Research Topics
| Yu OyamaSummaryAffiliation: Northwestern University Country: USA Publications
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Detail Information
Publications
Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's diseaseYu Oyama
Division of Immunotherapy, Department of Medicine, Northwestern University Medical Center, Chicago, Illinois 60611, USA
Gastroenterology 128:552-63. 2005..Due to a high morbidity and/or an increase in mortality in refractory cases, a new treatment approach is needed. In theory, maximum immune ablation by autologous hematopoietic stem cell transplantation (HSCT) can induce a remission...- High-dose therapy and bone marrow transplantation in cutaneous T-cell lymphomaYu Oyama
Division of Immunotherapy, Department of Medicine, The Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
Hematol Oncol Clin North Am 17:1475-83, xi. 2003..Allogeneic HSCT, in contrast, provides durable long-term remissions and is currently the only potentially curative therapy... - Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosusRichard K Burt
Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
JAMA 295:527-35. 2006..Nevertheless, there remains a subset of SLE patients for whom current strategies are insufficient to control disease... - Non-myeloablative stem cell transplantation for autoimmune diseasesRichard K Burt
Division of Immunotherapy, Northwestern University Feinberg School of Medicine, 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
Springer Semin Immunopathol 26:57-69. 2004..In addition, for allogeneic hematopoietic stem cell transplantation engraftment of disease resistant donor stem cells will alter the genetic predisposition towards autoimmune disease susceptibility... - Stem cell transplantation for autoimmune diseasesRichard K Burt
Division of Immunotherapy, Northwestern University Feinberg Medical Center, Chicago, IL 60611, USA
Clin Adv Hematol Oncol 2:313-9. 2004.... - Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II studyRichard K Burt
Division of Immunotherapy, Department of Medicine, Northwestern University, Chicago, IL 60611, USA
Lancet Neurol 8:244-53. 2009..We evaluated the safety and clinical outcome of autologous non-myeloablative haemopoietic stem cell transplantation in patients with relapsing-remitting multiple sclerosis (MS) who had not responded to treatment with interferon beta... - Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory Crohn disease: long-term follow-upRichard K Burt
Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Blood 116:6123-32. 2010..This trial was registered at www.clinicaltrials.gov as NCT0027853... - Hematopoietic mixed chimerism derived from allogeneic embryonic stem cells prevents autoimmune diabetes mellitus in NOD miceLarissa Verda
Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Stem Cells 26:381-6. 2008..ESC-derived HSC can induce an islet cell tolerizing GVA effect without GVHD. This study represents the first instance, to our knowledge, of ESC-derived HSC cells treating disease in an animal model... - Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimensRichard K Burt
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60011, USA
Arthritis Rheum 54:3750-60. 2006 - Induction of remission of severe and refractory rheumatoid arthritis by allogeneic mixed chimerismRichard K Burt
Division of Immunotherapy, Northwestern University School of Medicine, Chicago, Illinois 60611, USA
Arthritis Rheum 50:2466-70. 2004..This is the first published report of allogeneic HSCT performed for the indication of RA. Mixed chimerism has resulted in marked amelioration of RA, without GVHD... - Development of a secondary autoimmune disorder after hematopoietic stem cell transplantation for autoimmune diseases: role of conditioning regimen usedYvonne Loh
Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Blood 109:2643-548. 2007..011). In contrast, sex, type of ATG used, and CD34-selection of peripheral blood stem cells were not found to be significantly associated with development of a secondary autoimmune disorder... - Embryonic stem cells as an alternate marrow donor source: engraftment without graft-versus-host diseaseRichard K Burt
Division of Immunotherapy, Department of Medicine, Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Searle, Room 3 489, Chicago, IL 60611, USA
J Exp Med 199:895-904. 2004..ESCs might be used as a renewable alternate marrow donor source that reconstitutes hematopoiesis with intact immune responsiveness without GVHD despite crossing MHC barriers... - High-dose immune suppression and autologous hematopoietic stem cell transplantation in refractory Crohn diseaseRichard K Burt
