Donald M Lloyd-Jones

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint The impact of traditional risk factor development on the life course of cardiovascular diseases
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA
    Ethn Dis 22:S1-30-4. 2012
  2. ncbi request reprint Narrative review: Assessment of C-reactive protein in risk prediction for cardiovascular disease
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ann Intern Med 145:35-42. 2006
  3. pmc Risk factor burden in middle age and lifetime risks for cardiovascular and non-cardiovascular death (Chicago Heart Association Detection Project in Industry)
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Cardiol 99:535-40. 2007
  4. ncbi request reprint Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Ste 1102, Chicago, IL 60611, USA
    Circulation 115:1004-11. 2007
  5. pmc Association of electrocardiographic abnormalities with coronary artery calcium and carotid artery intima-media thickness in individuals without clinical coronary heart disease (from the Multi-Ethnic Study of Atherosclerosis [MESA])
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Cardiol 104:1086-91. 2009
  6. ncbi request reprint Short-term versus long-term risk for coronary artery disease: implications for lipid guidelines
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611, USA
    Curr Opin Lipidol 17:619-25. 2006
  7. ncbi request reprint Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Circulation 113:791-8. 2006
  8. ncbi request reprint Lifetime risk for development of atrial fibrillation: the Framingham Heart Study
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1102, Chicago, IL, 60611, USA
    Circulation 110:1042-6. 2004
  9. ncbi request reprint Ethnic variation in hypertension among premenopausal and perimenopausal women: Study of Women's Health Across the Nation
    Donald M Lloyd-Jones
    Division of Cardiology, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hypertension 46:689-95. 2005
  10. ncbi request reprint Novel approach to examining first cardiovascular events after hypertension onset
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Suite 1120, Chicago, IL 60611, USA
    Hypertension 45:39-45. 2005

Collaborators

Detail Information

Publications88

  1. ncbi request reprint The impact of traditional risk factor development on the life course of cardiovascular diseases
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA
    Ethn Dis 22:S1-30-4. 2012
    ..In this context, the agenda of the Jackson Heart Study should promote understanding of and identify means for enhancing the roles of CVD prevention and health promotion among African Americans...
  2. ncbi request reprint Narrative review: Assessment of C-reactive protein in risk prediction for cardiovascular disease
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ann Intern Med 145:35-42. 2006
    ..The authors propose that many questions still must be addressed before CRP is incorporated into risk prediction algorithms and before universal screening with CRP can be recommended...
  3. pmc Risk factor burden in middle age and lifetime risks for cardiovascular and non-cardiovascular death (Chicago Heart Association Detection Project in Industry)
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Cardiol 99:535-40. 2007
    ..These results should encourage efforts aimed at preventing the development of risk factors in younger subjects to decrease CVD mortality and promote longevity...
  4. ncbi request reprint Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Ste 1102, Chicago, IL 60611, USA
    Circulation 115:1004-11. 2007
    ..Data are sparse regarding the association of stable body mass index (BMI) over the long term with metabolic syndrome components in young adults...
  5. pmc Association of electrocardiographic abnormalities with coronary artery calcium and carotid artery intima-media thickness in individuals without clinical coronary heart disease (from the Multi-Ethnic Study of Atherosclerosis [MESA])
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Cardiol 104:1086-91. 2009
    ..Lack of association remained consistent when using log CAC and CC-IMT as continuous variables. In conclusion, ECG abnormalities are not associated with markers of subclinical atherosclerosis in a large multiethnic cohort...
  6. ncbi request reprint Short-term versus long-term risk for coronary artery disease: implications for lipid guidelines
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611, USA
    Curr Opin Lipidol 17:619-25. 2006
    ..The aim of this article is to describe recent advances in our understanding of lifetime risks for cardiovascular disease and their implications for lipid guidelines...
  7. ncbi request reprint Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Circulation 113:791-8. 2006
    ..Lifetime risk for atherosclerotic cardiovascular disease (CVD) has not previously been estimated, and the effect of risk factor burden on lifetime risk is unknown...
  8. ncbi request reprint Lifetime risk for development of atrial fibrillation: the Framingham Heart Study
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1102, Chicago, IL, 60611, USA
    Circulation 110:1042-6. 2004
    ..Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated...
