Research Topics
| SEEMA AHSAN KHANSummaryAffiliation: Northwestern University Country: USA Publications
Research Grants
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Detail Information
Publications
Soy isoflavone supplementation for breast cancer risk reduction: a randomized phase II trialSeema A Khan
Department of Surgery, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL 60611, USA
Cancer Prev Res (Phila) 5:309-19. 2012....- COX-2 and PPARgamma expression are potential markers of recurrence risk in mammary duct carcinoma in-situSwati Kulkarni
Lynn Sage Breast Center and Feinberg School of Medicine of Northwestern University, Chicago USA
BMC Cancer 8:36. 2008..We performed a case-control study to identify protein markers of local recurrence risk in DCIS... - Primary tumor resection in stage IV breast cancer: consistent benefit, or consistent bias?Seema A Khan
Ann Surg Oncol 14:3285-7. 2007 - Ductal lavage findings in women with known breast cancer undergoing mastectomySeema A Khan
Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago IL, USA
J Natl Cancer Inst 96:1510-7. 2004..To assess the utility of ductal lavage as a cancer diagnostic test, we investigated the association between ductal lavage cytologic findings and histologic findings in women with known breast cancer undergoing mastectomy... - The local hormonal environment and related biomarkers in the normal breastS A Khan
Department of Surgery, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine of Northwestern University, Chicago, Illinois, USA
Endocr Relat Cancer 12:497-510. 2005..These studies are already providing new insights into the hormonal etiology of breast cancer, and should lead to the identification of robust, reversible biomarkers for use in breast cancer prevention studies... - Does resection of an intact breast primary improve survival in metastatic breast cancer?Seema A Khan
Department of Surgery, Northwestern University Medical School, Chicago, Illinois 60611, USA
Oncology (Williston Park) 21:924-31; discussion 931-2, 934, 942, passim. 2007..In view of these data, the role of local therapy in women with stage IV breast cancer needs to be reevaluated, and local therapy plus systemic therapy should be compared to systemic therapy alone in a randomized trial... - Ductal lavage findings in women with mammographic microcalcifications undergoing biopsySeema A Khan
Lynn Sage Comprehensive Breast Center, Feinberg School of Medicine of Northwestern University, 675 North St Clair Street, Galter 13 174, Chicago, Illinois, 60614, USA
Ann Surg Oncol 12:689-96. 2005..We designed a prospective study to assess the likelihood that early lesions presenting as mammographic calcifications could be accessed for cytological diagnosis by ductal lavage (DL)... - Ductal lavage is an inefficient method of biomarker measurement in high-risk womenSeema A Khan
Department of Surgery, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Lurie 4 133, Chicago, Illinois 60611, USA
Cancer Prev Res (Phila) 2:265-73. 2009.... - Cellular and hormonal content of breast nipple aspirate fluid in relation to the risk of breast cancerSeema A Khan
Department of Surgery and the Robert H Lurie Comprehensive Cancer of Northwestern University, 301 East Superior Street, Chicago, IL, USA
Biomark Med 2:479-93. 2008.... - Optimal surgical treatment of breast cancer: implications for local control and survivalSeema A Khan
Department of Surgery and the Lynn Sage Comprehensive Breast Center, Feinberg School of Medicine of Northwestern University, Chicago, Illinois 60611, USA
J Surg Oncol 101:677-86. 2010..Each component of surgical therapy has the potential for maximizing local control, and therefore for extending survival... - Office ductoscopy for surgical selection in women with pathologic nipple dischargeSeema A Khan
Department of Surgery, Lynn Sage Breast Center, Northwestern Feinberg School of Medicine, Chicago, IL, USA
Ann Surg Oncol 18:3785-90. 2011..Mammary ductoscopy in the office setting may change this standard. We performed a prospective study to assess the utility of office ductoscopy for surgical selection in women with nipple discharge... - Reproducibility of ductal lavage cytology and cellularity over a six month interval in high risk womenDeepa B Patil
Department of Surgery, The Robert H Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Breast Cancer Res Treat 112:327-33. 2008..Ductal lavage (DL) allows repeat sampling of breast epithelium for serial observation in a chemoprevention setting; however, the reproducibility of duct cannulation, cell yield and cytology has not been addressed... - Does aggressive local therapy improve survival in metastatic breast cancer?Seema A Khan
