Peter James Kahrilas

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc The spectrum of achalasia: lessons from studies of pathophysiology and high-resolution manometry
    Peter J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois Electronic address
    Gastroenterology 145:954-65. 2013
  2. pmc Management of the patient with incomplete response to PPI therapy
    Peter J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Best Pract Res Clin Gastroenterol 27:401-14. 2013
  3. doi request reprint The acid pocket: a target for treatment in reflux disease?
    Peter J Kahrilas
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Am J Gastroenterol 108:1058-64. 2013
  4. doi request reprint Impact of persistent, frequent regurgitation on quality of life in heartburn responders treated with acid suppression: a multinational primary care study
    P J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University, Chicago, IL, USA
    Aliment Pharmacol Ther 37:1005-10. 2013
  5. pmc Response of chronic cough to acid-suppressive therapy in patients with gastroesophageal reflux disease
    Peter J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Chest 143:605-12. 2013
  6. doi request reprint Republished: failure of reflux inhibitors in clinical trials: bad drugs or wrong patients?
    Peter J Kahrilas
    Northwestern University, Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, 676 N St Clair Street, 14th Floor, Chicago, IL 60611, USA
    Postgrad Med J 89:111-9. 2013
  7. doi request reprint Concomitant symptoms itemized in the Reflux Disease Questionnaire are associated with attenuated heartburn response to acid suppression
    Peter J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 107:1354-60. 2012
  8. doi request reprint Failure of reflux inhibitors in clinical trials: bad drugs or wrong patients?
    Peter J Kahrilas
    Northwestern University, Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, 676 N St Clair Street, Chicago, IL 60611, USA
    Gut 61:1501-9. 2012
  9. doi request reprint Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease
    Peter J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Clin Gastroenterol Hepatol 10:612-9. 2012
  10. doi request reprint Evaluation of the esophagogastric junction using high resolution manometry and esophageal pressure topography
    P J Kahrilas
    Department of Medicine, Division of Gastroenterology and Hepatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neurogastroenterol Motil 24:11-9. 2012

Research Grants

  1. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter Kahrilas; Fiscal Year: 2007
  2. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter Kahrilas; Fiscal Year: 2009
  3. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter Kahrilas; Fiscal Year: 2005
  4. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter James Kahrilas; Fiscal Year: 2010

Collaborators

Detail Information

Publications92

  1. pmc The spectrum of achalasia: lessons from studies of pathophysiology and high-resolution manometry
    Peter J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois Electronic address
    Gastroenterology 145:954-65. 2013
    ..Moving forward, we need to integrate the knowledge we have gained into treatment paradigms that are specific for individual phenotypes of achalasia and away from the one-size-fits-all approach. ..
  2. pmc Management of the patient with incomplete response to PPI therapy
    Peter J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Best Pract Res Clin Gastroenterol 27:401-14. 2013
    ..Treating visceral hypersensitivity may also benefit the subset of GERD patients whose symptoms are driven by this mechanism. ..
  3. doi request reprint The acid pocket: a target for treatment in reflux disease?
    Peter J Kahrilas
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Am J Gastroenterol 108:1058-64. 2013
    ....
  4. doi request reprint Impact of persistent, frequent regurgitation on quality of life in heartburn responders treated with acid suppression: a multinational primary care study
    P J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University, Chicago, IL, USA
    Aliment Pharmacol Ther 37:1005-10. 2013
    ..In gastro-oesophageal reflux disease (GERD), heartburn responds well to acid suppression, but regurgitation is a common cause of incomplete treatment response...
  5. pmc Response of chronic cough to acid-suppressive therapy in patients with gastroesophageal reflux disease
    Peter J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Chest 143:605-12. 2013
    ..This systematic review aimed to reevaluate the response of chronic cough to antireflux therapy in trials that allowed us to distinguish patients with or without objective evidence of GERD...
  6. doi request reprint Republished: failure of reflux inhibitors in clinical trials: bad drugs or wrong patients?
    Peter J Kahrilas
    Northwestern University, Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, 676 N St Clair Street, 14th Floor, Chicago, IL 60611, USA
    Postgrad Med J 89:111-9. 2013
    ....
