SEEMA AHSAN KHAN

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Does resection of an intact breast primary improve survival in metastatic breast cancer?
    Seema A Khan
    Department of Surgery, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Oncology (Williston Park) 21:924-31; discussion 931-2, 934, 942, passim. 2007
  2. doi request reprint Lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer
    Jun Wang
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Cancer Prev Res (Phila) 6:321-30. 2013
  3. pmc Soy isoflavone supplementation for breast cancer risk reduction: a randomized phase II trial
    Seema A Khan
    Department of Surgery, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL 60611, USA
    Cancer Prev Res (Phila) 5:309-19. 2012
  4. pmc COX-2 and PPARgamma expression are potential markers of recurrence risk in mammary duct carcinoma in-situ
    Swati Kulkarni
    Lynn Sage Breast Center and Feinberg School of Medicine of Northwestern University, Chicago USA
    BMC Cancer 8:36. 2008
  5. pmc Primary tumor resection in stage IV breast cancer: consistent benefit, or consistent bias?
    Seema A Khan
    Ann Surg Oncol 14:3285-7. 2007
  6. ncbi request reprint The local hormonal environment and related biomarkers in the normal breast
    S A Khan
    Department of Surgery, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine of Northwestern University, Chicago, Illinois, USA
    Endocr Relat Cancer 12:497-510. 2005
  7. ncbi request reprint Ductal lavage findings in women with known breast cancer undergoing mastectomy
    Seema A Khan
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago IL, USA
    J Natl Cancer Inst 96:1510-7. 2004
  8. ncbi request reprint Optimal surgical treatment of breast cancer: implications for local control and survival
    Seema A Khan
    Department of Surgery and the Lynn Sage Comprehensive Breast Center, Feinberg School of Medicine of Northwestern University, Chicago, Illinois 60611, USA
    J Surg Oncol 101:677-86. 2010
  9. doi request reprint Office ductoscopy for surgical selection in women with pathologic nipple discharge
    Seema A Khan
    Department of Surgery, Lynn Sage Breast Center, Northwestern Feinberg School of Medicine, Chicago, IL, USA
    Ann Surg Oncol 18:3785-90. 2011
  10. pmc Ductal lavage is an inefficient method of biomarker measurement in high-risk women
    Seema A Khan
    Department of Surgery, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Lurie 4 133, Chicago, Illinois 60611, USA
    Cancer Prev Res (Phila) 2:265-73. 2009

Research Grants

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Does resection of an intact breast primary improve survival in metastatic breast cancer?
    Seema A Khan
    Department of Surgery, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Oncology (Williston Park) 21:924-31; discussion 931-2, 934, 942, passim. 2007
    ..In view of these data, the role of local therapy in women with stage IV breast cancer needs to be reevaluated, and local therapy plus systemic therapy should be compared to systemic therapy alone in a randomized trial...
  2. doi request reprint Lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer
    Jun Wang
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Cancer Prev Res (Phila) 6:321-30. 2013
    ..These data suggest that differential expression of lipid metabolism genes may be involved in the risk for subtypes of breast cancer, and are potential biomarkers of ER-specific breast cancer risk...
  3. pmc Soy isoflavone supplementation for breast cancer risk reduction: a randomized phase II trial
    Seema A Khan
    Department of Surgery, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL 60611, USA
    Cancer Prev Res (Phila) 5:309-19. 2012
    ....
  4. pmc COX-2 and PPARgamma expression are potential markers of recurrence risk in mammary duct carcinoma in-situ
    Swati Kulkarni
    Lynn Sage Breast Center and Feinberg School of Medicine of Northwestern University, Chicago USA
    BMC Cancer 8:36. 2008
    ..We performed a case-control study to identify protein markers of local recurrence risk in DCIS...
  5. pmc Primary tumor resection in stage IV breast cancer: consistent benefit, or consistent bias?
    Seema A Khan
    Ann Surg Oncol 14:3285-7. 2007
  6. ncbi request reprint The local hormonal environment and related biomarkers in the normal breast
    S A Khan
    Department of Surgery, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine of Northwestern University, Chicago, Illinois, USA
    Endocr Relat Cancer 12:497-510. 2005
    ..These studies are already providing new insights into the hormonal etiology of breast cancer, and should lead to the identification of robust, reversible biomarkers for use in breast cancer prevention studies...