  9. ncbi request reprint Ethnic variation in hypertension among premenopausal and perimenopausal women: Study of Women's Health Across the Nation
    Donald M Lloyd-Jones
    Division of Cardiology, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hypertension 46:689-95. 2005
    ..Treatment and control rates vary considerably across ethnicities. Greater efforts must be made to improve hypertension awareness, treatment, and control in all middle-aged women, particularly those in ethnic minority groups...
  10. ncbi request reprint Novel approach to examining first cardiovascular events after hypertension onset
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Suite 1120, Chicago, IL 60611, USA
    Hypertension 45:39-45. 2005
    ..These results represent a novel approach to understanding the complications of hypertension and may help target therapies for patients with new-onset hypertension to optimize prevention strategies...
  11. ncbi request reprint Hypertension in adults across the age spectrum: current outcomes and control in the community
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill 60611, USA
    JAMA 294:466-72. 2005
    ..Data are sparse regarding current rates of hypertension treatment and control, and risks associated with hypertension, among persons older than 80 years...
  12. pmc Natural history of the early repolarization pattern in a biracial cohort: CARDIA (Coronary Artery Risk Development in Young Adults) Study
    Joseph A Walsh
    Department of Medicine, Divisions of Cardiology and Electrophysiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Am Coll Cardiol 61:863-9. 2013
    ..The objective of this analysis was to determine the natural history and prospective association of cardiovascular risk factors with early repolarization (ER)...
  13. pmc Lifetime risk for heart failure among white and black Americans: cardiovascular lifetime risk pooling project
    Mark D Huffman
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Am Coll Cardiol 61:1510-7. 2013
    ..This study sought to estimate lifetime risk for heart failure (HF) by sex and race...
  14. pmc Prevalence, prospective risk markers, and prognosis associated with the presence of left ventricular diastolic dysfunction in young adults: the coronary artery risk development in young adults study
    Chintan S Desai
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Epidemiol 177:20-32. 2013
    ..Diastolic dysfunction in young adults is associated with increased morbidity and mortality, and the identification of prospective risk markers associated with diastolic dysfunction could allow for targeted primary prevention efforts...
  15. pmc Chicago Healthy Aging Study: objectives and design
    Amber Pirzada
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Am J Epidemiol 178:635-44. 2013
    ....
  16. pmc Prediction of coronary artery calcium progression in individuals with low Framingham Risk Score: the Multi-Ethnic Study of Atherosclerosis
    Tochi M Okwuosa
    Wayne State University School of Medicine, Division of Cardiology, Detroit, Michigan, USA
    JACC Cardiovasc Imaging 5:144-53. 2012
    ..This study sought to determine whether novel markers not involving ionizing radiation could predict coronary artery calcium (CAC) progression in a low-risk population...
  17. pmc Prospective relationship of low cardiovascular risk factor profile at younger ages to ankle-brachial index: 39-year follow-up--the Chicago Healthy Aging Study
    Thanh Huyen T Vu
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Am Heart Assoc 1:e001545. 2012
    ..Data are sparse regarding the long-term association of favorable levels of all major cardiovascular disease risk factors (RFs) (ie, low risk [LR]) with ankle-brachial index (ABI)...
  18. ncbi request reprint Favorable cardiovascular risk profile in young women and long-term risk of cardiovascular and all-cause mortality
    Martha L Daviglus
    Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Ill 60611, USA
    JAMA 292:1588-92. 2004
    ..For women, impact of cardiovascular risk factors measured in young adulthood, particularly favorable (low-risk) profile, on mortality has been difficult to assess due to low short-term death rates...
  19. pmc Association of QRS duration with left ventricular structure and function and risk of heart failure in middle-aged and older adults: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Leonard Ilkhanoff
    Department of Medicine, Division of Cardiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Eur J Heart Fail 14:1285-92. 2012
    ..We sought to determine whether QRSd is associated with incident HF and measures of cardiac structure and function by cardiac MRI...
  20. pmc Incident obesity and cardiovascular risk factors between young adulthood and middle age by religious involvement: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Matthew Feinstein
    Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Prev Med 54:117-21. 2012
    ..No longitudinal study of young adults has examined the prospective association of religious involvement with incident cardiovascular risk factors (RFs) and subclinical disease (subCVD)...
  21. pmc Competing cardiovascular outcomes associated with subclinical atherosclerosis (from the Multi-Ethnic Study of Atherosclerosis)
    Chintan S Desai
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Cardiol 111:1541-6. 2013
    ....
