Research Topics
Species | Kevin McVarySummaryAffiliation: Northwestern University Country: USA Publications
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Detail Information
Publications
A review of combination therapy in patients with benign prostatic hyperplasiaKevin T McVary
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 3008, USA
Clin Ther 29:387-98. 2007..The differing mechanisms of action and areas of efficacy of these 2 drug classes make them promising candidates for combination therapy...- Editorial comment on: The natural history of Peyronie's disease: an ultrasonography-based studyKevin T McVary
Eur Urol 53:650-1. 2008 - Autonomic nervous system overactivity in men with lower urinary tract symptoms secondary to benign prostatic hyperplasiaKevin T McVary
Department of Urology, Feinberg School of Medicine, Northwestern University Chicago, Illinois 60611, USA
J Urol 174:1327-433. 2005..We investigated the relationship of ANS activity to LUTS as well as to objective measures of BPH in men with BPH... - Sildenafil citrate improves erectile function: a randomised double-blind trial with open-label extensionK T McVary
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
Int J Clin Pract 61:1843-9. 2007..To evaluate once-daily 100-mg sildenafil for the treatment of erectile dysfunction (ED) in men with ED and lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH)... - Interrelation of erectile dysfunction and lower urinary tract symptomsKevin T McVary
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Drugs Today (Barc) 41:527-36. 2005..Using Hill's causality method to separate causal from non-causal explanations linking ED with LUTS, it appears that most epidemiological components are fulfilled... - Alfuzosin for symptomatic benign prostatic hyperplasia: long-term experienceKevin T McVary
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
J Urol 175:35-42. 2006..Evidence of the long-term efficacy and safety of alfuzosin treatment for LUTS indicative of BPH was examined... - Non-steroidal anti-inflammatory drugs and urinary retentionKevin T McVary
Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Lancet 367:195-6. 2006 - Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiologyKevin McVary
Northwestern University School of Medicine, Chicago, USA
BJU Int 97:23-8; discussion 44-5. 2006..Studies treating one condition (e.g. ED) and measuring the impact on the other (e.g. LUTS) should further contribute to support this common link... - BPH: epidemiology and comorbiditiesKevin T McVary
Northwestern University, Feinberg School of Medicine, Department of Urology, Chicago, IL 60611 3008, USA
Am J Manag Care 12:S122-8. 2006..When selecting an appropriate course of therapy, these side effects and any impact they may have on existing comorbid conditions must be considered... - Metabolic syndrome and lower urinary tract symptoms secondary to benign prostatic hyperplasiaSanjay Kasturi
Northwestern University Medical School, Department of Urology, Tarry 11 725, 303 East Chicago Avenue, Chicago, IL 60611, USA
Curr Urol Rep 7:288-92. 2006.... - Sildenafil citrate improves erectile function and urinary symptoms in men with erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized, double-blind trialKevin T McVary
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
J Urol 177:1071-7. 2007..We evaluated sildenafil for erectile dysfunction and lower urinary tract symptoms in men with the 2 conditions... - Erectile dysfunction and lower urinary tract symptoms secondary to BPHKevin T McVary
Department of Urology, Feinberg School of Medicine, Northwestern University Medical School, Tarry 16 749, 303 E Chicago Ave, Chicago, IL 60611, USA
Eur Urol 47:838-45. 2005..The association between these two diseases has also garnered attention as investigators have hypothesized a common pathophysiology to explain the assertion that they are causally linked... - Clinical practice. Erectile dysfunctionKevin T McVary
Northwestern University Feinberg School of Medicine, Department of Urology, Chicago, IL 60611, USA
N Engl J Med 357:2472-81. 2007 
Update on AUA guideline on the management of benign prostatic hyperplasiaKevin T McVary
