Thomas J Lukas

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Smooth muscle myosin filament assembly under control of a kinase-related protein (KRP) and caldesmon
    Dmitry S Kudryashov
    Laboratory of Cell Motility, Cardiology Research Center, 3rd Cherepkovskaya Street 15A, Moscow 121552, Russia
    J Muscle Res Cell Motil 23:341-51. 2002
  2. pmc Hydrostatic pressure-dependent changes in cyclic AMP signaling in optic nerve head astrocytes from Caucasian and African American donors
    Lin Chen
    Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Vis 15:1664-72. 2009
  3. doi request reprint Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression
    Thomas J Lukas
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, United States Electronic address
    Bioorg Med Chem Lett 24:1532-7. 2014
  4. pmc A signal transduction pathway model prototype I: From agonist to cellular endpoint
    Thomas J Lukas
    Department of Molecular Pharmacology and Drug Discovery Program, Northwestern University, Chicago, Illinois 60611, USA
    Biophys J 87:1406-16. 2004
  5. pmc Early cellular signaling responses to axonal injury
    Thomas J Lukas
    Forsythe Laboratory for the Investigation of the Aging Retina, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cell Commun Signal 7:5. 2009
  6. pmc Susceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors
    Thomas J Lukas
    Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, E Chicago Ave, Chicago, IL 60611, USA
    Genome Biol 9:R111. 2008
  7. doi request reprint Isolation and culture of astrocytes from the retina and optic nerve
    Thomas J Lukas
    Molecular Pharmacology and Biological Chemistry Ward 8 200, Northwestern University, Chicago, IL, USA
    Methods Mol Biol 814:105-15. 2012
  8. ncbi request reprint Informatics-assisted protein profiling in a transgenic mouse model of amyotrophic lateral sclerosis
    Thomas J Lukas
    Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Cell Proteomics 5:1233-44. 2006
  9. pmc A signal transduction pathway model prototype II: Application to Ca2+-calmodulin signaling and myosin light chain phosphorylation
    Thomas J Lukas
    Department of Molecular Pharmacology and Drug Discovery Program, Northwestern University, Chicago, Illinois 60611, USA
    Biophys J 87:1417-25. 2004
  10. pmc Changes in iron-regulatory proteins in the aged rodent neural retina
    Huiyi Chen
    The Forsythe Laboratory for Investigation of Aging Retina, Department of Ophthalmology, Northwestern University School of Medicine, Tarry 13 753, 303 East Chicago Avenue, Chicago, IL 60611, United States
    Neurobiol Aging 30:1865-76. 2009

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Smooth muscle myosin filament assembly under control of a kinase-related protein (KRP) and caldesmon
    Dmitry S Kudryashov
    Laboratory of Cell Motility, Cardiology Research Center, 3rd Cherepkovskaya Street 15A, Moscow 121552, Russia
    J Muscle Res Cell Motil 23:341-51. 2002
    ..We propose a new model that through their independent binding to myosin and differential effects on myosin dynamics, caldesmon and KRP can, in concert, control the length and polymerization state of myosin filaments...
  2. pmc Hydrostatic pressure-dependent changes in cyclic AMP signaling in optic nerve head astrocytes from Caucasian and African American donors
    Lin Chen
    Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Vis 15:1664-72. 2009
    ....
  3. doi request reprint Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression
    Thomas J Lukas
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, United States Electronic address
    Bioorg Med Chem Lett 24:1532-7. 2014
    ..Development of small molecules that reduce the expression of etiologically relevant toxic proteins is a strategy that may also be extended to familial ALS linked to gain of function mutations in other genes. ..
  4. pmc A signal transduction pathway model prototype I: From agonist to cellular endpoint
    Thomas J Lukas
    Department of Molecular Pharmacology and Drug Discovery Program, Northwestern University, Chicago, Illinois 60611, USA
    Biophys J 87:1406-16. 2004
    ..These investigations may be directed at the timing of multiple phosphorylation/dephosphorylation events affecting key enzymatic activities in the signaling pathway...
