RICHARD MORIMOTO

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
    Richard I Morimoto
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    Genes Dev 22:1427-38. 2008
  2. pmc Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity
    Tali Gidalevitz
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America
    PLoS Genet 5:e1000399. 2009
  3. pmc Proteostasis and the aging proteome in health and disease
    Richard I Morimoto
    Department of Molecular Biosciences, Northwestern University, Evanston, Illinois
    J Gerontol A Biol Sci Med Sci 69:S33-8. 2014
  4. pmc Structural properties and neuronal toxicity of amyotrophic lateral sclerosis-associated Cu/Zn superoxide dismutase 1 aggregates
    Gen Matsumoto
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    J Cell Biol 171:75-85. 2005
  5. pmc Small-molecule proteostasis regulators for protein conformational diseases
    Barbara Calamini
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, USA
    Nat Chem Biol 8:185-96. 2012
  6. pmc A genetic screening strategy identifies novel regulators of the proteostasis network
    M Catarina Silva
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America
    PLoS Genet 7:e1002438. 2011
  7. pmc Spreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegans
    Carmen I Nussbaum-Krammer
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America
    PLoS Genet 9:e1003351. 2013
  8. pmc Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response
    M Catarina Silva
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America
    PLoS Genet 9:e1003711. 2013
  9. pmc Identification of a tissue-selective heat shock response regulatory network
    Eric Guisbert
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America
    PLoS Genet 9:e1003466. 2013
  10. pmc Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases
    Carmen I Nussbaum-Krammer
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Dis Model Mech 7:31-9. 2014

Research Grants

Collaborators

  • Margarida D Amaral
  • Carina I Holmberg
  • Klaus Richter
  • Peter Hodder
  • Darren M Hutt
  • A Matouschek
  • D S Latchman
  • Gillian P Bates
  • Jeffery Kelly
  • ANDREW G DILLIN
  • Dick D Mosser
  • Paul J Muchowski
  • Christian Landles
  • ANA M CUERVO
  • Caroline Jolly
  • Tali Gidalevitz
  • Sandy D Westerheide
  • Heather R Brignull
  • M Catarina Silva
  • Carmen I Nussbaum-Krammer
  • Barbara Calamini
  • James F Morley
  • Gen Matsumoto
  • Veena Prahlad
  • Soojin Kim
  • Theodore R Rieger
  • Elise A Kikis
  • William E Balch
  • Anat Ben-Zvi
  • Susana M Garcia
  • Eric Guisbert
  • Janine Kirstein-Miles
  • Ellen A A Nollen
  • Amy Trott
  • Alexandra Zourlidou
  • Richard B Silverman
  • Steven Finkbeiner
  • Vassily Hatzimanikatis
  • Tiara L A Kawahara
  • Aharon Solomon
  • Li Jung Tai
  • Daniel M Czyz
  • Kyung Won Park
  • Ronald Melki
  • Patrick D McMullen
  • Liming Li
  • Shilpi Khanna
  • Franck Madoux
  • Monica A Chalfant
  • Maria Catarina Silva
  • Bradley D Tait
  • Dan Garza
  • S Adrian Saldanha
  • Monica Beam
  • Susan Fox
  • Happy Thakkar
  • Stanley M Stevens
  • Lea Sistonen
  • Julius Anckar
  • Elizabeth A Miller
  • Thomas Krupinski
  • Susana Garcia
  • Kevin A Morano
  • Tyler Cornelius
  • Lada Klaić
  • James D West
  • Jackie de Belleroche
  • Dominic J Wells
  • Ben Woodman
  • Mark Kristiansen
  • Sarah J Tabrizi
  • M Olivia Casanueva
  • Kim H Ho
  • Stephanie J Tang
  • Finola E Moore
  • Kai Orton
  • Aleksandar Stojanovic
  • Bessie N A Mbadugha
  • Greg J Beitel
  • Joshua D Bosman
  • John P Devlin
  • Wenxin Gu
  • Sean Jabbar
  • Rena Shah
  • Sricharan Bandhakavi
  • Vytautas P Bindokas
  • Borries Demeler
  • Kurt Brubaker
  • Kai Huang
  • Ishwar Radhakrishnan

