Research Topics
| Peter James KahrilasSummaryAffiliation: Northwestern University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Republished: Failure of reflux inhibitors in clinical trials: bad drugs or wrong patients?Peter J Kahrilas
Northwestern University, Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, 676 N St Clair Street, 14th Floor, Chicago, IL 60611, USA
Postgrad Med J 89:111-9. 2013....- Concomitant symptoms itemized in the Reflux Disease Questionnaire are associated with attenuated heartburn response to acid suppressionPeter J Kahrilas
Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 2951, USA
Am J Gastroenterol 107:1354-60. 2012..However, clinical trials have generally focused only on the "substernal burning" item and limited data exist on the effect of concomitant items on the treatment response of "substernal burning"... - Failure of reflux inhibitors in clinical trials: bad drugs or wrong patients?Peter J Kahrilas
Northwestern University, Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, 676 N St Clair Street, Chicago, IL 60611, USA
Gut 61:1501-9. 2012.... - Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux diseasePeter J Kahrilas
Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Clin Gastroenterol Hepatol 10:612-9. 2012..We evaluated the responsiveness of regurgitation, characterized by the reflux disease questionnaire (RDQ) to potent acid suppression... - Evaluation of the esophagogastric junction using high resolution manometry and esophageal pressure topographyP J Kahrilas
Department of Medicine, Division of Gastroenterology and Hepatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Neurogastroenterol Motil 24:11-9. 2012..Finally, although the accomplishments summarized above are substantial, much work remains to fully exploit the potential of EPT in the clinical characterization of the EGJ... 
Prospective randomized controlled trial of an injectable esophageal prosthesis versus a sham procedure for endoscopic treatment of gastroesophageal reflux diseasePaul Fockens
Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
Surg Endosc 24:1387-97. 2010..This study aimed to assess whether endoscopic implantation of an injectable esophageal prosthesis, the Gatekeeper Reflux Repair System (GK), is a safe and effective therapy for controlling gastroesophageal reflux disease (GERD)...- Esophageal motor disorders in terms of high-resolution esophageal pressure topography: what has changed?Peter J Kahrilas
Division of Gastroenterology, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
Am J Gastroenterol 105:981-7. 2010..Ultimately, clinical experience will be the judge, but it seems likely that HREPT data, along with its well-defined functional implications, will improve the clinical management of esophageal motility disorders... 
Review article: gastro-oesophageal reflux disease as a functional gastrointestinal disorderP J Kahrilas
Northwestern University, Feinberg School of Medicine, Department of Medicine, Division of Gastroenterology, Chicago, IL 60611 2951, USA
Aliment Pharmacol Ther 20:50-5. 2004....- Pathophysiology of gastroesophageal reflux diseasePeter J Kahrilas
Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 1400, Chicago, IL 60611, USA
Thorac Surg Clin 15:323-33. 2005..These abnormalities exhibit a complicated interplay that degrades the ability of the EGJ to contain gastric juice within the stomach and to clear the esophagus of gastric juice effectively once reflux has occurred... - Response of unexplained chest pain to proton pump inhibitor treatment in patients with and without objective evidence of gastro-oesophageal reflux diseasePeter J Kahrilas
Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 2951, USA
Gut 60:1473-8. 2011..We explored the response of unexplained chest pain to proton pump inhibitor (PPI) therapy in randomised clinical trials (RCTs), differentiating patients with and without objective evidence of GORD... - Efficacy of rabeprazole in the treatment of symptomatic gastroesophageal reflux diseasePeter J Kahrilas
Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Dig Dis Sci 50:2009-18. 2005..g., regurgitation, belching, early satiety) by week 4 compared with placebo (P < or = .05). Rabeprazole provides fast and potent relief from heartburn and other symptoms of nonerosive gastroesophageal reflux disease... - Response of regurgitation to proton pump inhibitor therapy in clinical trials of gastroesophageal reflux diseasePeter J Kahrilas
Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 2951, USA
Am J Gastroenterol 106:1419-25; quiz 1426. 2011..This study aimed to evaluate the response of regurgitation to PPI therapy in GERD trials... - Review article: oesophageal pH monitoring--technologies, interpretation and correlation with clinical outcomesP J Kahrilas
Division of Gastroeneterology, Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
Aliment Pharmacol Ther 22:2-9. 2005..More research is needed to determine whether the detection of reflux events with Bravo will provide a good correlation with symptom episodes... - Management of GERD: medical versus surgicalP J Kahrilas
Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
Semin Gastrointest Dis 12:3-15. 2001..However, regardless of the motivation for pursuing surgical management, patients must be advised of potential suboptimal results and the irreversibility of the procedure... - Refractory heartburnPeter J Kahrilas
Department of Medicine, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, 676 St. Clair Street, Suite 1400, Chicago, IL 60611-2951, USA
Gastroenterology 124:1941-5. 2003 - Challenging the limits of esophageal manometryPeter J Kahrilas
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Gastroenterology 134:16-8. 2008 - A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitisPeter J Kahrilas
Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
Clin Gastroenterol Hepatol 5:1385-91. 2007..AZD0865 belongs to a new class of acid-suppressing agents with rapid onset of action and potent acid inhibition. We evaluated its effectiveness for healing reflux esophagitis... - Pressure morphology of the relaxed lower esophageal sphincter: the formation and collapse of the phrenic ampullaMonika A Kwiatek
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Am J Physiol Gastrointest Liver Physiol 302:G389-96. 2012.... - Gatekeeper reflux repair system; a mechanistic hypothesisP J Kahrilas
Northwestern University, Feinberg School of Medicine, Division of Gastroenterology, Department of Medicine, 676 N St Clair Street, Suite 1400, Chicago, Illinois 60611, USA
Gut 54:179-80. 2005 - High-resolution manometry and impedance-pH/manometry: valuable tools in clinical and investigational esophagologyPeter J Kahrilas
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
Gastroenterology 135:756-69. 2008..Ultimately, however, both technologies will be strengthened as outcome studies evaluating their utilization become available... - Approaches to the diagnosis and grading of hiatal herniaPeter J Kahrilas
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
Best Pract Res Clin Gastroenterol 22:601-16. 2008.... - Clinical practice. Gastroesophageal reflux diseasePeter J Kahrilas
Division of Gastroenterology, Feinberg School of Medicine, Chicago IL 60611-2951, USA
N Engl J Med 359:1700-7. 2008 - Esophageal motility disorders in terms of pressure topography: the Chicago ClassificationPeter J Kahrilas
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
J Clin Gastroenterol 42:627-35. 2008.... - The target of therapies: pathophysiology of gastroesophageal reflux diseasePeter J Kahrilas
Department of Medicine, Northwestern University s Feinberg School of Medicine, Division of Gastroenterology, Searle Bldg, 10th Floor, Suite 541, 303 East Chicago Avenue, Chicago, IL 60611, USA
Gastrointest Endosc Clin N Am 13:1-17. 2003.... - Restoration of normal distensive characteristics of the esophagogastric junction after fundoplicationJohn E Pandolfino
Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
Ann Surg 242:43-8. 2005..Since trans-EGJ flow is related to EGJ length and EGJ diameter, these findings suggest that retrograde flow through the EGJ would be decreased by both a reduction in diameter and an increase in length of the EGJ... - Functional esophagogastric junction obstruction with intact peristalsis: a heterogeneous syndrome sometimes akin to achalasiaJohn R Scherer
Department of Medicine, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
J Gastrointest Surg 13:2219-25. 2009..Some patients with suspected achalasia are found on manometry to have preserved peristalsis, thereby excluding that diagnosis. This study evaluated a series of such patients with functional esophagogastric junction (EGJ) obstruction... - Esophageal pressure topography criteria indicative of incomplete bolus clearance: a study using high-resolution impedance manometryWilliam J Bulsiewicz