Division of Immunotherapy, Northwestern University Medical School, Chicago, IL 60611, USA
Blood 101:2064-6. 2003..Patients have remained in remission (CDAI < 100) for 1 year since HSCT. We conclude that further HSCT studies for severe Crohn disease appear warranted... - Antiphospholipid syndrome in patients with systemic lupus erythematosus treated by autologous hematopoietic stem cell transplantationLaisvyde Statkute
Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Blood 106:2700-9. 2005..There was no treatment-related mortality. Autologous HSCT may be performed safely in patients with APS and appears to be effective therapy for eliminating ALPAs and preventing thrombotic complications in patients with SLE... - Hematopoietic stem cell transplantation for severe and refractory lupus. Analysis after five years and fifteen patientsAnn E Traynor
Northwestern Memorial Hospital and Northwestern University School of Medicine, Chicago, Illinois, USA
Arthritis Rheum 46:2917-23. 2002..A phase III randomized trial is warranted to determine the relative efficacy and durability of remission of HSCT compared with standard therapies... - Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusionsRichard K Burt
Northwestern University School of Medicine, Division of Immunotherapy, Chicago, Illinois 60611, USA
Exp Hematol 31:903-10. 2003..To this end, we also report on a study of whether HSVtk-DLI induces GVHD/GVL and if infusion of GCV allows abrogation of GVHD by selective killing of donor lymphocytes... - Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation-based conditioning regimen to prevent disease progression in patients with high disability scoresRichard K Burt
Department of Neurology, Northwestern University Medical School, Chicago, IL, USA
Blood 102:2373-8. 2003..Specifically, more patients and longer follow-up would be required in patients with an EDSS of 6.0 or less before drawing conclusions on this subgroup... - Hematopoietic stem cell therapy for type 1 diabetes: induction of tolerance and islet cell neogenesisRichard K Burt
Department of Medicine, Northwestern University Medical Center, Chicago, IL 60611, USA
Autoimmun Rev 1:133-8. 2002..It is possible that HSC may also be able to switch lineage and, therefore, be a convenient source of stem cells for both inducing tolerance and islet cell regeneration... - Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores: is neoangiogenesis occurring?R K Burt
Department of Medicine, Division of Immunotherapy, Northwestern University Medical Center, 320 East Superior, Searle 3-489, Chicago, IL 60611, USA
Bone Marrow Transplant 32:S65-7. 2003..Engraftment occurred rapidly (day 8) with minimal unexpected toxicity, no infections, and unexpectedly rapid improvement in the modified Rodnan Skin Score... - Hematopoietic stem cell transplantation for multiple sclerosisRichard K Burt
Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
Arch Neurol 62:860-4. 2005 - A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantationYu Oyama
Department of Medicine, Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
J Neuroophthalmol 29:43-9. 2009..Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome... - Long-term remission after allogeneic hematopoietic stem cell transplantation for refractory cutaneous T-cell lymphomaJoan Guitart
Department of Dermatology, Northwestern University Medical School, Chicago, IL 60611, USA
Arch Dermatol 138:1359-65. 2002..Because patients with advanced cutaneous T-cell lymphoma have a poor prognosis, with minimal possibilities of sustained remission, we studied the therapeutic potential of hematopoietic stem cell transplantation... - [Autologous and allogeneic stem cell transplantation for severe autoimmune diseases]Yu Oyama
Division of Immunotherapy, Northwestern University Medical School, USA
Nippon Rinsho 61:1643-54. 2003..Ongoing and future trials will prove the value of these approaches... - Prevalence and reversibility of pulmonary dysfunction in refractory systemic lupus: improvement correlates with disease remission following hematopoietic stem cell transplantationAnn E Traynor
Division of Hematology Oncology and Bone Marrow Transplantation, University of Massachusetts Memorial Medical Center and Medical School, Worcester, MA, USA
Chest 127:1680-9. 2005..To report the prevalence and reversibility of pulmonary function test (PFT) abnormalities among systemic lupus erythematosus (SLE) patients, refractory to therapy, undergoing hematopoietic stem cell transplantation (HSCT)... - Plasticity of hematopoietic stem cells: enough to induce tolerance and repair tissue?Richard K Burt
Arthritis Rheum 46:855-8. 2002