Pascale N Lacor

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Advances on the Understanding of the Origins of Synaptic Pathology in AD
    Pascale Nathalie Lacor
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL, USA
    Curr Genomics 8:486-508. 2007
  2. ncbi request reprint Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    Pascale N Lacor
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 27:796-807. 2007
  3. ncbi request reprint Synaptic targeting by Alzheimer's-related amyloid beta oligomers
    Pascale N Lacor
    Neurobiology and Physiology Department, Northwestern University, Evanston, Illinois 60208, USA5
    J Neurosci 24:10191-200. 2004
  4. ncbi request reprint Monoclonal antibodies that target pathological assemblies of Abeta
    Mary P Lambert
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurochem 100:23-35. 2007
  5. pmc Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Neurobiol Aging 29:1334-47. 2008
  6. pmc Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 284:18742-53. 2009
  7. pmc Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies
    Pauline T Velasco
    Department of Neurobiology, Department of Chemistry, Recombinant Protein Production Core, and Departments of Molecular Biosciences and Radiology, Northwestern University, Evanston, Illinois 60208, United States
    ACS Chem Neurosci 3:972-81. 2012
  8. pmc Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    Yuesong Gong
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 100:10417-22. 2003
  9. pmc Aβ oligomer-induced synapse degeneration in Alzheimer's disease
    Kyle C Wilcox
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Cell Mol Neurobiol 31:939-48. 2011
  10. ncbi request reprint Self-assembly of Abeta(1-42) into globular neurotoxins
    Brett A Chromy
    Biodefense Division, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, 7000 East Avenue, L 446, Livermore, California 94551, USA
    Biochemistry 42:12749-60. 2003

Research Grants

Collaborators

Detail Information

Publications10

  1. pmc Advances on the Understanding of the Origins of Synaptic Pathology in AD
    Pascale Nathalie Lacor
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL, USA
    Curr Genomics 8:486-508. 2007
    ..However, the exact mechanism is not yet fully understood but is suspected to involve some membrane receptor(s)...
  2. ncbi request reprint Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    Pascale N Lacor
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 27:796-807. 2007
    ..The observed disruption of dendritic spines links ADDLs to a major facet of AD pathology, providing strong evidence that ADDLs in AD brain cause neuropil damage believed to underlie dementia...
  3. ncbi request reprint Synaptic targeting by Alzheimer's-related amyloid beta oligomers
    Pascale N Lacor
    Neurobiology and Physiology Department, Northwestern University, Evanston, Illinois 60208, USA5
    J Neurosci 24:10191-200. 2004
    ..Results suggest the hypothesis that targeting and functional disruption of particular synapses by Abeta oligomers may provide a molecular basis for the specific loss of memory function in early AD...
  4. ncbi request reprint Monoclonal antibodies that target pathological assemblies of Abeta
    Mary P Lambert
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurochem 100:23-35. 2007
    ....
  5. pmc Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Neurobiol Aging 29:1334-47. 2008
    ..A beta oligomers have been increasingly implicated as the main neurotoxins in AD, and the current results provide a unifying mechanism in which oligomer activity is directly linked to tau hyperphosphorylation in AD pathology...
  6. pmc Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 284:18742-53. 2009
    ..Our results suggest that dysfunctions of brain insulin and IGF-1 receptors contribute to Abeta aggregation and subsequent synaptic loss...
  7. pmc Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies
    Pauline T Velasco
    Department of Neurobiology, Department of Chemistry, Recombinant Protein Production Core, and Departments of Molecular Biosciences and Radiology, Northwestern University, Evanston, Illinois 60208, United States
    ACS Chem Neurosci 3:972-81. 2012
    ..Results indicate that distinct species of Aβ oligomers are generated by alternative assembly pathways and that synapse-binding subpopulations of Aβ oligomers could be specifically targeted for Alzheimer's therapeutics...
  8. pmc Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    Yuesong Gong
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 100:10417-22. 2003
    ..Current results confirm the prediction that soluble oligomeric A beta ligands are intrinsic to AD pathology, and validate their use in new approaches to therapeutic AD drugs and vaccines...
  9. pmc Aβ oligomer-induced synapse degeneration in Alzheimer's disease
    Kyle C Wilcox
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Cell Mol Neurobiol 31:939-48. 2011
    ..We also discuss ways in which mechanistic insights from other diseases offer clues in the pursuit of the molecular basis of Alzheimer's disease...
  10. ncbi request reprint Self-assembly of Abeta(1-42) into globular neurotoxins
    Brett A Chromy
    Biodefense Division, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, 7000 East Avenue, L 446, Livermore, California 94551, USA
    Biochemistry 42:12749-60. 2003
    ..The observed neurotoxicity, structure, and stability of synthetic Abeta(1-42) globular assemblies support the hypothesis that Abeta(1-42) oligomers play a role in triggering nerve cell dysfunction and death in Alzheimer's disease...

Research Grants1

  1. Loss of synapses in physiological and pathological aging
    Pascale Lacor; Fiscal Year: 2003
    ..Therefore, the neutralization of ADDLs synaptotoxic effects by those oligomer-specific antibodies will be asses on the models described above. ..