MAREK MARSEL M MESULAM

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Words and objects at the tip of the left temporal lobe in primary progressive aphasia
    M Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Centre, Northwestern University, 320 East Superior Street Feinberg School of Medicine, Chicago, IL 60611, USA
    Brain 136:601-18. 2013
  2. pmc Quantitative classification of primary progressive aphasia at early and mild impairment stages
    M Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Centre, Northwestern University, Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA
    Brain 135:1537-53. 2012
  3. ncbi request reprint Primary progressive aphasia: reversed asymmetry of atrophy and right hemisphere language dominance
    M Mesulam
    Cognitive Neurology and Alzheimer s Disease Center and the Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Neurology 64:556-7. 2005
  4. ncbi request reprint A plasticity-based theory of the pathogenesis of Alzheimer's disease
    M M Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Medical School, 520 East Superior Street, 11 450, Chicago, Illinois 60611, USA
    Ann N Y Acad Sci 924:42-52. 2000
  5. ncbi request reprint Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center and Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Arch Neurol 64:43-7. 2007
  6. ncbi request reprint Primary progressive aphasia: a 25-year retrospective
    M Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Alzheimer Dis Assoc Disord 21:S8-S11. 2007
  7. pmc Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Ann Neurol 63:709-19. 2008
  8. doi request reprint Representation, inference, and transcendent encoding in neurocognitive networks of the human brain
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Ann Neurol 64:367-78. 2008
  9. doi request reprint Defining neurocognitive networks in the BOLD new world of computed connectivity
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University, Chicago, IL 60611, USA
    Neuron 62:1-3. 2009
  10. pmc Neurology of anomia in the semantic variant of primary progressive aphasia
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Brain 132:2553-65. 2009

Research Grants

  1. Neurology of Attention and Neglect-A Network Approach
    Marek Marsel Mesulam; Fiscal Year: 2007
  2. Language in Primary Progressive Aphasia
    Marek Marsel Mesulam; Fiscal Year: 2007
  3. Language in Primary Progressive Aphasia
    MAREK MARSEL M MESULAM; Fiscal Year: 2010
  4. NEUROLOGY OF ATTENTION AND NEGLECT --A NETWORK APPROACH
    Marek Marsel Mesulam; Fiscal Year: 2001
  5. Language in Primary Progressive Aphasia
    Marek Marsel Mesulam; Fiscal Year: 2009