Department of Surgery, Northwestern University Medical School, and the American College of Surgeons, Chicago, Ill 60611, USA
Surgery 132:620-6; discussion 626-7. 2002..Women with metastatic breast cancer and an intact primary tumor are currently treated with systemic therapy. Local therapy of the primary tumor is considered irrelevant to the outcome, and is recommended only for palliation of symptoms... - Tamoxifen use in patients with ductal carcinoma in situ and T1a/b N0 invasive carcinomaFaina Nakhlis
Department of Surgery, Lynn Sage Breast Program, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
J Am Coll Surg 201:688-94. 2005..02) and accepting tamoxifen (p = 0.002) on univariate analysis. CONCLUSIONS: Factors associated with tamoxifen risks and benefits correlate poorly with the use of the drug... - A comparison of ductoscopy-guided and conventional surgical excision in women with spontaneous nipple dischargeRobyn M Moncrief
Department of Surgery, Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA
Ann Surg 241:575-81. 2005..A prospective study is required to obtain an unbiased assessment of these possible advantages... - Endocrine biomarkers in ductal lavage samples from women at high risk for breast cancerDeepa Bhandare
Lynn Sage Breast Center, 675 North St. Clair, Galter 13-174, Chicago, IL 60611, USA
Cancer Epidemiol Biomarkers Prev 14:2620-7. 2005..001).CONCLUSIONS: Biomarker analyses in epithelial cells and DLS are feasible. The significant associations of EGF with other markers suggest a possible role in increasing epithelial cell mass... - The role of ductal lavage in the management of women at high risk for breast carcinomaSeema A Khan
Northwestern University, Feinberg School of Medicine, 675 North St Clair Street, Galter 13 174, Chicago, IL 60611, USA
Curr Treat Options Oncol 5:145-51. 2004.... - Lobular carcinoma in situ variants in breast cores: potential for misdiagnosis, upgrade rates at surgical excision, and practical implicationsMegan E Sullivan
Departments of Pathology, Northwestern Memorial Hospital, 251 E Huron St, Chicago, IL 60611 2908, USA
Arch Pathol Lab Med 134:1024-8. 2010..Lobular carcinoma in situ variants, including LCIS with necrosis and pleomorphic LCIS, share morphologic features with solid DCIS that may lead to misclassification... - Ductal lavage and ductoscopy: the opportunities and the limitationsSeema A Khan
The Lynn Sage Breast Center and the Department of Surgery, Northwestern University Medical School, Chicago, IL 60611, USA
Clin Breast Cancer 3:185-91; discussion 192-5. 2002..In this review of the rationale and early results of these procedures, we attempt to define some of these evidentiary requirements... - Estrogen receptor alpha expression in normal human breast epithelium is consistent over timeSeema A Khan
Department of Surgery, Upstate Medical University, Syracuse, NY, USA
Int J Cancer 102:334-7. 2002..These data suggest that ER expression of normal breast tissue is fairly consistent over time and support the notion that overexpression of ER in normal epithelium is a constant feature of the high risk breast... - Normal breast lobular architecture in breast biopsy samples from breast cancer cases and benign disease controlsRathi Ramakrishnan
Department of Surgery, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Breast Cancer Res Treat 86:259-68. 2004.... - Expression of interleukin-6 and tumor necrosis factor alpha and histopathologic findings in painful and nonpainful breast tissueRathi Ramakrishnan
Department of Surgery, Northwestern Medical School, Chicago, Illinois 60611, USA
Breast J 9:91-7. 2003..Further investigation of the role of cytokines in breast pain is warranted, especially in view of the possible association between mastalgia and breast cancer risk... - alphaB-crystallin is a novel predictor of resistance to neoadjuvant chemotherapy in breast cancerOlga Ivanov
Department of Surgery, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA
Breast Cancer Res Treat 111:411-7. 2008..We examined whether alphaB-crystallin expression in breast cancer was associated with a poor response to neoadjuvant (preoperative) chemotherapy... - Mastalgia and breast cancer: a protective association?Seema A Khan
Department of Surgery, Northwestern Medical School, Chicago, IL 60611, USA
Cancer Detect Prev 26:192-6. 2002..Further investigation of this possible protective association is warranted... - Array-based multiplex analysis of DNA methylation in breast cancer tissuesAnatoliy A Melnikov
Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago Illinois, USA
