H Y Meltzer

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi A six month randomized controlled trial of long acting injectable risperidone 50 and 100mg in treatment resistant schizophrenia
    H Y Meltzer
    Northwestern Feinberg School of Medicine, Chicago, IL, United States Electronic address
    Schizophr Res 154:14-22. 2014
  2. doi Update on typical and atypical antipsychotic drugs
    Herbert Y Meltzer
    Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Annu Rev Med 64:393-406. 2013
  3. ncbi Clozapine: balancing safety with superior antipsychotic efficacy
    Herbert Y Meltzer
    Northwestern Feinberg School of Medicine, Ward Building 12 104, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Clin Schizophr Relat Psychoses 6:134-44. 2012
  4. doi Pimavanserin, a selective serotonin (5-HT)2A-inverse agonist, enhances the efficacy and safety of risperidone, 2mg/day, but does not enhance efficacy of haloperidol, 2mg/day: comparison with reference dose risperidone, 6mg/day
    Herbert Y Meltzer
    Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Ward Bldg 12 104, 303 East Chicago Ave Chicago, IL 60611, USA
    Schizophr Res 141:144-52. 2012
  5. ncbi Serotonin receptors as targets for drugs useful to treat psychosis and cognitive impairment in schizophrenia
    H Y Meltzer
    Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Pharm Biotechnol 13:1572-86. 2012
  6. ncbi The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens
    J Ichikawa
    The First Floor Laboratory, Psychopharmacology Division, Department of Psychiatry, Vanderbilt University School of Medicine, 1601 23rd Avenue South, Suite 306, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 858:252-63. 2000
  7. ncbi Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens
    J Ichikawa
    Department of Psychiatry, Vanderbilt University School of Medicine, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Eur J Pharmacol 351:163-71. 1998
  8. ncbi The blunted plasma cortisol response to apomorphine and its relationship to treatment response in patients with schizophrenia
    H Y Meltzer
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Neuropsychopharmacology 24:278-90. 2001
  9. ncbi Lower plasma CC16, a natural anti-inflammatory protein, and increased plasma interleukin-1 receptor antagonist in schizophrenia: effects of antipsychotic drugs
    M Maes
    Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
    Schizophr Res 21:39-50. 1996
  10. ncbi R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum
    J Ichikawa
    Department of Psychiatry, Psychopharmacology Division, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Pharmacol Exp Ther 291:1227-32. 1999