  22. pmc Racial differences in risks for first cardiovascular events and noncardiovascular death: the Atherosclerosis Risk in Communities study, the Cardiovascular Health Study, and the Multi-Ethnic Study of Atherosclerosis
    Matthew Feinstein
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Dr, Suite 1400, Chicago, IL 60611, USA
    Circulation 126:50-9. 2012
    ..No studies have compared first cardiovascular disease (CVD) events and non-CVD death between races in a competing risks framework, which examines risks for numerous events simultaneously...
  23. pmc Gene expression variation between African Americans and whites is associated with coronary artery calcification: the multiethnic study of atherosclerosis
    Chiang Ching Huang
    Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA
    Physiol Genomics 43:836-43. 2011
    ..Our data suggest a connection between immune response and vascular calcification and the result provides a potential mechanistic explanation for the lower prevalence and severity of CAC in African Americans compared with whites...
  24. pmc Prognostic value of frontal QRS-T angle in patients without clinical evidence of cardiovascular disease (from the Multi-Ethnic Study of Atherosclerosis)
    Joseph A Walsh
    Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
    Am J Cardiol 112:1880-4. 2013
    ..QRS-T angle provides an easily interpretable continuous marker of abnormal ventricular repolarization that can aid the everyday clinician in risk prediction. ..
  25. doi request reprint Trends in vascular risk factor treatment and control in US stroke survivors: the National Health and Nutrition Examination Surveys (1999-2010)
    Nilay S Shah
    Northwestern University Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL 60611, USA
    Circ Cardiovasc Qual Outcomes 6:270-7. 2013
    ..Treatment and control of vascular risk factors reduce the likelihood of recurrent stroke. Present nationally representative data are sparse regarding secondary prevention treatment and control rates...
  26. ncbi request reprint Clinical significance of minor nonspecific ST-segment and T-wave abnormalities in asymptomatic subjects: a systematic review
    Anita Kumar
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cardiol Rev 15:133-42. 2007
    ....
  27. pmc Associations of noninvasive measures of arterial compliance and ankle-brachial index: the Multi-Ethnic Study of Atherosclerosis (MESA)
    John T Wilkins
    The Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Hypertens 25:535-41. 2012
    ..Early changes in arterial wall compliance could be a useful marker of patients at high risk for developing lower extremity atherosclerosis...
  28. pmc Lifetime risks of cardiovascular disease
    Jarett D Berry
    University of Texas Southwestern Medical Center, Department of Medicine, Division of Cardiology, Dallas, USA
    N Engl J Med 366:321-9. 2012
    ..The lifetime risks of cardiovascular disease have not been reported across the age spectrum in black adults and white adults...
  29. pmc Distribution of 10-year and lifetime predicted risks for cardiovascular disease in US adults: findings from the National Health and Nutrition Examination Survey 2003 to 2006
    Amanda K Marma
    Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Circ Cardiovasc Qual Outcomes 3:8-14. 2010
    ....
  30. pmc Effects of respiratory motion on coronary wall MR imaging: a quantitative study of older adults
    Kai Lin
    Department of Radiology, Northwestern University, 737 N Michigan Avenue, Suite 1600, Chicago, IL 60611, USA
    Int J Cardiovasc Imaging 29:1069-76. 2013
    ..The stability of respiratory motion significantly influences the image quality of 2D, free-breathing, black-blood coronary wall MR imaging...
  31. doi request reprint White blood cell count in young adulthood and coronary artery calcification in early middle age: coronary artery risk development in young adults (CARDIA) study
    Lifang Hou
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr suite 1400, Chicago, IL, 60611, USA
    Eur J Epidemiol 28:735-42. 2013
    ..Results are attenuated when other risk factors are accounted for. Our results suggest the possible early involvement of WBC, particularly eosinophils, in the early stages of atherosclerosis...
  32. pmc Quantifying options for reducing coronary heart disease mortality by 2020
    Mark D Huffman
    Northwestern University Feinberg School of Medicine, Department of Preventive Medicine, 680 N Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA
    Circulation 127:2477-84. 2013
    ..The American Heart Association (AHA) 2020 Strategic Impact Goal proposes a 20% improvement in cardiovascular health of all Americans. We aimed to estimate the potential reduction in coronary heart disease (CHD) deaths...
