H C Kwaan

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint The coagulopathy in acute promyelocytic leukaemia--what have we learned in the past twenty years
    Hau C Kwaan
    Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, and Robert H Lurie Comprehensive Cancer Center, Olson Pavilion, 710 N Fairbanks Court, Chicago, IL 60611, USA Electronic address
    Best Pract Res Clin Haematol 27:11-8. 2014
  2. doi request reprint The apparent uPA/PAI-1 paradox in cancer: more than meets the eye
    Hau C Kwaan
    Division of Hematology Oncology, Northwestem University Feinberg School of Medicine, Chicago, Illinois, USA
    Semin Thromb Hemost 39:382-91. 2013
  3. doi request reprint Microvascular thrombosis: a serious and deadly pathologic process in multiple diseases
    Hau C Kwaan
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Thromb Hemost 37:961-78. 2011
  4. doi request reprint The significance of endothelial heterogeneity in thrombosis and hemostasis
    Hau C Kwaan
    Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Semin Thromb Hemost 36:286-300. 2010
  5. ncbi request reprint Hyperviscosity in polycythemia vera and other red cell abnormalities
    Hau C Kwaan
    Hematology Oncology Division, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Semin Thromb Hemost 29:451-8. 2003
  6. ncbi request reprint Anticoagulant drugs: an update
    Hau C Kwaan
    Division of Hematology Oncology, Northwestern University, Feinberg School of Medicine, 333 East Huron Street, Chicago, IL 60011 3008, USA
    Expert Rev Cardiovasc Ther 2:511-22. 2004
  7. ncbi request reprint Rheological abnormalities and thromboembolic complications in heart disease: spontaneous echo contrast and red cell aggregation
    Hau C Kwaan
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Semin Thromb Hemost 29:529-34. 2003
  8. doi request reprint Role of plasma proteins in whole blood viscosity: a brief clinical review
    Hau C Kwaan
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Clin Hemorheol Microcirc 44:167-76. 2010
  9. ncbi request reprint Incidence and pathogenesis of thrombosis in hematologic malignancies
    Hau C Kwaan
    Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Semin Thromb Hemost 33:303-12. 2007
  10. doi request reprint Thromboembolic and bleeding complications in acute leukemia
    Hau C Kwaan
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, 710 Fairbanks Court, Chicago, IL 60611, USA
    Expert Rev Hematol 3:719-30. 2010

Detail Information

Publications42

  1. ncbi request reprint The coagulopathy in acute promyelocytic leukaemia--what have we learned in the past twenty years
    Hau C Kwaan
    Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, and Robert H Lurie Comprehensive Cancer Center, Olson Pavilion, 710 N Fairbanks Court, Chicago, IL 60611, USA Electronic address
    Best Pract Res Clin Haematol 27:11-8. 2014
    ..Unless the coagulopathy can be effectively controlled, bleeding complications will remain an obstacle to achieving a cure for this disease. The issues that need to be addressed in next phase of investigations are also discussed. ..
  2. doi request reprint The apparent uPA/PAI-1 paradox in cancer: more than meets the eye
    Hau C Kwaan
    Division of Hematology Oncology, Northwestem University Feinberg School of Medicine, Chicago, Illinois, USA
    Semin Thromb Hemost 39:382-91. 2013
    ..Meaningful drug designs for therapeutic intervention require a thorough understanding of the role of all of the components involved in this complex mechanism of tumor progression...
  3. doi request reprint Microvascular thrombosis: a serious and deadly pathologic process in multiple diseases
    Hau C Kwaan
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Thromb Hemost 37:961-78. 2011
    ..Simultaneous management of all the contributory factors should therefore be considered...
  4. doi request reprint The significance of endothelial heterogeneity in thrombosis and hemostasis
    Hau C Kwaan
    Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Semin Thromb Hemost 36:286-300. 2010
    ..It also helps in the understanding of the pathogenesis of many bleeding and thrombotic disorders, and in the development of new drug designs for site-specific therapy...
  5. ncbi request reprint Hyperviscosity in polycythemia vera and other red cell abnormalities
    Hau C Kwaan
    Hematology Oncology Division, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Semin Thromb Hemost 29:451-8. 2003
    ..The hemodynamic principle is aptly applied in the management of PV. The most important objective is the reduction of the patient's hematocrit...
  6. ncbi request reprint Anticoagulant drugs: an update
    Hau C Kwaan
    Division of Hematology Oncology, Northwestern University, Feinberg School of Medicine, 333 East Huron Street, Chicago, IL 60011 3008, USA
    Expert Rev Cardiovasc Ther 2:511-22. 2004
    ..Development of newer agents with properties closer to that of the ideal drug remains a challenge...