  5. pmc Early cellular signaling responses to axonal injury
    Thomas J Lukas
    Forsythe Laboratory for the Investigation of the Aging Retina, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cell Commun Signal 7:5. 2009
    ..In the current study, we investigated early changes in cellular signaling and gene expression that occur within the first 6 hrs post optic nerve injury...
  6. pmc Susceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors
    Thomas J Lukas
    Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, E Chicago Ave, Chicago, IL 60611, USA
    Genome Biol 9:R111. 2008
    ....
  7. doi request reprint Isolation and culture of astrocytes from the retina and optic nerve
    Thomas J Lukas
    Molecular Pharmacology and Biological Chemistry Ward 8 200, Northwestern University, Chicago, IL, USA
    Methods Mol Biol 814:105-15. 2012
    ..Included is the immunopanning method used for ONH astrocyte isolation as well as cell characterization. The isolation of purified retinal astrocytes is outlined as a method applicable to rodent and other mammalian retinas...
  8. ncbi request reprint Informatics-assisted protein profiling in a transgenic mouse model of amyotrophic lateral sclerosis
    Thomas J Lukas
    Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Cell Proteomics 5:1233-44. 2006
    ..Thus, concordance of proteomic and mRNA expression data within multiple categories validates the use of gene ontology analysis to compare different types of "omic" data...
  9. pmc A signal transduction pathway model prototype II: Application to Ca2+-calmodulin signaling and myosin light chain phosphorylation
    Thomas J Lukas
    Department of Molecular Pharmacology and Drug Discovery Program, Northwestern University, Chicago, Illinois 60611, USA
    Biophys J 87:1417-25. 2004
    ..Simulation results are in accord with literature measurements of MLCP and CPI-17 phosphorylation states during agonist stimulation, validating the predictive capabilities of the system...
  10. pmc Changes in iron-regulatory proteins in the aged rodent neural retina
    Huiyi Chen
    The Forsythe Laboratory for Investigation of Aging Retina, Department of Ophthalmology, Northwestern University School of Medicine, Tarry 13 753, 303 East Chicago Avenue, Chicago, IL 60611, United States
    Neurobiol Aging 30:1865-76. 2009
    ....
  11. pmc Gene expression and functional studies of the optic nerve head astrocyte transcriptome from normal African Americans and Caucasian Americans donors
    Haixi Miao
    Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    PLoS ONE 3:e2847. 2008
    ....
  12. pmc Modulation of factors affecting optic nerve head astrocyte migration
    Haixi Miao
    Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Invest Ophthalmol Vis Sci 51:4096-103. 2010
    ..They further investigated how the expression of these genes is altered by elevated hydrostatic pressure (HP)...
  13. doi request reprint Age-related increase in mitochondrial DNA damage and loss of DNA repair capacity in the neural retina
    Ai Ling Wang
    Forsythe Laboratory for the Investigation of the Aging Retina, Department of Ophthalmology, Northwestern University School of Medicine, Tarry 13 762, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Neurobiol Aging 31:2002-10. 2010
    ..Our results suggest that normal, age-related, increased mtDNA damage, likely due to decreased repair capacity in aged retinas, may be a susceptibility factor that underlies age-related retinal diseases...
  14. pmc Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration
    Ai Ling Wang
    Department of Ophthalmology, Forsythe Laboratory for the Investigation of the Aging Retina, Northwestern University School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 4:e4160. 2009
    ..Molecular and cellular changes in the old RPE may underlie susceptibility to genetic mutations that are found in AMD patients and may be associated with the pathogenesis of AMD in the elderly...
  15. doi request reprint Dysfunction of the retinal pigment epithelium with age: increased iron decreases phagocytosis and lysosomal activity
    Huiyi Chen
    Forsythe Laboratory for the Investigation of the Aging Retina, Department of Ophthalmology, Northwestern University School of Medicine, Chicago, Illinois 60611, USA
    Invest Ophthalmol Vis Sci 50:1895-902. 2009
    ..Young and old rodent RPE/choroid were compared to assess iron homeostasis during normal aging and the effects of increased iron on the functions of retinal pigment epithelial cells...