  7. doi request reprint Concomitant symptoms itemized in the Reflux Disease Questionnaire are associated with attenuated heartburn response to acid suppression
    Peter J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 107:1354-60. 2012
    ..However, clinical trials have generally focused only on the "substernal burning" item and limited data exist on the effect of concomitant items on the treatment response of "substernal burning"...
  8. doi request reprint Failure of reflux inhibitors in clinical trials: bad drugs or wrong patients?
    Peter J Kahrilas
    Northwestern University, Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, 676 N St Clair Street, Chicago, IL 60611, USA
    Gut 61:1501-9. 2012
    ....
  9. doi request reprint Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease
    Peter J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Clin Gastroenterol Hepatol 10:612-9. 2012
    ..We evaluated the responsiveness of regurgitation, characterized by the reflux disease questionnaire (RDQ) to potent acid suppression...
  10. doi request reprint Evaluation of the esophagogastric junction using high resolution manometry and esophageal pressure topography
    P J Kahrilas
    Department of Medicine, Division of Gastroenterology and Hepatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neurogastroenterol Motil 24:11-9. 2012
    ....
  11. pmc Prospective randomized controlled trial of an injectable esophageal prosthesis versus a sham procedure for endoscopic treatment of gastroesophageal reflux disease
    Paul Fockens
    Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Surg Endosc 24:1387-97. 2010
    ..This study aimed to assess whether endoscopic implantation of an injectable esophageal prosthesis, the Gatekeeper Reflux Repair System (GK), is a safe and effective therapy for controlling gastroesophageal reflux disease (GERD)...
  12. pmc Gatekeeper reflux repair system; a mechanistic hypothesis
    P J Kahrilas
    Northwestern University, Feinberg School of Medicine, Division of Gastroenterology, Department of Medicine, 676 N St Clair Street, Suite 1400, Chicago, Illinois 60611, USA
    Gut 54:179-80. 2005
  13. pmc Esophageal motor disorders in terms of high-resolution esophageal pressure topography: what has changed?
    Peter J Kahrilas
    Division of Gastroenterology, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 105:981-7. 2010
    ..Ultimately, clinical experience will be the judge, but it seems likely that HREPT data, along with its well-defined functional implications, will improve the clinical management of esophageal motility disorders...
  14. pmc Pressure morphology of the relaxed lower esophageal sphincter: the formation and collapse of the phrenic ampulla
    Monika A Kwiatek
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Physiol Gastrointest Liver Physiol 302:G389-96. 2012
    ....
  15. pmc Clinical practice. Gastroesophageal reflux disease
    Peter J Kahrilas
    Division of Gastroenterology, Feinberg School of Medicine, Chicago IL 60611 2951, USA
    N Engl J Med 359:1700-7. 2008
  16. ncbi request reprint Pathophysiology of gastroesophageal reflux disease
    Peter J Kahrilas
    Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Thorac Surg Clin 15:323-33. 2005
    ..These abnormalities exhibit a complicated interplay that degrades the ability of the EGJ to contain gastric juice within the stomach and to clear the esophagus of gastric juice effectively once reflux has occurred...
  17. ncbi request reprint Efficacy of rabeprazole in the treatment of symptomatic gastroesophageal reflux disease
    Peter J Kahrilas
    Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Dig Dis Sci 50:2009-18. 2005
    ..g., regurgitation, belching, early satiety) by week 4 compared with placebo (P < or = .05). Rabeprazole provides fast and potent relief from heartburn and other symptoms of nonerosive gastroesophageal reflux disease...
  18. pmc Approaches to the diagnosis and grading of hiatal hernia
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    Best Pract Res Clin Gastroenterol 22:601-16. 2008
    ....
  19. ncbi request reprint Review article: oesophageal pH monitoring--technologies, interpretation and correlation with clinical outcomes
    P J Kahrilas
    Division of Gastroeneterology, Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
    Aliment Pharmacol Ther 22:2-9. 2005
    ..More research is needed to determine whether the detection of reflux events with Bravo will provide a good correlation with symptom episodes...
  20. pmc High-resolution manometry and impedance-pH/manometry: valuable tools in clinical and investigational esophagology
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Gastroenterology 135:756-69. 2008
    ..Ultimately, however, both technologies will be strengthened as outcome studies evaluating their utilization become available...
  21. pmc Esophageal motility disorders in terms of pressure topography: the Chicago Classification
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    J Clin Gastroenterol 42:627-35. 2008
    ....
