- A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression dataReuben Thomas
Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
BMC Bioinformatics 8:228. 2007..These considerations should be taken into account in the development of methods for the inference of regulatory interactions in genetic networks...
- Validation and characterization of DNA microarray gene expression data distribution and associated momentsReuben Thomas
Department of Industrial Engineering and Management Sciences, Northwestern University, Evanston, IL, USA
BMC Bioinformatics 11:576. 2010..Several different methods have been proposed to analyze these data under different distributional assumptions on gene expression. However, the empirical validation of these assumptions is lacking...
- Outcome based state budget allocation for diabetes prevention programs using multi-criteria optimization with robust weightsSanjay Mehrotra
Industrial Engineering and Management Science, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Health Care Manag Sci 14:324-37. 2011..Parametric analysis suggests that money should be allocated to states to promote diabetes education and to increase patient-healthcare provider interactions to reduce disparity across the US...
- A model-based optimization framework for the inference on gene regulatory networks from DNA array dataReuben Thomas
Department of Industrial Engineering and Management Science, Northwestern University, Evanston, IL 60208-3120, USA
Bioinformatics 20:3221-35. 2004..This is the first method that also allows the identification of every possible regulatory network that could explain the data, when the number of experiments does not allow identification of unique regulatory structure...