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
Am J Gastroenterol 104:2721-8. 2009..This study used high-resolution impedance manometry (HRIM) to determine pressure topography thresholds of peristaltic integrity predictive of incomplete esophageal bolus clearance... - Acidity surrounding the squamocolumnar junction in GERD patients: "acid pocket" versus "acid film"John E Pandolfino
Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
Am J Gastroenterol 102:2633-41. 2007..This study aimed to localize the gastric-to-esophageal pH transition point relative to the squamocolumnar junction (SCJ) and esophagogastric junction (EGJ) high-pressure zone in controls and GERD patients... - Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjectsJohn E Pandolfino
Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Gastroenterology 125:1018-24. 2003..Therapy focused on EGJ compliance may benefit GERD patients... - Deglutitive inhibition affects both esophageal peristaltic amplitude and shorteningGuoxiang Shi
Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
Am J Physiol Gastrointest Liver Physiol 284:G575-82. 2003..Deglutitive inhibition affects both the longitudinal and circular muscle layers of the esophageal wall, and the occurrence of inhibition evident in one layer is strongly correlated with the other... - GERD pathogenesis, pathophysiology, and clinical manifestationsPeter J Kahrilas
Division of Gastroenterology and Hepatology, Northwestern University Medical School, Chicago, Ill, USA
Cleve Clin J Med 70:S4-19. 2003..GERD is typically chronic, and while it is generally nonprogressive, some cases are associated with development of complications of increasing severity and significance... - Diagnosis of symptomatic gastroesophageal reflux diseasePeter J Kahrilas
Department of Medicine, Section of Gastroenterology, Northwestern University Feinberg School of Medicine, Suite 1400, 676 N St Clair Street, Chicago, IL 60611-2927, USA
Am J Gastroenterol 98:S15-23. 2003..It has been shown effective in about 75% of patients, and offers a simple approach to managing the difficult-to-diagnose patient even while further diagnostic procedures are carried out... - Esophagogastric junction distensibility: a factor contributing to sphincter incompetenceJohn E Pandolfino
Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611-3008, USA
Am J Physiol Gastrointest Liver Physiol 282:G1052-8. 2002.... - Esophagogastric junction morphology predicts susceptibility to exercise-induced refluxJohn E Pandolfino
Northwestern University's Feinberg School of Medicine, Chicago, Illinois 60611, USA
Am J Gastroenterol 99:1430-6. 2004..The degree of exercise-induced reflux is strongly correlated with EGJ morphology and this supports the hypothesis that anatomical integrity of the EGJ is of cardinal importance in preventing strain-induced reflux... - Utilizing intraluminal pressure gradients to predict esophageal clearance: a validation studyJohn E Pandolfino
Departments of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Am J Gastroenterol 103:1898-905. 2008..Esophageal bolus clearance requires a preferential esophagogastric pressure gradient sustained for a sufficient period. We aimed to validate a high-resolution manometry (HRM) paradigm for predicting bolus clearance... - Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteersJohn E Pandolfino
Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
Am J Physiol Gastrointest Liver Physiol 290:G1033-40. 2006..In addition to providing conventional EGJ relaxation parameters, this technology also creates opportunities to quantify more precise measures of EGJ relaxation and morphology... - Radiofrequency therapy of the lower esophageal sphincter for treatment of GERDPeter J Kahrilas
Department of Medicine, Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
Gastrointest Endosc 57:723-31. 2003 - Deglutitive upper esophageal sphincter relaxation: a study of 75 volunteer subjects using solid-state high-resolution manometrySudip K Ghosh
Northwestern University, Feinberg School of Medicine, Div of Gastroenterology, Dept of Medicine, 676 N St Clair St, Suite 1400, Chicago, IL 60611, USA
