PETER ANDREAS KOPP

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi Perspective: genetic defects in the etiology of congenital hypothyroidism
    Peter Kopp
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Endocrinology 143:2019-24. 2002
  2. ncbi Acute diabetes insipidus mediated by vasopressinase after placental abruption
    Amisha Wallia
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Tarry 15, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 98:881-6. 2013
  3. ncbi TSH regulates pendrin membrane abundance and enhances iodide efflux in thyroid cells
    Liuska Pesce
    Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Endocrinology 153:512-21. 2012
  4. ncbi Clinical and molecular characteristics of Pendred syndrome
    P Kopp
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago IL60611, USA
    Ann Endocrinol (Paris) 72:88-94. 2011
  5. ncbi [Molecular tests for (early) recognition of endocrine disorders - towards a sophisticated management of complex endocrine and metabolic diseases]
    Peter Kopp
    Division of Endocrinology, Metabolism, and Molecular Medicine, and Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ther Umsch 67:367-73. 2010
  6. ncbi Theodor kocher (1841-1917) Nobel prize centenary 2009
    Peter Kopp
    Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University Chicago, Illinois 60611, USA
    Arq Bras Endocrinol Metabol 53:1176-80. 2009
  7. ncbi Pendred syndrome and iodide transport in the thyroid
    Peter Kopp
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
    Trends Endocrinol Metab 19:260-8. 2008
  8. ncbi Applications of molecular biology and genetics in endocrinology
    Peter Kopp
    The Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Endocr Pract 13:534-41. 2007
  9. ncbi The TSH receptor and its role in thyroid disease
    P Kopp
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cell Mol Life Sci 58:1301-22. 2001
  10. ncbi Genetics and phenomics of Pendred syndrome
    Aigerim Bizhanova
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Tarry 15, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Mol Cell Endocrinol 322:83-90. 2010

Research Grants

  1. Function and structure of pendrin in thyroid cells
    Peter Kopp; Fiscal Year: 2003
  2. Function and structure of pendrin in thyroid cells
    Peter Kopp; Fiscal Year: 2006
  3. Function and structure of pendrin in thyroid cells
    Peter Kopp; Fiscal Year: 2007