Detail Information

Publications48

  1. pmc Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
    Richard I Morimoto
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    Genes Dev 22:1427-38. 2008
    ....
  2. pmc Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity
    Tali Gidalevitz
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America
    PLoS Genet 5:e1000399. 2009
    ....
  3. pmc Proteostasis and the aging proteome in health and disease
    Richard I Morimoto
    Department of Molecular Biosciences, Northwestern University, Evanston, Illinois
    J Gerontol A Biol Sci Med Sci 69:S33-8. 2014
    ..Here, we discuss some of the unresolved questions on proteostasis that need to be addressed to enhance healthspan and to diminish the pathology associated with persistent protein damage. ..
  4. pmc Structural properties and neuronal toxicity of amyotrophic lateral sclerosis-associated Cu/Zn superoxide dismutase 1 aggregates
    Gen Matsumoto
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    J Cell Biol 171:75-85. 2005
    ..Our results demonstrate that SOD1 G85R and G93A mutants form a distinct class of aggregate structures in cells destined for neuronal cell death...
  5. pmc Small-molecule proteostasis regulators for protein conformational diseases
    Barbara Calamini
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, USA
    Nat Chem Biol 8:185-96. 2012
    ..We suggest that modulation of the proteostasis network by proteostasis regulators may be a promising therapeutic approach for the treatment of a variety of protein conformational diseases...
  6. pmc A genetic screening strategy identifies novel regulators of the proteostasis network
    M Catarina Silva
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America
    PLoS Genet 7:e1002438. 2011
    ....
  7. pmc Spreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegans
    Carmen I Nussbaum-Krammer
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America
    PLoS Genet 9:e1003351. 2013
    ..elegans and adapts to different requirements for propagation that involve the autophagy-lysosome pathway to transmit cytosolic aggregation-prone proteins between tissues...
  8. pmc Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response
    M Catarina Silva
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America
    PLoS Genet 9:e1003711. 2013
    ..This demonstrates that the heat shock response (HSR) can be activated in muscle cells by neuronal signaling across the NMJ to protect proteome health. ..
  9. pmc Identification of a tissue-selective heat shock response regulatory network
    Eric Guisbert
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America
    PLoS Genet 9:e1003466. 2013
    ..We propose that the HSN identifies a key subset of the proteostasis machinery that regulates the HSR according to the unique functional requirements of each tissue...
  10. pmc Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases
    Carmen I Nussbaum-Krammer
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Dis Model Mech 7:31-9. 2014
    ..These findings emphasize the potential of C. elegans to provide insights into non-cell-autonomous proteotoxic mechanisms underlying age-related protein-misfolding diseases. ..
  11. pmc Protein homeostasis as a therapeutic target for diseases of protein conformation
    Barbara Calamini
    Department of Neurobiology and Center for Drug Discovery, Duke University, Durham, NC, USA
    Curr Top Med Chem 12:2623-40. 2012
    ....
  12. ncbi request reprint The heat shock response: systems biology of proteotoxic stress in aging and disease
    Richard I Morimoto
    Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    Cold Spring Harb Symp Quant Biol 76:91-9. 2011
    ..This complex, systems-wide interdependence ensures cellular health span and organismal life span...
  13. ncbi request reprint Dynamic remodeling of transcription complexes by molecular chaperones
    Richard I Morimoto
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Cell 110:281-4. 2002
    ..Through their capacity to remodel the conformation of these activators, chaperones ensure tight control, dynamic range, and rapid reversible transcriptional response...
  14. ncbi request reprint Polyglutamine protein aggregates are dynamic
    Soojin Kim
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Nat Cell Biol 4:826-31. 2002
    ..These studies provide new insights into the composite organization and formation of protein aggregates and show that molecular chaperones are not sequestered into aggregates, but are instead transiently associated...
  15. ncbi request reprint Stress, aging, and neurodegenerative disease
    Richard I Morimoto
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, USA
    N Engl J Med 355:2254-5. 2006
  16. ncbi request reprint Heat shock response modulators as therapeutic tools for diseases of protein conformation
    Sandy D Westerheide
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 280:33097-100. 2005
    ....
  17. pmc Protein homeostasis in models of aging and age-related conformational disease
    Elise A Kikis
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, 2205 Tech Drive, Hogan 2 100, Northwestern University, Evanston, Illinois 60208, USA
    Adv Exp Med Biol 694:138-59. 2010
    ..Invertebrate models have been instrumental in studying the processes related to aggregation and toxicity of disease-associated proteins and how dysregulation ofproteostasis leads to neurodegenerative diseases of aging...
  18. pmc Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
    Anat Ben-Zvi
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 106:14914-9. 2009
    ..We propose that the collapse of proteostasis represents an early molecular event of aging that amplifies protein damage in age-associated diseases of protein conformation...
  19. pmc Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons
    Veena Prahlad
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Science 320:811-4. 2008
    ..We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change...
  20. pmc Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
    James F Morley
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    Mol Biol Cell 15:657-64. 2004
    ..The interaction of ILS with HSF-1 could represent an important molecular strategy to couple the regulation of longevity with an ancient genetic switch that governs the ability of cells to sense and respond to stress...
  21. ncbi request reprint The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging
    Heather R Brignull
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, 2153 North Campus Drive, Evanston, Illinois 60208, USA
    Adv Exp Med Biol 594:167-89. 2007
    ....
  22. ncbi request reprint Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins
    Ellen A A Nollen
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    J Cell Sci 115:2809-16. 2002
    ....
  23. ncbi request reprint Celastrols as inducers of the heat shock response and cytoprotection
    Sandy D Westerheide
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    J Biol Chem 279:56053-60. 2004
