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Genomes and GenesSpecies | H C KwaanSummaryAffiliation: Northwestern University Country: USA Publications
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Publications
Microvascular thrombosis: a serious and deadly pathologic process in multiple diseasesHau C Kwaan
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Thromb Hemost 37:961-78. 2011..Simultaneous management of all the contributory factors should therefore be considered...
Anticoagulant drugs: an updateHau C Kwaan
Division of Hematology Oncology, Northwestern University, Feinberg School of Medicine, 333 East Huron Street, Chicago, IL 60011 3008, USA
Expert Rev Cardiovasc Ther 2:511-22. 2004..Development of newer agents with properties closer to that of the ideal drug remains a challenge...- The thrombogenic effect of an inflammatory cytokine on trophoblasts from women with preeclampsiaHau C Kwaan
Division of Hematology Oncology, Department of Medicine, Northwestern University Feinberg, School of Medicine, 333 E Huron St, Room 805, Chicago, IL 60611, USA
Am J Obstet Gynecol 191:2142-7. 2004..This study was undertaken to investigate whether the increased thrombogenic potential of cytotrophoblastic cells of women with preeclampsia can be accounted for by increased rates of apoptosis... - Thrombotic thrombocytopenic purpura: a diagnostic and therapeutic challengeHau C Kwaan
Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Thromb Hemost 31:615-24. 2005..A call for clinical trials to address the question of efficacy of various agents is made... - The clinical spectrum of thrombotic thrombocytopenic purpuraHau C Kwaan
Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Thromb Hemost 31:673-80. 2005..The distinguishing features are useful not only in providing an accurate diagnosis but also help to determine the best therapeutic strategy... - Incidence and pathogenesis of thrombosis in hematologic malignanciesHau C Kwaan
Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Semin Thromb Hemost 33:303-12. 2007..Likewise, the factors contributing to bleeding are similar to those seen in solid tumors, with the exception of a higher frequency of thrombocytopenia... - The role of plasminogen-plasmin system in cancerHau C Kwaan
Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Cancer Treat Res 148:43-66. 2009..Therapeutic interventions, either using plasminogen activators or experimental inhibitor agents against PAI-1, have shown encouraging results in experimental tumors but not been verified clinically... - Role of plasma proteins in whole blood viscosity: a brief clinical reviewHau C Kwaan
Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Clin Hemorheol Microcirc 44:167-76. 2010..Therapeutic approaches should include both removing the abnormal plasma protein and treating the primary cause... - The significance of endothelial heterogeneity in thrombosis and hemostasisHau C Kwaan
Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Semin Thromb Hemost 36:286-300. 2010..It also helps in the understanding of the pathogenesis of many bleeding and thrombotic disorders, and in the development of new drug designs for site-specific therapy... - Role of microparticles in the hemostatic dysfunction in acute promyelocytic leukemiaHau C Kwaan
Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Thromb Hemost 36:917-24. 2010..Comparison of the various populations of MP was made between samples collected at the time of diagnosis with those collected at molecular remission. Preliminary data suggest that this approach is feasible... - Thromboembolic and bleeding complications in acute leukemiaHau C Kwaan
Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, 710 Fairbanks Court, Chicago, IL 60611, USA
Expert Rev Hematol 3:719-30. 2010..As regards the bleeding complications, thrombocytopenia is a major cause. Corrective measures, including recent guidelines on platelet transfusions, are provided... - Infection and anemiaHau C Kwaan
Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Olson Pavilion, 303 East Chicago Ave, Chicago, IL 60611, USA
Infect Disord Drug Targets 11:40-4. 2011..A clear understanding of these diverse causes and a recognition that they often occur in combination can be of enormous assistance in forming a proper diagnosis and an appropriate management plan... - Rheological abnormalities and thromboembolic complications in heart disease: spontaneous echo contrast and red cell aggregationHau C Kwaan
Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Semin Thromb Hemost 29:529-34. 2003..The results, which show correlation between the plasma fibrinogen and triglyceride levels, are presented. As yet, there are only a few therapeutic guidelines for the correction of abnormally high fibrinogen levels in patients at risk... - Hereditary and acquired defects in the fibrinolytic system associated with thrombosisHau C Kwaan
Division of Hematology and Oncology, Department of Medicine, Northwestern University Medical School, Robert H Lurie Comprehensive Cancer Center of Northwestern University, 333 East Huron Street, Chicago, IL 60611, USA
Hematol Oncol Clin North Am 17:103-14. 2003..Thus, a thorough investigation into other hereditary and acquired risk factors for thrombosis is recommended... - Thrombotic microangiopathy in the cancer patientH C Kwaan
Division of Hematology Oncology, Northwestern University Medical School, 333 East Huron Street, Chicago, IL 60611, USA
Acta Haematol 106:52-6. 2001..The prognosis is not as favorable as in classical TTP. Anecdotal reports indicate that responses are seen with plasma exchange and with immunoadsorption... - Hyperviscosity in polycythemia vera and other red cell abnormalitiesHau C Kwaan
Hematology Oncology Division, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Semin Thromb Hemost 29:451-8. 2003..The hemodynamic principle is aptly applied in the management of PV. The most important objective is the reduction of the patient's hematocrit... - The plasminogen activator system and cancerBrandon McMahon
Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Pathophysiol Haemost Thromb 36:184-94. 2008..Information provided in this brief review is aimed to promote greater interest in the role of the plasminogen activator system in cancer... 
Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosisH C Kwaan
Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
Br J Cancer 82:1702-8. 2000..The anti-apoptotic effect was also found in non-tumoural cells including human umbilical vein endothelial cells and the benign human breast epithelial cell line MCF-10A, suggesting that this is a novel physiologic function of PAI-1...
Oestradiol regulation of the components of the plasminogen-plasmin system in MDA-MB-231 human breast cancer cells stably expressing the oestrogen receptorA S Levenson
Robert H Lurie Cancer Center, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
Br J Cancer 78:88-95. 1998..Our findings indicate that down-regulation of uPA by E2 is an upstream event of inhibitory effects of E2 on growth of these cells as the addition of exogenous uPA did not block the growth inhibition by E2...- Effects of all-trans retinoic acid or chemotherapy on the molecular regulation of systemic blood coagulation and fibrinolysis in patients with acute promyelocytic leukemiaM S Tallman
Department of Medicine, Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA
J Thromb Haemost 2:1341-50. 2004..However, our data also suggests that cytokine expression in some patients may be accelerated by either chemotherapy or ATRA. The implications of this observation for understanding the retinoic acid syndrome will require further studies... - Thrombogenic role of cells undergoing apoptosisJ Wang
Division of Hematology/Oncology, Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
Br J Haematol 115:382-91. 2001..This indicates that the exteriorization and exposure of phosphatidylserine on the cell surface membrane during apoptosis were essential for both thrombin generation and tissue factor activation... - Adverse effects on hemostatic function of drugs used in hematologic malignanciesAnaadriana Zakarija
Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Semin Thromb Hemost 33:355-64. 2007..In addition, the syndrome of thrombotic microangiopathy may be brought on by several other drugs. Thus, a full understanding of these adverse effects is necessary in treating these disorders... - Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR ProjectCharles L Bennett
VA Center for Management of Complex Chronic Care at Jesse Brown VA Medical Center, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Am Coll Cardiol 50:1138-43. 2007..We sought to describe clinical and laboratory findings for a large cohort of patients with thienopyridine-associated thrombotic thrombocytopenic purpura (TTP)... - Intravascular clotting activation and bleeding in patients with hematologic malignanciesMartin S Tallman
Division of Hematology Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois 60611, USA
Rev Clin Exp Hematol 8:E1. 2004..A number of medications have thrombogenic potential, including corticosteroids, thalidomide, L-asparaginase, all-trans retinoic acid and arsenic trioxide... - Meeting report. Acute promyelocytic leukemia-associated coagulopathy, 21 January 2004, London, United KingdomMartin S Tallman
Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Centre, 676 N St Clair Street, Suite 850, Chicago, IL 60611, USA
Leuk Res 29:347-51. 2005..Eight speakers participated in the workshop. This meeting report provides synopses of their presentations and a summary of highlights from the meeting... - Clopidogrel-associated TTP: an update of pharmacovigilance efforts conducted by independent researchers, pharmaceutical suppliers, and the Food and Drug AdministrationAnaadriana Zakarija
VA Chicago Healthcare System, VA Midwest Center for Health Services and Policy Research, Division of Hematology/Oncology, Department of Medicine, Northwestern University Medical Center, Chicago, Ill, USA
Stroke 35:533-7. 2004..Clopidogrel-associated TTP often occurs within 2 weeks of drug initiation, occasionally relapses, and has a high mortality if not treated promptly... - Thalidomide-associated deep vein thrombosis and pulmonary embolismCharles L Bennett
Midwest Center for Health Services and Policy Research, Chicago VA Healthcare System/Lakeside Division, 400 East Ontario, Room 205, Chicago, IL 60611, USA
Am J Med 113:603-6. 2002 - Bleeding and thrombosis in the cancer patientAnaadriana Zakarija
Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
Expert Rev Cardiovasc Ther 1:271-81. 2003..Potential effects of cancer treatment on these risks magnify the hazards encountered by the managing team. Wherever management is discussed, emphasis is placed on the scientific basis for the rationale of the therapeutic approach... - Pathogenesis of increased risk of thrombosis in cancerHau C Kwaan