Detail Information

Publications25

  1. ncbi A six month randomized controlled trial of long acting injectable risperidone 50 and 100mg in treatment resistant schizophrenia
    H Y Meltzer
    Northwestern Feinberg School of Medicine, Chicago, IL, United States Electronic address
    Schizophr Res 154:14-22. 2014
    ..Further study of RLAI, ≥ 50-100mg biweekly, should compare it with clozapine and oral risperidone in TRS, with duration of treatment ≥ six months...
  2. doi Update on typical and atypical antipsychotic drugs
    Herbert Y Meltzer
    Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Annu Rev Med 64:393-406. 2013
    ..Overall, choosing among the atypical APDs as first-line treatment represents the best course for schizophrenia and most likely other disorders for which APDs are used...
  3. ncbi Clozapine: balancing safety with superior antipsychotic efficacy
    Herbert Y Meltzer
    Northwestern Feinberg School of Medicine, Ward Building 12 104, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Clin Schizophr Relat Psychoses 6:134-44. 2012
    ..Awareness of the benefits and risks of clozapine is essential for increasing the use of this lifesaving agent...
  4. doi Pimavanserin, a selective serotonin (5-HT)2A-inverse agonist, enhances the efficacy and safety of risperidone, 2mg/day, but does not enhance efficacy of haloperidol, 2mg/day: comparison with reference dose risperidone, 6mg/day
    Herbert Y Meltzer
    Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Ward Bldg 12 104, 303 East Chicago Ave Chicago, IL 60611, USA
    Schizophr Res 141:144-52. 2012
    ..These results support the conclusion that 5-HT(2A) receptor blockade is a key component of the action of some atypical APDs and can reduce EPS due to a typical APD...
  5. ncbi Serotonin receptors as targets for drugs useful to treat psychosis and cognitive impairment in schizophrenia
    H Y Meltzer
    Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Pharm Biotechnol 13:1572-86. 2012
    ....
  6. ncbi The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens
    J Ichikawa
    The First Floor Laboratory, Psychopharmacology Division, Department of Psychiatry, Vanderbilt University School of Medicine, 1601 23rd Avenue South, Suite 306, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 858:252-63. 2000
    ..The significance of these results for EPS and antipsychotic action is discussed...
  7. ncbi Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens
    J Ichikawa
    Department of Psychiatry, Vanderbilt University School of Medicine, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Eur J Pharmacol 351:163-71. 1998
    ....
  8. ncbi The blunted plasma cortisol response to apomorphine and its relationship to treatment response in patients with schizophrenia
    H Y Meltzer
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Neuropsychopharmacology 24:278-90. 2001
    ..These results provide further evidence of dopaminergic dysfunction in SCH. Furthermore, the APO-stimulated cortisol response may be predictive of subsequent clinical response to antipsychotic drug treatment...
  9. ncbi Lower plasma CC16, a natural anti-inflammatory protein, and increased plasma interleukin-1 receptor antagonist in schizophrenia: effects of antipsychotic drugs
    M Maes
    Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
    Schizophr Res 21:39-50. 1996
    ..e. CC16, and that the latter may constitute a trait market of schizophrenia; and that (ii) chronic treatment with atypical antipsychotic agents, i.e., risperidone, may normalize lower plasma CC16 and increase plasma sIL-2R...
  10. ncbi R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum
    J Ichikawa
    Department of Psychiatry, Psychopharmacology Division, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Pharmacol Exp Ther 291:1227-32. 1999
    ..05 mg/kg s.c.), which alone had no effect on DA release. These results suggest that 5-HT(1A) receptor agonism facilitates DA release in mPFC and NAC but not STR in combination with D(2) receptor antagonism...
  11. ncbi Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens
    D L Willins
    Department of Psychiatry, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    Brain Res 781:291-9. 1998
    ..These results suggest that the activation of 5-HT2C receptors selectively inhibits morphine-induced DA release in the NAc in a manner which is independent of the inhibition of 5-HT neurons...
  12. ncbi The effect of ipsapirone and S(-)-pindolol on dopamine release in rat striatum and nucleus accumbens
    J Ichikawa
    Department of Psychiatry, Psychopharmacology Division, Vanderbilt University School of Medicine, Nashville, USA
    Brain Res 842:445-51. 1999
    ..The mechanism and clinical significance of these results for developing antipsychotic drugs is discussed...
  13. ncbi Age at onset and gender of schizophrenic patients in relation to neuroleptic resistance
    H Y Meltzer
    Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, USA
    Am J Psychiatry 154:475-82. 1997
    ..The authors compared age at onset in neuroleptic-resistant and -responsive schizophrenic patients to determine whether the gender difference in age at onset is related to response to neuroleptic treatment...
  14. doi Blonanserin reverses the phencyclidine (PCP)-induced impairment in novel object recognition (NOR) in rats: role of indirect 5-HT(1A) partial agonism
    M Horiguchi
    Division of Psychiatry and Behavioural Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Behav Brain Res 247:158-64. 2013
    ....
  15. ncbi 5-HT(1A) receptor dysfunction in female patients with schizophrenia
    M A Lee
    Department of Psychiatry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37212, USA
    Biol Psychiatry 50:758-66. 2001
    ....
  16. ncbi Relationship between dopaminergic and serotonergic neuronal activity in the frontal cortex and the action of typical and atypical antipsychotic drugs
    J Ichikawa
    Department of Psychiatry, Vanderbilt University School of Medicine, Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Eur Arch Psychiatry Clin Neurosci 249:90-8. 1999
    ..The mechanism of action of these drugs is a matter of keen interest. We review here the evidence that some, or all, of these advantages are related to their actions at serotonin and dopamine receptors...
  17. ncbi Reduced levels of norepinephrine transporters in the locus coeruleus in major depression
    V Klimek
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    J Neurosci 17:8451-8. 1997
    ....
  18. doi The role of serotonin receptors in the action of atypical antipsychotic drugs
    H Y Meltzer
    Vanderbilt University School of Medicine, Department of Psychiatry, 1601 23rd Avenue South, Suite 306, Nashville, TN 37212, USA
    Curr Opin Pharmacol 11:59-67. 2011
    ..5-HT(2C) receptor antagonism appears to contribute to the weight gain produced by some atypical APDs and may also affect cognition and psychosis via its influence on cortical and limbic dopaminergic activity...
  19. ncbi Low-dose loxapine in the treatment of schizophrenia: is it more effective and more "atypical" than standard-dose loxapine?
    H Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tenn 37212, USA
    J Clin Psychiatry 60:47-51. 1999
    ..Further study of the dose-response curve for loxapine and its usefulness in treating neuroleptic-resistant schizophrenia is indicated...
  20. ncbi Prediction of changes in memory performance by plasma homovanillic acid levels in clozapine-treated patients with schizophrenia
    Tomiki Sumiyoshi
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    Psychopharmacology (Berl) 177:79-83. 2004
    ..Cognitive dysfunction in schizophrenia has been demonstrated to be dependent, in part, on dopaminergic activity. Clozapine has been found to improve some domains of cognition, including verbal memory, in patients with schizophrenia...
  21. ncbi 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release
    J Ichikawa
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Neurochem 76:1521-31. 2001
    ....
  22. ncbi Melperone in the treatment of neuroleptic-resistant schizophrenia
    H Y Meltzer
    Department of Psychiatry, Psychopharmacology Division, Vanderbilt University School of Medicine, Psychiatric Hospital at Vanderbilt, 1601 23rd Avenue South, Suite 306, Nashville, TN 37212, USA
    Psychiatry Res 105:201-9. 2001
    ..The results suggest that a proportion of neuroleptic-resistant patients with schizophrenia respond to melperone, which requires further controlled study...
  23. ncbi A novel augmentation strategy for treating resistant major depression
    R C Shelton
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Am J Psychiatry 158:131-4. 2001
    ..The authors hypothesized that fluoxetine could be augmented with olanzapine to successfully treat resistant depression...
  24. ncbi Quantitative distribution of monoamine oxidase A in brainstem monoamine nuclei is normal in major depression
    G A Ordway
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, MS, USA
    Brain Res 847:71-9. 1999
    ..These findings demonstrate that the pathophysiology of major depression is not likely to involve abnormalities in MAO-A...
  25. ncbi Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor
    R Kohen
    Department of Psychiatry and Behavioral Sciences, University of Washington, USA
    J Neurochem 66:47-56. 1996
    ..Comparison of genomic and cDNA clones for the human 5-HT6 receptor also reveals an Rsal restriction fragment length polymorphism within the coding region...