Thomas Mustoe

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Scars and keloids
    Thomas A Mustoe
    BMJ 328:1329-30. 2004
  2. ncbi request reprint Adenoviral human telomerase reverse transcriptase dramatically improves ischemic wound healing without detrimental immune response in an aged rabbit model
    Jon E Mogford
    Wound Healing Research Laboratory, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hum Gene Ther 17:651-60. 2006
  3. ncbi request reprint Chronic wound pathogenesis and current treatment strategies: a unifying hypothesis
    Thomas A Mustoe
    Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Ill 60611, USA
    Plast Reconstr Surg 117:35S-41S. 2006
  4. ncbi request reprint Alteration of Smad3 signaling in ischemic rabbit dermal ulcer wounds
    Oliver Kloeters
    Division of Plastic and Reconstructive Surgery, Wound Healing Research Laboratory, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Wound Repair Regen 15:341-9. 2007
  5. doi request reprint The safe management of anesthesia, sedation, and pain in plastic surgery
    Thomas A Mustoe
    Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Plast Reconstr Surg 126:165e-176e. 2010
  6. pmc Positional differences in the wound transcriptome of skin and oral mucosa
    Lin Chen
    Center for Wound Healing and Tissue Regeneration, University of Illinois, Chicago, IL, USA
    BMC Genomics 11:471. 2010
  7. ncbi request reprint Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy
    Thomas Mustoe
    Department of Surgery, Plastic Surgery, Galter 19 250, 675 North St Clair Street, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Surg 187:65S-70S. 2004
  8. doi request reprint Modified deep plane rhytidectomy with a lateral approach to the neck: an alternative to submental incision and dissection
    Thomas A Mustoe
    Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Ill 60611, USA
    Plast Reconstr Surg 127:357-70. 2011
  9. ncbi request reprint International clinical recommendations on scar management
    Thomas A Mustoe
    Division of Plastic and Reconstructive Surgery, Northwestern University School of Medicine, Chicago, Ill 60611, USA
    Plast Reconstr Surg 110:560-71. 2002
  10. pmc The role of the epidermis and the mechanism of action of occlusive dressings in scarring
    Thomas A Mustoe
    Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Wound Repair Regen 19:s16-21. 2011

Research Grants

Collaborators

  • Ulrich E Ziegler
  • Stephane Roy
  • Michael H Gold
  • Richard FD Hobbs
  • Albert Adrien Ramelet
  • Clark F Schierle
  • Gregory S Schultz
  • P Shakespeare
  • C Andrew Salzberg
  • Luc TEot
  • Calvin B Harley
  • Jon E Mogford
  • Mark Sisco
  • Russell R Reid
  • Oliver Kloeters
  • Nakshatra K Roy
  • Zol B Kryger
  • Andrea A Tandara
  • Hakim K Said
  • Nakshatra Roy
  • Robert C Fang
  • Alexandrina S Saulis
  • Injoong Kim
  • Kristina D O'Shaughnessy
  • W Robert Liu
  • Leonard Lu
  • Michael J Lee
  • Joshua Vorstenbosch
  • Jerome D Chao
  • Neil A Fine
  • Corrie L Gallant-Behm
  • Lin Chen
  • Kevin J Cross
  • Mauricio de la Garza
  • Minghua Wu
  • Richard J Brown
  • Andrea Tandara
  • Jeffrey R Marcus
  • Marguerite E Aitken
  • Anie Philip
  • Corrie Gallant-Behm
  • Alissa Trzeciak
  • Shujuan Guo
  • Luisa A DiPietro
  • Samuel J Lin
  • Zarema H Arbieva
  • Phillip T Marucha
  • Warren G Tourtellotte
  • John Varga
  • Denisa S Melichian
  • Shiva Shahrara
  • Anandev N Gurjala
  • Luke Barr
  • Katherine Gruner
  • Swati Bhattacharyya
  • Peter H S Sporn
  • Bill Tawil
  • Shengxian Jia
  • Aisha Nair
  • Nicholas M Dean
  • John Y S Kim
  • Peter S Kim
  • Xian Zhong Ding
  • Sheng Xian Jia
  • Hannah Zimmerman
  • Gabrielle Leinfellner
  • Chung Lee
  • David Rosenberg
  • Tanya N Mayadas
  • Shu Jen Chen
  • Alex deGiorgio-Miller
  • Hakim Said