  33. pmc Framingham risk score and prediction of coronary heart disease death in young men
    Jarett D Berry
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Am Heart J 154:80-6. 2007
    ..Although prediction with individual risk factors has been tested in individuals <30 years, current multivariate risk prediction strategies have not been applied to prediction of clinical CHD in this age range...
  34. pmc Yield of screening for coronary artery calcium in early middle-age adults based on the 10-year Framingham Risk Score: the CARDIA study
    Tochi M Okwuosa
    Division of Cardiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    JACC Cardiovasc Imaging 5:923-30. 2012
    ....
  35. pmc Distribution of coronary artery calcium scores by Framingham 10-year risk strata in the MESA (Multi-Ethnic Study of Atherosclerosis) potential implications for coronary risk assessment
    Tochi M Okwuosa
    Division of Cardiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Am Coll Cardiol 57:1838-45. 2011
    ....
  36. pmc Lifetime risk and years lived free of total cardiovascular disease
    John T Wilkins
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    JAMA 308:1795-801. 2012
    ..To date, no lifetime risk estimates of total CVD have been reported...
  37. pmc Impact of blood pressure and blood pressure change during middle age on the remaining lifetime risk for cardiovascular disease: the cardiovascular lifetime risk pooling project
    NORRINA ALLEN
    Department of Preventive Medicine and Division of Cardiology, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Ste 1102, Chicago, IL 60611, USA
    Circulation 125:37-44. 2012
    ..We examined how changes in BP during middle age affect LTR for CVD, coronary heart disease, and stroke...
  38. ncbi request reprint Framingham risk score and prediction of lifetime risk for coronary heart disease
    Donald M Lloyd-Jones
    Department of Preventive Medicine and Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
    Am J Cardiol 94:20-4. 2004
    ..Further work is needed to generate multivariate risk models that can reliably predict lifetime risk for CHD...
  39. pmc Prevalence of electrocardiographic abnormalities in a middle-aged, biracial population: Coronary Artery Risk Development in Young Adults study
    Joseph A Walsh
    Department of Preventive Medicine and Bluhm Cardiovascular Institute, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Electrocardiol 43:385.e1-9. 2010
    ..Few studies to date have described the prevalence of electrocardiographic (ECG) abnormalities in a biracial middle-aged cohort...
  40. ncbi request reprint Associations of dietary fiber intake with long-term predicted cardiovascular disease risk and C-reactive protein levels (from the National Health and Nutrition Examination Survey Data [2005-2010])
    Hongyan Ning
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
    Am J Cardiol 113:287-91. 2014
    ..A greater amount of dietary fiber intake might be associated with lower C-reactive protein levels. ..
  41. ncbi request reprint Association of traditional risk factors with cardiovascular death across 0 to 10, 10 to 20, and >20 years follow-up in men and women
    Jarett D Berry
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Cardiol 101:89-94. 2008
    ..In women, the increased risk associated with both diabetes mellitus and smoking was most prominent in the early follow-up periods...
  42. pmc Factors associated with presence and extent of coronary calcium in those predicted to be at low risk according to Framingham risk score (from the Multi-Ethnic Study of Atherosclerosis)
    Tochi M Okwuosa
    Division of Cardiology, Wayne State University School of Medicine, Detroit, MI, USA
    Am J Cardiol 107:879-85. 2011
    ....
  43. ncbi request reprint Cardiovascular health behavior and health factor changes (1988-2008) and projections to 2020: results from the National Health and Nutrition Examination Surveys
    Mark D Huffman
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Circulation 125:2595-602. 2012
    ..We sought to define current trends and forward projections to 2020 in cardiovascular health...
  44. pmc Healthy lifestyle through young adulthood and the presence of low cardiovascular disease risk profile in middle age: the Coronary Artery Risk Development in (Young) Adults (CARDIA) study
    Kiang Liu
    Department of Preventive Medicine, Feinberg School of Medicine, 680 N Lake Shore Dr, Ste 1400, Chicago, IL 60611, USA
    Circulation 125:996-1004. 2012
    ..We examined whether adopting a healthy lifestyle throughout young adulthood is associated with the presence of the low cardiovascular disease risk profile in middle age...
  45. pmc Competing cardiovascular outcomes associated with electrocardiographic left ventricular hypertrophy: the Atherosclerosis Risk in Communities Study
    Chintan S Desai
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1402, Chicago, IL 60611, USA
    Heart 98:330-4. 2012
    ..The study sought to characterise the competing incidences for subtypes of first CVD events or non-CVD death in those with and without ECG LVH...
