Research Topics
| J LevitskySummaryAffiliation: Northwestern University Country: USA Publications
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Publications
Operational tolerance: past lessons and future prospectsJosh Levitsky
Division of Hepatology and Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Liver Transpl 17:222-32. 2011....
Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipientsJosh Levitsky
Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Hepatology 57:239-48. 2013..CONCLUSIONS: TAC to SRL conversion increases systemic Tregs, DCregs, and immunoregulatory proteogenomic signatures in liver transplant recipients and may therefore facilitate IS minimization or withdrawal...- Meeting report of the International Liver Transplantation Society's 18th annual international congress: Hilton San Francisco Hotel, San Francisco, CA, May 16-19, 2012Josh Levitsky
Division of Gastroenterology and Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Liver Transpl 19:27-35. 2013..As always, the new data herein are presented in the context of the published literature to further enhance knowledge in the field... - Risk for immune-mediated graft dysfunction in liver transplant recipients with recurrent HCV infection treated with pegylated interferonJosh Levitsky
Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, Chicago, Illinois 60611, USA
Gastroenterology 142:1132-1139.e1. 2012..Patients with recurrent hepatitis C virus infection treated with pegylated interferon (PEG) after liver transplantation can develop severe immune-mediated graft dysfunction (IGD) characterized by plasma cell hepatitis or rejection... - Meeting report of the 2011 Joint International Congress of the International Liver Transplantation Society, the European Liver and Intestine Transplant Association, and the Liver Intensive Care Group of EuropeJosh Levitsky
Division of Gastroenterology and Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Chicago, IL 60611, USA
Liver Transpl 18:282-9. 2012..It is not meant to be a critical or comprehensive evaluation of all the meeting presentations and is merely intended to highlight presentations and associated published literature dealing with key topics... - Alemtuzumab induction in non-hepatitis C positive liver transplant recipientsJosh Levitsky
Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Liver Transpl 17:32-7. 2011..In conclusion, a steroid-free AL induction regimen was associated with less hypertension and rejection but with more infectious complications; thus, the overall benefit of AL induction in LT recipients is called into question... 
A survey of CMV prevention strategies after liver transplantationJ Levitsky
Department of Medicine, Division of Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Am J Transplant 8:158-61. 2008..In conclusion, the majority of LT centers utilize CMV prophylaxis over other strategies. Valganciclovir is the most commonly used agent for both antiviral prophylaxis and treatment of CMV viremia in the preemptive approach...- Immunoregulatory profiles in liver transplant recipients on different immunosuppressive agentsJosh Levitsky
Division of Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Hum Immunol 70:146-50. 2009..However, TAC patients may have other regulatory characteristics, supporting the need for larger, prospective studies to clarify differences... - Allospecific regulatory effects of sirolimus and tacrolimus in the human mixed lymphocyte reactionJosh Levitsky
Division of Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Transplantation 91:199-206. 2011.... - Detection and diagnosis of herpes simplex virus infection in adults with acute liver failureJosh Levitsky
Northwestern Memorial Hospital Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Liver Transpl 14:1498-504. 2008.... - Hepatic complications of hematopoietic cell transplantationJosh Levitsky
Department of Medicine, Division of Hepatology, Northwestern University Feinberg School of Medicine, 675 N St Clair, 15 250, Chicago, IL 60611, USA
Curr Gastroenterol Rep 9:60-5. 2007..Because treatments are directed at the underlying etiology of liver disease, prompt diagnosis by means of laboratory tests, hepatic imaging, and often liver biopsy is required after HCT... - The liver transplant recipient: what you need to know for long-term careJosh Levitsky
Hepatology Division, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, 675 North St Clair Street, Chicago, IL 60611, USA
J Fam Pract 55:136-44. 2006..Patients should wait at least 2 years before considering pregnancy and use barrier-type methods in this period. Vaccinate patients against hepatitis A and B, influenza, and pneumococcus. Avoid live vaccines... - Next level of immunosuppression: drug/immune monitoringJosh Levitsky
Division of Hepatology and Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Liver Transpl 17:S60-5. 2011..6. Future immune monitoring assays should be focused on genomic or immunological predispositions and on specific reactivities to donor antigens to guide the appropriate dosing and minimization of IS after LT... - Clinical and plasma proteomic markers correlating with chronic kidney disease after liver transplantationJ Levitsky
Comprehensive Transplant Center Division of Hepatology, Northwestern University, Chicago, IL, USA
Am J Transplant 11:1972-8. 2011..These preliminary results are currently being validated in a prospective, multicenter study to determine if this signature precedes the onset of CKD and resolves with early interventions aimed at preserving kidney function... - Factors associated with sustained virological response in liver transplant recipients with recurrent hepatitis CA A Pillai
Department of Transplant Surgery and Hepatology, Northwestern Memorial Hospital, and Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Transplant Proc 42:3647-51. 2010..Antiviral therapy has achieved sustained virological response (SVR) in less than one third of orthotopic liver transplantation (OLT) patients with recurrent hepatitis C... - Acid-base and potassium disorders in liver diseaseShubhada N Ahya
Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Semin Nephrol 26:466-70. 2006..Potassium disorders are often the result of the therapies used to treat advanced liver disease... - Posttransplant hyperglycemia is associated with increased risk of liver allograft rejectionAmisha Wallia
Division of Endocrinology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Transplantation 89:222-6. 2010..Intensive glycemic control has been shown to positively impact outcomes in an intensive care setting. Whether this practice is beneficial after liver transplantation (LT) is not known... - Outcomes and native renal recovery following simultaneous liver-kidney transplantationJ Levitsky
