William Muller

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment
    Zahra Mamdouh
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Exp Med 206:2795-808. 2009
  2. pmc PECAM-independent thioglycollate peritonitis is associated with a locus on murine chromosome 2
    Michael A Seidman
    Department of Pathology, Weill Cornell Medical College, New York, New York, United States of America
    PLoS ONE 4:e4316. 2009
  3. pmc Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment
    Zahra Mamdouh
    Department of Pathology and Laboratory Medicine and the Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10021, USA
    J Exp Med 205:951-66. 2008
  4. pmc How endothelial cells regulate transmigration of leukocytes in the inflammatory response
    William A Muller
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois Electronic address
    Am J Pathol 184:886-96. 2014
  5. pmc Getting leukocytes to the site of inflammation
    W A Muller
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Vet Pathol 50:7-22. 2013
  6. pmc Regulate globally, act locally: adrenergic nerves promote leukocyte recruitment
    William A Muller
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 3008, USA
    Immunity 37:189-91. 2012
  7. pmc Mechanisms of leukocyte transendothelial migration
    William A Muller
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Annu Rev Pathol 6:323-44. 2011
  8. pmc Mechanisms of transendothelial migration of leukocytes
    William A Muller
    Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Ward Building 3 140, Chicago, IL 60611, USA
    Circ Res 105:223-30. 2009
  9. doi Sorting the signals from the signals in the noisy environment of inflammation
    William A Muller
    Department of Pathology, Ward Building 3 140, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Sci Signal 4:pe23. 2011
  10. pmc Phosphorylation of leukocyte PECAM and its association with detergent-resistant membranes regulate transendothelial migration
    Oliver Florey
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 185:1878-86. 2010

Collaborators

Detail Information

Publications14

  1. pmc Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment
    Zahra Mamdouh
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Exp Med 206:2795-808. 2009
    ..Similar to their effects on paracellular transmigration, antibodies against PECAM or CD99, but not JAM-A, block transcellular migration. We conclude that similar molecular mechanisms promote both para- and transcellular migration...
  2. pmc PECAM-independent thioglycollate peritonitis is associated with a locus on murine chromosome 2
    Michael A Seidman
    Department of Pathology, Weill Cornell Medical College, New York, New York, United States of America
    PLoS ONE 4:e4316. 2009
    ....
  3. pmc Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment
    Zahra Mamdouh
    Department of Pathology and Laboratory Medicine and the Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10021, USA
    J Exp Med 205:951-66. 2008
    ..Furthermore, these data provide the first demonstration of a role for endothelial microtubules and kinesins in promoting diapedesis, and a mechanism to explain targeted recycling...
  4. pmc How endothelial cells regulate transmigration of leukocytes in the inflammatory response
    William A Muller
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois Electronic address
    Am J Pathol 184:886-96. 2014
    ..How these events are coordinated is not known, but their regulation shares common signaling pathways that may serve to connect these steps. ..
  5. pmc Getting leukocytes to the site of inflammation
    W A Muller
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Vet Pathol 50:7-22. 2013
    ..A hypothesis that integrates the various known mechanisms of transmigration is proposed...
  6. pmc Regulate globally, act locally: adrenergic nerves promote leukocyte recruitment
    William A Muller
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 3008, USA
    Immunity 37:189-91. 2012
    ....
  7. pmc Mechanisms of leukocyte transendothelial migration
    William A Muller
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Annu Rev Pathol 6:323-44. 2011
    ..Surprisingly, many of the same molecules and mechanisms that regulate paracellular migration also control transcellular migration. A hypothesis that integrates the various known mechanisms of transmigration is proposed...
  8. pmc Mechanisms of transendothelial migration of leukocytes
    William A Muller
    Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Ward Building 3 140, Chicago, IL 60611, USA
    Circ Res 105:223-30. 2009
    ..A hypothesis that integrates the various known mechanisms is proposed...
  9. doi Sorting the signals from the signals in the noisy environment of inflammation
    William A Muller
    Department of Pathology, Ward Building 3 140, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Sci Signal 4:pe23. 2011
    ....
  10. pmc Phosphorylation of leukocyte PECAM and its association with detergent-resistant membranes regulate transendothelial migration
    Oliver Florey
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 185:1878-86. 2010
    ..These signals are then downregulated following PECAM translocation to DRMs...
  11. ncbi Locomotion of monocytes on endothelium is a critical step during extravasation
    Alan R Schenkel
    Department of Pathology, Weill Medical College of Cornell University, Room C320, 1300 York Avenue, New York, New York 10021, USA
    Nat Immunol 5:393-400. 2004
    ..The blocked monocytes spun in circles as if they were unable to direct their movement despite being able to adhere and polarize normally. This step fills a gap in the paradigm of extravasation as a multistep process...
  12. ncbi Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response
    William A Muller
    Department of Pathology, and Laboratory Medicine, Graduate Program in Immunology, Weill Medical College, 1300 York Avenue, New York, NY 10021, USA
    Trends Immunol 24:327-34. 2003
    ..In addition, this Review introduces a new and unified nomenclature for the junctional adhesion molecule (JAM) family...
  13. pmc Assays of transendothelial migration in vitro
    William A Muller
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Methods Enzymol 443:155-76. 2008
    ....
  14. ncbi CD99 plays a major role in the migration of monocytes through endothelial junctions
    Alan R Schenkel
    Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nat Immunol 3:143-50. 2002
    ..Therefore, diapedesis, the forward migration of leukocytes through endothelial junctions, is regulated sequentially by two distinct molecules, PECAM-1 and CD99...