American Urological Association Education and Research, Inc, Linthicum Maryland, USA
J Urol 185:1793-803. 2011..To revise the 2003 version of the American Urological Association's (AUA) Guideline on the management of benign prostatic hyperplasia (BPH)...- Medical therapy for benign prostatic hyperplasia progressionKevin T McVary
Department of Urology, Feinberg School of Medicine, Northwestern University, Tarry Building Room 11 715, 303 East Chicago Avenue, Chicago, IL 60611 3008, USA
Curr Urol Rep 3:269-75. 2002..Interestingly, finasteride and combination therapy reduced the long-term risk of acute urinary retention... - Sildenafil citrate improves erectile function and lower urinary tract symptoms independent of baseline body mass index or LUTS severityKevin T McVary
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
Urology 72:575-9. 2008..To evaluate the body mass index (BMI) and lower urinary tract symptom (LUTS) severity on treatment response to sildenafil in men with erectile dysfunction (ED) and moderate to severe LUTS associated with benign prostatic hyperplasia... - Tadalafil relieves lower urinary tract symptoms secondary to benign prostatic hyperplasiaKevin T McVary
Department of Urology, Northwestern University Medical School, Chicago, Illinois 60611, USA
J Urol 177:1401-7. 2007..We assessed the efficacy and safety of tadalafil dosed once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia... - Identifying patients with benign prostatic hyperplasia through a diagnosis of, or treatment for, erectile dysfunctionKevin McVary
Department of Urology, Feinberg School of Medicine, Northwestern University School of Medicine, Chicago, IL 60611, USA
Curr Med Res Opin 24:775-84. 2008..Multivariate analyses were used to examine times to screening, diagnosis, and treatment... - The relationship between erectile dysfunction and lower urinary tract symptoms: epidemiological, clinical, and basic science evidenceKevin T McVary
Department of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 16 749, Chicago, IL 60611, USA
Curr Urol Rep 5:251-7. 2004..The association is supported by the consistent linear relationship of more severe LUTS with more severe ED. The link between ED and LUTS has biologic plausibility given the four leading theories of how these diseases inter-relate... - Lower urinary tract symptoms, benign prostatic hyperplasia, and obesityAnne K Mongiu
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Curr Urol Rep 10:247-53. 2009..Future studies may lead to office detection of a patient's particular polymorphisms, which may help guide individual treatment and lifestyle modifications that are more likely to succeed... - Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a dose finding studyClaus G Roehrborn
Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9110, USA
J Urol 180:1228-34. 2008..Preliminary data have suggested phosphodiesterase type 5 inhibitor efficacy in men with lower urinary tract symptoms associated with clinical benign prostatic hyperplasia... - The role of combination therapy for lower urinary tract symptoms secondary to benign prostatic hyperplasiaChris M Gonzalez
Department of Urology, Northwestern University Medical School, 303 E. Chicago Ave, Tarry 11-715, Chicago, IL 60611, USA
Curr Urol Rep 4:276-81. 2003 - Posterior Hox gene expression in developing genitaliaCarol Podlasek
Department of Urology, Northwestern University Medical School, Chicago, IL 60611, USA
Evol Dev 4:142-63. 2002 - Erectile function, sexual drive, and ejaculatory function after reconstructive surgery for anterior urethral stricture diseaseBradley A Erickson
Department of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
BJU Int 99:607-11. 2007..To evaluate the effect of urethral reconstructive surgery on sexual drive, erectile function and ejaculation... - Altered Sonic hedgehog signaling is associated with morphological abnormalities in the penis of the BB/WOR diabetic ratCarol A Podlasek
Departments of Urology, Northwestern University Medical School, Chicago, Illinois 60611, USA
Biol Reprod 69:816-27. 2003..Increasing our understanding of the molecular mechanisms that regulate Shh signaling may provide valuable insight into improving treatment options for diabetic impotence... 
Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehogCarol A Podlasek
Department of Urology, Northwestern University Medical School, Chicago, Illinois 60611, USA
Biol Reprod 76:19-28. 2007..These results show that SHH stabilizes the alterations of the corpora cavernosal smooth muscle following nerve injury...- Sonic hedgehog cascade is required for penile postnatal morphogenesis, differentiation, and adult homeostasisCarol A Podlasek
Department of Urology and Physiology, Northwestern University Medical School, Chicago, Illinois 60611, USA
Biol Reprod 68:423-38. 2003..These studies provide valuable insight that may be applied to improve treatment options for erectile dysfunction... - Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunctionHerbert M User
Department of Urology, Northwestern University Medical School, Chicago, Illinois, USA
J Urol 169:1175-9. 2003..These effects were significantly moderated in the unilateral model, reinforcing the critical nature of neural integrity... - Holmium laser prostatic resection for patients presenting with acute urinary retentionChristopher B Anderson
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
BJU Int 102:1623-8. 2008.... - Established medical therapy for benign prostatic hyperplasiaGregory B Auffenberg
Department of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 16 703, Chicago, IL 60611 3008, USA
Urol Clin North Am 36:443-59, v-vi. 2009..The available clinical trial data for all of these types of therapy is discussed in this article... - Consequences of switching 5alpha-reductase inhibitors on prostate specific antigen velocityBrian T Helfand
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
J Urol 184:218-23. 2010..We examined prostate specific antigen velocity after changes in 5alpha-reductase inhibitor formularies... - Lower urinary tract symptoms, obesity and the metabolic syndromeSamdeep Moul
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
Curr Opin Urol 20:7-12. 2010..The epidemic of obesity and concomitant metabolic syndrome is well documented. New evidence points to a connection between the components of metabolic syndrome and benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS)... - Management of lower urinary tract symptoms secondary to benign prostatic hyperplasia with open prostatectomy: results of a contemporary seriesBrian Helfand
Department of Urology, Feinberg School of Medicine, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
J Urol 176:2557-61; discussion 2561. 2006.... - Topical agents and erectile dysfunction: is there a place?Ronald L Yap
Department of Urology, Northwestern University Medical School, Tarry 11 725, 303 East Chicago Avenue, Chicago, IL 60611, USA
Curr Urol Rep 3:471-6. 2002..Although still in the investigative stage, topical medications can be another tool in the urologist's armamentarium against ED... - Lower urinary tract symptoms and erectile dysfunction: epidemiology and treatment in the aging manShane Russell
Northwestern University Feinberg School of Medicine, Department of Urology, Tarry Building, Room 16-749, 303 East Chicago Avenue, Chicago, IL 60611, USA
Curr Urol Rep 6:445-53. 2005..This newly recognized independent relationship between ED and LUTS has the potential to have a profound impact on the way we diagnose and treat these common urologic disorders... - Microarray analysis and description of SMR1 gene in rat penis in a post-radical prostatectomy model of erectile dysfunctionHerbert M User
Department of Urology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
J Urol 170:298-301. 2003..The role of SMR as a clinically relevant change in penile and/or urethral function following cavernous nerve injury is speculative... - Alpha-blockers and intraoperative floppy iris syndrome: ophthalmic adverse events following cataract surgeryZuhair K Al-Hussaini
Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 16 703, Chicago, IL 60611 3008, USA
Curr Urol Rep 11:242-8. 2010..There is still much to learn about IFIS and its exact causes, as well as a need for agreed upon guidelines that would enable physicians to properly anticipate and successfully manage or even prevent the condition... - Preoperative clinical and diagnostic characteristics of patients who require delayed IPP after primary Peyronies repairHannah H Alphs
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL60611 3008, USA
J Sex Med 7:1262-8. 2010..However, precisely which parameters can be used to predict those patients with PD at risk for developing erectile dysfunction (ED) after intervention without inflatable penile prosthesis (IPP) has not been previously elucidated... - Holmium laser ablation and enucleation of the prostate: a pilot study of the hybrid techniqueBrian T Helfand