Collaborators

Detail Information

Publications21

  1. ncbi Perspective: genetic defects in the etiology of congenital hypothyroidism
    Peter Kopp
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Endocrinology 143:2019-24. 2002
    ....
  2. ncbi Acute diabetes insipidus mediated by vasopressinase after placental abruption
    Amisha Wallia
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Tarry 15, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 98:881-6. 2013
    ..Postpartum, diabetes insipidus (DI) can be part of Sheehan's syndrome or lymphocytic hypophysitis in combination with anterior pituitary hormone deficiencies. In contrast, acute onset of isolated DI in the postpartum period is unusual...
  3. ncbi TSH regulates pendrin membrane abundance and enhances iodide efflux in thyroid cells
    Liuska Pesce
    Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Endocrinology 153:512-21. 2012
    ..These results demonstrate that pendrin translocates to the membrane in response to TSH and suggest that it may have a physiological role in apical iodide transport and thyroid hormone synthesis...
  4. ncbi Clinical and molecular characteristics of Pendred syndrome
    P Kopp
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago IL60611, USA
    Ann Endocrinol (Paris) 72:88-94. 2011
    ....
  5. ncbi [Molecular tests for (early) recognition of endocrine disorders - towards a sophisticated management of complex endocrine and metabolic diseases]
    Peter Kopp
    Division of Endocrinology, Metabolism, and Molecular Medicine, and Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ther Umsch 67:367-73. 2010
    ..This review provides a short overview about genetic analyses in the field of endocrinology that are relevant for the practicing physician...
  6. ncbi Theodor kocher (1841-1917) Nobel prize centenary 2009
    Peter Kopp
    Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University Chicago, Illinois 60611, USA
    Arq Bras Endocrinol Metabol 53:1176-80. 2009
    ..Kocher served as the chairman of surgery at the University of Bern in Switzerland, his alma mater, until his death in 1917...
  7. ncbi Pendred syndrome and iodide transport in the thyroid
    Peter Kopp
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
    Trends Endocrinol Metab 19:260-8. 2008
    ..This review discusses the controversies surrounding the potential role of pendrin in mediating apical iodide efflux into the lumen of thyroid follicles, and discusses its functional role in the kidney and the inner ear...
  8. ncbi Applications of molecular biology and genetics in endocrinology
    Peter Kopp
    The Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Endocr Pract 13:534-41. 2007
    ..To review the growing impact of molecular biology and genetics on clinical endocrinology...
  9. ncbi The TSH receptor and its role in thyroid disease
    P Kopp
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cell Mol Life Sci 58:1301-22. 2001
    ..Inactivating germline mutations of both TSH receptor alleles lead to variable degrees of resistance to TSH, encompassing a spectrum ranging from euthyroid hyperthyrotropinemia to overt hypothyroidism with thyroid hypoplasia...
  10. ncbi Genetics and phenomics of Pendred syndrome
    Aigerim Bizhanova
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Tarry 15, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Mol Cell Endocrinol 322:83-90. 2010
    ..Elucidation of the function of pendrin has provided unexpected novel insights into the pathophysiology of thyroid hormone biosynthesis, chloride retention in the kidney, and composition of the endolymph...
  11. ncbi Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA male hormone study
    Susan M Gapstur
    Department of Preventive Medicine, Northwestern University Medical School, and the Robert H Laurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Epidemiol Biomarkers Prev 11:1041-7. 2002
    ..Results also suggest that the previously observed difference in total testosterone between black and white men could be attributed, for the most part, to racial differences in abdominal obesity...
  12. ncbi Association of endogenous sex hormones with diabetes and impaired fasting glucose in men: multi-ethnic study of atherosclerosis
    Laura A Colangelo
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Diabetes Care 32:1049-51. 2009
    ..To assess associations of sex hormones with impaired fasting glucose (IFG) and type 2 diabetes in men...
  13. ncbi Serum IGF-I and C-reactive protein in healthy black and white young men: the CARDIA male hormone study
    Laura A Colangelo
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Growth Horm IGF Res 19:420-5. 2009
    ..However, most human studies have not controlled adequately for confounding factors, particularly nutritional intake. This population-based study examined whether CRP is inversely associated with IGF-I and IGFBP-3 concentrations...
  14. ncbi Longitudinal associations of age, anthropometric and lifestyle factors with serum total insulin-like growth factor-I and IGF binding protein-3 levels in Black and White men: the CARDIA Male Hormone Study
    Susan M Gapstur
    Department of Preventive Medicine, Northwestern University, 680 North Lake Shore Drive, Suite 1102, Chicago, IL, USA
    Cancer Epidemiol Biomarkers Prev 13:2208-16. 2004
    ..Importantly, they suggest that IGF-I and/or IGFBP-3 levels could be influenced by changes in BMI, and perhaps by physical activity, alcohol intake, and cigarette smoking...
  15. ncbi Total testosterone, androgen receptor polymorphism, and depressive symptoms in young black and white men: the CARDIA Male Hormone Study
    Laura A Colangelo
    Department of Preventive Medicine, Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1102, Chicago, IL 60611, USA
    Psychoneuroendocrinology 32:951-8. 2007
    ..Clinical trials assessing the effects of T replacement therapy on depressive symptoms in hypogonadal men should consider including CAG RL in their design and/or analysis...
  16. ncbi Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid
    Aigerim Bizhanova
    Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Endocrinology 150:1084-90. 2009
    ..Functional in vitro data and the impaired iodide organification observed in patients with Pendred syndrome support a role of pendrin as an apical iodide transporter...
  17. ncbi Functional characterization of pendrin in a polarized cell system. Evidence for pendrin-mediated apical iodide efflux
    Mary P Gillam
    Division of Endocrinology, Metabolism and Molecular Medicine, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Tarry 15, 303 Chicago Avenue, Chicago, IL 60611, USA
    J Biol Chem 279:13004-10. 2004
    ..Consistent with the partial organification defect observed in patients with Pendred's syndrome, naturally occurring mutations of pendrin lead to impaired transport of iodide...
  18. ncbi Naturally occurring mutations in the thyroglobulin gene
    Jussara Vono-Toniolo
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Thyroid 15:1021-33. 2005
    ..Recent recommendations for the nomenclature of mutations have led to different numbering systems, an aspect that is discussed in order to clarify discrepancies between different publications...
  19. ncbi Thyroglobulin gene mutations and other genetic defects associated with congenital hypothyroidism
    Jussara Vono-Toniolo
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago 60611, USA
    Arq Bras Endocrinol Metabol 48:70-82. 2004
    ....
  20. ncbi Quantitative trait loci associated with elevated thyroid-stimulating hormone in the Wistar-Kyoto rat
    Amber E Baum
    Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Endocrinology 146:870-8. 2005
    ..These findings suggest that one or more genetic alterations within the TSH-1 locus significantly contribute to the altered thyroid function tests of the WKY rat...
  21. ncbi Men with acquired hypogonadotropic hypogonadism treated with testosterone may be fertile
    Andjela Drincic
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, The Feinberg Medical School, Chicago, Illinois 60611, USA
    Pituitary 6:5-10. 2003
    ..This may be related to fact that gonadotropin levels in such patients are present, albeit low. Semen analyses in such men should be routinely carried out so that they can be appropriately counseled regarding potential fertility...

Research Grants5

  1. Function and structure of pendrin in thyroid cells
    Peter Kopp; Fiscal Year: 2003
    ..These studies will provide fundamental insights into the (patho) physiology of this novel anion transporter that has important functions in the thyroid, the kidney and the inner ear. ..
  2. Function and structure of pendrin in thyroid cells
    Peter Kopp; Fiscal Year: 2006
    ..These studies will provide fundamental insights into the (patho) physiology of this novel anion transporter that has important functions in the thyroid, the kidney and the inner ear. ..
  3. Function and structure of pendrin in thyroid cells
    Peter Kopp; Fiscal Year: 2007
    ..These studies will provide fundamental insights into the (patho)physiology of this novel anion transporter that has important functions in the thyroid, the kidney and the inner ear. ..