Detail Information

Publications38

  1. pmc Words and objects at the tip of the left temporal lobe in primary progressive aphasia
    M Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Centre, Northwestern University, 320 East Superior Street Feinberg School of Medicine, Chicago, IL 60611, USA
    Brain 136:601-18. 2013
    ....
  2. pmc Quantitative classification of primary progressive aphasia at early and mild impairment stages
    M Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Centre, Northwestern University, Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA
    Brain 135:1537-53. 2012
    ..An emphasis on early diagnosis will promote a better characterization of the disease stages where therapeutic interventions are the most likely to succeed...
  3. ncbi request reprint Primary progressive aphasia: reversed asymmetry of atrophy and right hemisphere language dominance
    M Mesulam
    Cognitive Neurology and Alzheimer s Disease Center and the Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Neurology 64:556-7. 2005
    ..This suggests that neuronal damage in PPA is therefore tightly linked to the underlying anatomy of the language network...
  4. ncbi request reprint A plasticity-based theory of the pathogenesis of Alzheimer's disease
    M M Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Medical School, 520 East Superior Street, 11 450, Chicago, Illinois 60611, USA
    Ann N Y Acad Sci 924:42-52. 2000
    ..The two pathological markers of AD are therefore independent manifestations of a more fundamental process through which the many different genotypes of AD trigger an identical clinical and neuropathological phenotype...
  5. ncbi request reprint Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center and Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Arch Neurol 64:43-7. 2007
    ..Primary progressive aphasia (PPA) is a language-based dementia characterized by fluent or nonfluent language disorder as its principal feature...
  6. ncbi request reprint Primary progressive aphasia: a 25-year retrospective
    M Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Alzheimer Dis Assoc Disord 21:S8-S11. 2007
    ..Initially brought to the attention of contemporary literature 25 years ago, PPA has recently witnessed substantial progress related to its neurolinguistic features, neuroanatomy, imaging, neuropathology, genetics, and risk factors...
  7. pmc Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Ann Neurol 63:709-19. 2008
    ..To identify predictors of Alzheimer's disease (AD) versus frontotemporal lobar degeneration pathology in primary progressive aphasia (PPA), and determine whether the AD pathology is atypically distributed to fit the aphasic phenotype...
  8. doi request reprint Representation, inference, and transcendent encoding in neurocognitive networks of the human brain
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Ann Neurol 64:367-78. 2008
    ..The reciprocal sensory-processing pathways and their top-down modulations collectively define the conscious interpretation of experience...
  9. doi request reprint Defining neurocognitive networks in the BOLD new world of computed connectivity
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University, Chicago, IL 60611, USA
    Neuron 62:1-3. 2009
    ..In this issue, Seeley and colleagues use resting-state fluctuations of the BOLD signal to highlight the relevance of networks to human brain function and dysfunction...
  10. pmc Neurology of anomia in the semantic variant of primary progressive aphasia
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Brain 132:2553-65. 2009
    ....
  11. pmc Quantitative template for subtyping primary progressive aphasia
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University, Chicago, Illinois 60611, USA
    Arch Neurol 66:1545-51. 2009
    ..The syndrome of primary progressive aphasia (PPA) is diagnosed when a gradual failure of word usage or comprehension emerges as the principal feature of a neurodegenerative disease...
  12. ncbi request reprint Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Ann Neurol 55:815-28. 2004
    ..These results show that cytopathology in cortical cholinergic pathways is a very early event in the course of the continuum that leads from advanced age to MCI and AD...
  13. ncbi request reprint The cholinergic innervation of the human cerebral cortex
    M Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Departments of Neurology and Psychiatry, Feinberg Medical School, Northwestern University, 320 East Superior Street, Chicago, IL 60611, USA
    Prog Brain Res 145:67-78. 2004
  14. ncbi request reprint Primary progressive aphasia--a language-based dementia
    M Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern Cognitive Brain Mapping Group, Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    N Engl J Med 349:1535-42. 2003
  15. ncbi request reprint Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine
    M M Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Department of Neurology, Northwestern University, Chicago, IL 60611, USA
    Neuroscience 110:627-39. 2002
