Pascale N Lacor

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    Pascale N Lacor
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 27:796-807. 2007
  2. ncbi Synaptic targeting by Alzheimer's-related amyloid beta oligomers
    Pascale N Lacor
    Neurobiology and Physiology Department, Northwestern University, Evanston, Illinois 60208, USA5
    J Neurosci 24:10191-200. 2004
  3. ncbi Monoclonal antibodies that target pathological assemblies of Abeta
    Mary P Lambert
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurochem 100:23-35. 2007
  4. ncbi Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Neurobiol Aging 29:1334-47. 2008
  5. ncbi Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 284:18742-53. 2009
  6. ncbi Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    Yuesong Gong
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 100:10417-22. 2003
  7. ncbi Aβ oligomer-induced synapse degeneration in Alzheimer's disease
    Kyle C Wilcox
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Cell Mol Neurobiol 31:939-48. 2011
  8. ncbi Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies
    Pauline T Velasco
    Department of Neurobiology, Department of Chemistry, Recombinant Protein Production Core, and Departments of Molecular Biosciences and Radiology, Northwestern University, Evanston, Illinois 60208, United States
    ACS Chem Neurosci 3:972-81. 2012
  9. ncbi Self-assembly of Abeta(1-42) into globular neurotoxins
    Brett A Chromy
    Biodefense Division, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, 7000 East Avenue, L-446, Livermore, California 94551, USA
    Biochemistry 42:12749-60. 2003

Research Grants

  1. Loss of synapses in physiological and pathological aging
    Pascale Lacor; Fiscal Year: 2003

Collaborators

Detail Information

Publications9

  1. ncbi Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    Pascale N Lacor
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 27:796-807. 2007
    ..The observed disruption of dendritic spines links ADDLs to a major facet of AD pathology, providing strong evidence that ADDLs in AD brain cause neuropil damage believed to underlie dementia...
  2. ncbi Synaptic targeting by Alzheimer's-related amyloid beta oligomers
    Pascale N Lacor
    Neurobiology and Physiology Department, Northwestern University, Evanston, Illinois 60208, USA5
    J Neurosci 24:10191-200. 2004
    ..Results suggest the hypothesis that targeting and functional disruption of particular synapses by Abeta oligomers may provide a molecular basis for the specific loss of memory function in early AD...
  3. ncbi Monoclonal antibodies that target pathological assemblies of Abeta
    Mary P Lambert
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurochem 100:23-35. 2007
    ....
  4. ncbi Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Neurobiol Aging 29:1334-47. 2008
    ..A beta oligomers have been increasingly implicated as the main neurotoxins in AD, and the current results provide a unifying mechanism in which oligomer activity is directly linked to tau hyperphosphorylation in AD pathology...
  5. ncbi Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 284:18742-53. 2009
    ..Our results suggest that dysfunctions of brain insulin and IGF-1 receptors contribute to Abeta aggregation and subsequent synaptic loss...
  6. ncbi Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    Yuesong Gong
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 100:10417-22. 2003
    ..Current results confirm the prediction that soluble oligomeric A beta ligands are intrinsic to AD pathology, and validate their use in new approaches to therapeutic AD drugs and vaccines...
  7. ncbi Aβ oligomer-induced synapse degeneration in Alzheimer's disease
    Kyle C Wilcox
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Cell Mol Neurobiol 31:939-48. 2011
    ..We also discuss ways in which mechanistic insights from other diseases offer clues in the pursuit of the molecular basis of Alzheimer's disease...
  8. ncbi Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies
    Pauline T Velasco
    Department of Neurobiology, Department of Chemistry, Recombinant Protein Production Core, and Departments of Molecular Biosciences and Radiology, Northwestern University, Evanston, Illinois 60208, United States
    ACS Chem Neurosci 3:972-81. 2012
    ..Results indicate that distinct species of Aβ oligomers are generated by alternative assembly pathways and that synapse-binding subpopulations of Aβ oligomers could be specifically targeted for Alzheimer's therapeutics...
  9. ncbi Self-assembly of Abeta(1-42) into globular neurotoxins
    Brett A Chromy
    Biodefense Division, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, 7000 East Avenue, L-446, Livermore, California 94551, USA
    Biochemistry 42:12749-60. 2003
    ..The observed neurotoxicity, structure, and stability of synthetic Abeta(1-42) globular assemblies support the hypothesis that Abeta(1-42) oligomers play a role in triggering nerve cell dysfunction and death in Alzheimer's disease...

Research Grants1

  1. Loss of synapses in physiological and pathological aging
    Pascale Lacor; Fiscal Year: 2003
    ..Therefore, the neutralization of ADDLs synaptotoxic effects by those oligomer-specific antibodies will be asses on the models described above. ..