  • Richard Butt
  • Choy Pik Chiu
  • Russell Reid
  • Jon Mogford
  • John Hijjawi
  • Steven Ledbetter
  • Alan M Robinson
  • William P Schiemann
  • Alan C Sull
  • Steve R Bonomo
  • Mehdi Nafissi
  • Claudia Witschi
  • Julius W Few
  • Jon H Mogford
  • Nabil Tawil
  • Alexandria Chen
  • Yuping Xia
  • David Gies

Detail Information

Publications48

  1. pmc Scars and keloids
    Thomas A Mustoe
    BMJ 328:1329-30. 2004
  2. ncbi request reprint Adenoviral human telomerase reverse transcriptase dramatically improves ischemic wound healing without detrimental immune response in an aged rabbit model
    Jon E Mogford
    Wound Healing Research Laboratory, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hum Gene Ther 17:651-60. 2006
    ..We conclude that Ad-hTERT is an effective and novel approach to treating the ischemic wounds of elderly patients...
  3. ncbi request reprint Chronic wound pathogenesis and current treatment strategies: a unifying hypothesis
    Thomas A Mustoe
    Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Ill 60611, USA
    Plast Reconstr Surg 117:35S-41S. 2006
    ..These innovative ideas and therapies could be of substantial interest for clinicians and researchers, while further offering significant benefit to patients with chronic wounds...
  4. ncbi request reprint Alteration of Smad3 signaling in ischemic rabbit dermal ulcer wounds
    Oliver Kloeters
    Division of Plastic and Reconstructive Surgery, Wound Healing Research Laboratory, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Wound Repair Regen 15:341-9. 2007
    ..Furthermore, the lack of alteration of Smad-dependent intermediates by Smad3 overexpression suggests the activation of Smad-independent pathways in ischemia...
  5. doi request reprint The safe management of anesthesia, sedation, and pain in plastic surgery
    Thomas A Mustoe
    Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Plast Reconstr Surg 126:165e-176e. 2010
    ..3. Describe current methods for achieving postoperative pain control. 4. Evaluate and manage postoperative nausea and vomiting...
  6. pmc Positional differences in the wound transcriptome of skin and oral mucosa
    Lin Chen
    Center for Wound Healing and Tissue Regeneration, University of Illinois, Chicago, IL, USA
    BMC Genomics 11:471. 2010
    ..The current study was designed to compare the transcriptomes of oral mucosal and skin wounds in order to identify critical differences in the healing response at these two sites using an unbiased approach...
  7. ncbi request reprint Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy
    Thomas Mustoe
    Department of Surgery, Plastic Surgery, Galter 19 250, 675 North St Clair Street, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Surg 187:65S-70S. 2004
    ..Additionally, treatment comprising a combination of these approaches has demonstrated success...
  8. doi request reprint Modified deep plane rhytidectomy with a lateral approach to the neck: an alternative to submental incision and dissection
    Thomas A Mustoe
    Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Ill 60611, USA
    Plast Reconstr Surg 127:357-70. 2011
    ..Therefore, most investigators rely on supraplatysmal dissection and medial plication of the platysma to achieve satisfactory cervical contours, especially in patients with difficult necks...
  9. ncbi request reprint International clinical recommendations on scar management
    Thomas A Mustoe
    Division of Plastic and Reconstructive Surgery, Northwestern University School of Medicine, Chicago, Ill 60611, USA
    Plast Reconstr Surg 110:560-71. 2002
    ..However, it is highly desirable that many standard practices and new emerging therapies undergo large-scale studies with long-term follow-up before being recommended conclusively as alternative therapies for scar management...