Division of Hematology and Oncology, Department of Medicine, Northwestern University Medical School and Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois 60611, USA
Semin Thromb Hemost 29:283-90. 2003..These developments have obvious basic and clinical implications... - TTP/HUS occurring in a simultaneous pancreas/kidney transplant recipient after clopidogrel treatment: evidence of a nonimmunological etiologyAndrew M Evens
Department of Internal Medicine--Oncology/Hematology, Lakeside VA, Chicago, IL 60611, USA
Transplantation 74:885-7. 2002..DISCUSSION: Our findings suggest a nonimmunological etiology for TTP/HUS in clopidogrel-treated transplant recipients. Furthermore, mechanistic focused laboratory studies can facilitate interpretation of case report findings... - Expression of receptors for plasminogen activators on endothelial cell surface depends on their originH C Kwaan
Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
J Thromb Haemost 2:306-12. 2004..In contrast, expression of u-PA receptor was the same for all ECs. This has implications for higher risk of intracranial bleeding during thrombolytic therapy, and for a role of t-PA in neurological development and function... - Current concepts in the diagnosis and management of thrombotic thrombocytopenic purpuraChadi Nabhan
Division of Hematology and Oncology, Department of Medicine, Northwestern University Medical School, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, 333 East Huron Street, Chicago, IL 60611, USA
Hematol Oncol Clin North Am 17:177-99. 2003..This disease also has been described in association with HIV, pregnancy, cancer, and chemotherapy. TTP remains an ideal example of how knowledge about the etiology of a disease can improve therapeutic interventions... - Thrombotic thrombocytopenic purpura-2005Hau C Kwaan
Division of Hematology/Oncology, Northwestern University Medical School, Chicago, Illinois, USA
Semin Thromb Hemost 31:611-4. 2005 - Dissemination of information on potentially fatal adverse drug reactions for cancer drugs from 2000 to 2002: first results from the research on adverse drug events and reports projectLisa A Ladewski
Veterans Affairs Midwest Center for Health and Policy Research, Lakeside Division, Northwestern University Medical Center, Chicago, IL 60611, USA
J Clin Oncol 21:3859-66. 2003..This suggests a need for continued vigilance and efficient strategies for dissemination of information about ADRs associated with cancer drugs... - Abnormalities in hemostasis in acute promyelocytic leukemiaHau C Kwaan
Division of Hematology/Oncology, Department of Medicine, Northwestern University Medical School, the Robert H.Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA
Hematol Oncol 20:33-41. 2002..Its pathogenesis and management still remain to be the challenge for the present... - Catastrophic multiple organ ischemia due to an anti-Pr cold agglutinin developing in a patient with mixed cryoglobulinemia after treatment with rituximabJoshua Ruch
Division of Hematology Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Am J Hematol 84:120-2. 2009..Unlike previous reports of patients with cryoglobulinemia and cold agglutinin disease, our patient did not have a detectable cryoprecipitate when his cold agglutinin manifested... - Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reportsKaren K Swisher
Hematology Oncology Section, Department of Medicine, College of Medicine, The University of Oklahoma Health Science Center, Oklahoma City, OK 73190, USA
Haematologica 92:936-43. 2007..We describe the occurrence of TTP-HUS following pancreatitis and consider whether pancreatitis may be a triggering event for acute episodes of TTP-HUS... - The life and vision of a pioneer: a tribute to Tage Astrup, D.Sc., Dr.Med.h.cHau C Kwaan
Division of Hematology/Oncology, Feinberg School of Medicine, Northwestern University Chicago, Illinois, USA
Semin Thromb Hemost 33:299-300. 2007 - Correction of hyperviscosity by apheresisMirjana Zarkovic
Hematology/Oncology Division, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Semin Thromb Hemost 29:535-42. 2003..Erythrocytapheresis and plateletpheresis are mostly used in the acute management of symptomatic patients with polycythemia vera (PV), essential thrombocytosis, and sickle cell disease... - Tumor microenvironment and hemorheological abnormalitiesGianfranco Baronzio
Family Medicine Area, ASl 1 Legnano, Milano, Italy
Semin Thromb Hemost 29:489-97. 2003..The implications of these abnormalities on therapeutic approach are discussed...