    ..These results suggest that celastrols exhibit promise as a new class of pharmacologically active regulators of the heat shock response...
  24. pmc Bistability explains threshold phenomena in protein aggregation both in vitro and in vivo
    Theodore R Rieger
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA
    Biophys J 90:886-95. 2006
    ..Therefore, our results offer a possible theoretical explanation for neuronal vulnerability observed in vivo and the onset of neurodegenerative phenotypes in neurons lacking an effective heat-shock response...
  25. ncbi request reprint Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death
    Sandy D Westerheide
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 281:9616-22. 2006
    ..The ability of triptolide to inhibit the heat shock response renders these cells sensitive to stress-induced cell death, which may be of great relevance to cancer treatments...
  26. pmc Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases
    Janine Kirstein-Miles
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    Dev Dyn 239:1529-38. 2010
    ..Studies using Caenorhabditis elegans as a model system have greatly contributed to our current knowledge of inter-compartmental proteostasis on the cellular and organismal levels...
  27. ncbi request reprint Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain
    Li Jung Tai
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 277:735-45. 2002
    ..Because the highly conserved hydrophobic heptad repeats extend over 60% of HSBP1, we propose that HSBP most likely regulates the function of other proteins through coiled-coil interactions...
  28. pmc Mathematical modeling of the eukaryotic heat-shock response: dynamics of the hsp70 promoter
    Theodore R Rieger
    Department of Chemical and Biological Engineering, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, USA
    Biophys J 88:1646-58. 2005
    ....
  29. pmc Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells
    Susana M Garcia
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    Genes Dev 21:3006-16. 2007
    ..These results demonstrate the importance of intercellular communication in intracellular homeostasis...
  30. pmc A cellular perspective on conformational disease: the role of genetic background and proteostasis networks
    Tali Gidalevitz
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    Curr Opin Struct Biol 20:23-32. 2010
    ....
  31. ncbi request reprint Progressive disruption of cellular protein folding in models of polyglutamine diseases
    Tali Gidalevitz
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Science 311:1471-4. 2006
    ..Thus, weak folding mutations throughout the genome can function as modifiers of polyglutamine phenotypes and toxicity...
  32. ncbi request reprint Modeling polyglutamine pathogenesis in C. elegans
    Heather R Brignull
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    Methods Enzymol 412:256-82. 2006
    ..Throughout these studies, we used fluorescence-based, live-cell biological and biophysical methods to study the behavior of these proteins in a complex multicellular environment...
  33. doi request reprint Integrating the stress response: lessons for neurodegenerative diseases from C. elegans
    Veena Prahlad
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Trends Cell Biol 19:52-61. 2009
    ....
  34. ncbi request reprint Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model
    Heather R Brignull
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University Institute for Neuroscience, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 26:7597-606. 2006
    ..These results provide direct experimental evidence that the expression of a single species of a toxic misfolded protein can exhibit a range of neuronal consequences...
  35. pmc Inefficient degradation of truncated polyglutamine proteins by the proteasome
    Carina I Holmberg
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL 60208, USA
    EMBO J 23:4307-18. 2004
    ..We propose that polyglutamine-containing proteins are kinetically trapped within proteasomes, which could explain their deleterious effects on cellular function over time...
  36. ncbi request reprint Huntingtin and mutant SOD1 form aggregate structures with distinct molecular properties in human cells
    Gen Matsumoto
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 281:4477-85. 2006
    ....
  37. pmc Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
    Sandy D Westerheide
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA
    Science 323:1063-6. 2009
    ..These results provide a mechanistic basis for the requirement of HSF1 in the regulation of life span and establish a role for SIRT1 in protein homeostasis and the HSR...
  38. pmc Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments
    Aharon Solomon
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    Genetics 167:161-70. 2004
    ..We suggest that OSR-1 plays a central role in integrating stress detection and adaptation responses by invoking multiple signaling pathways to promote survival under hyperosmotic environments...
  39. pmc The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
    James F Morley
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 99:10417-22. 2002
    ....
  40. ncbi request reprint Molecular chaperones and the stress of oncogenesis
    Dick D Mosser
    Department of Molecular Biology and Genetics, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Oncogene 23:2907-18. 2004
    ..The involvement of chaperones, therefore, in such diverse roles might suggest novel anticancer therapeutic approaches targeting heat-shock protein function for a broad spectrum of tumor types...
  41. pmc In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress
    Caroline Jolly
    DyOGen, INSERM U309, Institut A Bonniot, Domaine de la Merci, 38706 La Tronche Cedex, France
    J Cell Biol 156:775-81. 2002
    ..This is the first example of a transcriptional activator that accumulates transiently and reversibly on a chromosome-specific heterochromatic locus...
  42. doi request reprint Adapting proteostasis for disease intervention
    William E Balch
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 319:916-9. 2008
    ....
  43. pmc Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule
    Amy Trott
    Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, TX 77030, USA
    Mol Biol Cell 19:1104-12. 2008
    ....
  44. ncbi request reprint Disease-modifying pathways in neurodegeneration
    Steven Finkbeiner
    Gladstone Institute of Neurological Disease and Department of Physiology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 26:10349-57. 2006
  45. ncbi request reprint Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation
    Alexandra Zourlidou
    Department of Medical and Molecular Genetics, King s College London, School of Medicine, London SE1 9RT, UK
    Hum Mol Genet 16:1078-90. 2007
    ..Our study is the first to suggest a differential modulation of Hsp27 activation in vivo and, importantly, it illustrates the diverse effect of Hsp27 on acute versus chronic models of disease...