  46. doi request reprint Multimarker prediction of coronary heart disease risk: the Women's Health Initiative
    Hyeon Chang Kim
    Department of Preventive Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Am Coll Cardiol 55:2080-91. 2010
    ..The aim of this study was to investigate whether multiple biomarkers contribute to improved coronary heart disease (CHD) risk prediction in post-menopausal women compared with assessment using traditional risk factors (TRFs) only...
  47. ncbi request reprint Predictive utility of pulse pressure and other blood pressure measures for cardiovascular outcomes
    William J Mosley
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago
    Hypertension 49:1256-64. 2007
    ..These findings support the approach of current guidelines in the use of systolic and diastolic blood pressure to assess risk and the need for treatment...
  48. ncbi request reprint Social avoidance and long-term risk for cardiovascular disease death in healthy men: the Western Electric study
    Jarett D Berry
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Ann Epidemiol 17:591-6. 2007
    ..Data are sparse on the "social avoidance" (SA) subscale that measures more indirectly negative traits such as shyness. Thus, we sought to examine the association between SA and CVD, coronary heart disease (CHD), and non-CVD death...
  49. pmc Association of electrocardiographically determined left ventricular mass with incident diabetes, 1985-1986 to 2010-2011: Coronary Artery Risk Development in Young Adults (CARDIA) study
    Mercedes R Carnethon
    Department of Preventive Medicine, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA
    Diabetes Care 36:645-7. 2013
    ..We tested whether electrocardiographically determined left ventricular mass was positively associated with incident diabetes in a population sample...
  50. pmc Lifetime risk for cancer death by sex and smoking status: the lifetime risk pooling project
    Andrew Gawron
    Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Suite 1400, Chicago, IL 60611, USA
    Cancer Causes Control 23:1729-37. 2012
    ..Understanding how sex and tobacco exposure may modify lifetime risks for cancer mortality is important for effective communication of risk in targeted public health messages...
  51. pmc Potential quantitative magnetic resonance imaging biomarkers of coronary remodeling in older hypertensive patients
    Kai Lin
    Department of Radiology, Northwestern University, Chicago, IL 60611, USA
    Arterioscler Thromb Vasc Biol 32:1742-7. 2012
    ..To detect differences in potential magnetic resonance imaging biomarkers of coronary remodeling between older hypertensive patients and healthy controls...
  52. ncbi request reprint Clinical Characteristics and Outcomes Associated With the Natural History of Early Repolarization in a Young, Biracial Cohort Followed to Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Leonard Ilkhanoff
    From the Division of Cardiology, Section of Electrophysiology L I, Division of Cardiology, Department of Medicine J A W, D M L J, and Department of Preventive Medicine H N, K L, D M L J, Northwestern University, Chicago, IL Department of Epidemiology and Prevention and Department of Internal Medicine, Epidemiological Cardiology Research Center EPICARE E Z S, Department of Epidemiology, Division of Public Health Sciences R J P, and Department of Radiology J J C, Wake Forest University School of Medicine, Winston Salem, NC and Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN D R J
    Circ Arrhythm Electrophysiol 7:392-9. 2014
    ..Early repolarization (ER), a common electrocardiographic phenotype, has been associated with increased mortality risk in middle-aged adults. Data are sparse on long-term follow-up and outcomes associated with ER in younger adults...
  53. pmc Electronic health record-based patient identification and individualized mailed outreach for primary cardiovascular disease prevention: a cluster randomized trial
    Stephen D Persell
    Division of General Internal Medicine and Geriatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    J Gen Intern Med 28:554-60. 2013
    ..Many individuals at higher risk for cardiovascular disease (CVD) do not receive recommended treatments. Prior interventions using personalized risk information to promote prevention did not test clinic-wide effectiveness...
  54. ncbi request reprint Comparison of long-term mortality across the spectrum of acute coronary syndromes
    Larry A Allen
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am Heart J 151:1065-71. 2006
    ..Data are sparse regarding comparative long-term mortality across the spectrum of patients presenting with acute coronary syndrome (ACS)...
  55. pmc Multiple behavior changes in diet and activity: a randomized controlled trial using mobile technology
    Bonnie Spring
    Department of Preventive Medicine, Northwestern University, 680 N Lake Shore Drive, Chicago, IL 60611, USA
    Arch Intern Med 172:789-96. 2012
    ..Many patients exhibit multiple chronic disease risk behaviors. Research provides little information about advice that can maximize simultaneous health behavior changes...