J Mol Diagn 10:93-101. 2008..These results indicate that informative cancer-specific methylation signatures can be detected in heterogeneous tissue specimens, suggesting that a diagnostic assay can then be developed... - Tissue-specific transcripts of human steroid sulfatase are under control of estrogen signaling pathways in breast carcinomaTetiana Zaichuk
Department of Surgery, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
J Steroid Biochem Mol Biol 105:76-84. 2007..Our results indicate that STS isoforms are under control of estrogen signaling pathways and their differential expression may play a significant role in breast cancer biology... - Surgical resection of the primary tumor, chest wall control, and survival in women with metastatic breast cancerHannah W Hazard
Lynn Sage Comprehensive Breast Center, Chicago, Illinois, USA
Cancer 113:2011-9. 2008..The authors reviewed chest wall status, time to first progression (TTFP), and overall survival (OS) in this group of women... - Variation in estradiol, estradiol precursors, and estrogen-related products in nipple aspirate fluid from normal premenopausal womenRobert T Chatterton
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, 710 N Fairbanks Court, Chicago, IL 60611, USA
Cancer Epidemiol Biomarkers Prev 13:928-35. 2004.... - Novel agents for chemoprevention, screening methods, and sampling issuesMary Jo Fackler
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231-1000, USA
J Mammary Gland Biol Neoplasia 8:75-89. 2003..Factors that could contribute to a meaningful choice of the chemopreventive agents and the design of clinical trials are discussed... - Selecting patients for breast-conserving therapy: the importance of lobular histologyMonica Morrow
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
Cancer 106:2563-8. 2006..The purpose of this study was to compare the conversion rate from BCT to mastectomy among patients with lobular (ILC) and ductal carcinoma (IDC), and to compare the number of resections needed to obtain negative margins... - Identification of biomarkers for breast cancer in nipple aspiration and ductal lavage fluidJinong Li
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Clin Cancer Res 11:8312-20. 2005..To establish a comprehensive proteomic approach for biomarker discovery and validation in breast fluid... - The characteristics of cyclical and non-cyclical mastalgia: a prospective study using a modified McGill Pain QuestionnaireSeema A Khan
Department of Surgery, Northwestern University, Chicago, IL 60611, USA
Breast Cancer Res Treat 75:147-57. 2002..96). Studies of breast pain should include both groups to better understand and characterize these differences, particularly with regard to a possible connection with breast cancer risk... - Morphological changes in breast tissue with menstrual cycleRathi Ramakrishnan
Department of Surgery, Northwestern University Medical School, Chicago, Illinois, USA
Mod Pathol 15:1348-56. 2002..It will also aid the design of epidemiological studies for breast cancer risk assessment... - Formation of estrone and estradiol from estrone sulfate by normal breast parenchymal tissueRobert T Chatterton
Department of Obstetrics and Gynecology, Feinberg School of Medicine of Northwestern University, 710 N Fairbanks Court, Chicago, IL 60611, USA
J Steroid Biochem Mol Biol 86:159-66. 2003..It is concluded that estrone sulfate can serve as a precursor for estradiol in normal breast tissue. Conversion of estrone to estradiol is a limiting step in the process... - Quantitative multiplex methylation-specific PCR analysis doubles detection of tumor cells in breast ductal fluidMary Jo Fackler
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore Maryland, USA
Clin Cancer Res 12:3306-10. 2006..This study provides proof of principle by showing the advantages of using methylation analyses to query cytologic specimens and indicates its potential use in diagnosis and in stratifying risk... - Pathologic findings in contralateral reduction mammaplasty specimens in patients with breast cancerRathi Ramakrishnan
Breast J 11:372-3. 2005 - Ki-67 expression in benign breast ductal cells obtained by random periareolar fine needle aspirationDeepa Bhandare
Cancer Epidemiol Biomarkers Prev 14:2278; author reply 2278-9. 2005 - Ductal lavage and the clinical management of women at high risk for breast carcinoma: a commentaryBritt Marie Ljung
Baylor-Sammons Cancer Center, Dallas, Texas 75246, USA
Cancer 94:292-8. 2002
Research Grants
- Nipple Fluid Hormone Levels and Breast Cancer RiskSeema Khan; Fiscal Year: 2007....
- Nipple Fluid Hormone Levels and Breast Cancer RiskSEEMA AHSAN KHAN; Fiscal Year: 2010....