Research Grants12

  1. C. Elegans Model for Neurodegenerative Diseases of Aging
    RICHARD MORIMOTO; Fiscal Year: 2005
    ..elegans offers a unique opportunity to understand how these various processes are integrated, the basis for differences between neuronal and non-neuronal cells, and the role of damaged proteins on homeostasis and aging. ..
  2. A Systems Approach to Stress Biology and Proteostasis Networks
    Richard I Morimoto; Fiscal Year: 2010
    ....
  3. C. Elegans Model for Neurodegenerative Diseases of Aging
    RICHARD MORIMOTO; Fiscal Year: 2009
    ..elegans offers a unique opportunity to understand how these various processes are integrated, the basis for differences between neuronal and non-neuronal cells, and the role of damaged proteins on homeostasis and aging. ..
  4. REGULATION AND EXPRESSION OF THE HSP70 GENE FAMILY
    RICHARD MORIMOTO; Fiscal Year: 2007
    ..Check if Number of publications andmanuscripts accepted orsubmitted for publication (not toexceed 10) 10 *^ inSu^ed"'IS Other items (list): PHS 398 (Rev. 4/98) (Form Page 3) Page 3 CC ..
  5. C. Elegans Model for Neurodegenerative Diseases of Aging
    RICHARD MORIMOTO; Fiscal Year: 2007
    ..elegans offers a unique opportunity to understand how these various processes are integrated, the basis for differences between neuronal and non-neuronal cells, and the role of damaged proteins on homeostasis and aging. ..
  6. C. Elegans Model for Neurodegenerative Diseases of Aging
    RICHARD MORIMOTO; Fiscal Year: 2007
    ..elegans offers a unique opportunity to understand how these various processes are integrated, the basis for differences between neuronal and non-neuronal cells, and the role of damaged proteins on homeostasis and aging. ..
  7. Small Molecule Screen for Novel Regulators of Chaperone Expression
    RICHARD MORIMOTO; Fiscal Year: 2007
    ....
  8. Protein Folding in the Cell
    RICHARD MORIMOTO; Fiscal Year: 2006
    ..Poster sessions will allow all participants to interact scientifically with other investigators. Young investigators and women will be well-represented among speakers and encouraged to attend the conference. ..
  9. C. Elegans Model for Neurodegenerative Diseases of Aging
    RICHARD MORIMOTO; Fiscal Year: 2006
    ..elegans offers a unique opportunity to understand how these various processes are integrated, the basis for differences between neuronal and non-neuronal cells, and the role of damaged proteins on homeostasis and aging. ..
  10. C. Elegans Model for Neurodegenerative Diseases of Aging
    Richard I Morimoto; Fiscal Year: 2010
    ....