  22. pmc Challenging the limits of esophageal manometry
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Gastroenterology 134:16-8. 2008
  23. ncbi request reprint A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis
    Peter J Kahrilas
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Clin Gastroenterol Hepatol 5:1385-91. 2007
    ..AZD0865 belongs to a new class of acid-suppressing agents with rapid onset of action and potent acid inhibition. We evaluated its effectiveness for healing reflux esophagitis...
  24. ncbi request reprint Review article: gastro-oesophageal reflux disease as a functional gastrointestinal disorder
    P J Kahrilas
    Northwestern University, Feinberg School of Medicine, Department of Medicine, Division of Gastroenterology, Chicago, IL 60611 2951, USA
    Aliment Pharmacol Ther 20:50-5. 2004
    ....
  25. ncbi request reprint Refractory heartburn
    Peter J Kahrilas
    Department of Medicine, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, 676 St Clair Street, Suite 1400, Chicago, IL 60611 2951, USA
    Gastroenterology 124:1941-5. 2003
  26. ncbi request reprint Management of GERD: medical versus surgical
    P J Kahrilas
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Semin Gastrointest Dis 12:3-15. 2001
    ..However, regardless of the motivation for pursuing surgical management, patients must be advised of potential suboptimal results and the irreversibility of the procedure...
  27. ncbi request reprint The target of therapies: pathophysiology of gastroesophageal reflux disease
    Peter J Kahrilas
    Department of Medicine, Northwestern University s Feinberg School of Medicine, Division of Gastroenterology, Searle Bldg, 10th Floor, Suite 541, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Gastrointest Endosc Clin N Am 13:1-17. 2003
    ....
  28. doi request reprint Response of unexplained chest pain to proton pump inhibitor treatment in patients with and without objective evidence of gastro-oesophageal reflux disease
    Peter J Kahrilas
    Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 2951, USA
    Gut 60:1473-8. 2011
    ..We explored the response of unexplained chest pain to proton pump inhibitor (PPI) therapy in randomised clinical trials (RCTs), differentiating patients with and without objective evidence of GORD...
  29. doi request reprint Response of regurgitation to proton pump inhibitor therapy in clinical trials of gastroesophageal reflux disease
    Peter J Kahrilas
    Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 106:1419-25; quiz 1426. 2011
    ..This study aimed to evaluate the response of regurgitation to PPI therapy in GERD trials...
  30. pmc Restoration of normal distensive characteristics of the esophagogastric junction after fundoplication
    John E Pandolfino
    Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
    Ann Surg 242:43-8. 2005
    ..To study the mechanical characteristics of the esophagogastric junction (EGJ) of postfundoplication patients and compare them with previously reported data on normal subjects and GERD patients...
  31. pmc Functional esophagogastric junction obstruction with intact peristalsis: a heterogeneous syndrome sometimes akin to achalasia
    John R Scherer
    Department of Medicine, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    J Gastrointest Surg 13:2219-25. 2009
    ..Some patients with suspected achalasia are found on manometry to have preserved peristalsis, thereby excluding that diagnosis. This study evaluated a series of such patients with functional esophagogastric junction (EGJ) obstruction...
  32. ncbi request reprint Acidity surrounding the squamocolumnar junction in GERD patients: "acid pocket" versus "acid film"
    John E Pandolfino
    Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Gastroenterol 102:2633-41. 2007
    ..This study aimed to localize the gastric-to-esophageal pH transition point relative to the squamocolumnar junction (SCJ) and esophagogastric junction (EGJ) high-pressure zone in controls and GERD patients...
  33. pmc Esophageal pressure topography criteria indicative of incomplete bolus clearance: a study using high-resolution impedance manometry
    William J Bulsiewicz
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 104:2721-8. 2009
    ..This study used high-resolution impedance manometry (HRIM) to determine pressure topography thresholds of peristaltic integrity predictive of incomplete esophageal bolus clearance...
  34. ncbi request reprint Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects
    John E Pandolfino
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Gastroenterology 125:1018-24. 2003
    ..Flow across the esophagogastric junction (EGJ) is strongly related to opening dimensions. This study aimed to determine whether opening of the relaxed EGJ was altered in patients with gastroesophageal reflux disease (GERD)...