    ..The inhibition of butyrylcholinesterase may therefore provide a desirable feature of cholinergic therapies, including those aimed at treating Alzheimer's disease...
  16. ncbi request reprint Cholinergic denervation in a pure multi-infarct state: observations on CADASIL
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center and the Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Neurology 60:1183-5. 2003
    ....
  17. ncbi request reprint Altered effective connectivity within the language network in primary progressive aphasia
    Sreepadma P Sonty
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 27:1334-45. 2007
    ..These results demonstrate for the first time that dysfunctional network interactions (effective connectivity), rather than hypoactivity within individual brain regions, may contribute to the emergence of language deficits seen in PPA...
  18. pmc Shifts of effective connectivity within a language network during rhyming and spelling
    Tali Bitan
    Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 25:5397-403. 2005
    ....
  19. ncbi request reprint Monetary incentives enhance processing in brain regions mediating top-down control of attention
    Dana M Small
    Northwestern University Brain Mapping Group and Cognitive Neurology and Alzheimer s Disease Center, Chicago, IL 60611, USA
    Cereb Cortex 15:1855-65. 2005
    ..They also show that different cognitive and motivational mechanisms may produce a common effect upon unimodal cortices in order to enhance processing to serve the current behavioral goal...
  20. ncbi request reprint Functional anatomy of visual search: regional segregations within the frontal eye fields and effective connectivity of the superior colliculus
    Darren R Gitelman
    The Northwestern Cognitive Brain Mapping Group, Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Neuroimage 15:970-82. 2002
    ..In contrast to the existing literature on functional imaging, which has focused on covert shifts of spatial attention, this study helps to characterize the functional anatomy of overt spatial exploration...
  21. ncbi request reprint Brain networks for analyzing eye gaze
    Christine I Hooker
    Department of Psychology, Northwestern University, 2029 Sheridan Road, Evanston, IL 60208 2710, USA
    Brain Res Cogn Brain Res 17:406-18. 2003
    ....
  22. ncbi request reprint Neuronal ubiquitinated intranuclear inclusions in familial and non-familial frontotemporal dementia of the motor neuron disease type associated with amyotrophic lateral sclerosis
    Eileen H Bigio
    Northwestern Cognitive Neurology and Alzheimer Disease Center, and Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neuropathol Exp Neurol 63:801-11. 2004
    ..In addition, the current study confirms that Ub-INIs are found in familial FTD-MND-type, but also extends the presence of Ub-INIs to familial FTD-MND (with concomitant ALS), and probably also to non-familial FTD-MND-type...
  23. ncbi request reprint Neural correlates of successful encoding identified using functional magnetic resonance imaging
    Paul J Reber
    Department of Psychology, Northwestern University, Evanston, Illinois 60201, USA
    J Neurosci 22:9541-8. 2002
    ..Prefrontal activation was strongly associated with intentional verbal encoding, whereas left medial temporal activation was crucial for the encoding that actually led to successful memory on the subsequent test...
  24. doi request reprint Neural integration of top-down spatial and feature-based information in visual search
    Tobias Egner
    Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 28:6141-51. 2008
    ....
  25. ncbi request reprint Priming effects in the fusiform gyrus: changes in neural activity beyond the second presentation
    Paul J Reber
    Department of Psychology, Northwestern University, 2029 Sheridan Road, Evanston, IL 60208, USA
    Cereb Cortex 15:787-95. 2005
    ..This region exhibits a pattern of activity consistent with a gradual and cumulative enhancement of the fluency effect across trials, suggesting that it may mediate the link between priming and the development of visual expertise...
  26. ncbi request reprint Language network specializations: an analysis with parallel task designs and functional magnetic resonance imaging
    Darren R Gitelman
    Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, 3230 E Superior Street, Chicago, IL 60611, USA
    Neuroimage 26:975-85. 2005
    ..Within the inferior frontal cortex (Broca's regional complex), segregated activations were seen for the semantic and phonological tasks. These findings demonstrate both common and task specific activations within the language system...
  27. pmc Familiarity and conceptual priming engage distinct cortical networks
    Joel L Voss
    Interdepartmental Neuroscience Program, Department of Psychology, 2029 Sheridan Road, Northwestern University, Evanston, IL 60208 2710, USA
    Cereb Cortex 18:1712-9. 2008
    ..This neuroimaging evidence implicates separate neurocognitive processes operative in explicit stimulus recognition versus implicit conceptual priming...
  28. pmc Neural correlates of verb argument structure processing