Am J Physiol Gastrointest Liver Physiol 291:G525-31. 2006..Normative values were established to aid in future clinical and investigative studies... - Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometryJohn E Pandolfino
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Gastroenterology 131:1725-33. 2006.... - High-resolution manometry of the EGJ: an analysis of crural diaphragm function in GERDJohn E Pandolfino
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Am J Gastroenterol 102:1056-63. 2007..This study compared CD function of subjects with and without gastroesophageal reflux disease (GERD)... - Impaired deglutitive EGJ relaxation in clinical esophageal manometry: a quantitative analysis of 400 patients and 75 controlsSudip K Ghosh
Dept of Medicine, Feinberg School of Medicine, Northwestern Univ, Chicago, IL 60611, USA
Am J Physiol Gastrointest Liver Physiol 293:G878-85. 2007.... - Utilizing intraluminal pressure differences to predict esophageal bolus flow dynamicsSudip K Ghosh
Department of Medicine, Northwestern University, Feinberg School of Medicine, Division of Gastroenterology, Chicago, IL 60611, USA
Am J Physiol Gastrointest Liver Physiol 293:G1023-8. 2007..This may help predict abnormal bolus transit and the underlying mechanical properties of the EGJ... - Oropharyngeal swallow in younger and older women: videofluoroscopic analysisJeri A Logemann
Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208, USA
J Speech Lang Hear Res 45:434-45. 2002..Older women also exhibited an increased range of motion relative to the old men. This increase may indicate a compensation for aging effects not seen in older men... - Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteersSudip K Ghosh
Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
Am J Physiol Gastrointest Liver Physiol 290:G988-97. 2006.... - Ambulatory esophageal pH monitoring using a wireless systemJohn E Pandolfino
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611-3008, USA
Am J Gastroenterol 98:740-9. 2003..The 95th percentile for the 2-day recordings in control subjects was 5.3%, slightly higher than observed with conventional systems... - Absence of a deglutitive inhibition equivalent with secondary peristalsisJohn E Pandolfino
Division of Gastroenterology, Dept of Medicine, Northwestern Univ Feinberg School of Medicine, Suite 1400, 676 N St Clair St, Chicago, IL 60611, USA
Am J Physiol Gastrointest Liver Physiol 288:G671-6. 2005..Being that the elicitation of SP in the smooth muscle esophagus is intramurally mediated, this suggests that deglutitive inhibition is a centrally mediated phenomenon rather than an intrinsic property of peristalsis... - Hyperdynamic upper esophageal sphincter pressure: a manometric observation in patients reporting globus sensationMonika A Kwiatek
Division of Gastroenterology, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Am J Gastroenterol 104:289-98. 2009.... - New technologies in the gastrointestinal clinic and research: impedance and high-resolution manometryJohn E Pandolfino
Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, Illinois 60611, USA
World J Gastroenterol 15:131-8. 2009..This review describes the potential benefits that these new technologies may have over conventional techniques for the evaluation of dysphagia... - Prolonged pH monitoring: Bravo capsuleJohn E Pandolfino
Department of Medicine, Northwestern University, The Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
Gastrointest Endosc Clin N Am 15:307-18. 2005..Further refinements in methodology and recording protocol are likely to be made, which will improve diagnostic accuracy and lower cost... - Classifying esophageal motility by pressure topography characteristics: a study of 400 patients and 75 controlsJohn E Pandolfino
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Am J Gastroenterol 103:27-37. 2008..This study aimed to devise a scheme for the systematic analysis of esophageal high-resolution manometry (HRM) studies displayed using topographic plotting... - The pathophysiologic basis for epidemiologic trends in gastroesophageal reflux diseaseJohn E Pandolfino
Division of Gastroenterology, Department of Medicine, Northwestern University s Feinberg School of Medicine, 676 North St Clair Street, Suite 1400, Chicago, IL 60611, USA