  56. ncbi request reprint National Cholesterol Education Program risk assessment and potential for risk misclassification
    Stephen D Persell
    Division of General Internal Medicine, Northwestern University, 676 N St Clair Street, Suite 200, Chicago, IL 60611 2927, USA
    Prev Med 43:368-71. 2006
    ..We aimed to determine who would be falsely classified as low risk using this approach...
  57. ncbi request reprint Comparison of risk factors for cardiovascular mortality in black and white adults
    Mercedes R Carnethon
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill 60611, USA
    Arch Intern Med 166:1196-202. 2006
    ..We investigated whether traditional cardiovascular disease (CVD) risk factors were similarly associated with CVD mortality in black and white men and women...
  58. doi request reprint Coronary heart disease risks associated with high levels of HDL cholesterol
    John T Wilkins
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL
    J Am Heart Assoc 3:e000519. 2014
    ..The association between high-density lipoprotein cholesterol (HDL-C) and coronary heart disease (CHD) events is not well described in individuals with very high levels of HDL-C (>80 mg/dL)...
  59. doi request reprint Association of isolated minor non-specific ST-segment and T-wave abnormalities with subclinical atherosclerosis in a middle-aged, biracial population: coronary Artery Risk Development in Young Adults (CARDIA) study
    Joseph A Walsh
    Bluhm Cardiovascular Institute, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA
    Eur J Prev Cardiol 20:1035-41. 2013
    ..The association of NSSTTA with subclinical atherosclerosis is not well defined, but has been postulated as a potential mechanism of association with future clinical events...
  60. ncbi request reprint Epidemiology of hypertension in the elderly
    William J Mosley
    Department of Medicine, The Bluhm Cardiovascular Institute, Feinberg School Medicine, Northwestern University, 711 Austin St 202, Evanston, IL 60202, USA
    Clin Geriatr Med 25:179-89. 2009
    ..The author's findings both justify and encourage antihypertensive treatment in all hypertensive adults...
  61. ncbi request reprint Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring
    Donald M Lloyd-Jones
    Department of Preventive Medicine and Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
    JAMA 291:2204-11. 2004
    ..Whether parental cardiovascular disease confers increased risk independent of other risk factors remains controversial. Prior studies relied on offspring report, without complete validation of parental events...
  62. pmc Prevalence, prognosis, and implications of isolated minor nonspecific ST-segment and T-wave abnormalities in older adults: Cardiovascular Health Study
    Anita Kumar
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Dr, Suite 1102, Chicago, IL 60611, USA
    Circulation 118:2790-6. 2008
    ..The prevalence and prognostic significance of isolated minor nonspecific ST-segment and T-wave abnormalities (NSSTTAs) in older adults are poorly understood...
  63. doi request reprint Adding a life-course perspective to cardiovascular-risk communication
    Kunal N Karmali
    Department of Medicine Cardiology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 600, Chicago, IL 60611, USA
    Nat Rev Cardiol 10:111-5. 2013
    ....
  64. pmc Dietary fish intake and incident atrial fibrillation (from the Women's Health Initiative)
    Jarett D Berry
    Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical School, Dallas, Texas, USA
    Am J Cardiol 105:844-8. 2010
    ..Similar findings were observed in the multivariate models and in the subgroup analyses. In conclusion, in a large cohort of healthy women, we found no evidence of an association between fish or omega-3 fatty acid intake and incident AF...
  65. pmc Lifetime risks for cardiovascular disease mortality by cardiorespiratory fitness levels measured at ages 45, 55, and 65 years in men. The Cooper Center Longitudinal Study
    Jarett D Berry
    Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9047, USA
    J Am Coll Cardiol 57:1604-10. 2011
    ..The purpose of this study was to determine the association between fitness and lifetime risk for cardiovascular disease (CVD)...
  66. pmc Implications of changing national cholesterol education program goals for the treatment and control of hypercholesterolemia
    Stephen D Persell
    Division of General Internal Medicine, Department of Medicine, and the Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2927, USA
    J Gen Intern Med 21:171-6. 2006
    ..Modifications to the National Cholesterol Education Program (NCEP) guidelines lowered optional low-density lipoprotein cholesterol (LDL-C) treatment goals...
