Thomas MeadeSummaryAffiliation: Northwestern University Country: USA Publications
Research Grants
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Publications
Quantitative imaging of cell-permeable magnetic resonance contrast agents using x-ray fluorescencePaul J Endres
Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
Mol Imaging 5:485-97. 2006..The transduction efficiency of the intracellular agents was evaluated by T(1) analysis and inductively coupled plasma mass spectrometry to determine the efficacy of each chelate-transporter combination...
Rational design of [Co(acacen)L2]+ inhibitors of protein functionLauren M Matosziuk
Department of Chemistry, Northwestern University, Evanston, Illinois 60208 3113, USA
Dalton Trans 42:4002-12. 2013..These investigations will aid in the design of the next generation of [Co(acacen)L(2)](2+), allowing researchers to develop new, more effective inhibitors...- New magnetic resonance contrast agents as biochemical reportersThomas J Meade
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60201 3113, USA
Curr Opin Neurobiol 13:597-602. 2003..These new classes of magnetic resonance contrast agents represent a substantial leap in the type of information that can be derived from imaging experiments, and are the focus of this review... 
Molecular imaging of in vivo gene expressionAllison S Harney
Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
Future Med Chem 2:503-19. 2010..The ability to use contrast agents coupled with functional information on cellular events will allow for sensitive assessment of individual patient therapies, leading to an accurately tailored treatment regimen...- DNA-TiO2 nanoconjugates labeled with magnetic resonance contrast agentsPaul J Endres
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
J Am Chem Soc 129:15760-1. 2007.... - Mechanistic investigation of beta-galactosidase-activated MR contrast agentsLauren M Urbanczyk-Pearson
Department of Chemistry, Northwestern University, Evanston, IL 60201, USA
Inorg Chem 47:56-68. 2008.... - Modification of embolic-PVA particles with MR contrast agentsRenee Cilliers
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois, USA
Magn Reson Med 59:898-902. 2008..Images of particles in capillary tubes of similar size to catheters used in TAE procedures are clearly visible by MRI... - Synthesis of multimeric MR contrast agents for cellular imagingYing Song
Departments of Chemistry, Biochemistry and Molecular and Cell Biology, Neurobiology and Physiology, Radiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
J Am Chem Soc 130:6662-3. 2008..The relaxivities of the agents range from 17 to 85 mM(-1) s(-1). Cellular uptake is concentration dependent and viability is excellent. MR images of cell pellets reveal a marked increase in observed signal intensity... - Cell-permeable MR contrast agents with increased intracellular retentionPaul J Endres
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
Bioconjug Chem 19:2049-59. 2008..This reaction prolongs the cell-associated lifetime of the chelated Gd(III) by cleaving it from the cell transduction domain... - Mechanisms of ZnII-activated magnetic resonance imaging agentsJody L Major
Department of Chemistry, Biochemistry and Molecular Cell Biology, Neurobiology and Physiology, and Radiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
Inorg Chem 47:10788-95. 2008..13)C isotopic labeling of the acetate binding groups for NMR spectroscopy provides evidence of a change in the metal coordination of these groups upon the addition of Zn (II) supporting our proposed mechanism of activation as presented... - Bioresponsive, cell-penetrating, and multimeric MR contrast agentsJody L Major
Department of Chemistry, Northwestern University, Evanston, Illinois 60208 3113, USA
Acc Chem Res 42:893-903. 2009..Finally, we describe strategies for signal amplification, and cell delivery vehicles attached to imaging probes for in vivo long-term fate mapping experiments... - Gd(III)-nanodiamond conjugates for MRI contrast enhancementLisa M Manus
Department of Chemistry, Northwestern University, Evanston, Illinois 60208 3113, USA
Nano Lett 10:484-9. 2010..82 +/- 1.18 mM(-1) s(-1) at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r(1) = 5.42 +/- 0.20 mM(-1) s(-1)) and is among the highest per-Gd(III) relaxivities reported... - Multivalent protein polymer MRI contrast agents: controlling relaxivity via modulation of amino acid sequenceLindsay S Karfeld-Sulzer
Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
Biomacromolecules 11:1429-36. 2010..The protein polymer CAs can be customized for different clinical diagnostic applications, including biomaterial tracking, as a balanced agent with high relaxivity and appropriate molar mass... - Use of a genetically engineered protein for the design of a multivalent MRI contrast agentLindsay S Karfeld
Department of Chemical and Biological Engineering and Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA
Bioconjug Chem 18:1697-700. 2007..Thus, these protein polymer CAs could be a useful tool for following the evolution of tissue engineering scaffolds... - The synthesis and in vitro testing of a zinc-activated MRI contrast agentJody L Major
