Affiliation: Northwestern University
Escobedo N, Oliver G. Lymphangiogenesis: Origin, Specification, and Cell Fate Determination. Annu Rev Cell Dev Biol. 2016;32:677-691 pubmed
..We also summarize some of the current views about embryonic lymphangiogenesis, particularly about the source(s), commitment, and differentiation of lymphatic endothelial cells. ..
Geng X, Acosta S, Lagutin O, Gil H, Oliver G. Six3 dosage mediates the pathogenesis of holoprosencephaly. Development. 2016;143:4462-4473 pubmed
..Consistent with these results, in vivo activation of the Shh signaling pathway rescued the semilobar phenotype but not the alobar phenotype. Our findings show that variations in Six3 dosage result in different forms of HPE. ..
Escobedo N, Oliver G. The Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity. Cell Metab. 2017;26:598-609 pubmed publisher
..Here we review our current knowledge of the mechanisms by which defective lymphatics contribute to obesity and fat accumulation in mouse models, as well as our understanding of the lymphatic-adipose tissue relationship. ..
Takata N, Abbey D, Fiore L, Acosta S, Feng R, Gil H, et al
. An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation. Cell Rep. 2017;21:1534-1549 pubmed publisher
..Our results further validate the organoid culture system as a reliable and fast alternative to identify and evaluate genes involved in eye morphogenesis and neuroretina differentiation in vivo. ..