Franck Mauvais-Jarvis

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Androgen excess produces systemic oxidative stress and predisposes to beta-cell failure in female mice
    Suhuan Liu
    Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 5:e11302. 2010
  2. pmc Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival
    Suhuan Liu
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University School of Medicine, Chicago, Illinois, USA
    Diabetes 58:2292-302. 2009
  3. pmc Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes
    S Liu
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USA
    Diabetologia 56:370-81. 2013
  4. pmc The role of estrogens in control of energy balance and glucose homeostasis
    Franck Mauvais-Jarvis
    Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Endocr Rev 34:309-38. 2013
  5. pmc Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity
    Franck Mauvais-Jarvis
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Trends Endocrinol Metab 22:24-33. 2011
  6. pmc Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice
    Kazunari Nohara
    Division of Endocrinology, Metabolism and Molecular Medicine and Comprehensive Center on Obesity, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA Division of Endocrinology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2632, USA Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA INSERM U1048, Institute of Metabolic and Cardiovascular Diseases of Rangueil, Toulouse 31432, France
    J Endocrinol 219:259-68. 2013
  7. pmc Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis
    Winifred P S Wong
    Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 107:13057-62. 2010
  8. pmc Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice
    Kazunari Nohara
    Division of Endocrinology, Metabolism, and Molecular Medicine, and
    Am J Physiol Endocrinol Metab 304:E1321-30. 2013
  9. pmc Rapid, nongenomic estrogen actions protect pancreatic islet survival
    Suhuan Liu
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Islets 1:273-5. 2009
  10. pmc Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes
    Joseph P Tiano
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Clin Invest 121:3331-42. 2011