Comprehensive Transplant Center, Northwestern University, Chicago, IL Division of Gastroenterology and Hepatology, Northwestern University, Chicago, IL Division of Nephrology, Northwestern University, Chicago, IL Preventive Medicine, Northwestern University, Chicago, IL Department of Radiology, Northwestern University, Chicago, IL Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA
Am J Transplant 12:2949-57. 2012..85, CI 1.22-12.5). Our data support the need to refine SLK selection utilizing more definitive biomarkers and predictors of native renal recovery than current clinical criteria... - American Association for the Study of Liver Diseases--53rd Annual Meeting. 1-5 November 2002, Boston, MA, USAJosh Levitsky
Gastroenterology Division, University of Chicago Hospitals, 5842 South Maryland Avenue, Chicago, IL 60637, USA
IDrugs 6:30-3. 2003 - Evaluation of the coagulation and inflammatory responses in solid organ transplant recipients and donorsJosh Levitsky
Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Clin Transplant 23:943-50. 2009..This activation diminishes over time unless transplant complications occur. Our results support further research in approaches to altering these cascades in SOT recipients... - A non-induction renal sparing approach after liver transplantation: high dose mycophenolate mofetil with delayed, low-dose tacrolimusV Rao
Department of Internal Medicine, Loyola University Medical Center, Chicago, Illinois, USA
Transplant Proc 45:320-2. 2013.... - The human "Treg MLR": immune monitoring for FOXP3+ T regulatory cell generationJosh Levitsky
Division of Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Transplantation 88:1303-11. 2009..Controversy exists about the conditions effecting the development of forkhead/winghead helix transcription factor P3 (FOXP3) expressing T cells and their relevance in transplant recipients... - Outcomes of patients with hepatitis C undergoing simultaneous liver-kidney transplantationLisa B Van Wagner
Division of Hepatology, Medicine Northwestern University, Chicago, IL, USA
J Hepatol 51:874-80. 2009..The number of simultaneous liver-kidney transplants (SLK) has increased since the MELD era. Data on short- and long-term outcomes of hepatitis C virus positive (HCV+) SLK compared to HCV+ liver transplant alone (LTA) recipients are limited... - Herpes simplex virus hepatitis: an analysis of the published literature and institutional casesJohn P Norvell
Department of Internal Medicine, Division of Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Liver Transpl 13:1428-34. 2007..Based on the frequent delay in HSV diagnosis, low risk-benefit ratio, and significantly improved outcomes, empiric acyclovir therapy for patients presenting with ALF of unknown etiology is recommended until HSV hepatitis is excluded... - The safety and outcome of joint replacement surgery in liver transplant recipientsJosh Levitsky
Center for Liver Diseases, Gastroenterology Division, University of Chicago Hospitals, IL, USA
Liver Transpl 9:373-6. 2003..Our study suggests that joint replacement surgery may be safely and successfully performed in this population, although larger, randomized, prospective trials are needed to confirm our findings... - Operative risk of total hip and knee arthroplasty in cirrhotic patientsStanley Martin Cohen
University of Chicago, Division of Gastroenterology, Liver Study Unit, Chicago, IL, USA
J Arthroplasty 20:460-6. 2005..However, emergent THA to repair fractures in cirrhotic patients is associated with significantly increased morbidity and mortality... - Chicken pox after pediatric liver transplantationJosh Levitsky
Department of Medicine, Division of Hepatology, Northwestern Memorial Hospital, Feinberg School of Medicine, Chicago, IL, USA
Liver Transpl 11:1563-6. 2005..No risk factors were identified. Some cases required prolonged hospitalizations. Close monitoring for the development of late bacterial infections is warranted... - Cytomegalovirus viremia in solid organ transplantation: does the initial viral load correlate with risk factors and outcomes?Josh Levitsky
Division of Hepatology, Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Clin Transplant 22:222-8. 2008..Alternatively, late asymptomatic viremia and recurrent CMV are associated with lower PCR levels and a low likelihood to progress and result in clinical disease... - Meta-analysis: the efficacy of strategies to prevent organ disease by cytomegalovirus in solid organ transplant recipientsAndre C Kalil
University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
Ann Intern Med 143:870-80. 2005..Cytomegalovirus (CMV), the most common opportunistic viral infection in solid organ transplant recipients, is associated with substantial morbidity and mortality... - Fulminant liver failure associated with the use of black cohoshJosh Levitsky
Department of Gastroenterology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3285, USA
Dig Dis Sci 50:538-9. 2005 - Herpes zoster infection after liver transplantation: a case-control studyJosh Levitsky
Department of Internal Medicine/Gastroenterology, University of Nebraska Medical Center, University of Nebraska, Omaha, Nebraska, 68198-5400, USA
Liver Transpl 11:320-5. 2005..In conclusion, this study is the largest series on HZ after OLT. HZ is neither a common nor a serious infection after OLT and can be managed with antiviral therapy with a low likelihood of visceral dissemination... - The effect of immunosuppressive regimens on the recurrence of primary biliary cirrhosis after liver transplantationJosh Levitsky
Center for Liver Diseases, The University of Chicago Hospitals, IL 60637, USA
Liver Transpl 9:733-6. 2003..In conclusion, recurrent PBC developed in a small number of patients 2 years or longer after OLT. In our population, there was no difference in recurrence rates between those administered cyclosporine or tacrolimus for immunosuppression... - Varicella infection following varicella vaccination in a liver transplant recipientJosh Levitsky
Center for Liver Diseases. Section of Gastroenterology, University of Chicago Hospitals, IL, USA
Am J Transplant 2:880-2. 2002..We will discuss VZV infection, particularly in relation to liver transplantation, and review the prophylaxis and management of VZV infection after OLT... - Group G streptococcal bacteremia and de novo hepatocellular carcinoma after liver transplantationJosh Levitsky
Liver Transpl 8:572. 2002