Yu Oyama

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease
    Yu Oyama
    Division of Immunotherapy, Department of Medicine, Northwestern University Medical Center, Chicago, Illinois 60611, USA
    Gastroenterology 128:552-63. 2005
  2. ncbi request reprint High-dose therapy and bone marrow transplantation in cutaneous T-cell lymphoma
    Yu Oyama
    Division of Immunotherapy, Department of Medicine, The Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
    Hematol Oncol Clin North Am 17:1475-83, xi. 2003
  3. ncbi request reprint Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    JAMA 295:527-35. 2006
  4. ncbi request reprint Non-myeloablative stem cell transplantation for autoimmune diseases
    Richard K Burt
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
    Springer Semin Immunopathol 26:57-69. 2004
  5. ncbi request reprint Stem cell transplantation for autoimmune diseases
    Richard K Burt
    Division of Immunotherapy, Northwestern University Feinberg Medical Center, Chicago, IL 60611, USA
    Clin Adv Hematol Oncol 2:313-9. 2004
  6. doi request reprint Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University, Chicago, IL 60611, USA
    Lancet Neurol 8:244-53. 2009
  7. doi request reprint Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory Crohn disease: long-term follow-up
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 116:6123-32. 2010
  8. ncbi request reprint Hematopoietic mixed chimerism derived from allogeneic embryonic stem cells prevents autoimmune diabetes mellitus in NOD mice
    Larissa Verda
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Stem Cells 26:381-6. 2008
  9. ncbi request reprint Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimens
    Richard K Burt
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60011, USA
    Arthritis Rheum 54:3750-60. 2006
  10. ncbi request reprint Induction of remission of severe and refractory rheumatoid arthritis by allogeneic mixed chimerism
    Richard K Burt
    Division of Immunotherapy, Northwestern University School of Medicine, Chicago, Illinois 60611, USA
    Arthritis Rheum 50:2466-70. 2004

