Research Topics

Genomes and Genes


Chad A Mirkin


Affiliation: Northwestern University
Country: USA


  1. McGuirk C, Mendez Arroyo J, d Aquino A, Stern C, Liu Y, Mirkin C. A concerted two-prong approach to the in situ allosteric regulation of bifunctional catalysis. Chem Sci. 2016;7:6674-6683 pubmed publisher
  2. Lin Q, Mason J, Li Z, Zhou W, O Brien M, Brown K, et al. Building superlattices from individual nanoparticles via template-confined DNA-mediated assembly. Science. 2018;359:669-672 pubmed publisher
    ..The generality and potential of this approach are explored by identifying a broadband absorber with a solvent polarity response that allows dynamic tuning of visible light absorption. ..
  3. Alhasan A, Scott A, Wu J, Feng G, Meeks J, Thaxton C, et al. Circulating microRNA signature for the diagnosis of very high-risk prostate cancer. Proc Natl Acad Sci U S A. 2016;113:10655-60 pubmed publisher
    ..Biological pathway analysis showed the predictive capability of these miRNA biomarkers for the diagnosis and prognosis of VHR aggressive PCa. ..
  4. Radovic Moreno A, Chernyak N, Mader C, Nallagatla S, Kang R, Hao L, et al. Immunomodulatory spherical nucleic acids. Proc Natl Acad Sci U S A. 2015;112:3892-7 pubmed publisher
    ..Given the clinical potential of SNAs due to their potency, defined chemical nature, and good tolerability, SNAs are attractive new modalities for developing immunotherapies. ..
  5. Jones M, Seeman N, Mirkin C. Nanomaterials. Programmable materials and the nature of the DNA bond. Science. 2015;347:1260901 pubmed publisher
  6. Ross M, Ku J, Blaber M, Mirkin C, Schatz G. Defect tolerance and the effect of structural inhomogeneity in plasmonic DNA-nanoparticle superlattices. Proc Natl Acad Sci U S A. 2015;112:10292-7 pubmed publisher
    ..These data have important implications for understanding the role of particle and lattice inhomogeneity in determining the properties of plasmonic nanoparticle lattices with deliberately designed optical properties. ..
  7. Randeria P, Seeger M, Wang X, Wilson H, Shipp D, Mirkin C, et al. siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown. Proc Natl Acad Sci U S A. 2015;112:5573-8 pubmed publisher
    ..Moreover, the data further validate GM3 as a mediator of the delayed wound healing in type 2 diabetes and support regional GM3 depletion as a promising therapeutic direction. ..
  8. SITA T, Kouri F, Hurley L, Merkel T, Chalastanis A, May J, et al. Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo. Proc Natl Acad Sci U S A. 2017;114:4129-4134 pubmed publisher
  9. Yamankurt G, Berns E, Xue A, Lee A, Bagheri N, Mrksich M, et al. Exploration of the nanomedicine-design space with high-throughput screening and machine learning. Nat Biomed Eng. 2019;3:318-327 pubmed publisher
    ..Our methodology is general, can reduce the number of nanoparticles that need to be tested by an order of magnitude, and could serve as a screening tool for the development of nanoparticle therapeutics. ..