  35. ncbi request reprint Diagnosis of symptomatic gastroesophageal reflux disease
    Peter J Kahrilas
    Department of Medicine, Section of Gastroenterology, Northwestern University Feinberg School of Medicine, Suite 1400, 676 N St Clair Street, Chicago, IL 60611 2927, USA
    Am J Gastroenterol 98:S15-23. 2003
    ..It has been shown effective in about 75% of patients, and offers a simple approach to managing the difficult-to-diagnose patient even while further diagnostic procedures are carried out...
  36. pmc Utilizing intraluminal pressure gradients to predict esophageal clearance: a validation study
    John E Pandolfino
    Departments of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 103:1898-905. 2008
    ..Esophageal bolus clearance requires a preferential esophagogastric pressure gradient sustained for a sufficient period. We aimed to validate a high-resolution manometry (HRM) paradigm for predicting bolus clearance...
  37. ncbi request reprint Esophagogastric junction distensibility: a factor contributing to sphincter incompetence
    John E Pandolfino
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    Am J Physiol Gastrointest Liver Physiol 282:G1052-8. 2002
    ....
  38. ncbi request reprint Deglutitive inhibition affects both esophageal peristaltic amplitude and shortening
    Guoxiang Shi
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Physiol Gastrointest Liver Physiol 284:G575-82. 2003
    ..Deglutitive inhibition affects both the longitudinal and circular muscle layers of the esophageal wall, and the occurrence of inhibition evident in one layer is strongly correlated with the other...
  39. ncbi request reprint Esophagogastric junction morphology predicts susceptibility to exercise-induced reflux
    John E Pandolfino
    Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Gastroenterol 99:1430-6. 2004
    ..The aim of this study was to use vigorous exercise as a provocation for strain-induced reflux and examine the correlation between endoscopically assessed EGJ integrity and exercise-induced reflux...
  40. ncbi request reprint GERD pathogenesis, pathophysiology, and clinical manifestations
    Peter J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University Medical School, Chicago, Ill, USA
    Cleve Clin J Med 70:S4-19. 2003
    ..GERD is typically chronic, and while it is generally nonprogressive, some cases are associated with development of complications of increasing severity and significance...
  41. ncbi request reprint Utilizing intraluminal pressure differences to predict esophageal bolus flow dynamics
    Sudip K Ghosh
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Division of Gastroenterology, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1023-8. 2007
    ..This may help predict abnormal bolus transit and the underlying mechanical properties of the EGJ...
  42. ncbi request reprint Classifying esophageal motility by pressure topography characteristics: a study of 400 patients and 75 controls
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 103:27-37. 2008
    ..This study aimed to devise a scheme for the systematic analysis of esophageal high-resolution manometry (HRM) studies displayed using topographic plotting...
  43. pmc New technologies in the gastrointestinal clinic and research: impedance and high-resolution manometry
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, Illinois 60611, USA
    World J Gastroenterol 15:131-8. 2009
    ..This review describes the potential benefits that these new technologies may have over conventional techniques for the evaluation of dysphagia...
  44. pmc Esophagogastric junction distensibility assessed with an endoscopic functional luminal imaging probe (EndoFLIP)
    Monika A Kwiatek
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 2951, USA
    Gastrointest Endosc 72:272-8. 2010
    ..Increased esophagogastric junction (EGJ) compliance is a key abnormality in GERD leading to increased volumes of reflux. To date, EGJ distensibility has been measured only with investigational barostat-based prototype devices...
  45. doi request reprint Editorial: just how "difficult" is it to withdraw PPI treatment?
    Colin W Howden
    Division of Gastroenterology, Northwestern University Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, IL 60611 2951, USA
    Am J Gastroenterol 105:1538-40. 2010
    ..However, as with all drugs, PPIs should be dosed appropriately, and should be reserved for patients with conditions for which there is clear evidence of benefit from therapy...
  46. pmc Unique features of esophagogastric junction pressure topography in hiatus hernia patients with dysphagia
    John E Pandolfino
    Department of Medicine, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Surgery 147:57-64. 2010
    ....
  47. pmc Hyperdynamic upper esophageal sphincter pressure: a manometric observation in patients reporting globus sensation
    Monika A Kwiatek
    Division of Gastroenterology, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Gastroenterol 104:289-98. 2009
    ....