Collaborators

Detail Information

Publications20

  1. pmc Androgen excess produces systemic oxidative stress and predisposes to beta-cell failure in female mice
    Suhuan Liu
    Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 5:e11302. 2010
    ..This work has significance for hyperandrogenic women; excess activation of AR by testosterone may provoke systemic oxidative stress. In the presence of a prior beta-cell stress, this may predispose to beta-cell failure...
  2. pmc Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival
    Suhuan Liu
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University School of Medicine, Chicago, Illinois, USA
    Diabetes 58:2292-302. 2009
    ..E(2) also activates nongenomic signals via an extranuclear form of ERalpha and the G protein-coupled estrogen receptor (GPER). We studied the contribution of estrogen receptors to islet survival...
  3. pmc Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes
    S Liu
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USA
    Diabetologia 56:370-81. 2013
    ..The female hormone 17β-oestradiol (E2) favours islet survival and stimulates angiogenesis, raising the possibility that E2 may enhance islet engraftment following PIT...
  4. pmc The role of estrogens in control of energy balance and glucose homeostasis
    Franck Mauvais-Jarvis
    Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Endocr Rev 34:309-38. 2013
    ..Estrogen deficiency promotes metabolic dysfunction predisposing to obesity, the metabolic syndrome, and type 2 diabetes. We also discuss the effect of selective estrogen receptor modulators on metabolic disorders...
  5. pmc Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity
    Franck Mauvais-Jarvis
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Trends Endocrinol Metab 22:24-33. 2011
    ..We suggest that ERs and AR could be potential targets in the prevention of age-related metabolic disorders...
  6. pmc Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice
    Kazunari Nohara
    Division of Endocrinology, Metabolism and Molecular Medicine and Comprehensive Center on Obesity, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA Division of Endocrinology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2632, USA Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA INSERM U1048, Institute of Metabolic and Cardiovascular Diseases of Rangueil, Toulouse 31432, France
    J Endocrinol 219:259-68. 2013
    ..They displayed a delayed increase in subcutaneous white adipose tissue amounts. Thus, excessive neonatal androgenization disrupts reproduction and energy homeostasis and predisposes to hypogonadism and obesity in adult male mice. ..
  7. pmc Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis
    Winifred P S Wong
    Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 107:13057-62. 2010
    ..This study supports the importance of ERalpha in beta cells as a regulator of insulin synthesis in vivo...
  8. pmc Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice
    Kazunari Nohara
    Division of Endocrinology, Metabolism, and Molecular Medicine, and
    Am J Physiol Endocrinol Metab 304:E1321-30. 2013
    ....
  9. pmc Rapid, nongenomic estrogen actions protect pancreatic islet survival
    Suhuan Liu
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Islets 1:273-5. 2009
    ..These studies identify novel estrogen pathways and targets to protect islet survival...
  10. pmc Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes
    Joseph P Tiano
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Clin Invest 121:3331-42. 2011
    ..Accordingly, pancreas-specific deletion of Stat3 in mice curtailed ER-mediated suppression of lipid synthesis. These data suggest that extranuclear ERs may be promising therapeutic targets to prevent β cell failure in T2D...
  11. pmc Molecular mechanisms of estrogen receptors' suppression of lipogenesis in pancreatic β-cells
    Joseph P Tiano
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Endocrinology 153:2997-3005. 2012
    ..This study identifies extranuclear ER pathways involving STAT3 and AMP-activated protein kinase in the genetic control of lipogenesis with therapeutic implications to protect β-cells in type 2 diabetes...
  12. pmc Central mechanisms of adiposity in adult female mice with androgen excess
    Kazunari Nohara
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA Comprehensive Center on Obesity, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Obesity (Silver Spring) 22:1477-84. 2014
    ..Androgen excess in women is associated with visceral adiposity. However, little is known on the mechanism through which androgen promotes visceral fat accumulation...
  13. doi request reprint Importance of oestrogen receptors to preserve functional β-cell mass in diabetes
    Joseph P Tiano
    Feinberg School of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine and Comprehensive Center on Obesity, Northwestern University, Chicago, IL 60611, USA
    Nat Rev Endocrinol 8:342-51. 2012
    ..Moreover, we discuss why and how enhancing ER action in β cells without the undesirable effect of general oestrogen therapy is a therapeutic avenue to preserve functional β-cell mass in patients with diabetes mellitus...
  14. pmc Minireview: Estrogenic protection of beta-cell failure in metabolic diseases
    Suhuan Liu
    Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 15 761, Chicago, Illinois 60611, USA
    Endocrinology 151:859-64. 2010
    ..They also improve islet lipid homeostasis and insulin biosynthesis. We also discuss evidence that ERs modulate insulin sensitivity and energy homeostasis, which indirectly alter beta-cell biology in diabetic and obese conditions...
  15. ncbi request reprint PAX4 gene variations predispose to ketosis-prone diabetes
    Franck Mauvais-Jarvis
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 13:3151-9. 2004
    ....
  16. pmc Selective estrogen receptor modulation in pancreatic β-cells and the prevention of type 2 diabetes
    Joseph Tiano
    Department of Medicine, Division of Endocrinology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Islets 4:173-6. 2012
    ..Additional studies using novel generation SERMs are needed to address this issue...
  17. ncbi request reprint Antidiabetic actions of estrogen: insight from human and genetic mouse models
    Jean Francois Louet
    Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, One Baylor Plaza, 520B, Houston, TX 77030, USA
    Curr Atheroscler Rep 6:180-5. 2004
    ....
  18. pmc Early-life exposure to testosterone programs the hypothalamic melanocortin system
    Kazunari Nohara
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 15 761, Chicago, Illinois 60611, USA
    Endocrinology 152:1661-9. 2011
    ..Thus, NT programs a sexual differentiation of POMC neurons in female mice via DHT but also predisposes to leptin resistance and obesity in an estrogen-dependent manner...

Research Grants6

  1. Estrogen receptor signaling in diabetes prevention
    Franck Mauvais Jarvis; Fiscal Year: 2005
    ....
  2. Role of estrogen receptors in pancreatic beta-cell survival and insulin secretion
    Franck Mauvais Jarvis; Fiscal Year: 2007
    ....
  3. Role of estrogen receptors in pancreatic beta-cell survival and insulin secretion
    Franck Mauvais Jarvis; Fiscal Year: 2009
    ....
  4. Role of estrogen receptors in pancreatic beta-cell survival and insulin secretion
    Franck Mauvais Jarvis; Fiscal Year: 2009
    ..Verification was completed by DMAPS/PSB PAGE(S) "2., M was not included in Original Application Package Date > 2>D/ (* Initials Principal Investigator/Program Director (Last, First, Middle): MaUVaiS-JarvJS, Franck ..
  5. Role of estrogen receptors in pancreatic beta-cell survival and insulin secretion
    Franck Mauvais Jarvis; Fiscal Year: 2010
    ....