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
Can J Urol 17:5190-4. 2010.... - Prospective analysis of ejaculatory function after anterior urethral reconstructionBradley A Erickson
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
J Urol 184:238-42. 2010..We prospectively evaluated the effects of urethral reconstruction on ejaculatory function... - Medications and surgical interventions for benign prostatic hyperplasia are potential confounders of prostate-specific antigenParth Modi
Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 16 703, Chicago, IL 60611, USA
Curr Urol Rep 11:224-7. 2010.... - Determining the utility of recalled lower urinary tract symptomsBrian T Helfand
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 3008, USA
Urology 76:442-7. 2010..The AUA-SI is a validated questionnaire used to assess a patient's lower urinary tract symptoms (LUTS) over a 4-week period. However, patient recall of their LUTS at greater time points is currently unknown... - Phytotherapy for lower urinary tract symptoms secondary to benign prostatic hyperplasiaRaj C Dedhia
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Urol 179:2119-25. 2008.... - Variation in institutional review board responses to a standard protocol for a multicenter randomized, controlled surgical trialBrian T Helfand
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Urol 181:2674-9. 2009.... - Postoperative PSA and PSA velocity identify presence of prostate cancer after various surgical interventions for benign prostatic hyperplasiaBrian T Helfand
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinios 60611, USA
Urology 74:177-83. 2009..Although the PSA level can be used for CaP screening in this population, it might be influenced by the efficacies of different BPH procedures... - Impact of phytotherapy on utility scores for 5 benign prostatic hyperplasia/lower urinary tract symptoms health statesRaj C Dedhia
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Urol 179:220-5. 2008.... - Unexpected insights into pelvic function following phosphodiesterase manipulation--what's next for urology?Kevin T McVary
Eur Urol 50:1153-6. 2006 - The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasiaJohn D McConnell
University of Texas Southwestern Medical Center, Dallas, TX 75390-9110, USA
N Engl J Med 349:2387-98. 2003..Combination therapy and finasteride alone reduced the long-term risk of acute urinary retention and the need for invasive therapy... - Beneficial effects of extended-release doxazosin and doxazosin standard on sexual healthSteven A Kaplan
Columbia University, New York, NY, USA
BJU Int 97:559-66. 2006..Increasing clinical evidence attests to the effectiveness of doxazosin in relieving ED, even in patients refractory to ED-specific treatment, as well as in reducing BPH symptoms and elevated blood pressure... - Urologic complications of diabetesJeanette S Brown
University of California, San Francisco, San Francisco, California 94115, USA
Diabetes Care 28:177-85. 2005 - The clinical significance of residual urine--how much is too much and when should a urologist start treatment?Kevin T McVary
J Urol 180:14. 2008 - Correlation of the International Prostate Symptom Score bother question with the Benign Prostatic Hyperplasia Impact Index in a clinical practice settingMICHAEL P O'LEARY
Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
BJU Int 101:1531-5. 2008....
Research Grants
- The Efficacy of TUMT and Neoadjuvant Finasteride for BPHKevin McVary; Fiscal Year: 2005..We are proposing a 3-arm, placebo/sham controlled, randomized clinical trial using changes in symptoms as the primary ..
- Saw palmetto and Pygeum africanum on BPH ProgressionKevin McVary; Fiscal Year: 2004..Secondary Aim: Unique to this submission is whether a chief complaint analysis, sleep scale measures or direct/indirect healthcare costs analysis provides reliable or useful information. ..
- N O S AND NEUROPATHIC AND ENDOTHELIAL INDUCED EDKevin McVary; Fiscal Year: 2002..Results of this research will aid in the understanding of how diabetic neuropathy contributes to sexual dysfunction and elucidate possible mechanisms to prevent them. ..
- REGULATION OF PROSTATE GROWTH BY NEURAL FACTORSKevin McVary; Fiscal Year: 2001..Using this model allows one to explore the limits of understanding prostatic neuroregulation, to explore neurotrophic influences on exocrine gland development, and to possibly uncover novel methods to influence prostate disease. ..