MAREK MARSEL M MESULAM
Affiliation: Northwestern University
Mesulam M, Wieneke C, Thompson C, Rogalski E, Weintraub S. Quantitative classification of primary progressive aphasia at early and mild impairment stages. Brain. 2012;135:1537-53 pubmed publisher
..An emphasis on early diagnosis will promote a better characterization of the disease stages where therapeutic interventions are the most likely to succeed. ..
Mesulam M, Rader B, Sridhar J, Nelson M, Hyun J, Rademaker A, et al
. Word comprehension in temporal cortex and Wernicke area: A PPA perspective. Neurology. 2019;92:e224-e233 pubmed publisher
..Conceptualizations of the Wernicke area that appear to conflict, therefore, can be reconciled by considering the hodologic and physiologic differences of the underlying lesions. ..
Mesulam M, Johnson N, Krefft T, Gass J, Cannon A, Adamson J, et al
. Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families. Arch Neurol. 2007;64:43-7 pubmed
..In both families, the disease segregated with progranulin gene mutations. Whether progranulin dysfunction also extends to sporadic PPA and how it affects the initial anatomical specificity of neurodegeneration remain to be determined. ..
Mesulam M. Primary progressive aphasia: a 25-year retrospective. Alzheimer Dis Assoc Disord. 2007;21:S8-S11 pubmed
..Initially brought to the attention of contemporary literature 25 years ago, PPA has recently witnessed substantial progress related to its neurolinguistic features, neuroanatomy, imaging, neuropathology, genetics, and risk factors. ..
Mesulam M, Wicklund A, Johnson N, Rogalski E, Léger G, Rademaker A, et al
. Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Ann Neurol. 2008;63:709-19 pubmed publisher
Mesulam M, Wieneke C, Rogalski E, Cobia D, Thompson C, Weintraub S. Quantitative template for subtyping primary progressive aphasia. Arch Neurol. 2009;66:1545-51 pubmed publisher
..Prospective studies will show whether this subtyping can improve clinical prediction of the underlying neuropathologic condition. ..
Mesulam M, Siddique T, Cohen B. Cholinergic denervation in a pure multi-infarct state: observations on CADASIL. Neurology. 2003;60:1183-5 pubmed
Mesulam M. The cholinergic innervation of the human cerebral cortex. Prog Brain Res. 2004;145:67-78 pubmed
Mesulam M, Thompson C, Weintraub S, ROGALSKI E. The Wernicke conundrum and the anatomy of language comprehension in primary progressive aphasia. Brain. 2015;138:2423-37 pubmed publisher