Gastroenterol Clin North Am 37:827-43, viii. 2008..This article explores the interplay between pathophysiology and epidemiology by focusing on these risk factors and their potential effect on GERD pathogenesis... - Esophagogastric junction distensibility assessed with an endoscopic functional luminal imaging probe (EndoFLIP)Monika A Kwiatek
Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 2951, USA
Gastrointest Endosc 72:272-8. 2010..Increased esophagogastric junction (EGJ) compliance is a key abnormality in GERD leading to increased volumes of reflux. To date, EGJ distensibility has been measured only with investigational barostat-based prototype devices... - Comparison of the Bravo wireless and Digitrapper catheter-based pH monitoring systems for measuring esophageal acid exposureJohn E Pandolfino
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Am J Gastroenterol 100:1466-76. 2005..Accuracy of pH data sets from both systems can be improved by scrutiny for artifacts and use of an in vivo pH reference... - Relationship between manometric and videofluoroscopic measures of swallow function in healthy adults and patients treated for head and neck cancer with various modalitiesBarbara Roa Pauloski
Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3540, USA
Dysphagia 24:196-203. 2009.... - Editorial: just how "difficult" is it to withdraw PPI treatment?Colin W Howden
Division of Gastroenterology, Northwestern University Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, IL 60611 2951, USA
Am J Gastroenterol 105:1538-40. 2010..However, as with all drugs, PPIs should be dosed appropriately, and should be reserved for patients with conditions for which there is clear evidence of benefit from therapy... - Four-day Bravo pH capsule monitoring with and without proton pump inhibitor therapyIkuo Hirano
Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Chicago, IL 60611 2951, USA
Clin Gastroenterol Hepatol 3:1083-8. 2005..The aim of the present study was to determine the feasibility of 4-day pH recordings using a pH system that would encompass time periods both before and during PPI therapy... - Unique features of esophagogastric junction pressure topography in hiatus hernia patients with dysphagiaJohn E Pandolfino
Department of Medicine, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Surgery 147:57-64. 2010.... - Achalasia: a new clinically relevant classification by high-resolution manometryJohn E Pandolfino
Northwestern University, The Feinberg School of Medicine, Department of Medicine, Chicago, Illinois, USA
Gastroenterology 135:1526-33. 2008..This study aimed to compare the clinical characteristics and treatment response of these 3 subtypes... - Achalasia treatment: improved outcome of laparoscopic myotomy with operative manometryJennifer R Chapman
Surgical Service, Veterans Affairs Chicago Health Care System-Lakeside Division, and Department of Surgery, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Arch Surg 139:508-13; discussion 513. 2004..Laparoscopic myotomy improves quality of life and dysphagia symptoms and may be the treatment of choice in most patients with achalasia... - Comparison of inter- and intraobserver consistency for grading of esophagitis by expert and trainee endoscopistsJohn E Pandolfino
Northwestern University Medical School, Chicago, Illinois 60611, USA
Gastrointest Endosc 56:639-43. 2002..2%). CONCLUSIONS: Reproducibility in grading esophagitis was good for both expert endoscopists and fellows, although there was greater consistency among the experts. Both the Los Angeles and Hetzel-Dent scoring systems are reproducible... - Obesity: a challenge to esophagogastric junction integrityJohn E Pandolfino
Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
Gastroenterology 130:639-49. 2006..CONCLUSIONS: Obese subjects are more likely to have EGJ disruption (leading to hiatal hernia) and an augmented GEPG providing a perfect scenario for reflux to occur. Whether or not weight loss can reverse these abnormalities is unknown... - Conferencia magistral oropharyngeal disorders: diagnosis and treatmentPeter J Kahrilas
Northwestern University, Chicago, Illinois, USA
Rev Gastroenterol Mex 68:34-9. 2003..Until further well designed studies in clearly defined subsets of patients are conducted, the decision about myotomy will remain empirical after informing the patient of the risk and possible, but unproven, benefit... - The economics of laparoscopic Nissen fundoplicationChristopher A Dire
Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
Clin Gastroenterol Hepatol 1:328-32. 2003..LNF cost is impacted greatly by the cost of associated complications. Based on these data, LNF does not appear to significantly reduce the direct cost of health care for GERD patients on a population basis... - Has high-resolution manometry changed the approach to esophageal motility disorders?Ajay Bansal
Department of Medicine, Veterans Affairs Medical Center and University of Kansas, Kansas City, Missouri, USA
Curr Opin Gastroenterol 26:344-51. 2010..The purpose of the current review is to discuss the salient advantages of HRM that are likely to change the clinical practice of manometry... - Effects of voluntary maneuvers on tongue base function for swallowingCathy Lazarus
Veterans Administration Lakeside Medical Center, Northwestern University Medical School, Chicago, Ill, USA
Folia Phoniatr Logop 54:171-6. 2002..Preliminary data are provided to support the use of swallow maneuvers to improve tongue base posterior motion and pressures generated at the tongue base-pharyngeal wall level during swallowing in patients who exhibit this disorder... - Medical management of Barrett's esophagusThomas J Lee
Division of Gastroenterology, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
Gastrointest Endosc Clin N Am 13:405-18. 2003..The optimal management of HGD, however, remains controversial, as evidenced by the multitude of ablation therapies that have been introduced recently. These techniques will be discussed in depth in subsequent articles in this volume... - GERD pathophysiology: the importance of acid controlPeter J Kahrilas
Northwestern University, Chicago IL, USA
Rev Gastroenterol Mex 68:14-9. 2003..Patients on effective maintenance therapy may opt to have elective antireflux surgery after a thorough discussion of the associated risks and benefits... - American Gastroenterological Association medical position statement: Clinical use of esophageal manometryJohn E Pandolfino
Northwestern University, Chicago, Illinois, USA
Gastroenterology 128:207-8. 2005 - AGA technical review on the clinical use of esophageal manometryJohn E Pandolfino
Northwestern University, Chicago, Illinois, USA
Gastroenterology 128:209-24. 2005 - Endoluminal therapy for gastroesophageal reflux disease: is the evidence for efficacy any stronger?Thomas J Lee
Feinberg School of Medicine, Division of Gastroenterology, Department of Medicine, Northwestern University, Chicago, IL 60611, USA
Curr Gastroenterol Rep 7:202-6. 2005..This review examines published reports of endoluminal reflux therapies from January 2004 to January 2005. After another year, there are still no compelling data supporting the efficacy of any of the available endoluminal treatments... - Bravo capsule placement in the gastric cardia: a novel method for analysis of proximal stomach acid environmentJohn E Pandolfino
Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Am J Gastroenterol 100:1721-7. 2005..Instantaneous cardia pH defines the potential nadir esophageal pH during reflux events... - American Gastroenterological Association Medical Position Statement on the management of gastroesophageal reflux diseasePeter J Kahrilas
Department of Medicine, Gastroenterology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Gastroenterology 135:1383-1391, 1391.e1-5. 2008 - Effectiveness of esophageal dilation for symptomatic cricopharyngeal barAndrew Y Wang
Divison of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-3008, USA
Gastrointest Endosc 61:148-52. 2005..CONCLUSIONS: CP bar is an important cause of dysphagia in elderly patients. Esophageal dilation of a CP bar can produce long-term relief of dysphagia... - American Gastroenterological Association Institute technical review on the management of gastroesophageal reflux diseasePeter J Kahrilas
Department of Medicine, Gastroenterology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Gastroenterology 135:1392-1413, 1413.e1-5. 2008 - A randomized, comparative trial of a potassium-competitive acid blocker (AZD0865) and esomeprazole for the treatment of patients with nonerosive reflux diseaseJohn Dent
Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, Australia
Am J Gastroenterol 103:20-6. 2008..This double-blind, randomized, multicenter study investigated the efficacy and safety of AZD0865 in the treatment of patients with nonerosive reflux disease (NERD)... - Patterns of esophageal inhibition during swallowing, pharyngeal stimulation, and transient LES relaxation. Lower esophageal sphincterPhilippe Pouderoux
