Thomas Meade

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Quantitative imaging of cell-permeable magnetic resonance contrast agents using x-ray fluorescence
    Paul J Endres
    Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
    Mol Imaging 5:485-97. 2006
  2. pmc High dynamic range processing for magnetic resonance imaging
    Andy H Hung
    Department of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 8:e77883. 2013
  3. pmc Rational design of [Co(acacen)L2]+ inhibitors of protein function
    Lauren M Matosziuk
    Department of Chemistry, Northwestern University, Evanston, Illinois 60208 3113, USA
    Dalton Trans 42:4002-12. 2013
  4. ncbi request reprint New magnetic resonance contrast agents as biochemical reporters
    Thomas J Meade
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60201 3113, USA
    Curr Opin Neurobiol 13:597-602. 2003
  5. doi request reprint Molecular imaging of in vivo gene expression
    Allison S Harney
    Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
    Future Med Chem 2:503-19. 2010
  6. ncbi request reprint DNA-TiO2 nanoconjugates labeled with magnetic resonance contrast agents
    Paul J Endres
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    J Am Chem Soc 129:15760-1. 2007
  7. ncbi request reprint Mechanistic investigation of beta-galactosidase-activated MR contrast agents
    Lauren M Urbanczyk-Pearson
    Department of Chemistry, Northwestern University, Evanston, IL 60201, USA
    Inorg Chem 47:56-68. 2008
  8. doi request reprint Modification of embolic-PVA particles with MR contrast agents
    Renee Cilliers
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois, USA
    Magn Reson Med 59:898-902. 2008
  9. pmc Synthesis of multimeric MR contrast agents for cellular imaging
    Ying Song
    Departments of Chemistry, Biochemistry and Molecular and Cell Biology, Neurobiology and Physiology, Radiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
    J Am Chem Soc 130:6662-3. 2008
  10. pmc Cell-permeable MR contrast agents with increased intracellular retention
    Paul J Endres
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    Bioconjug Chem 19:2049-59. 2008

Research Grants

Collaborators

  • Reed Omary
  • Andrew C Larson
  • Devkumar Mustafi
  • Mike Modo
  • Jody L Major
  • Keith W MacRenaris
  • Paul J Endres
  • Matthew J Allen
  • Steve R Bull
  • Luca Frullano
  • Lisa M Manus
  • Emily A Waters
  • Ying Song
  • Stefan Vogt
  • Lauren M Matosziuk
  • Andy H Hung
  • Elise A Schultz-Sikma
  • Lindsay S Karfeld-Sulzer
  • Allison S Harney
  • Fengqin Hu
  • AMANDA L ECKERMANN
  • Annelise E Barron
  • Nicolynn E Davis
  • Renee Cilliers
  • Lauren M Urbanczyk-Pearson
  • Ellen K Kohlmeir
  • Giacomo Parigi
  • Claudio Luchinat
  • Lindsay S Karfeld
  • Jiyoun Lee
  • Cecilie Brekke
  • Mustafa O Guler
  • Samuel I Stupp
  • Rafael E Bras
  • Preeti A Sukerkar
  • Taiyang Liang
  • Marie C Heffern
  • Mark A Ratner
  • Robert J Holbrook
  • Xue Qing Zhang
  • Daniel J Mastarone
  • Dean Ho
  • Rene M Boiteau
  • Frank J Femia
  • Joseph A Duimstra
  • Jeffrey Smith
  • Joanna E Burdette
  • Steve C R Williams
  • Sarah C Morgan
  • Gayle E Woloschak
  • Tatjana Paunesku
  • Jack Price
  • Andrew S Lowe
  • Teresa K Woodruff
  • Baudilio Tejerina
  • Palamadai N Venkatasubramanian
  • P N Venkatasubramanian

