Melina R Kibbe

..These findings are important as they will serve as the foundation for the development of a drug-eluting vascular graft...

..The purpose of this study was to assess indebtedness among academic surgeons and its repercussions on personal finances, quality of life, and career choices...

....

..This heightened efficacy may be secondary to greater inhibition of VSMC proliferation through cell cycle arrest and regulation of ROS expression, in addition to other possible unidentified mechanisms that deserve further exploration...

..Thus, the aim of this study was to evaluate the perivascular application of spontaneously self-assembling NO-releasing nanofiber gels. Our hypothesis was that this application would prevent neointimal hyperplasia...

..Thus insulin may play a role in regulating the downstream beneficial effects of NO in the vasculature...

..The aims of this study are to determine the effect of IPA/NO on endothelial and vascular smooth muscle cells (VSMC) in vitro and to determine if IPA/NO inhibits neointimal hyperplasia in vivo...

..Vascular surgeons have increasingly become proficient in carotid artery stenting (CAS) as an alternative treatment modality for cervical carotid artery occlusive disease. We analyzed our early and late outcomes of CAS over the last 8 years...

..Since the PA28 subunits are involved in the breakdown of peptides during inflammation, PA28 inhibition may be one mechanism by which NO inhibits neointimal hyperplasia...

..These changes in UbcH10 levels correlate with VSMC proliferation and neointimal hyperplasia, making UbcH10 a promising therapeutic target for inhibiting this proliferative disease...

..In 1994, our hospital reported a significant gender disparity in the treatment of peripheral artery disease (PAD). The objective of this study was to determine if this gender-based treatment disparity still persists after 15 years...

..The aim of this study was to characterize the effect of sex, hormones, and NO on the extracellular signal-regulated kinase (ERK) and Akt signaling pathways after arterial injury...

..The aim of this study was to investigate the effect of AA on SNO-mediated NO release, proliferation, cell cycle progression, cell death, and oxidative stress in vascular cells...

..A preexisting contralateral carotid artery occlusion has been described as a risk factor for inferior outcomes after carotid endarterectomy, but its impact on CAS outcomes is less understood...

..Late stent fatigue is a known complication after carotid artery stenting (CAS) for cervical carotid occlusive disease. The purpose of this study was to determine the prevalence and clinical significance of carotid stent fractures...

..Despite advances in endoluminal salvage for failed endografts, certain circumstances necessitate open endovascular abdominal aneurysm repair (EVAR) conversion. We review the indications for and outcomes after late EVAR explants...

..Endovascular repair of abdominal aortic aneurysms (EVAR) has largely supplanted open surgery over the past 2 decades. Faced with an aging population, the outcomes of EVAR among various age groups were examined...

..The aim of this study was to evaluate the role of estrogen receptor (ER) in mediating proliferation in male and female VSMC...

..Thoracic endovascular aortic repair (TEVAR) for acute blunt thoracic aortic injury has good early and mid-term results...

..Thus, the objective of this study is to determine if a WBC within the normal range is predictive of outcomes following vascular interventions...

..NTS. Early CAS outcomes between TS and NTS are comparable. In contrast, self-expanding nitinol TS may have a lower incidence of significant restenosis or asymptomatic occlusion when compared to NTS...

..Our hypothesis is that ultra-short duration NO delivery using a permeable balloon catheter will inhibit neointimal hyperplasia...

....

..Given the short half-life of NO release from PROLI/NO, our goal was to determine if inhibition of neointimal hyperplasia by PROLI/NO was due to NO, or its metabolites nitrite and nitrate...

....

....

..In an effort to preserve cerebral function, urgent early CEA has been recommended in many circumstances. We analyzed outcomes of different time intervals in early CEA in comparison with delayed treatment...

..This review describes common prosthetic materials, as well as approaches currently in use and under investigation to modify and improve prosthetic conduits for bypass grafting in an effort to improve graft patency rates...

..The aim of this study is to characterize the effect of arterial injury and NO on K48- or K63-linked ubiquitination of cellular proteins...

