Affiliation: Northwestern University
Zhu Y, Cankova Z, Iwanaszko M, Lichtor S, Mrksich M, Ameer G. Potent laminin-inspired antioxidant regenerative dressing accelerates wound healing in diabetes. Proc Natl Acad Sci U S A. 2018;115:6816-6821 pubmed publisher
..This peptide-hydrogel system represents a paradigm shift in dermoconductive and dermoinductive strategies for treating DFU without the need for soluble biological or pharmacological factors. ..
Yamankurt G, Berns E, Xue A, Lee A, Bagheri N, Mrksich M, et al
. Exploration of the nanomedicine-design space with high-throughput screening and machine learning. Nat Biomed Eng. 2019;3:318-327 pubmed publisher
..Our methodology is general, can reduce the number of nanoparticles that need to be tested by an order of magnitude, and could serve as a screening tool for the development of nanoparticle therapeutics. ..
Szymczak L, Huang C, Berns E, Mrksich M. Combining SAMDI Mass Spectrometry and Peptide Arrays to Profile Phosphatase Activities. Methods Enzymol. 2018;607:389-403 pubmed publisher
..In this chapter, we describe the process of combining SAMDI mass spectrometry with peptide arrays to study the substrate specificities of two protein tyrosine phosphatases. ..
Sobers C, Wood S, Mrksich M. A gene expression-based comparison of cell adhesion to extracellular matrix and RGD-terminated monolayers. Biomaterials. 2015;52:385-94 pubmed publisher
..This study suggests that biomaterials presenting the cyclic RGD peptide are substantially better mimics of extracellular matrix than are uncoated materials or materials presenting the common linear RGD peptide. ..
Sodji Q, Kornacki J, McDonald J, Mrksich M, Oyelere A. Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids. Eur J Med Chem. 2015;96:340-59 pubmed publisher
..Our observation further supports the previous results which suggest that for a drug to be successfully targeted using the FR, it must be extremely potent against its primary target as the FR has a low delivery efficiency. ..
Kightlinger W, Lin L, Rosztoczy M, Li W, DeLisa M, Mrksich M, et al
. Design of glycosylation sites by rapid synthesis and analysis of glycosyltransferases. Nat Chem Biol. 2018;14:627-635 pubmed publisher
..We find that GlycoSCORES is a broadly applicable method to facilitate fundamental understanding of glycosyltransferases and engineer synthetic glycoproteins. ..