Detail Information

Publications28

  1. ncbi request reprint Quantitative imaging of cell-permeable magnetic resonance contrast agents using x-ray fluorescence
    Paul J Endres
    Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
    Mol Imaging 5:485-97. 2006
    ..The transduction efficiency of the intracellular agents was evaluated by T(1) analysis and inductively coupled plasma mass spectrometry to determine the efficacy of each chelate-transporter combination...
  2. pmc High dynamic range processing for magnetic resonance imaging
    Andy H Hung
    Department of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 8:e77883. 2013
    ..To minimize feature loss in T1- and T2-weighted MRI by merging multiple MR images acquired at different TR and TE to generate an image with increased dynamic range...
  3. pmc Rational design of [Co(acacen)L2]+ inhibitors of protein function
    Lauren M Matosziuk
    Department of Chemistry, Northwestern University, Evanston, Illinois 60208 3113, USA
    Dalton Trans 42:4002-12. 2013
    ..These investigations will aid in the design of the next generation of [Co(acacen)L(2)](2+), allowing researchers to develop new, more effective inhibitors...
  4. ncbi request reprint New magnetic resonance contrast agents as biochemical reporters
    Thomas J Meade
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60201 3113, USA
    Curr Opin Neurobiol 13:597-602. 2003
    ..These new classes of magnetic resonance contrast agents represent a substantial leap in the type of information that can be derived from imaging experiments, and are the focus of this review...
  5. doi request reprint Molecular imaging of in vivo gene expression
    Allison S Harney
    Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
    Future Med Chem 2:503-19. 2010
    ..The ability to use contrast agents coupled with functional information on cellular events will allow for sensitive assessment of individual patient therapies, leading to an accurately tailored treatment regimen...
  6. ncbi request reprint DNA-TiO2 nanoconjugates labeled with magnetic resonance contrast agents
    Paul J Endres
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    J Am Chem Soc 129:15760-1. 2007
    ....
  7. ncbi request reprint Mechanistic investigation of beta-galactosidase-activated MR contrast agents
    Lauren M Urbanczyk-Pearson
    Department of Chemistry, Northwestern University, Evanston, IL 60201, USA
    Inorg Chem 47:56-68. 2008
    ....
  8. doi request reprint Modification of embolic-PVA particles with MR contrast agents
    Renee Cilliers
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois, USA
    Magn Reson Med 59:898-902. 2008
    ..Images of particles in capillary tubes of similar size to catheters used in TAE procedures are clearly visible by MRI...
  9. pmc Synthesis of multimeric MR contrast agents for cellular imaging
    Ying Song
    Departments of Chemistry, Biochemistry and Molecular and Cell Biology, Neurobiology and Physiology, Radiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
    J Am Chem Soc 130:6662-3. 2008
    ..The relaxivities of the agents range from 17 to 85 mM(-1) s(-1). Cellular uptake is concentration dependent and viability is excellent. MR images of cell pellets reveal a marked increase in observed signal intensity...
  10. pmc Cell-permeable MR contrast agents with increased intracellular retention
    Paul J Endres
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    Bioconjug Chem 19:2049-59. 2008
    ..This reaction prolongs the cell-associated lifetime of the chelated Gd(III) by cleaving it from the cell transduction domain...
  11. pmc Mechanisms of ZnII-activated magnetic resonance imaging agents
    Jody L Major
    Department of Chemistry, Biochemistry and Molecular Cell Biology, Neurobiology and Physiology, and Radiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
    Inorg Chem 47:10788-95. 2008
    ..13)C isotopic labeling of the acetate binding groups for NMR spectroscopy provides evidence of a change in the metal coordination of these groups upon the addition of Zn (II) supporting our proposed mechanism of activation as presented...
  12. pmc Bioresponsive, cell-penetrating, and multimeric MR contrast agents
    Jody L Major
    Department of Chemistry, Northwestern University, Evanston, Illinois 60208 3113, USA
    Acc Chem Res 42:893-903. 2009
    ..Finally, we describe strategies for signal amplification, and cell delivery vehicles attached to imaging probes for in vivo long-term fate mapping experiments...
  13. pmc Gd(III)-nanodiamond conjugates for MRI contrast enhancement
    Lisa M Manus
    Department of Chemistry, Northwestern University, Evanston, Illinois 60208 3113, USA
    Nano Lett 10:484-9. 2010
    ..82 +/- 1.18 mM(-1) s(-1) at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r(1) = 5.42 +/- 0.20 mM(-1) s(-1)) and is among the highest per-Gd(III) relaxivities reported...
  14. pmc Multivalent protein polymer MRI contrast agents: controlling relaxivity via modulation of amino acid sequence
    Lindsay S Karfeld-Sulzer
    Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
    Biomacromolecules 11:1429-36. 2010
    ..The protein polymer CAs can be customized for different clinical diagnostic applications, including biomaterial tracking, as a balanced agent with high relaxivity and appropriate molar mass...
  15. pmc Use of a genetically engineered protein for the design of a multivalent MRI contrast agent
    Lindsay S Karfeld
    Department of Chemical and Biological Engineering and Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA
    Bioconjug Chem 18:1697-700. 2007
    ..Thus, these protein polymer CAs could be a useful tool for following the evolution of tissue engineering scaffolds...
  16. pmc The synthesis and in vitro testing of a zinc-activated MRI contrast agent
    Jody L Major