Service d Hépato Gastroentérologie et Alcoologie, Hopital Caremeau, Centre Hospitalier et Universitaire de Nimes, 30900 France
Am J Physiol Gastrointest Liver Physiol 284:G242-7. 2003..We conclude that LES relaxation is a necessary but not sufficient condition for reflux. LES relaxation and esophageal body inhibition are independent events that may be concurrent (swallowing) or dissociated (tLESR)... - When proton pump inhibitors failPeter J Kahrilas
Clin Gastroenterol Hepatol 6:482-3. 2008 - Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitisDonald O Castell
Department of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston 29425, USA
Am J Gastroenterol 97:575-83. 2002..CONCLUSIONS: Esomeprazole (40 mg) is more effective than lansoprazole (30 mg) in healing erosive esophagitis and resolving heartburn. Healing rates are consistently high with esomeprazole, irrespective of baseline disease severity... - The mechanical basis of impaired esophageal emptying postfundoplicationSudip K Ghosh
Department of Mechanical Engineering, The Pennsylvania State University, University Park, Pennsylvania, University Park, PA 16802, USA
Am J Physiol Gastrointest Liver Physiol 289:G21-35. 2005..Immobilization of the intrinsic sphincter by the surgical procedure may contribute to this deficiency, impaired emptying, and possibly, dysphagia... - Endoscopic appraisal of the gastroesophageal valve after antireflux surgeryBlair A Jobe
Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA
Am J Gastroenterol 99:233-43. 2004..These criteria can be employed when evaluating upper gastrointestinal complaints after antireflux surgery and may ultimately serve as a dependable outcome measure... - Endoscopic measurement of cardia circumference as an indicator of GERDAnn K Seltman
Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA
Gastrointest Endosc 63:22-31. 2006..This finding augments our understanding of the anatomic contributions of the esophagogastric junction in the pathogenesis of GERD. Cardia measurement may prove to be a useful diagnostic tool... - Magnetic enhancement of the lower esophageal sphincterPeter J Kahrilas
Gastrointest Endosc 67:295-6. 2008 - Dilated intercellular spaces: extending the reach of the endoscopePeter J Kahrilas
Am J Gastroenterol 100:549-50. 2005..The other study demonstrated that DIS resolved with effective GERD therapy in essentially every instance. Both studies suggest that DIS are an objective structural marker of endoscopy-negative reflux disease... - Radiofrequency energy treatment of GERDPeter J Kahrilas
Gastroenterology 125:970-3. 2003 - Ineffective esophageal motility does not equate to GERDPeter J Kahrilas
Am J Gastroenterol 98:715-7. 2003 - EUS characteristics of Nissen fundoplication: normal appearance and mechanisms of failureDeepak V Gopal
Section of Gastroenterology and Hepatology, University of Wisconsin-Hospitals and Clinics, Madison, Wisconsin, USA
Gastrointest Endosc 63:35-44. 2006..EUS may enable a precise determination of the anatomic causes of failure after antireflux surgery... - Canadian Consensus Conference on the management of gastroesophageal reflux disease in adults - update 2004David Armstrong
Division of Gastroenterology, McMaster University, Hamilton
Can J Gastroenterol 19:15-35. 2005..Since the last Canadian Consensus Conference in 1996, GERD management has evolved substantially...
Research Grants
- THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASEPeter Kahrilas; Fiscal Year: 2007..A future direction for this research group will be to devise and test a "corrective intervention" based on those physiological objectives. ..
- THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASEPeter Kahrilas; Fiscal Year: 2009..A future direction for this research group will be to devise and test a "corrective intervention" based on those physiological objectives. ..
- THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASEPeter Kahrilas; Fiscal Year: 2005..abstract_text> ..
- THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASEPeter James Kahrilas; Fiscal Year: 2010..A future direction for this research group will be to devise and test a "corrective intervention" based on those physiological objectives. ..