  67. doi request reprint Are novel serum biomarkers informative?
    John T Wilkins
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Med Clin North Am 96:1-11. 2012
    ..Continued basic science and population-based research into CHD biomarkers may help to further the capacity for CHD risk assessment...
  68. pmc The association of heart rate recovery immediately after exercise with coronary artery calcium: the coronary artery risk development in young adults study
    Mohammad Ali Kizilbash
    Dept of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Clin Auton Res 17:46-9. 2007
    ..99, p = 0.91 per standard deviation change in HRR). Slow HRR in young adulthood is not associated with the presence of CAC at middle age...
  69. pmc Burden of cardiovascular risk factors, subclinical atherosclerosis, and incident cardiovascular events across dimensions of religiosity: The multi-ethnic study of atherosclerosis
    Matthew Feinstein
    Department of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA
    Circulation 121:659-66. 2010
    ....
  70. pmc Factors associated with development of prolonged QRS duration over 20 years in healthy young adults: the Coronary Artery Risk Development in Young Adults study
    Leonard Ilkhanoff
    Department of Medicine, Division of Cardiology, Section of Electrophysiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Electrocardiol 45:178-84. 2012
    ..Data describing factors associated with the development of a prolonged QRS duration (QRSd) from young adulthood to middle age are sparse...
  71. pmc Potential use of 10-year and lifetime coronary risk information for preventive cardiology prescribing decisions: a primary care physician survey
    Stephen D Persell
    Northwestern University, Chicago, IL 60611, USA
    Arch Intern Med 170:470-7. 2010
    ..Data are sparse regarding how physicians use coronary risk information for prescribing decisions...
  72. ncbi request reprint Major and minor ECG abnormalities in asymptomatic women and risk of cardiovascular events and mortality
    Pablo Denes
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Ill 60611, USA
    JAMA 297:978-85. 2007
    ..There is no information on the effect, if any, of hormonal treatment on the prognostic value of the ECG...
  73. doi request reprint Reference values of right ventricular end-diastolic area defined by ethnicity and gender in a young adult population: the CARDIA study
    Kofo O Ogunyankin
    Division of Cardiology Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Echocardiography 28:142-9. 2011
    ..Therefore, we derived gender-based normative values for echocardiographic measurements of RVED area, in a large bi-racial cohort of young adults...
  74. doi request reprint Coronary artery calcium testing: dos and don'ts
    Tamar S Polonsky
    Section of Cardiology, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 6080, Chicago, IL 60637, USA
    Cardiol Clin 30:49-55. 2012
    ..The authors have outlined several principles of CAC testing into a list of dos and don'ts to help maximize its potential benefit while minimizing potential harm...
  75. ncbi request reprint The association of Framingham and Reynolds risk scores with incidence and progression of coronary artery calcification in MESA (Multi-Ethnic Study of Atherosclerosis)
    Andrew P DeFilippis
    Division of Cardiology, University of Louisville, Rudd Heart and Lung Center, Louisville, Kentucky, USA
    J Am Coll Cardiol 58:2076-83. 2011
    ..The purpose of this study was to compare the association of the Framingham risk score (FRS) and Reynolds risk score (RRS) with subclinical atherosclerosis, assessed by incidence and progression of coronary artery calcium (CAC)...
  76. pmc Association of number of live births with left ventricular structure and function. The Multi-Ethnic Study of Atherosclerosis (MESA)
    Nisha I Parikh
    Division of Cardiology, Queens Medical Center and John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Am Heart J 163:470-6. 2012
    ..Pregnancy is associated with marked maternal cardiovascular/hemodynamic changes. A greater number of pregnancies may be associated with long-term subclinical changes in left ventricular (LV) remodeling...
  77. doi request reprint Heart failure in women: epidemiology, biology and treatment
    Rashmee U Shah
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Womens Health (Lond Engl) 5:517-27. 2009
    ..Focused research is needed to understand and guide the management of women with heart failure...
  78. pmc Activated TLR signaling in atherosclerosis among women with lower Framingham risk score: the multi-ethnic study of atherosclerosis
    Chiang Ching Huang
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 6:e21067. 2011
    ....
  79. doi request reprint Biomarkers for coronary heart disease clinical risk prediction: a critical appraisal. Counterpoint
    John T Wilkins
    Departments of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Prev Cardiol 13:160-5. 2010
    ..The following articles include points from the debate, rebuttal, and questions raised by the audience. We thank all authors for sharing this debate with the readership...