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Proc Natl Acad Sci U S A 104:13881-6. 2007..38 x 10(-4) M for the Gd(III)-Zn(II) complex. In vitro magnetic resonance images confirm that Zn(II) concentrations as low as 100 microM can be detected by using this contrast agent... - Multimodal MRI contrast agentsLuca Frullano
Department of Chemistry, Biochemistry and Molecular and Cell Biology, Neurobiology and Physiology, Radiology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
J Biol Inorg Chem 12:939-49. 2007 - Cellular delivery of MRI contrast agentsMatthew J Allen
Departments of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Chem Biol 11:301-7. 2004..Furthermore, the effect of incubation time, concentration, and cell type on uptake is explored. Toxicity and washout studies are performed in addition to MRI phantom studies... - Magnetic resonance contrast agents for medical and molecular imagingMatthew J Allen
Departments of Chemistry, Biochemistry and Molecular and Cell Biology, Neurobiology, and Physiology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Met Ions Biol Syst 42:1-38. 2004 - Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agentsSteve R Bull
Department of Chemistry, Feinberg School of Medicine, Northwestern University, 2145 Sheridan Road, Evanston, Illinois, USA
Nano Lett 5:1-4. 2005..This new class of MR contrast agents can potentially be used to combine high-resolution three-dimensional MR fate mapping of tissue-engineered scaffolds with targeting of specific cellular receptors... - Magnetic resonance imaging of self-assembled biomaterial scaffoldsSteve R Bull
Department of Chemistry, Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60208, USA
Bioconjug Chem 16:1343-8. 2005..1 mM Gd(III) conjugate of the PA we observed a T(1) three times that of a control gel. The PA derivative was doped into various epitope bearing PA solutions and upon gelling resulted in a homogeneous biomaterial as imaged by MRI... - Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: a new approach toward prodrug-procontrast complexesLuca Frullano
Department of Chemistry, Biochemistry and Molecular and Cell Biology, Neurobiology and Physiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA
Inorg Chem 45:8489-91. 2006..We have prepared the first MRI prodrug-procontrast complex by conjugating doxorubicin to a Gd(III) chelate using an acid-labile linker. The relaxometric properties of the adduct and pH activation are reported... - Rational design, synthesis, and biological evaluation of progesterone-modified MRI contrast agentsJiyoun Lee
Departments of Chemistry, Biochemistry and Molecular, Northwestern University, Evanston, IL 60208, USA
Chem Biol 14:824-34. 2007..Transcriptional assays using the progesterone response element linked to luciferase indicated that the contrast agents entered the cell, interacted with the biological target, and drove specific progesterone-mediated transcription... - Highly dispersible, superparamagnetic magnetite nanoflowers for magnetic resonance imagingFengqin Hu
Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
Chem Commun (Camb) 46:73-5. 2010..A one-pot reaction process was developed to synthesize highly dispersible, superparamagnetic Fe(3)O(4) nanoflowers; the potential of these nanoflowers as MRI contrast agents was investigated... - The in vitro effects of a bimodal contrast agent on cellular functions and relaxometryCecilie Brekke
NeuroImaging Research Group Department of Neurology, Institute of Psychiatry, King s College London, UK
NMR Biomed 20:77-89. 2007..Further in vivo testing will be required to ensure that cell labeling with gadolinium-based MRI contrast agents does not impair their ability to repair... - Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging studyMichel Modo
Neuroimaging Research Group Neurology P042, Institute of Psychiatry, King s College London, SE5 8AF, London, UK
Neuroimage 21:311-7. 2004.... - Synthesis and visualization of a membrane-permeable MRI contrast agentMatthew J Allen
Division of Biology and the Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA
J Biol Inorg Chem 8:746-50. 2003..We confirmed cellular uptake of the agent using two-photon laser microscopy to visualize a Eu(III) derivative of the contrast agent in cell culture, and verified this uptake by T(1) analysis of the Gd(III) agent in cells... - Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imagingMichel Modo
Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
Neuroimage 17:803-11. 2002..These results demonstrate that GRID-enhanced MRI can reliably identify transplanted stem cells and their migration in the brain...
Research Grants
- q-Modulated Magnetic Resonance Contrast AgentsThomas Meade; Fiscal Year: 2007..IV. Synthesize multimodal probes for in vivo validation and co-registration. V. Evaluate the effectiveness of the bioactivated contrast agents in vitro and in vivo. ..
- NEW CONTRAST AGENTS FOR MR IMAGING OF THE IMMUME SYSTEMThomas Meade; Fiscal Year: 2003..A MR contrast agent that is uniquely sensitive to this enzyme process would be of great utility in dissecting this mechanism. ..
- q-Modulated Magnetic Resonance Imaging Contrast AgentsThomas J Meade; Fiscal Year: 2010..The development of bioactivated contrast agents for tracking gene expression is a powerful tool for developmental biology which has wide-ranging applications in areas such as prevention of cancer metastasis. ..