  16. pmc The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration
    Huiyi Chen
    Forsythe Laboratory for the Investigation of the Aging Retina, Department of Ophthalmology, Northwestern University School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 3:e2339. 2008
    ..A major focus of AMD research is the retinal pigment epithelium (RPE)/choroid. The purpose of this study was to characterize the changes in the RPE/choroid with age that may provide a background for the development of AMD...
  17. pmc Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related macular degeneration
    Ai Ling Wang
    Forsythe Laboratory for the Investigation of the Aging Retina, Department of Ophthalmology, Northwestern University School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 4:e5304. 2009
    ..These altered cell biological processes in the RPE may contribute to the formation of drusen in individuals who are cigarette smokers and underlie susceptibility to genetic mutations associated with AMD...
  18. ncbi request reprint Autophagy, exosomes and drusen formation in age-related macular degeneration
    Ai Ling Wang
    Forsythe Laboratory for the Investigation of the Aging Retina, Department of Ophthalmology, Northwestern University School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Autophagy 5:563-4. 2009
    ..Molecular and cellular changes in the old RPE may underlie susceptibility to genetic mutations that are found in AMD patients...
  19. ncbi request reprint Gender difference in levels of Cu/Zn superoxide dismutase (SOD1) in cerebrospinal fluid of patients with amyotrophic lateral sclerosis
    Katrin Frutiger
    Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Amyotroph Lateral Scler 9:184-7. 2008
    ..Further investigation of larger sample groups is needed to determine whether it is relevant to gender related differences in disease incidence...
  20. ncbi request reprint Peroxynitrite-mediated tau modifications stabilize preformed filaments and destabilize microtubules through distinct mechanisms
    Matthew R Reynolds
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Biochemistry 45:4314-26. 2006
    ..Moreover, assumption of the Alz-50 conformation may be the mechanism through which tau nitration modulates MT stability...
  21. pmc Using LC3 to monitor autophagy flux in the retinal pigment epithelium
    Ai Ling Wang
    Forsythe Laboratory for the Investigation of the Aging Retina, Department of Ophthalmology, Northwestern University School of Medicine, Chicago, IL, USA
    Autophagy 5:1190-3. 2009
    ..Autophagy plays a role in aging and age-related diseases. However, few studies of autophagy in retinal disease have been reported...
  22. pmc Increased mitochondrial DNA damage and down-regulation of DNA repair enzymes in aged rodent retinal pigment epithelium and choroid
    Ai Ling Wang
    Forsythe Laboratory for the Investigation of the Aging Retina, Department of Ophthalmology, Northwestern University School of Medicine, Chicago, IL
    Mol Vis 14:644-51. 2008
    ....
  23. pmc Tumor-suppressive maspin functions as a reactive oxygen species scavenger: importance of cysteine residues
    Nitin Mahajan
    Department of Molecular Pharmacology and Biological Chemistry and the Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 288:11611-20. 2013
    ..These findings establish a novel mechanism by which maspin utilizes its cysteine thiols to inhibit oxidative stress and cell growth...
  24. doi request reprint Selectivity in the post-translational, transglutaminase-dependent acylation of lysine residues
    S N Prasanna Murthy
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Biochemistry 48:2654-60. 2009
    ....
  25. ncbi request reprint Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS
    Senda Ajroud-Driss
    Davee Department of Neurology and Clinical Neurosciences, Northwestern University Institute of Neuroscience, Chicago, Illinois 60611, USA
    Amyotroph Lateral Scler 8:305-9. 2007
    ..In conclusion, genetic variations in CYP1A1 and CYP1A2 genes do not seem to influence riluzole levels. Further work is needed to better understand the genetic regulation of CYP1A enzymes and their role in riluzole metabolism...
  26. ncbi request reprint Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain
    Dmitry S Kudryashov
    Russian Cardiology Research Center, Moscow 121552, Russia
    Exp Cell Res 298:407-17. 2004
    ....