  10. pmc The role of the epidermis and the mechanism of action of occlusive dressings in scarring
    Thomas A Mustoe
    Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Wound Repair Regen 19:s16-21. 2011
    ..In the spectrum of factors contributing to dermal scar, the epidermis and its downstream effectors offer promising new targets for the development of antiscar therapies...
  11. ncbi request reprint Evolution of silicone therapy and mechanism of action in scar management
    Thomas A Mustoe
    Division of Plastic Surgery, Northwestern University School of Medicine, 675 North Street Clair 19 250, Chicago, IL 60611, USA
    Aesthetic Plast Surg 32:82-92. 2008
    ..The mechanism of action of silicone therapy has not been completely determined but is likely to involve occlusion and hydration of the stratum corneum with subsequent cytokine-mediated signaling from keratinocytes to dermal fibroblasts...
  12. doi request reprint Transgenic mice overexpressing CD109 in the epidermis display decreased inflammation and granulation tissue and improved collagen architecture during wound healing
    Joshua Vorstenbosch
    Department of Surgery, Division of Plastic Surgery, McGill University, Montreal, Quebec, Canada
    Wound Repair Regen 21:235-46. 2013
    ..Taken together, our findings demonstrate that CD109 overexpression in the epidermis reduces inflammation and granulation tissue area and improves collagen organization in vivo...
  13. ncbi request reprint A retrospective analysis of patient satisfaction with immediate postmastectomy breast reconstruction: comparison of three common procedures
    Alexandrina S Saulis
    Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Plast Reconstr Surg 119:1669-76; discussion 1677-8. 2007
    ..The authors aimed to quantify overall patient satisfaction with three breast reconstruction techniques and identify factors that have influenced satisfaction...
  14. doi request reprint Fibrin sealant combined with fibroblasts and platelet-derived growth factor enhance wound healing in excisional wounds
    Jon E Mogford
    Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Wound Repair Regen 17:405-10. 2009
    ..The findings suggest the progress of cutaneous defect repair can be enhanced by ex vivo cell delivery in fibrin sealant...
  15. doi request reprint Homeostasis of the epidermal barrier layer: a theory of how occlusion reduces hypertrophic scarring
    Kristina D O'Shaughnessy
    Wound Healing Research Laboratory, Department of Surgery, Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, 675 N St Clair St, Chicago, IL 60611, USA
    Wound Repair Regen 17:700-8. 2009
    ..Ultrastructural analysis suggests that occluded wounds may be in an advanced state of wound repair. Occlusion may mediate its effects through establishing homeostasis of the epidermal barrier layer...
  16. ncbi request reprint The prevention of emesis in plastic surgery: a randomized, prospective study
    Jeffrey R Marcus
    Division of Plastic and Reconstructive Surgery, Northwestern University Medical School, 707 North Fairbanks Court, Chicago, IL 60611 2923, USA
    Plast Reconstr Surg 109:2487-94. 2002
    ..By remaining attentive to patient concerns and optimizing perioperative care, we can improve the subjective experience for our patients...
  17. ncbi request reprint The outcome of abdominoplasty performed under conscious sedation: six-year experience in 153 consecutive cases
    Zol B Kryger
    Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University Medical Center, 675 North St Clair Street, Chicago, IL 60611, USA
    Plast Reconstr Surg 113:1807-17; discussion 1818-9. 2004
    ..Increasing experience and small modifications in local anesthesia and surgical technique have strengthened the authors' conviction that conscious sedation is the preferred method of anesthesia for most patients undergoing abdominoplasty...
  18. ncbi request reprint Transdermal sustained-delivery oxygen improves epithelial healing in a rabbit ear wound model
    Hakim K Said
    Wound Healing Research Lab, Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, 675 North St Clair, Chicago, IL 60611, USA
    Arch Surg 140:998-1004. 2005
    ..Transdermal sustained-delivery oxygen therapy improves wound healing...