  7. ncbi request reprint Rheological abnormalities and thromboembolic complications in heart disease: spontaneous echo contrast and red cell aggregation
    Hau C Kwaan
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Semin Thromb Hemost 29:529-34. 2003
    ..The results, which show correlation between the plasma fibrinogen and triglyceride levels, are presented. As yet, there are only a few therapeutic guidelines for the correction of abnormally high fibrinogen levels in patients at risk...
  8. doi request reprint Role of plasma proteins in whole blood viscosity: a brief clinical review
    Hau C Kwaan
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Clin Hemorheol Microcirc 44:167-76. 2010
    ..Therapeutic approaches should include both removing the abnormal plasma protein and treating the primary cause...
  9. ncbi request reprint Incidence and pathogenesis of thrombosis in hematologic malignancies
    Hau C Kwaan
    Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Semin Thromb Hemost 33:303-12. 2007
    ..Likewise, the factors contributing to bleeding are similar to those seen in solid tumors, with the exception of a higher frequency of thrombocytopenia...
  10. doi request reprint Thromboembolic and bleeding complications in acute leukemia
    Hau C Kwaan
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, 710 Fairbanks Court, Chicago, IL 60611, USA
    Expert Rev Hematol 3:719-30. 2010
    ..As regards the bleeding complications, thrombocytopenia is a major cause. Corrective measures, including recent guidelines on platelet transfusions, are provided...
  11. ncbi request reprint Infection and anemia
    Hau C Kwaan
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Olson Pavilion, 303 East Chicago Ave, Chicago, IL 60611, USA
    Infect Disord Drug Targets 11:40-4. 2011
    ..A clear understanding of these diverse causes and a recognition that they often occur in combination can be of enormous assistance in forming a proper diagnosis and an appropriate management plan...
  12. ncbi request reprint Hereditary and acquired defects in the fibrinolytic system associated with thrombosis
    Hau C Kwaan
    Division of Hematology and Oncology, Department of Medicine, Northwestern University Medical School, Robert H Lurie Comprehensive Cancer Center of Northwestern University, 333 East Huron Street, Chicago, IL 60611, USA
    Hematol Oncol Clin North Am 17:103-14. 2003
    ..Thus, a thorough investigation into other hereditary and acquired risk factors for thrombosis is recommended...
  13. ncbi request reprint The thrombogenic effect of an inflammatory cytokine on trophoblasts from women with preeclampsia
    Hau C Kwaan
    Division of Hematology Oncology, Department of Medicine, Northwestern University Feinberg, School of Medicine, 333 E Huron St, Room 805, Chicago, IL 60611, USA
    Am J Obstet Gynecol 191:2142-7. 2004
    ..This study was undertaken to investigate whether the increased thrombogenic potential of cytotrophoblastic cells of women with preeclampsia can be accounted for by increased rates of apoptosis...
  14. doi request reprint Role of microparticles in the hemostatic dysfunction in acute promyelocytic leukemia
    Hau C Kwaan
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Thromb Hemost 36:917-24. 2010
    ..Comparison of the various populations of MP was made between samples collected at the time of diagnosis with those collected at molecular remission. Preliminary data suggest that this approach is feasible...
  15. doi request reprint The role of plasminogen-plasmin system in cancer
    Hau C Kwaan
    Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Cancer Treat Res 148:43-66. 2009
    ..Therapeutic interventions, either using plasminogen activators or experimental inhibitor agents against PAI-1, have shown encouraging results in experimental tumors but not been verified clinically...
  16. ncbi request reprint Thrombotic microangiopathy in the cancer patient
    H C Kwaan
    Division of Hematology Oncology, Northwestern University Medical School, 333 East Huron Street, Chicago, IL 60611, USA
    Acta Haematol 106:52-6. 2001
    ..The prognosis is not as favorable as in classical TTP. Anecdotal reports indicate that responses are seen with plasma exchange and with immunoadsorption...
  17. ncbi request reprint Thrombotic thrombocytopenic purpura: a diagnostic and therapeutic challenge
    Hau C Kwaan
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Thromb Hemost 31:615-24. 2005
    ..A call for clinical trials to address the question of efficacy of various agents is made...
  18. ncbi request reprint The clinical spectrum of thrombotic thrombocytopenic purpura
    Hau C Kwaan
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Thromb Hemost 31:673-80. 2005
    ..The distinguishing features are useful not only in providing an accurate diagnosis but also help to determine the best therapeutic strategy...
