Genomes and Genes
Affiliation: Northwestern University
- Thrombotic and bleeding complications in classical myeloproliferative neoplasmsBrandon McMahon
Division of Hematology Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Semin Thromb Hemost 39:101-11. 2013..The impact of new mutations and novel therapies, including JAK-inhibitors and interferon, on the thrombotic and hemorrhagic tendency remains to be determined...
- Central Role of ULK1 in Type I Interferon SignalingDiana Saleiro
Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Cell Rep 11:605-17. 2015..Together, these data reveal a role for ULK1 as a key mediator of type I IFNR-generated signals that control gene transcription and induction of antineoplastic responses. ..
- Critical roles for Rictor/Sin1 complexes in interferon-dependent gene transcription and generation of antiproliferative responsesSurinder Kaur
From the Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611
J Biol Chem 289:6581-91. 2014..Altogether, these findings provide evidence for critical functions for Rictor/Sin1 complexes in type I IFN signaling and the generation of type I IFN antineoplastic responses. ..
- Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursorsSwarna Mehrotra
Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Biol Chem 288:23814-22. 2013..Altogether, these findings provide evidence for key and essential roles of the Mnk kinase pathway in the generation of the antineoplastic effects of type I IFNs in Jak2V617F-dependent MPNs. ..