More Information


  1. Yeo D, Wiraja C, Paller A, Mirkin C, Xu C. Abnormal scar identification with spherical-nucleic-acid technology. Nat Biomed Eng. 2018;2:227-238 pubmed publisher
    ..Our proof-of-concept studies of topically applied NanoFlare technology as a means of biopsy-free scar diagnosis may eventually inform therapeutic decisions on the basis of the mRNA-expression patterns of skin disorders. ..
  2. Chen P, Liu M, Du J, Meckes B, Wang S, Lin H, et al. Interface and heterostructure design in polyelemental nanoparticles. Science. 2019;363:959-964 pubmed publisher
    ..From these observations, design rules have been established for making polyelemental systems with specific heterostructures, including tetraphase nanoparticles with as many as six junctions. ..
  3. Kluender E, Hedrick J, Brown K, Rao R, Meckes B, Du J, et al. Catalyst discovery through megalibraries of nanomaterials. Proc Natl Acad Sci U S A. 2019;116:40-45 pubmed publisher
    ..Au3Cu, a composition not previously known to catalyze SWNT growth, has been identified as the most active composition. ..
  4. Seo S, Girard M, Olvera de la Cruz M, Mirkin C. Non-equilibrium anisotropic colloidal single crystal growth with DNA. Nat Commun. 2018;9:4558 pubmed publisher
  5. Liu Y, Zhou J, Wasielewski M, Xing H, Mirkin C. A four-state fluorescent molecular switch. Chem Commun (Camb). 2018;54:12041-12044 pubmed publisher
    ..The fluorescence of the compound in both the solution and solid phases can be manipulated through reversible coordination chemistry at the PtII center. ..
  6. Macfarlane R, Thaner R, Brown K, Zhang J, Lee B, Nguyen S, et al. Importance of the DNA "bond" in programmable nanoparticle crystallization. Proc Natl Acad Sci U S A. 2014;111:14995-5000 pubmed publisher
    ..The agreement between bulk crystallization and the behavior of free oligonucleotides may bear important consequences for constructing novel classes of crystals and incorporating new interparticle bonds in a rational manner. ..
  7. Xie Z, Zhou Y, Hedrick J, Chen P, He S, Shahjamali M, et al. On-Tip Photo-Modulated Molecular Printing. Angew Chem Int Ed Engl. 2015;54:12894-9 pubmed publisher
  8. Shade C, Kennedy R, Rouge J, Rosen M, Wang M, Seo S, et al. Duplex-selective ruthenium-based DNA intercalators. Chemistry. 2015;21:10983-7 pubmed publisher
    ..This complex shows promise as a new dye capable of selectively staining double- versus single-stranded DNA in gel electrophoresis, which cannot be done with conventional SYBR dyes. ..
  9. Clingerman D, Morris W, Mondloch J, Kennedy R, Sarjeant A, Stern C, et al. Stabilization of a highly porous metal-organic framework utilizing a carborane-based linker. Chem Commun (Camb). 2015;51:6521-3 pubmed publisher
    ..In contrast to the analogous MOF-143, NU-700 can be activated with retention of porosity, yielding a BET surface area of 1870 m(2) g(-1). ..
  10. Wang S, Morris W, Liu Y, McGuirk C, Zhou Y, Hupp J, et al. Surface-Specific Functionalization of Nanoscale Metal-Organic Frameworks. Angew Chem Int Ed Engl. 2015;54:14738-42 pubmed publisher
    ..Importantly, the surface modification strategy described will allow for the general and divergent synthesis and study of a wide variety of nanoscale MOFs as stable colloidal materials. ..
  11. Briley W, Bondy M, Randeria P, Dupper T, Mirkin C. Quantification and real-time tracking of RNA in live cells using Sticky-flares. Proc Natl Acad Sci U S A. 2015;112:9591-5 pubmed publisher
  12. Brodin J, Auyeung E, Mirkin C. DNA-mediated engineering of multicomponent enzyme crystals. Proc Natl Acad Sci U S A. 2015;112:4564-9 pubmed publisher
  13. O Brien M, Girard M, Lin H, Millan J, Olvera de la Cruz M, Lee B, et al. Exploring the zone of anisotropy and broken symmetries in DNA-mediated nanoparticle crystallization. Proc Natl Acad Sci U S A. 2016;113:10485-90 pubmed publisher
    ..Through comparison of the zone of anisotropy for each particle we develop a foundational roadmap to guide future investigations. ..
  14. O Brien M, Jones M, Mirkin C. The nature and implications of uniformity in the hierarchical organization of nanomaterials. Proc Natl Acad Sci U S A. 2016;113:11717-11725 pubmed
    ..Thus, we define the nature of nonuniformity at each length scale as a means to guide ongoing research efforts and highlight potential problems in the field. ..
  15. Chen P, Liu X, Hedrick J, Xie Z, Wang S, Lin Q, et al. Polyelemental nanoparticle libraries. Science. 2016;352:1565-9 pubmed publisher
    ..Important insight into the factors that lead to alloy formation and phase segregation at the nanoscale were obtained, and routes to libraries of nanostructures that cannot be made by conventional methods were developed. ..
  16. Kim Y, Macfarlane R, Jones M, Mirkin C. Transmutable nanoparticles with reconfigurable surface ligands. Science. 2016;351:579-82 pubmed publisher
    ..As a result, a nascent set of "transmutable nanoparticles" can be driven to crystallize along multiple thermodynamic trajectories, resulting in rational control over the phase and time evolution of nanoparticle-based matter. ..
  17. request reprint
    Vega R, Maspoch D, Salaita K, Mirkin C. Nanoarrays of single virus particles. Angew Chem Int Ed Engl. 2005;44:6013-5 pubmed