  7. ncbi request reprint Ductal lavage findings in women with known breast cancer undergoing mastectomy
    Seema A Khan
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago IL, USA
    J Natl Cancer Inst 96:1510-7. 2004
    ..To assess the utility of ductal lavage as a cancer diagnostic test, we investigated the association between ductal lavage cytologic findings and histologic findings in women with known breast cancer undergoing mastectomy...
  8. ncbi request reprint Optimal surgical treatment of breast cancer: implications for local control and survival
    Seema A Khan
    Department of Surgery and the Lynn Sage Comprehensive Breast Center, Feinberg School of Medicine of Northwestern University, Chicago, Illinois 60611, USA
    J Surg Oncol 101:677-86. 2010
    ..Each component of surgical therapy has the potential for maximizing local control, and therefore for extending survival...
  9. doi request reprint Office ductoscopy for surgical selection in women with pathologic nipple discharge
    Seema A Khan
    Department of Surgery, Lynn Sage Breast Center, Northwestern Feinberg School of Medicine, Chicago, IL, USA
    Ann Surg Oncol 18:3785-90. 2011
    ..Mammary ductoscopy in the office setting may change this standard. We performed a prospective study to assess the utility of office ductoscopy for surgical selection in women with nipple discharge...
  10. pmc Ductal lavage is an inefficient method of biomarker measurement in high-risk women
    Seema A Khan
    Department of Surgery, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Lurie 4 133, Chicago, Illinois 60611, USA
    Cancer Prev Res (Phila) 2:265-73. 2009
    ....
  11. ncbi request reprint Cellular and hormonal content of breast nipple aspirate fluid in relation to the risk of breast cancer
    Seema A Khan
    Department of Surgery and the Robert H Lurie Comprehensive Cancer of Northwestern University, 301 East Superior Street, Chicago, IL, USA
    Biomark Med 2:479-93. 2008
    ....
  12. ncbi request reprint Ductal lavage findings in women with mammographic microcalcifications undergoing biopsy
    Seema A Khan
    Lynn Sage Comprehensive Breast Center, Feinberg School of Medicine of Northwestern University, 675 North St Clair Street, Galter 13 174, Chicago, Illinois, 60614, USA
    Ann Surg Oncol 12:689-96. 2005
    ..We designed a prospective study to assess the likelihood that early lesions presenting as mammographic calcifications could be accessed for cytological diagnosis by ductal lavage (DL)...
  13. ncbi request reprint Reproducibility of ductal lavage cytology and cellularity over a six month interval in high risk women
    Deepa B Patil
    Department of Surgery, The Robert H Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Breast Cancer Res Treat 112:327-33. 2008
    ..Ductal lavage (DL) allows repeat sampling of breast epithelium for serial observation in a chemoprevention setting; however, the reproducibility of duct cannulation, cell yield and cytology has not been addressed...
  14. ncbi request reprint Does aggressive local therapy improve survival in metastatic breast cancer?
    Seema A Khan
    Department of Surgery, Northwestern University Medical School, and the American College of Surgeons, Chicago, Ill 60611, USA
    Surgery 132:620-6; discussion 626-7. 2002
    ..Women with metastatic breast cancer and an intact primary tumor are currently treated with systemic therapy. Local therapy of the primary tumor is considered irrelevant to the outcome, and is recommended only for palliation of symptoms...
  15. ncbi request reprint Tamoxifen use in patients with ductal carcinoma in situ and T1a/b N0 invasive carcinoma
    Faina Nakhlis
    Department of Surgery, Lynn Sage Breast Program, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Am Coll Surg 201:688-94. 2005
    ..The purpose of this study was to determine how often patients with ductal carcinoma in situ and T1a/b N0 cancer are offered and accept tamoxifen for secondary chemoprevention...
  16. pmc A comparison of ductoscopy-guided and conventional surgical excision in women with spontaneous nipple discharge
    Robyn M Moncrief
    Department of Surgery, Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA
    Ann Surg 241:575-81. 2005
    ..Ductoscopy has been reported to result in improved localization of intraductal lesions and may avoid surgery in women with endoscopically normal ducts...