  19. doi request reprint The role of the epidermis in the control of scarring: evidence for mechanism of action for silicone gel
    Andrea A Tandara
    Division of Plastic and Reconstructive Surgery, Wound Healing Research Laboratory, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Plast Reconstr Aesthet Surg 61:1219-25. 2008
    ..Oxygen can be ruled out as a mechanism of action of silicone occlusive treatment. Hydration of the keratinocytes seems to be the key stimulus...
  20. ncbi request reprint Reduced up-regulation of cytoprotective genes in rat cutaneous tissue during the second cycle of ischemia-reperfusion
    Mark Sisco
    Wound Healing Research Laboratory, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Wound Repair Regen 15:203-12. 2007
    ..These findings raise the possibility that reduced up-regulation of these cytoprotective genes may be causally linked to cutaneous I-R injury...
  21. pmc Occlusion regulates epidermal cytokine production and inhibits scar formation
    Corrie L Gallant-Behm
    Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, IL 60611, USA
    Wound Repair Regen 18:235-44. 2010
    ..In summary, the results of this study indicate that occlusive therapy was able to decrease dermal fibrosis by hydrating the epidermis and altering the pro- and antifibrotic signals produced following injury...
  22. doi request reprint Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model
    Clark F Schierle
    Laboratory for Repair and Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, Illinois, USA
    Wound Repair Regen 17:354-9. 2009
    ..deficient in biofilm formation. This represents the first direct evidence for the effect of bacterial biofilms on cutaneous wound healing...
  23. ncbi request reprint Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring
    Zol B Kryger
    Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Am Coll Surg 205:78-88. 2007
    ....
  24. doi request reprint Antisense inhibition of connective tissue growth factor (CTGF/CCN2) mRNA limits hypertrophic scarring without affecting wound healing in vivo
    Mark Sisco
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, 675 N St Clair, Chicago, IL 60611, USA
    Wound Repair Regen 16:661-73. 2008
    ..Its limited participation in early healing implies that it may be a useful and specific target for modulating hypertrophic scarring following injury...
  25. doi request reprint Abdominoplasty flap elevation in a more superficial plane: decreasing the need for drains
    Robert C Fang
    Division of Plastic Surgery, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Plast Reconstr Surg 125:677-82. 2010
    ..The authors' hypothesis was that a more superficial plane of abdominal flap elevation during abdominoplasty would decrease the postoperative need for drains...
  26. ncbi request reprint Hypertrophic scar model in the rabbit ear: a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction
    Oliver Kloeters
    Feinberg School of Medicine, Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, Illinois, USA
    Wound Repair Regen 15:S40-5. 2007
    ..Furthermore, our data suggest that the degree and the duration of occlusion are most important for reducing scar tissue formation...
  27. ncbi request reprint The future of wound healing: pursuing surgical models in transgenic and knockout mice
    Russell R Reid
    Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Am Coll Surg 199:578-85. 2004
    ..A convention is proposed for assessing the multiple dimensions of wound healing. An approach to phenotyping a transgenic or knockout animal in a reproducible fashion is presented using this convention...
  28. ncbi request reprint Effect of Mederma on hypertrophic scarring in the rabbit ear model
    Alexandrina S Saulis
    Division of Plastic and Reconstructive Surgery, Northwestern University Medical School, Galter Pavilion, 675 N Saint Claire, Chicago, IL 60611, USA
    Plast Reconstr Surg 110:177-83; discussion 184-6. 2002
    ....
  29. ncbi request reprint Inhibition of procollagen C-proteinase reduces scar hypertrophy in a rabbit model of cutaneous scarring
    Russell R Reid
    Northwestern University, Division of Plastic Surgery, Chicago, Illinois 60611, USA
    Wound Repair Regen 14:138-41. 2006
    ..01). Our results point not only to the potential use of PCP inhibitors to mitigate hypertrophic scarring but also to the temporal importance of drug delivery for antiscarring therapy...
