Lixin Kan

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. doi request reprint Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification
    Lixin Kan
    Department of Neurology, Northwestern University, Ward Building 10 233, 303 East Chicago Avenue, Chicago, IL, 60611 3008, USA
    Inflamm Res 63:207-15. 2014
  2. pmc Glast-expressing progenitor cells contribute to heterotopic ossification
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Bone 53:194-203. 2013
  3. doi request reprint CNS demyelination in fibrodysplasia ossificans progressiva
    Lixin Kan
    Department of Neurology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Neurol 259:2644-55. 2012
  4. pmc Inhibition of BMP signaling in P-Cadherin positive hair progenitor cells leads to trichofolliculoma-like hair follicle neoplasias
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Biomed Sci 18:92. 2011
  5. pmc Substance P signaling mediates BMP-dependent heterotopic ossification
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg Medical School, Chicago, Illinois 60611, USA
    J Cell Biochem 112:2759-72. 2011
  6. pmc Animal models of typical heterotopic ossification
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Biomed Biotechnol 2011:309287. 2011
  7. pmc Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg Medical School, Chicago, Illinois 60611 3008, USA
    Stem Cells 27:150-6. 2009
  8. pmc Dual function of Sox1 in telencephalic progenitor cells
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Ward 10 233, Chicago, IL 60611 3008, USA
    Dev Biol 310:85-98. 2007
  9. ncbi request reprint New tool for an old problem: can RNAi efficiently resolve the issue of genetic redundancy?
    Lixin Kan
    Department of Neurology, Northwestern University s Feinberg School of Medicine, Ward Building 10 185, 303 East Chicago Avenue, Chicago, IL 60611 3008, USA
    Bioessays 27:14-6. 2005
  10. pmc Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg School of Medicine, Ward Building 10 185, 303 East Chicago Avenue, Chicago, Illinois 60611 3008, USA
    Am J Pathol 165:1107-15. 2004