..To determine the incidence of isolated gastrocnemius and soleal vein thrombosis (IGSVT) and the effect of anticoagulation on venous thromboembolism (VTE) events in patients with IGSVT...

..This research demonstrates that p53 has antioxidant functions in stressed cells and also suggests that p53 has antiapoptotic properties...

..This may be one mechanism by which NO exerts its effects on the cell cycle and inhibits cellular proliferation in the vasculature...

..In this review, we will illustrate how diabetes affects the vasculature and how the molecular and cellular derangements that occur in diabetic environments lead to these pathophysiologic consequences...

..To review several cases of stent-graft infection with respective outcomes to identify clinical presentations and responses to treatment options...

....

..The aims of this study were to determine if hyperspectral imaging could accurately assess the presence or absence of PAD and accurately predict PAD severity...

..This review will summarize recent findings on the active role the adventitia plays toward the development of neointimal hyperplasia...

..To develop therapies that can improve upon current prosthetic vascular bypass grafting, a large animal model of prosthetic bypass grafting that results in reproducible neointimal hyperplasia is necessary...

..We prefer to use pedicled gracilis muscle flaps (PGMFs) to cover problematic groin wounds when more conventional management is not possible...

..A comparison of Excluder endograft deployment with femoral artery cutdown (FAC) versus percutaneous femoral access (PFA) for treatment of infrarenal AAA was undertaken...

..Early outcomes and restenosis rates in these patients were analyzed and compared with those in de novo lesions...

..This case report describes an early infection of an endoluminal aortic stent graft treated initially with percutaneous drainage and ultimately with staged extraanatomic bypass and graft explantation...

..Reported are our 30-day and midterm outcomes of CAS...

..Switching to a distal balloon occlusion system, which is well tolerated, may be preferred to unprotected predilation. Practitioners of CAS should be versed in both...

..Despite greater increases in LDL-C-lowering medication among female PAD patients, there was no difference in the degree of LDL-C lowering during the study between men and women with PAD...

..This review will focus on the differences in peripheral arterial disease based on gender and how these differences can affect the presentation, diagnosis and treatment of peripheral arterial disease in women...

..Vascular surgeons facile at CAS should expect 30-day results comparable to CEA in all age groups. Octogenarians, whether symptomatic or asymptomatic, should not be denied this form of treatment...

..Endovascular AAA repair did not acutely alter these anatomic findings. Patients with AAA may therefore be at lower risk of developing LCIV thrombosis owing to the nature of their anatomy...

..The use of specially designed devices appears to be technically feasible and durable, with acceptable morbidity and mortality rates...

..The Excluder endograft is a safe and effective treatment compared with open surgical repair for infrarenal abdominal aortic aneurysms with appropriate anatomy...

....

..We assessed the incidence and outcomes of graft-related secondary interventions (ie, open conversion or proximal or distal extensions) after elective thoracic endovascular aortic repair (TEVAR) for aneurysmal disease...

....

..Thus, the objective of this study was to develop and implement a computerized DVT risk assessment program in the electronic medical record and determine its effect on compliance with DVT prophylaxis guidelines...

....

..This article outlines the etiology, new diagnostic modalities, and treatment of aneurysms of the carotid artery...

..To evaluate a single center's experience with carotid artery stenting (CAS) and carotid endarterectomy (CEA) performed by vascular surgeons in an entirely veteran population...

..The aim of this study was to determine the effect of these mutations on patency of peripheral bypass procedures and preoperative and postoperative thromboembolic events...

..Therefore compression of the left iliac vein may represent a normal anatomic pattern that has thus far been thought of as a pathologic condition...

..Overall, this article highlights the need to have a high index of suspicion of bare metal stent infection, since prompt diagnosis and treatment can ultimately decrease the morbidity and mortality associated with this devastating problem...

....

..This review summarizes the clinical presentation, diagnosis, and treatment options, including both open and endovascular approaches, for acute and chronic mesenteric ischemia...

..The data from this study will serve as the basis for further studies of NO-mediated inhibition of neointimal hyperplasia. (End of Abstract) ..