  48. doi request reprint The pathophysiologic basis for epidemiologic trends in gastroesophageal reflux disease
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University s Feinberg School of Medicine, 676 North St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Gastroenterol Clin North Am 37:827-43, viii. 2008
    ..This article explores the interplay between pathophysiology and epidemiology by focusing on these risk factors and their potential effect on GERD pathogenesis...
  49. pmc Relationship between manometric and videofluoroscopic measures of swallow function in healthy adults and patients treated for head and neck cancer with various modalities
    Barbara Roa Pauloski
    Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3540, USA
    Dysphagia 24:196-203. 2009
    ....
  50. pmc Achalasia: a new clinically relevant classification by high-resolution manometry
    John E Pandolfino
    Northwestern University, The Feinberg School of Medicine, Department of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1526-33. 2008
    ..This study aimed to compare the clinical characteristics and treatment response of these 3 subtypes...
  51. ncbi request reprint Impaired deglutitive EGJ relaxation in clinical esophageal manometry: a quantitative analysis of 400 patients and 75 controls
    Sudip K Ghosh
    Dept of Medicine, Feinberg School of Medicine, Northwestern Univ, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 293:G878-85. 2007
    ....
  52. ncbi request reprint High-resolution manometry of the EGJ: an analysis of crural diaphragm function in GERD
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Gastroenterol 102:1056-63. 2007
    ..This study compared CD function of subjects with and without gastroesophageal reflux disease (GERD)...
  53. ncbi request reprint Absence of a deglutitive inhibition equivalent with secondary peristalsis
    John E Pandolfino
    Division of Gastroenterology, Dept of Medicine, Northwestern Univ Feinberg School of Medicine, Suite 1400, 676 N St Clair St, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 288:G671-6. 2005
    ..Being that the elicitation of SP in the smooth muscle esophagus is intramurally mediated, this suggests that deglutitive inhibition is a centrally mediated phenomenon rather than an intrinsic property of peristalsis...
  54. ncbi request reprint Prolonged pH monitoring: Bravo capsule
    John E Pandolfino
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Gastrointest Endosc Clin N Am 15:307-18. 2005
    ..Further refinements in methodology and recording protocol are likely to be made, which will improve diagnostic accuracy and lower cost...
  55. ncbi request reprint Comparison of the Bravo wireless and Digitrapper catheter-based pH monitoring systems for measuring esophageal acid exposure
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Gastroenterol 100:1466-76. 2005
    ..We compared esophageal acid exposure data obtained during simultaneous esophageal pH studies using the Bravo wireless and the Slimline catheter-Mark III Digitrapper pH systems...
  56. ncbi request reprint Four-day Bravo pH capsule monitoring with and without proton pump inhibitor therapy
    Ikuo Hirano
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Chicago, IL 60611 2951, USA
    Clin Gastroenterol Hepatol 3:1083-8. 2005
    ..The aim of the present study was to determine the feasibility of 4-day pH recordings using a pH system that would encompass time periods both before and during PPI therapy...
  57. ncbi request reprint Oropharyngeal swallow in younger and older women: videofluoroscopic analysis
    Jeri A Logemann
    Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208, USA
    J Speech Lang Hear Res 45:434-45. 2002
    ..Older women also exhibited an increased range of motion relative to the old men. This increase may indicate a compensation for aging effects not seen in older men...
  58. ncbi request reprint Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteers
    Sudip K Ghosh
    Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 290:G988-97. 2006
    ....
  59. ncbi request reprint Radiofrequency therapy of the lower esophageal sphincter for treatment of GERD
    Peter J Kahrilas
    Department of Medicine, Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Gastrointest Endosc 57:723-31. 2003
  60. ncbi request reprint Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Gastroenterology 131:1725-33. 2006
    ....
  61. ncbi request reprint Deglutitive upper esophageal sphincter relaxation: a study of 75 volunteer subjects using solid-state high-resolution manometry
    Sudip K Ghosh
    Northwestern University, Feinberg School of Medicine, Div of Gastroenterology, Dept of Medicine, 676 N St Clair St, Suite 1400, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 291:G525-31. 2006
    ..Normative values were established to aid in future clinical and investigative studies...
  62. ncbi request reprint Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteers
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1033-40. 2006
    ..In addition to providing conventional EGJ relaxation parameters, this technology also creates opportunities to quantify more precise measures of EGJ relaxation and morphology...