  30. ncbi request reprint Growth factors in wound healing
    Kevin J Cross
    Division of Plastic Surgery, Department of Surgery, Northwestern University School of Medicine, 675 North St Claire St, Chicago, IL 60611 2923, USA
    Surg Clin North Am 83:531-45, vi. 2003
    ..This article analyzes current knowledge on growth factors as therapeutic agents and speculates on their future potential, with an analysis of successes and failures to date...
  31. ncbi request reprint Inhibition of prolyl 4-hydroxylase reduces scar hypertrophy in a rabbit model of cutaneous scarring
    Injoong Kim
    Division of Plastic Surgery, Northwestern University, 675 N St Clair 19 250, Chicago, IL 60611, USA
    Wound Repair Regen 11:368-72. 2003
    ..These results suggest that inhibition of prolyl 4-hydroxylase may be a suitable agent for topical treatment for the prevention of hypertrophic scar tissue...
  32. ncbi request reprint Impact of aging on gene expression in a rat model of ischemic cutaneous wound healing
    Jon E Mogford
    Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, Illinois 60611, USA
    J Surg Res 118:190-6. 2004
    ..Tissue ischemia and aging are independent features associated with the healing impairment of cutaneous wounds. However, the pathophysiology of these processes as they relate to impaired-healing wounds is poorly understood...
  33. ncbi request reprint The temporal effects of anti-TGF-beta1, 2, and 3 monoclonal antibody on wound healing and hypertrophic scar formation
    Leonard Lu
    Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    J Am Coll Surg 201:391-7. 2005
    ..We propose that TGF-beta has a temporal effect on these processes. To test this hypothesis, we applied anti-TGF beta1, 2, and 3 monoclonal antibody topically to our dermal ulcer model in the rabbit ear...
  34. ncbi request reprint Oxygen in wound healing--more than a nutrient
    Andrea A Tandara
    Wound Healing Research Laboratory, Northwestern University, 303 East Chicago Avenue, Tarry Bldg 4 720, Chicago, IL 60611, USA
    World J Surg 28:294-300. 2004
    ..The article concludes with a discussion of why hypoxia and hyperoxia intercurrently play an important role in wound healing. Hypoxia-inducible factor 1 is crucial in that interplay...
  35. pmc Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing
    Minghua Wu
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, 240 E Huron St, Chicago, IL 60611, USA
    Am J Pathol 175:1041-55. 2009
    ..Together, these results point to the fundamental role that Egr-1 plays in the regulation of transforming growth factor-ss-dependent physiological and pathological matrix remodeling...
  36. ncbi request reprint Animal models of ischemic wound healing. Toward an approximation of human chronic cutaneous ulcers in rabbit and rat
    Mark Sisco
    Division of Plastic and Reconstructive Surgery, Wound Healing Research Laboratory, Northwestern University Medical School, Chicago, IL, USA
    Methods Mol Med 78:55-65. 2003
  37. ncbi request reprint A novel murine model of cyclical cutaneous ischemia-reperfusion injury
    Russell R Reid
    Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, Illinois 60611, USA
    J Surg Res 116:172-80. 2004
    ..An incomplete understanding of this process and the limitations of current animal models of chronic wounds mandate a reproducible model in mice, in which transgenic and knockout technology are continually evolving...
  38. ncbi request reprint Reduction of hypertrophic scar via retroviral delivery of a dominant negative TGF-beta receptor II
    Russell R Reid
    Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, 675 North Saint Clair, Suite 19 250, Chicago, IL 60611, USA
    J Plast Reconstr Aesthet Surg 60:64-72; discussion 73-4. 2007
    ..Optimisation of this novel application in retroviral gene therapy could lead to effective anti-scarring strategies...