Research Grants19

  1. Roles of Endothelial PECAM-1 in Leukocyte Transmigration
    William Muller; Fiscal Year: 2007
    ..These studies will show whether PECAM represents a reasonable therapeutic target for chronic anti-inflammatory therapy. ..
  2. Roles of Endothelial PECAM-1 in Leukocyte Transmigration
    William Muller; Fiscal Year: 2005
    ..These studies will show whether PECAM represents a reasonable therapeutic target for chronic anti-inflammatory therapy. ..
  3. Roles of Endothelial PECAM-1 in Leukocyte Transmigration
    William Muller; Fiscal Year: 2004
    ..These studies will show whether PECAM represents a reasonable therapeutic target for chronic anti-inflammatory therapy. ..
  4. PECAM-INDEPENDENT TRANSENDOTHELIAL MIGRATION
    William Muller; Fiscal Year: 2003
    ..We have generated mice that are genetically deficient in PECAM and mice in which PECAM does not function. These mice will be critical to evaluate PECAM-independent TEM. ..
  5. PECAM-1: ROLES IN LEUKOCYTE TRANSENDOTHELIAL MIGRATION
    William Muller; Fiscal Year: 2003
    ..These studies will shed light on how PECAM, a controller of inflammation, is itself regulated. ..
  6. PECAM-INDEPENDENT TRANSENDOTHELIAL MIGRATION
    William Muller; Fiscal Year: 2002
    ..We have generated mice that are genetically deficient in PECAM and mice in which PECAM does not function. These mice will be critical to evaluate PECAM-independent TEM. ..
  7. PECAM-1: ROLES IN LEUKOCYTE TRANSENDOTHELIAL MIGRATION
    William Muller; Fiscal Year: 2002
    ..These studies will shed light on how PECAM, a controller of inflammation, is itself regulated. ..
  8. The Roles of Endothelial PECAM and the LBRC in Leukocyte Transmigration
    William A Muller; Fiscal Year: 2010
    ..We will investigate how this compartment functions so that we can design better anti-inflammatory therapies. ..
  9. PECAM-INDEPENDENT TRANSENDOTHELIAL MIGRATION
    William Muller; Fiscal Year: 2000
    ..We have generated mice that are genetically deficient in PECAM and mice in which PECAM does not function. These mice will be critical to evaluate PECAM-independent TEM. ..
  10. PECAM-1: ROLES IN LEUKOCYTE TRANSENDOTHELIAL MIGRATION
    William Muller; Fiscal Year: 2000
    ..These studies will shed light on how PECAM, a controller of inflammation, is itself regulated. ..
  11. PECAM-INDEPENDENT TRANSENDOTHELIAL MIGRATION
    William Muller; Fiscal Year: 2001
    ..We have generated mice that are genetically deficient in PECAM and mice in which PECAM does not function. These mice will be critical to evaluate PECAM-independent TEM. ..
  12. PECAM-1--ROLES IN LEUKOCYTE TRANSENDOTHELIAL MIGRATION
    William Muller; Fiscal Year: 1999
    ..Intraviral microscopy will demonstrate the actions of anti-PECAM reagents in ongoing inflammation. We will study TEM itself and migration through the interstitium of the mesentery. ..
  13. PECAM-1: ROLES IN LEUKOCYTE TRANSENDOTHELIAL MIGRATION
    William Muller; Fiscal Year: 2001
    ..These studies will shed light on how PECAM, a controller of inflammation, is itself regulated. ..
  14. Roles of Endothelial PECAM-1 in Leukocyte Transmigration
    William Muller; Fiscal Year: 2006
    ..These studies will show whether PECAM represents a reasonable therapeutic target for chronic anti-inflammatory therapy. ..