  17. ncbi request reprint Ductal lavage and ductoscopy: the opportunities and the limitations
    Seema A Khan
    The Lynn Sage Breast Center and the Department of Surgery, Northwestern University Medical School, Chicago, IL 60611, USA
    Clin Breast Cancer 3:185-91; discussion 192-5. 2002
    ..In this review of the rationale and early results of these procedures, we attempt to define some of these evidentiary requirements...
  18. doi request reprint Lobular carcinoma in situ variants in breast cores: potential for misdiagnosis, upgrade rates at surgical excision, and practical implications
    Megan E Sullivan
    Departments of Pathology, Northwestern Memorial Hospital, 251 E Huron St, Chicago, IL 60611 2908, USA
    Arch Pathol Lab Med 134:1024-8. 2010
    ..Lobular carcinoma in situ variants, including LCIS with necrosis and pleomorphic LCIS, share morphologic features with solid DCIS that may lead to misclassification...
  19. ncbi request reprint Endocrine biomarkers in ductal lavage samples from women at high risk for breast cancer
    Deepa Bhandare
    Lynn Sage Breast Center, 675 North St Clair, Galter 13 174, Chicago, IL 60611, USA
    Cancer Epidemiol Biomarkers Prev 14:2620-7. 2005
    ..We report here the baseline findings from a study designed to assess the utility of ductal lavage in this setting...
  20. ncbi request reprint The role of ductal lavage in the management of women at high risk for breast carcinoma
    Seema A Khan
    Northwestern University, Feinberg School of Medicine, 675 North St Clair Street, Galter 13 174, Chicago, IL 60611, USA
    Curr Treat Options Oncol 5:145-51. 2004
    ....
  21. ncbi request reprint Mastalgia and breast cancer: a protective association?
    Seema A Khan
    Department of Surgery, Northwestern Medical School, Chicago, IL 60611, USA
    Cancer Detect Prev 26:192-6. 2002
    ..Further investigation of this possible protective association is warranted...
  22. ncbi request reprint Estrogen receptor alpha expression in normal human breast epithelium is consistent over time
    Seema A Khan
    Department of Surgery, Upstate Medical University, Syracuse, NY, USA
    Int J Cancer 102:334-7. 2002
    ..These data suggest that ER expression of normal breast tissue is fairly consistent over time and support the notion that overexpression of ER in normal epithelium is a constant feature of the high risk breast...
  23. ncbi request reprint Expression of interleukin-6 and tumor necrosis factor alpha and histopathologic findings in painful and nonpainful breast tissue
    Rathi Ramakrishnan
    Department of Surgery, Northwestern Medical School, Chicago, Illinois 60611, USA
    Breast J 9:91-7. 2003
    ..Further investigation of the role of cytokines in breast pain is warranted, especially in view of the possible association between mastalgia and breast cancer risk...
  24. ncbi request reprint alphaB-crystallin is a novel predictor of resistance to neoadjuvant chemotherapy in breast cancer
    Olga Ivanov
    Department of Surgery, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA
    Breast Cancer Res Treat 111:411-7. 2008
    ..We examined whether alphaB-crystallin expression in breast cancer was associated with a poor response to neoadjuvant (preoperative) chemotherapy...
  25. ncbi request reprint Normal breast lobular architecture in breast biopsy samples from breast cancer cases and benign disease controls
    Rathi Ramakrishnan
    Department of Surgery, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Breast Cancer Res Treat 86:259-68. 2004
    ....
  26. ncbi request reprint Tissue-specific transcripts of human steroid sulfatase are under control of estrogen signaling pathways in breast carcinoma
    Tetiana Zaichuk
    Department of Surgery, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Steroid Biochem Mol Biol 105:76-84. 2007
    ..Our results indicate that STS isoforms are under control of estrogen signaling pathways and their differential expression may play a significant role in breast cancer biology...
  27. ncbi request reprint Variation in estradiol, estradiol precursors, and estrogen-related products in nipple aspirate fluid from normal premenopausal women
    Robert T Chatterton
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, 710 N Fairbanks Court, Chicago, IL 60611, USA
    Cancer Epidemiol Biomarkers Prev 13:928-35. 2004
    ....
  28. doi request reprint Surgical resection of the primary tumor, chest wall control, and survival in women with metastatic breast cancer
    Hannah W Hazard
    Lynn Sage Comprehensive Breast Center, Chicago, Illinois, USA
    Cancer 113:2011-9. 2008
    ..The authors reviewed chest wall status, time to first progression (TTFP), and overall survival (OS) in this group of women...