  39. ncbi request reprint Use of hypoxia-inducible factor signal transduction pathway to measure O2 levels and modulate growth factor pathways
    Jon E Mogford
    Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Wound Repair Regen 11:496-503. 2003
    ..Smad3 is a positive effector of transforming growth factor-beta superfamily signal transduction. Such approaches are the latest evolution of work championed by Hunt and colleagues over the past 4 decades...
  40. ncbi request reprint Effect of age and hypoxia on TGFbeta1 receptor expression and signal transduction in human dermal fibroblasts: impact on cell migration
    Jon E Mogford
    Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, Illinois 60611, USA
    J Cell Physiol 190:259-65. 2002
    ....
  41. doi request reprint Quantifying tissue level ischemia: hypoxia response element-luciferase transfection in a rabbit ear model
    Hakim K Said
    Division of Plastic Surgery, University of Washington, Seattle, Washington, USA
    Wound Repair Regen 17:473-9. 2009
    ..The caudal ischemic rabbit ear model showed significantly higher levels of hypoxia. Use of a validated model that produces sufficient tissue levels of hypoxia is recommended for meaningful study of ischemic wound healing...
  42. ncbi request reprint Age effect on HSP70: decreased resistance to ischemic and oxidative stress in HDF
    Andrea A Tandara
    Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, Illinois 60611, USA
    J Surg Res 132:32-9. 2006
    ..The aim of this study was to investigate a possible connection by comparing the viability of heat pre-conditioned aged versus young human dermal fibroblasts (HDF) after exposure to stress...
  43. ncbi request reprint Delayed wound healing in Mac-1-deficient mice is associated with normal monocyte recruitment
    Mark Sisco
    Wound Healing Research Laboratory, Division of Plastic Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Wound Repair Regen 15:566-71. 2007
    ....
  44. doi request reprint High-dose ultraviolet light exposure reduces scar hypertrophy in a rabbit ear model
    Richard J Brown
    Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Ill 60611, USA
    Plast Reconstr Surg 121:1165-72. 2008
    ..This study sought to evaluate the effect of ultraviolet light exposure on scar hypertrophy in an established rabbit model of cutaneous scarring...
  45. pmc The use of a semiocclusive dressing reduces epidermal inflammatory cytokine expression and mitigates dermal proliferation and inflammation in a rat incisional model
    Oliver Kloeters
    Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Wound Repair Regen 16:568-75. 2008
    ....
  46. doi request reprint Animal models of wound healing: utility in transgenic mice
    Robert C Fang
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, 675 N St Clair Street, Chicago, IL 60611, USA
    J Biomater Sci Polym Ed 19:989-1005. 2008
    ..A battery of standard and impaired wound healing models, when used in a systematic and combinatorial fashion, should yield significant contributions to wound healing research...
  47. ncbi request reprint Fibulin-5 promotes wound healing in vivo
    Michael J Lee
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Northwestern University, Chicago, IL, USA
    J Am Coll Surg 199:403-10. 2004
    ..Because fibulin-5 expression is induced dramatically in endothelial and smooth muscle cells in response to mechanical injury, my colleagues and I studied its role in dermal wound healing...
  48. ncbi request reprint Why change a good thing? Revisiting the fleur-de-lis reconstruction of the breast
    Marguerite E Aitken
    Department of Plastic and Reconstructive Surgery, Northwestern University Medical School, Chicago, IL 60611, USA
    Plast Reconstr Surg 109:525-33; discussion 534-8. 2002
    ..With a relative paucity of complications, this conceptually ideal modification is technically simple and aesthetically comparable to our transverse rectus abdominis muscle flap results...

Research Grants12

  1. IMPACT OF AGING, ISCHEMIA AND CYTOKINES ON WOUND HEALING
    Thomas Mustoe; Fiscal Year: 2002
    ....
  2. Role of TGF-b In Excessive Scarring: A Cutaneous Model
    Thomas Mustoe; Fiscal Year: 2005
    ..abstract_text> ..