Collaborators

Detail Information

Publications19

  1. doi request reprint Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification
    Lixin Kan
    Department of Neurology, Northwestern University, Ward Building 10 233, 303 East Chicago Avenue, Chicago, IL, 60611 3008, USA
    Inflamm Res 63:207-15. 2014
    ..It is of interest great to know the pain responses in these mice and how the opioid signaling is involved in the downstream events such as mast cell (MC) activation...
  2. pmc Glast-expressing progenitor cells contribute to heterotopic ossification
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Bone 53:194-203. 2013
    ..Further, identification of Glast-expressing cells as precursors that give rise to HO should help with the molecular targeting of this population both for the prevention and for the treatment of HO...
  3. doi request reprint CNS demyelination in fibrodysplasia ossificans progressiva
    Lixin Kan
    Department of Neurology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Neurol 259:2644-55. 2012
    ..These findings suggest that dysregulated BMP signaling disturbs normal homeostasis of target tissues, including CNS where focal demyelination may manifest as the neurologic symptoms frequently observed in FOP...
  4. pmc Inhibition of BMP signaling in P-Cadherin positive hair progenitor cells leads to trichofolliculoma-like hair follicle neoplasias
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Biomed Sci 18:92. 2011
    ..Multiple signaling molecules, including bone morphogenetic proteins (BMPs), have been implicated in this process...
  5. pmc Substance P signaling mediates BMP-dependent heterotopic ossification
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg Medical School, Chicago, Illinois 60611, USA
    J Cell Biochem 112:2759-72. 2011
    ..These observations establish a potent neuro-inflammatory induction and amplification circuit for BMP-dependent HO lesion formation, and identify novel molecular targets for prevention of HO...
  6. pmc Animal models of typical heterotopic ossification
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Biomed Biotechnol 2011:309287. 2011
    ..This article reviews the major currently available animal models, summarizes some of the insights gained from these studies, and discusses the potential future challenges and directions in HO research...
  7. pmc Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg Medical School, Chicago, Illinois 60611 3008, USA
    Stem Cells 27:150-6. 2009
    ..These observations suggest that dysregulation of local stem/progenitor cells could be a common cellular mechanism for typical HO irrespective of the signal initiating the bone formation...
  8. pmc Dual function of Sox1 in telencephalic progenitor cells
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Ward 10 233, Chicago, IL 60611 3008, USA
    Dev Biol 310:85-98. 2007
    ....
  9. ncbi request reprint New tool for an old problem: can RNAi efficiently resolve the issue of genetic redundancy?
    Lixin Kan
    Department of Neurology, Northwestern University s Feinberg School of Medicine, Ward Building 10 185, 303 East Chicago Avenue, Chicago, IL 60611 3008, USA
    Bioessays 27:14-6. 2005
    ..Their somewhat conflicting findings are probably the typical scenario for most RNAi experiments: some expected results and some surprises...
  10. pmc Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype
    Lixin Kan
    Department of Neurology, Northwestern University Feinberg School of Medicine, Ward Building 10 185, 303 East Chicago Avenue, Chicago, Illinois 60611 3008, USA
    Am J Pathol 165:1107-15. 2004
    ..This remarkable animal model provides a unique opportunity to further study the role of the BMP signaling pathway in heterotopic ossification and to improve our understanding of the clinical aspects of FOP...
  11. ncbi request reprint Sox1 acts through multiple independent pathways to promote neurogenesis
    Lixin Kan
    Department of Neurology, Northwestern University s Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Dev Biol 269:580-94. 2004
    ..These observations suggest that Sox1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation...
  12. ncbi request reprint Beta-catenin signaling is required for neural differentiation of embryonic stem cells
    José Javier Otero
    Department of Neurology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Development 131:3545-57. 2004
    ....
  13. ncbi request reprint LIF and BMP signaling generate separate and discrete types of GFAP-expressing cells
    Michael A Bonaguidi
    Davee Department of Neurology, Northwestern University s Feinberg School of Medicine, Chicago, IL 60611, USA
    Development 132:5503-14. 2005
    ..We conclude that LIF and BMP signaling generate different astrocytic cell types, and propose that these cells are, respectively, adult progenitor cells and mature astrocytes...
  14. pmc HeyL promotes neuronal differentiation of neural progenitor cells
    Ali Jalali
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Neurosci Res 89:299-309. 2011
    ..These observations suggest that HeyL promotes neuronal differentiation of neural progenitor cells by activating proneural genes and by inhibiting the actions of other Hes and Hey family members...
  15. pmc Noggin protects against ischemic brain injury in rodents
    Jayshree Samanta
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Stroke 41:357-62. 2010
    ..The brain also expresses an inhibitor of bone morphogenetic protein signaling, noggin, but the role of noggin in ischemic disease outcome has not been studied...
  16. ncbi request reprint The presence of FGF2 signaling determines whether beta-catenin exerts effects on proliferation or neuronal differentiation of neural stem cells
    Nipan Israsena
    Department of Neurology, Northwestern University s Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Dev Biol 268:220-31. 2004
    ..We suggest that the balance between the mitogenic effects and the proneural effects of beta-catenin is determined by the presence of FGF signaling...
  17. pmc FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis
    Qi Quan Huang
    Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Blood 116:4968-77. 2010
    ..These observations demonstrate that FLIP is necessary for macrophage differentiation and the homeostatic regulation of granulopoiesis...
  18. pmc Bone morphogenetic protein signaling regulates postnatal hair follicle differentiation and cycling
    Udayan Guha
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 165:729-40. 2004
    ..BMPs likely promote a hair follicle-type differentiation pathway of keratinocytes while suppressing the sebaceous differentiation pathway of skin epithelium...
  19. ncbi request reprint Bone morphogenetic protein-2 and -4 limit the number of enteric neurons but promote development of a TrkC-expressing neurotrophin-3-dependent subset
    ALCMENE CHALAZONITIS
    Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 24:4266-82. 2004
    ..BMP-2 and/or BMP-4 thus limit the size of the ENS but promote the development of specific subsets of enteric neurons, including those that express TrkC...