  29. pmc Array-based multiplex analysis of DNA methylation in breast cancer tissues
    Anatoliy A Melnikov
    Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago Illinois, USA
    J Mol Diagn 10:93-101. 2008
    ..These results indicate that informative cancer-specific methylation signatures can be detected in heterogeneous tissue specimens, suggesting that a diagnostic assay can then be developed...
  30. ncbi request reprint Identification of biomarkers for breast cancer in nipple aspiration and ductal lavage fluid
    Jinong Li
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 11:8312-20. 2005
    ..To establish a comprehensive proteomic approach for biomarker discovery and validation in breast fluid...
  31. ncbi request reprint Selecting patients for breast-conserving therapy: the importance of lobular histology
    Monica Morrow
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    Cancer 106:2563-8. 2006
    ..The purpose of this study was to compare the conversion rate from BCT to mastectomy among patients with lobular (ILC) and ductal carcinoma (IDC), and to compare the number of resections needed to obtain negative margins...
  32. ncbi request reprint Novel agents for chemoprevention, screening methods, and sampling issues
    Mary Jo Fackler
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
    J Mammary Gland Biol Neoplasia 8:75-89. 2003
    ..Factors that could contribute to a meaningful choice of the chemopreventive agents and the design of clinical trials are discussed...
  33. ncbi request reprint Formation of estrone and estradiol from estrone sulfate by normal breast parenchymal tissue
    Robert T Chatterton
    Department of Obstetrics and Gynecology, Feinberg School of Medicine of Northwestern University, 710 N Fairbanks Court, Chicago, IL 60611, USA
    J Steroid Biochem Mol Biol 86:159-66. 2003
    ..It is concluded that estrone sulfate can serve as a precursor for estradiol in normal breast tissue. Conversion of estrone to estradiol is a limiting step in the process...
  34. ncbi request reprint Quantitative multiplex methylation-specific PCR analysis doubles detection of tumor cells in breast ductal fluid
    Mary Jo Fackler
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore Maryland, USA
    Clin Cancer Res 12:3306-10. 2006
    ..We hypothesized that quantitative analysis of methylated genes will provide enhanced detection of cancer cells present in cytologic specimens...
  35. ncbi request reprint The characteristics of cyclical and non-cyclical mastalgia: a prospective study using a modified McGill Pain Questionnaire
    Seema A Khan
    Department of Surgery, Northwestern University, Chicago, IL 60611, USA
    Breast Cancer Res Treat 75:147-57. 2002
    ..96). Studies of breast pain should include both groups to better understand and characterize these differences, particularly with regard to a possible connection with breast cancer risk...
  36. ncbi request reprint Ki-67 expression in benign breast ductal cells obtained by random periareolar fine needle aspiration
    Deepa Bhandare
    Cancer Epidemiol Biomarkers Prev 14:2278; author reply 2278-9. 2005
  37. ncbi request reprint Pathologic findings in contralateral reduction mammaplasty specimens in patients with breast cancer
    Rathi Ramakrishnan
    Breast J 11:372-3. 2005
  38. ncbi request reprint Morphological changes in breast tissue with menstrual cycle
    Rathi Ramakrishnan
    Department of Surgery, Northwestern University Medical School, Chicago, Illinois, USA
    Mod Pathol 15:1348-56. 2002
    ..It will also aid the design of epidemiological studies for breast cancer risk assessment...
  39. ncbi request reprint Ductal lavage and the clinical management of women at high risk for breast carcinoma: a commentary
    Joyce A O'Shaughnessy
    Baylor Sammons Cancer Center, Dallas, Texas 75246, USA
    Cancer 94:292-8. 2002

Research Grants4

  1. Nipple Fluid Hormone Levels and Breast Cancer Risk
    Seema Khan; Fiscal Year: 2007
    ....
  2. Nipple Fluid Hormone Levels and Breast Cancer Risk
    Seema Khan; Fiscal Year: 2009
    ....
  3. Nipple Fluid Hormone Levels and Breast Cancer Risk
    SEEMA AHSAN KHAN; Fiscal Year: 2010
    ....