Detail Information

Publications25

  1. ncbi request reprint Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease
    Yu Oyama
    Division of Immunotherapy, Department of Medicine, Northwestern University Medical Center, Chicago, Illinois 60611, USA
    Gastroenterology 128:552-63. 2005
    ..Due to a high morbidity and/or an increase in mortality in refractory cases, a new treatment approach is needed. In theory, maximum immune ablation by autologous hematopoietic stem cell transplantation (HSCT) can induce a remission...
  2. ncbi request reprint High-dose therapy and bone marrow transplantation in cutaneous T-cell lymphoma
    Yu Oyama
    Division of Immunotherapy, Department of Medicine, The Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
    Hematol Oncol Clin North Am 17:1475-83, xi. 2003
    ..Allogeneic HSCT, in contrast, provides durable long-term remissions and is currently the only potentially curative therapy...
  3. ncbi request reprint Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    JAMA 295:527-35. 2006
    ..Nevertheless, there remains a subset of SLE patients for whom current strategies are insufficient to control disease...
  4. ncbi request reprint Non-myeloablative stem cell transplantation for autoimmune diseases
    Richard K Burt
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
    Springer Semin Immunopathol 26:57-69. 2004
    ..In addition, for allogeneic hematopoietic stem cell transplantation engraftment of disease resistant donor stem cells will alter the genetic predisposition towards autoimmune disease susceptibility...
  5. ncbi request reprint Stem cell transplantation for autoimmune diseases
    Richard K Burt
    Division of Immunotherapy, Northwestern University Feinberg Medical Center, Chicago, IL 60611, USA
    Clin Adv Hematol Oncol 2:313-9. 2004
    ....
  6. doi request reprint Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University, Chicago, IL 60611, USA
    Lancet Neurol 8:244-53. 2009
    ..We evaluated the safety and clinical outcome of autologous non-myeloablative haemopoietic stem cell transplantation in patients with relapsing-remitting multiple sclerosis (MS) who had not responded to treatment with interferon beta...
  7. doi request reprint Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory Crohn disease: long-term follow-up
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 116:6123-32. 2010
    ..This trial was registered at www.clinicaltrials.gov as NCT0027853...
  8. ncbi request reprint Hematopoietic mixed chimerism derived from allogeneic embryonic stem cells prevents autoimmune diabetes mellitus in NOD mice
    Larissa Verda
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Stem Cells 26:381-6. 2008
    ..ESC-derived HSC can induce an islet cell tolerizing GVA effect without GVHD. This study represents the first instance, to our knowledge, of ESC-derived HSC cells treating disease in an animal model...
  9. ncbi request reprint Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimens
    Richard K Burt
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60011, USA
    Arthritis Rheum 54:3750-60. 2006
  10. ncbi request reprint Induction of remission of severe and refractory rheumatoid arthritis by allogeneic mixed chimerism
    Richard K Burt
    Division of Immunotherapy, Northwestern University School of Medicine, Chicago, Illinois 60611, USA
    Arthritis Rheum 50:2466-70. 2004
    ..This is the first published report of allogeneic HSCT performed for the indication of RA. Mixed chimerism has resulted in marked amelioration of RA, without GVHD...
  11. ncbi request reprint Development of a secondary autoimmune disorder after hematopoietic stem cell transplantation for autoimmune diseases: role of conditioning regimen used
    Yvonne Loh
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 109:2643-548. 2007
    ..011). In contrast, sex, type of ATG used, and CD34-selection of peripheral blood stem cells were not found to be significantly associated with development of a secondary autoimmune disorder...
  12. pmc Embryonic stem cells as an alternate marrow donor source: engraftment without graft-versus-host disease
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Searle, Room 3 489, Chicago, IL 60611, USA
    J Exp Med 199:895-904. 2004
    ..ESCs might be used as a renewable alternate marrow donor source that reconstitutes hematopoiesis with intact immune responsiveness without GVHD despite crossing MHC barriers...
  13. ncbi request reprint High-dose immune suppression and autologous hematopoietic stem cell transplantation in refractory Crohn disease
    Richard K Burt
    Division of Immunotherapy, Northwestern University Medical School, Chicago, IL 60611, USA
    Blood 101:2064-6. 2003
    ..Patients have remained in remission (CDAI < 100) for 1 year since HSCT. We conclude that further HSCT studies for severe Crohn disease appear warranted...
  14. ncbi request reprint Antiphospholipid syndrome in patients with systemic lupus erythematosus treated by autologous hematopoietic stem cell transplantation
    Laisvyde Statkute
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 106:2700-9. 2005
    ..There was no treatment-related mortality. Autologous HSCT may be performed safely in patients with APS and appears to be effective therapy for eliminating ALPAs and preventing thrombotic complications in patients with SLE...
  15. ncbi request reprint Hematopoietic stem cell transplantation for severe and refractory lupus. Analysis after five years and fifteen patients
    Ann E Traynor
    Northwestern Memorial Hospital and Northwestern University School of Medicine, Chicago, Illinois, USA
    Arthritis Rheum 46:2917-23. 2002
    ..To determine the safety and long-term efficacy of immune ablation and autologous hematopoietic stem cell transplantation (HSCT) in severe systemic lupus erythematosus (SLE)...
  16. ncbi request reprint Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions
    Richard K Burt
    Northwestern University School of Medicine, Division of Immunotherapy, Chicago, Illinois 60611, USA
    Exp Hematol 31:903-10. 2003
    ..To this end, we also report on a study of whether HSVtk-DLI induces GVHD/GVL and if infusion of GCV allows abrogation of GVHD by selective killing of donor lymphocytes...
  17. ncbi request reprint Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation-based conditioning regimen to prevent disease progression in patients with high disability scores
    Richard K Burt
    Department of Neurology, Northwestern University Medical School, Chicago, IL, USA
    Blood 102:2373-8. 2003
    ..Specifically, more patients and longer follow-up would be required in patients with an EDSS of 6.0 or less before drawing conclusions on this subgroup...
  18. ncbi request reprint Hematopoietic stem cell therapy for type 1 diabetes: induction of tolerance and islet cell neogenesis
    Richard K Burt
    Department of Medicine, Northwestern University Medical Center, Chicago, IL 60611, USA
    Autoimmun Rev 1:133-8. 2002
    ..It is possible that HSC may also be able to switch lineage and, therefore, be a convenient source of stem cells for both inducing tolerance and islet cell regeneration...
  19. ncbi request reprint Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores: is neoangiogenesis occurring?
    R K Burt
    Department of Medicine, Division of Immunotherapy, Northwestern University Medical Center, 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
    Bone Marrow Transplant 32:S65-7. 2003
    ..Engraftment occurred rapidly (day 8) with minimal unexpected toxicity, no infections, and unexpectedly rapid improvement in the modified Rodnan Skin Score...
  20. ncbi request reprint Hematopoietic stem cell transplantation for multiple sclerosis
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Arch Neurol 62:860-4. 2005
  21. doi request reprint A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation
    Yu Oyama
    Department of Medicine, Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Neuroophthalmol 29:43-9. 2009
    ..Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome...
  22. ncbi request reprint Long-term remission after allogeneic hematopoietic stem cell transplantation for refractory cutaneous T-cell lymphoma
    Joan Guitart
    Department of Dermatology, Northwestern University Medical School, Chicago, IL 60611, USA
    Arch Dermatol 138:1359-65. 2002
    ..Because patients with advanced cutaneous T-cell lymphoma have a poor prognosis, with minimal possibilities of sustained remission, we studied the therapeutic potential of hematopoietic stem cell transplantation...
  23. ncbi request reprint [Autologous and allogeneic stem cell transplantation for severe autoimmune diseases]
    Yu Oyama
    Division of Immunotherapy, Northwestern University Medical School, USA
    Nihon Rinsho 61:1643-54. 2003
    ..Ongoing and future trials will prove the value of these approaches...
  24. ncbi request reprint Prevalence and reversibility of pulmonary dysfunction in refractory systemic lupus: improvement correlates with disease remission following hematopoietic stem cell transplantation
    Ann E Traynor
    Division of Hematology Oncology and Bone Marrow Transplantation, University of Massachusetts Memorial Medical Center and Medical School, Worcester, MA, USA
    Chest 127:1680-9. 2005
    ..To report the prevalence and reversibility of pulmonary function test (PFT) abnormalities among systemic lupus erythematosus (SLE) patients, refractory to therapy, undergoing hematopoietic stem cell transplantation (HSCT)...
  25. ncbi request reprint Plasticity of hematopoietic stem cells: enough to induce tolerance and repair tissue?
    Richard K Burt
    Arthritis Rheum 46:855-8. 2002