  19. doi request reprint The plasminogen activator system and cancer
    Brandon McMahon
    Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Pathophysiol Haemost Thromb 36:184-94. 2008
    ..Information provided in this brief review is aimed to promote greater interest in the role of the plasminogen activator system in cancer...
  20. pmc Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosis
    H C Kwaan
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Br J Cancer 82:1702-8. 2000
    ..The anti-apoptotic effect was also found in non-tumoural cells including human umbilical vein endothelial cells and the benign human breast epithelial cell line MCF-10A, suggesting that this is a novel physiologic function of PAI-1...
  21. ncbi request reprint Effects of all-trans retinoic acid or chemotherapy on the molecular regulation of systemic blood coagulation and fibrinolysis in patients with acute promyelocytic leukemia
    M S Tallman
    Department of Medicine, Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA
    J Thromb Haemost 2:1341-50. 2004
    ..However, our data also suggests that cytokine expression in some patients may be accelerated by either chemotherapy or ATRA. The implications of this observation for understanding the retinoic acid syndrome will require further studies...
  22. pmc Oestradiol regulation of the components of the plasminogen-plasmin system in MDA-MB-231 human breast cancer cells stably expressing the oestrogen receptor
    A S Levenson
    Robert H Lurie Cancer Center, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Br J Cancer 78:88-95. 1998
    ..Our findings indicate that down-regulation of uPA by E2 is an upstream event of inhibitory effects of E2 on growth of these cells as the addition of exogenous uPA did not block the growth inhibition by E2...
  23. ncbi request reprint Thrombogenic role of cells undergoing apoptosis
    J Wang
    Division of Hematology/Oncology, Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
    Br J Haematol 115:382-91. 2001
    ..This indicates that the exteriorization and exposure of phosphatidylserine on the cell surface membrane during apoptosis were essential for both thrombin generation and tissue factor activation...
  24. ncbi request reprint Adverse effects on hemostatic function of drugs used in hematologic malignancies
    Anaadriana Zakarija
    Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Semin Thromb Hemost 33:355-64. 2007
    ..In addition, the syndrome of thrombotic microangiopathy may be brought on by several other drugs. Thus, a full understanding of these adverse effects is necessary in treating these disorders...
  25. ncbi request reprint Intravascular clotting activation and bleeding in patients with hematologic malignancies
    Martin S Tallman
    Division of Hematology Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois 60611, USA
    Rev Clin Exp Hematol 8:E1. 2004
    ..A number of medications have thrombogenic potential, including corticosteroids, thalidomide, L-asparaginase, all-trans retinoic acid and arsenic trioxide...
  26. ncbi request reprint Bleeding and thrombosis in the cancer patient
    Anaadriana Zakarija
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Expert Rev Cardiovasc Ther 1:271-81. 2003
    ..Potential effects of cancer treatment on these risks magnify the hazards encountered by the managing team. Wherever management is discussed, emphasis is placed on the scientific basis for the rationale of the therapeutic approach...
  27. ncbi request reprint Meeting report. Acute promyelocytic leukemia-associated coagulopathy, 21 January 2004, London, United Kingdom
    Martin S Tallman
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Centre, 676 N St Clair Street, Suite 850, Chicago, IL 60611, USA
    Leuk Res 29:347-51. 2005
    ..Eight speakers participated in the workshop. This meeting report provides synopses of their presentations and a summary of highlights from the meeting...
  28. ncbi request reprint Clopidogrel-associated TTP: an update of pharmacovigilance efforts conducted by independent researchers, pharmaceutical suppliers, and the Food and Drug Administration
    Anaadriana Zakarija
    VA Chicago Healthcare System, VA Midwest Center for Health Services and Policy Research, Division of Hematology Oncology, Department of Medicine, Northwestern University Medical Center, Chicago, Ill, USA
    Stroke 35:533-7. 2004
    ....
  29. ncbi request reprint Thalidomide-associated deep vein thrombosis and pulmonary embolism
    Charles L Bennett
    Midwest Center for Health Services and Policy Research, Chicago VA Healthcare System Lakeside Division, 400 East Ontario, Room 205, Chicago, IL 60611, USA
    Am J Med 113:603-6. 2002
  30. pmc Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project
    Charles L Bennett
    VA Center for Management of Complex Chronic Care at Jesse Brown VA Medical Center, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Am Coll Cardiol 50:1138-43. 2007
    ..We sought to describe clinical and laboratory findings for a large cohort of patients with thienopyridine-associated thrombotic thrombocytopenic purpura (TTP)...