  80. ncbi request reprint Systematic examination of the updated Framingham heart study general cardiovascular risk profile
    Amanda K Marma
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Dr, Suite 1102, Chicago, IL 60611, USA
    Circulation 120:384-90. 2009
    ..An updated Framingham risk prediction tool was recently published. It features an expanded end point of general cardiovascular disease and a "vascular age" risk communication analogy...
  81. pmc Genetic variability of smoking persistence in African Americans
    Ajna Hamidovic
    Department of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA
    Cancer Prev Res (Phila) 4:729-34. 2011
    ....
  82. ncbi request reprint Preventing cardiovascular disease in the 21st century: therapeutic and preventive implications of current evidence
    Martha L Daviglus
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Cardiovasc Drugs 6:87-101. 2006
    ..Public health policies must focus on prevention of all major risk factors simultaneously, using lifestyle approaches from early ages onwards to reduce population CVD risk to endemic levels, rather than current epidemic levels...
  83. ncbi request reprint Increased complication rates of cardiac rhythm management devices in ESRD patients
    Arijit Dasgupta
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Am J Kidney Dis 49:656-63. 2007
    ..The purpose of this study is to compare the incidence of complications after cardiac rhythm management device (CRMD) implantation in patients with and without ESRD...
  84. pmc Noninvasive evaluation of coronary distensibility in older adults: a feasibility study with MR angiography
    Kai Lin
    Department of Radiology, Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611, USA
    Radiology 261:771-8. 2011
    ..To assess the feasibility of using magnetic resonance (MR) angiography to noninvasively measure the coronary distensibility index (CDI) in older adults...
  85. doi request reprint Electronic health record-based cardiac risk assessment and identification of unmet preventive needs
    Stephen D Persell
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Med Care 47:418-24. 2009
    ..We compared EHR-based assessment with manual chart review to determine the accuracy of automated cardiac risk estimation and determination of candidates for antiplatelet or lipid-lowering interventions...
  86. pmc Longitudinal association of PCSK9 sequence variations with low-density lipoprotein cholesterol levels: the Coronary Artery Risk Development in Young Adults Study
    Chiang Ching Huang
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Circ Cardiovasc Genet 2:354-61. 2009
    ..Mutations of PCSK9 are associated cross-sectionally with plasma low-density lipoprotein cholesterol (LDL-C) levels, but little is known about their longitudinal association with LDL-C levels from young adulthood to middle age...
  87. doi request reprint The role of biomarkers and genetics in peripheral arterial disease
    Mary M McDermott
    Department of Medicine and Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Am Coll Cardiol 54:1228-37. 2009
    ..However, a genetic marker for PAD has not been identified...
  88. pmc Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
    Nona Sotoodehnia
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Nat Genet 42:1068-76. 2010
    ..These findings extend our current knowledge of ventricular depolarization and conduction...

Research Grants7

  1. Lifetime Risk of Cardiovascular Disease
    Donald Lloyd Jones; Fiscal Year: 2003
    ..abstract_text> ..
  2. Epidemiologic Study of Ethnicity and Lifetime Risks for Cardiovascular Disease
    Donald Lloyd Jones; Fiscal Year: 2007
    ..This application represents a novel approach to analyzing existing data that is likely to yield substantial new insights into the epidemiology of CVD among non-white ethnic groups. ..
  3. Epidemiology and Mechanisms of ECG Abnormalities: Young Adulthood to Middle Age
    Donald Lloyd Jones; Fiscal Year: 2007
    ....
  4. Chicago Healthy Aging Low Risk MRI Angiography (CHARISMA) Study
    Donald Lloyd Jones; Fiscal Year: 2009
    ..This research will fill critical gaps in our knowledge of the long-term consequences of low risk status, which may ultimately lead to improvements in public health and preventive strategies. ..
  5. Epidemiology and Mechanisms of ECG Abnormalities: Young Adulthood to Middle Age
    Donald Lloyd Jones; Fiscal Year: 2009
    ....
  6. Chicago Healthy Aging Low Risk MRI Angiography (CHARISMA) Study
    DONALD M contact LLOYD JONES; Fiscal Year: 2010
    ..This research will fill critical gaps in our knowledge of the long-term consequences of low risk status, which may ultimately lead to improvements in public health and preventive strategies. ..