models and human observation concur with this theory. Preliminary prevention studies with oral antihistamines provide evidence that early intervention might slow the atopic march... - AAD consensus statement on psoriasis therapiesJeffrey P Callen
J Am Acad Dermatol 49:897-9. 2003 - Patient perspectives on the management of atopic dermatitisTorsten Zuberbier
Department of Dermatology and Allergy, Allergy Centre Charité, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
J Allergy Clin Immunol 118:226-32. 2006..Atopic dermatitis (AD) is increasingly common, with a point prevalence of more than 30% in some countries, and is characterized by visible skin lesions and intense itching... - The acanthosis nigricans form of epidermal nevusSibel Ersoy-Evans
Department of Dermatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
J Am Acad Dermatol 55:696-8. 2006..Three patients had stable lesions since childhood. One patient concurrently had typical bilateral AN lesions. This condition may represent a mosaic form of AN... - Wnt signaling in focal dermal hypoplasiaAmy S Paller
Nat Genet 39:820-1. 2007 - Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosisOonagh Dowling
Department of Human Genetics, Mount Sinai School of Medicine, New York, NY 10029, USA
Am J Hum Genet 73:957-66. 2003.... - Acute generalized exanthematous pustulosis in childrenSibel Ersoy
Arch Dermatol 140:1172-3. 2004
Research Grants
- GANGLIOSIDE GENE MODULATION EFFECT ON CELL MOTILITYAmy Paller; Fiscal Year: 2002....
- GANGLIOSIDE GENE MODULATION EFFECT ON CELL MOTILITYAmy Paller; Fiscal Year: 2007..These studies will provide information about the role of gangliosides in caveolin-1 mediated signaling and may lead to novel therapies for patients with abnormal healing responses. ..