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 104:13881-6. 2007
    ..38 x 10(-4) M for the Gd(III)-Zn(II) complex. In vitro magnetic resonance images confirm that Zn(II) concentrations as low as 100 microM can be detected by using this contrast agent...
  17. ncbi request reprint Cellular delivery of MRI contrast agents
    Matthew J Allen
    Departments of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Chem Biol 11:301-7. 2004
    ..Furthermore, the effect of incubation time, concentration, and cell type on uptake is explored. Toxicity and washout studies are performed in addition to MRI phantom studies...
  18. ncbi request reprint Magnetic resonance contrast agents for medical and molecular imaging
    Matthew J Allen
    Departments of Chemistry, Biochemistry and Molecular and Cell Biology, Neurobiology, and Physiology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Met Ions Biol Syst 42:1-38. 2004
  19. ncbi request reprint Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents
    Steve R Bull
    Department of Chemistry, Feinberg School of Medicine, Northwestern University, 2145 Sheridan Road, Evanston, Illinois, USA
    Nano Lett 5:1-4. 2005
    ..This new class of MR contrast agents can potentially be used to combine high-resolution three-dimensional MR fate mapping of tissue-engineered scaffolds with targeting of specific cellular receptors...
  20. ncbi request reprint Magnetic resonance imaging of self-assembled biomaterial scaffolds
    Steve R Bull
    Department of Chemistry, Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60208, USA
    Bioconjug Chem 16:1343-8. 2005
    ..1 mM Gd(III) conjugate of the PA we observed a T(1) three times that of a control gel. The PA derivative was doped into various epitope bearing PA solutions and upon gelling resulted in a homogeneous biomaterial as imaged by MRI...
  21. ncbi request reprint Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: a new approach toward prodrug-procontrast complexes
    Luca Frullano
    Department of Chemistry, Biochemistry and Molecular and Cell Biology, Neurobiology and Physiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
    Inorg Chem 45:8489-91. 2006
    ..We have prepared the first MRI prodrug-procontrast complex by conjugating doxorubicin to a Gd(III) chelate using an acid-labile linker. The relaxometric properties of the adduct and pH activation are reported...
  22. ncbi request reprint Rational design, synthesis, and biological evaluation of progesterone-modified MRI contrast agents
    Jiyoun Lee
    Departments of Chemistry, Biochemistry and Molecular, Northwestern University, Evanston, IL 60208, USA
    Chem Biol 14:824-34. 2007
    ..Transcriptional assays using the progesterone response element linked to luciferase indicated that the contrast agents entered the cell, interacted with the biological target, and drove specific progesterone-mediated transcription...
  23. ncbi request reprint Multimodal MRI contrast agents
    Luca Frullano
    Department of Chemistry, Biochemistry and Molecular and Cell Biology, Neurobiology and Physiology, Radiology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    J Biol Inorg Chem 12:939-49. 2007
  24. doi request reprint Highly dispersible, superparamagnetic magnetite nanoflowers for magnetic resonance imaging
    Fengqin Hu
    Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
    Chem Commun (Camb) 46:73-5. 2010
    ..A one-pot reaction process was developed to synthesize highly dispersible, superparamagnetic Fe(3)O(4) nanoflowers; the potential of these nanoflowers as MRI contrast agents was investigated...
  25. ncbi request reprint The in vitro effects of a bimodal contrast agent on cellular functions and relaxometry
    Cecilie Brekke
    NeuroImaging Research Group Department of Neurology, Institute of Psychiatry, King s College London, UK
    NMR Biomed 20:77-89. 2007
    ..Further in vivo testing will be required to ensure that cell labeling with gadolinium-based MRI contrast agents does not impair their ability to repair...
  26. ncbi request reprint Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging study
    Michel Modo
    Neuroimaging Research Group Neurology P042, Institute of Psychiatry, King s College London, SE5 8AF, London, UK
    Neuroimage 21:311-7. 2004
    ....
  27. ncbi request reprint Synthesis and visualization of a membrane-permeable MRI contrast agent
    Matthew J Allen
    Division of Biology and the Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA
    J Biol Inorg Chem 8:746-50. 2003
    ..We confirmed cellular uptake of the agent using two-photon laser microscopy to visualize a Eu(III) derivative of the contrast agent in cell culture, and verified this uptake by T(1) analysis of the Gd(III) agent in cells...
  28. ncbi request reprint Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging
    Michel Modo
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Neuroimage 17:803-11. 2002
    ..These results demonstrate that GRID-enhanced MRI can reliably identify transplanted stem cells and their migration in the brain...

Research Grants10

  1. q-Modulated Magnetic Resonance Contrast Agents
    Thomas Meade; Fiscal Year: 2007
    ..IV. Synthesize multimodal probes for in vivo validation and co-registration. V. Evaluate the effectiveness of the bioactivated contrast agents in vitro and in vivo. ..
  2. NEW CONTRAST AGENTS FOR MR IMAGING OF THE IMMUME SYSTEM
    Thomas Meade; Fiscal Year: 2003
    ..A MR contrast agent that is uniquely sensitive to this enzyme process would be of great utility in dissecting this mechanism. ..
  3. q-Modulated Magnetic Resonance Imaging Contrast Agents
    Thomas J Meade; Fiscal Year: 2010
    ..The development of bioactivated contrast agents for tracking gene expression is a powerful tool for developmental biology which has wide-ranging applications in areas such as prevention of cancer metastasis. ..