Affiliation: Northwestern University
Country: USA


  1. Mesulam M, Wieneke C, Thompson C, Rogalski E, Weintraub S. Quantitative classification of primary progressive aphasia at early and mild impairment stages. Brain. 2012;135:1537-53 pubmed publisher
    ..An emphasis on early diagnosis will promote a better characterization of the disease stages where therapeutic interventions are the most likely to succeed. ..
  2. Mesulam M, Rader B, Sridhar J, Nelson M, Hyun J, Rademaker A, et al. Word comprehension in temporal cortex and Wernicke area: A PPA perspective. Neurology. 2019;92:e224-e233 pubmed publisher
    ..Conceptualizations of the Wernicke area that appear to conflict, therefore, can be reconciled by considering the hodologic and physiologic differences of the underlying lesions. ..
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    Mesulam M, Johnson N, Krefft T, Gass J, Cannon A, Adamson J, et al. Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families. Arch Neurol. 2007;64:43-7 pubmed
    ..In both families, the disease segregated with progranulin gene mutations. Whether progranulin dysfunction also extends to sporadic PPA and how it affects the initial anatomical specificity of neurodegeneration remain to be determined. ..
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    Mesulam M. Primary progressive aphasia: a 25-year retrospective. Alzheimer Dis Assoc Disord. 2007;21:S8-S11 pubmed
    ..Initially brought to the attention of contemporary literature 25 years ago, PPA has recently witnessed substantial progress related to its neurolinguistic features, neuroanatomy, imaging, neuropathology, genetics, and risk factors. ..
  5. Mesulam M, Wicklund A, Johnson N, Rogalski E, L├ęger G, Rademaker A, et al. Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Ann Neurol. 2008;63:709-19 pubmed publisher
  6. Mesulam M, Wieneke C, Rogalski E, Cobia D, Thompson C, Weintraub S. Quantitative template for subtyping primary progressive aphasia. Arch Neurol. 2009;66:1545-51 pubmed publisher
    ..Prospective studies will show whether this subtyping can improve clinical prediction of the underlying neuropathologic condition. ..
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    Mesulam M, Siddique T, Cohen B. Cholinergic denervation in a pure multi-infarct state: observations on CADASIL. Neurology. 2003;60:1183-5 pubmed
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    Mesulam M. The cholinergic innervation of the human cerebral cortex. Prog Brain Res. 2004;145:67-78 pubmed
  9. Mesulam M, Thompson C, Weintraub S, ROGALSKI E. The Wernicke conundrum and the anatomy of language comprehension in primary progressive aphasia. Brain. 2015;138:2423-37 pubmed publisher

More Information


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    Mesulam M, Guillozet A, Shaw P, Levey A, Duysen E, Lockridge O. Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine. Neuroscience. 2002;110:627-39 pubmed
    ..The inhibition of butyrylcholinesterase may therefore provide a desirable feature of cholinergic therapies, including those aimed at treating Alzheimer's disease. ..
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    Mesulam M, Shaw P, Mash D, Weintraub S. Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum. Ann Neurol. 2004;55:815-28 pubmed
    ..These results show that cytopathology in cortical cholinergic pathways is a very early event in the course of the continuum that leads from advanced age to MCI and AD. ..
  3. Mesulam M, Wieneke C, Hurley R, Rademaker A, Thompson C, Weintraub S, et al. Words and objects at the tip of the left temporal lobe in primary progressive aphasia. Brain. 2013;136:601-18 pubmed publisher
  4. Gefen T, Papastefan S, Rezvanian A, Bigio E, Weintraub S, Rogalski E, et al. Von Economo neurons of the anterior cingulate across the lifespan and in Alzheimer's disease. Cortex. 2018;99:69-77 pubmed publisher
    ..Their densities do not change throughout aging in individuals with average cognition, and they are more numerous in SuperAgers. ..