    Cynthia K Thompson
    Department of Communication Disorders, Northwestern University, IL 60208, USA
    J Cogn Neurosci 19:1753-67. 2007
    ..These findings are consistent with processing accounts, which suggest that these regions are crucial for semantic integration...
  29. pmc Neural correlates of person recognition
    Ken A Paller
    Department of Psychology, Northwestern University, Evanston, Illinois 60208, USA
    Learn Mem 10:253-60. 2003
    ....
  30. pmc Weaker top-down modulation from the left inferior frontal gyrus in children
    Tali Bitan
    Northwestern University, Evanston, Illinois 60208 3500, USA
    Neuroimage 33:991-8. 2006
    ..Adult language processing may thus involve greater top-down cognitive control compared to children, resulting in less interference from task-irrelevant information...
  31. ncbi request reprint When memory does not fail: familiarity-based recognition in mild cognitive impairment and Alzheimer's disease
    Carmen E Westerberg
    Northwestern University, Evanston, IL 60208, USA
    Neuropsychology 20:193-205. 2006
    ..Neuropathology in hippocampus and entorhinal cortex, known to be present in MCI, presumably disrupted recollection while leaving familiarity-based recognition intact...
  32. ncbi request reprint On the use of caffeine as a contrast booster for BOLD fMRI studies
    Todd A Mulderink
    Feinberg Neuroscience Institute, Northwestern Cognitive Brain Mapping Group, Department of Radiology, Northwestern University and Medical School, Chicago, Illinois 60611, USA
    Neuroimage 15:37-44. 2002
    ..Caffeine has the potential to be used as a contrast booster for fMRI experiments...
  33. ncbi request reprint Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia
    Xiaohong Li
    Department of Neurology, Pritzker School of Medicine and Center for Comprehensive Care and Research on Memory Disorders, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Ann Neurol 58:858-64. 2005
    ..However, the strong association between heterozygosity and PPA raises new questions about its cause and the role of PrP in other neurodegenerative diseases...
  34. ncbi request reprint Primary progressive aphasia: PPA and the language network
    Sreepadma P Sonty
    Cognitive Neurology and Alzheimer s Disease Center, Chicago, IL, USA
    Ann Neurol 53:35-49. 2003
    ..The additional activations in PPA may therefore represent a compensatory spread of language-related neural activity or a failure to suppress activity in areas normally inhibited during language tasks...
  35. ncbi request reprint The core and halo of primary progressive aphasia and semantic dementia
    M Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center and Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Ann Neurol 54:S11-4. 2003
  36. ncbi request reprint Cerebral hemispheric specialization for spatial attention: spatial distribution of search-related eye fixations in the absence of neglect
    Mark Mapstone
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Neuropsychologia 41:1396-409. 2003
    ..A theoretical model based on the salience of extrapersonal space appears useful for understanding alterations of attentional allocation, particularly after recovery from stroke...
  37. pmc Sleep deprivation alters functioning within the neural network underlying the covert orienting of attention
    Bryce A Mander
    Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Brain Res 1217:148-56. 2008
    ..These changes may render sleep-deprived individuals less able to anticipate the locations of upcoming events, and more susceptible to distraction by stimuli at irrelevant locations...
  38. ncbi request reprint Neural evidence that vivid imagining can lead to false remembering
    Brian Gonsalves
    Department of Psychology, Northwestern University, Stanford, CA 94305, USA
    Psychol Sci 15:655-60. 2004
    ..These findings indicate that brain activity reflecting the engagement of visual imagery can lead to falsely remembering something that was only imagined...

Research Grants21

  1. Neurology of Attention and Neglect-A Network Approach
    Marek Marsel Mesulam; Fiscal Year: 2007
    ..The results of these experiments will help to understand the neurological bases of spatial attention and may lead to more rational treatments of hemispatial neglect. ..
  2. Language in Primary Progressive Aphasia
    Marek Marsel Mesulam; Fiscal Year: 2007
    ..The work will use the resources of the Northwestern Alzheimer's Disease Center in a way that will enhance economy of effort. ..
  3. Language in Primary Progressive Aphasia
    MAREK MARSEL M MESULAM; Fiscal Year: 2010
    ..The work will use the resources of the Northwestern Alzheimer's Disease Center in a way that will enhance economy of effort. ..
  4. NEUROLOGY OF ATTENTION AND NEGLECT --A NETWORK APPROACH
    Marek Marsel Mesulam; Fiscal Year: 2001
    ....
  5. Language in Primary Progressive Aphasia
    Marek Marsel Mesulam; Fiscal Year: 2009
    ..The work will use the resources of the Northwestern Alzheimer's Disease Center in a way that will enhance economy of effort. ..