  31. ncbi request reprint TTP/HUS occurring in a simultaneous pancreas/kidney transplant recipient after clopidogrel treatment: evidence of a nonimmunological etiology
    Andrew M Evens
    Department of Internal Medicine Oncology Hematology, Lakeside VA, Chicago, IL 60611, USA
    Transplantation 74:885-7. 2002
    ..We present a second case of TTP/HUS developing in an SPK recipient who was also receiving clopidogrel...
  32. ncbi request reprint Pathogenesis of increased risk of thrombosis in cancer
    Hau C Kwaan
    Division of Hematology and Oncology, Department of Medicine, Northwestern University Medical School and Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois 60611, USA
    Semin Thromb Hemost 29:283-90. 2003
    ..These developments have obvious basic and clinical implications...
  33. ncbi request reprint Expression of receptors for plasminogen activators on endothelial cell surface depends on their origin
    H C Kwaan
    Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Thromb Haemost 2:306-12. 2004
    ..In contrast, expression of u-PA receptor was the same for all ECs. This has implications for higher risk of intracranial bleeding during thrombolytic therapy, and for a role of t-PA in neurological development and function...
  34. ncbi request reprint Thrombotic thrombocytopenic purpura-2005
    Hau C Kwaan
    Division of Hematology Oncology, Northwestern University Medical School, Chicago, Illinois, USA
    Semin Thromb Hemost 31:611-4. 2005
  35. ncbi request reprint Current concepts in the diagnosis and management of thrombotic thrombocytopenic purpura
    Chadi Nabhan
    Division of Hematology and Oncology, Department of Medicine, Northwestern University Medical School, Robert H Lurie Comprehensive Cancer Center of Northwestern University, 333 East Huron Street, Chicago, IL 60611, USA
    Hematol Oncol Clin North Am 17:177-99. 2003
    ..This disease also has been described in association with HIV, pregnancy, cancer, and chemotherapy. TTP remains an ideal example of how knowledge about the etiology of a disease can improve therapeutic interventions...
  36. ncbi request reprint Dissemination of information on potentially fatal adverse drug reactions for cancer drugs from 2000 to 2002: first results from the research on adverse drug events and reports project
    Lisa A Ladewski
    Veterans Affairs Midwest Center for Health and Policy Research, Lakeside Division, Northwestern University Medical Center, Chicago, IL 60611, USA
    J Clin Oncol 21:3859-66. 2003
    ..To describe the clinical findings, occurrence rates, causality evidence, and dissemination media for serious cancer drug-associated adverse drug reactions (ADRs) reported in the postmarketing setting...
  37. ncbi request reprint Abnormalities in hemostasis in acute promyelocytic leukemia
    Hau C Kwaan
    Division of Hematology Oncology, Department of Medicine, Northwestern University Medical School, The Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA
    Hematol Oncol 20:33-41. 2002
    ..Its pathogenesis and management still remain to be the challenge for the present...
  38. ncbi request reprint Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports
    Karen K Swisher
    Hematology Oncology Section, Department of Medicine, College of Medicine, The University of Oklahoma Health Science Center, Oklahoma City, OK 73190, USA
    Haematologica 92:936-43. 2007
    ..We describe the occurrence of TTP-HUS following pancreatitis and consider whether pancreatitis may be a triggering event for acute episodes of TTP-HUS...
  39. ncbi request reprint Correction of hyperviscosity by apheresis
    Mirjana Zarkovic
    Hematology Oncology Division, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Semin Thromb Hemost 29:535-42. 2003
    ..Erythrocytapheresis and plateletpheresis are mostly used in the acute management of symptomatic patients with polycythemia vera (PV), essential thrombocytosis, and sickle cell disease...
  40. ncbi request reprint The life and vision of a pioneer: a tribute to Tage Astrup, D.Sc., Dr.Med.h.c
    Hau C Kwaan
    Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University Chicago, Illinois, USA
    Semin Thromb Hemost 33:299-300. 2007
  41. ncbi request reprint Catastrophic multiple organ ischemia due to an anti-Pr cold agglutinin developing in a patient with mixed cryoglobulinemia after treatment with rituximab
    Joshua Ruch
    Division of Hematology Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Hematol 84:120-2. 2009
    ..Unlike previous reports of patients with cryoglobulinemia and cold agglutinin disease, our patient did not have a detectable cryoprecipitate when his cold agglutinin manifested...
  42. ncbi request reprint Tumor microenvironment and hemorheological abnormalities
    Gianfranco Baronzio
    Family Medicine Area, ASl 1 Legnano, Milano, Italy
    Semin Thromb Hemost 29:489-97. 2003
    ..The implications of these abnormalities on therapeutic approach are discussed...