  63. ncbi request reprint Ambulatory esophageal pH monitoring using a wireless system
    John E Pandolfino
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
    Am J Gastroenterol 98:740-9. 2003
    ..An alternative to conventional pH monitoring is the wireless Medtronic Bravo pH System. The aim of this study was to evaluate the safety, performance, and tolerability of this system...
  64. ncbi request reprint Achalasia treatment: improved outcome of laparoscopic myotomy with operative manometry
    Jennifer R Chapman
    Surgical Service, Veterans Affairs Chicago Health Care System Lakeside Division, and Department of Surgery, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Arch Surg 139:508-13; discussion 513. 2004
    ..Operative manometry detects residual esophagogastric junction (EGJ) high pressure, ensuring complete myotomy...
  65. ncbi request reprint Comparison of inter- and intraobserver consistency for grading of esophagitis by expert and trainee endoscopists
    John E Pandolfino
    Northwestern University Medical School, Chicago, Illinois 60611, USA
    Gastrointest Endosc 56:639-43. 2002
    ..This study evaluated intra- and interobserver variability in the endoscopic scoring of esophagitis by using two grading schemes, the Los Angeles and Hetzel-Dent scales...
  66. ncbi request reprint Obesity: a challenge to esophagogastric junction integrity
    John E Pandolfino
    Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 130:639-49. 2006
    ..The aim of the current study was to analyze the relationship between obesity and the morphology of the esophagogastric junction (EGJ) pressure segment using high-resolution manometry...
  67. pmc Has high-resolution manometry changed the approach to esophageal motility disorders?
    Ajay Bansal
    Department of Medicine, Veterans Affairs Medical Center and University of Kansas, Kansas City, Missouri, USA
    Curr Opin Gastroenterol 26:344-51. 2010
    ..The purpose of the current review is to discuss the salient advantages of HRM that are likely to change the clinical practice of manometry...
  68. ncbi request reprint The economics of laparoscopic Nissen fundoplication
    Christopher A Dire
    Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    Clin Gastroenterol Hepatol 1:328-32. 2003
    ..The aim was to analyze health care costs and use among a cohort of patients undergoing LNF and compare them with patients with medically treated gastroesophageal reflux disease (GERD)...
  69. ncbi request reprint Effects of voluntary maneuvers on tongue base function for swallowing
    Cathy Lazarus
    Veterans Administration Lakeside Medical Center, Northwestern University Medical School, Chicago, Ill, USA
    Folia Phoniatr Logop 54:171-6. 2002
    ..Preliminary data are provided to support the use of swallow maneuvers to improve tongue base posterior motion and pressures generated at the tongue base-pharyngeal wall level during swallowing in patients who exhibit this disorder...
  70. ncbi request reprint Conferencia magistral oropharyngeal disorders: diagnosis and treatment
    Peter J Kahrilas
    Northwestern University, Chicago, Illinois, USA
    Rev Gastroenterol Mex 68:34-9. 2003
    ..Until further well designed studies in clearly defined subsets of patients are conducted, the decision about myotomy will remain empirical after informing the patient of the risk and possible, but unproven, benefit...
  71. ncbi request reprint Bravo capsule placement in the gastric cardia: a novel method for analysis of proximal stomach acid environment
    John E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Gastroenterol 100:1721-7. 2005
    ..Intragastric pH monitoring is currently done using catheter-based pH systems. This study assessed the feasibility of proximal intragastric pH recording with the Bravo wireless pH monitoring system using novel methodology...
  72. ncbi request reprint Endoluminal therapy for gastroesophageal reflux disease: is the evidence for efficacy any stronger?
    Thomas J Lee
    Feinberg School of Medicine, Division of Gastroenterology, Department of Medicine, Northwestern University, Chicago, IL 60611, USA
    Curr Gastroenterol Rep 7:202-6. 2005
    ..This review examines published reports of endoluminal reflux therapies from January 2004 to January 2005. After another year, there are still no compelling data supporting the efficacy of any of the available endoluminal treatments...
  73. ncbi request reprint Medical management of Barrett's esophagus
    Thomas J Lee
    Division of Gastroenterology, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
    Gastrointest Endosc Clin N Am 13:405-18. 2003
    ..The optimal management of HGD, however, remains controversial, as evidenced by the multitude of ablation therapies that have been introduced recently. These techniques will be discussed in depth in subsequent articles in this volume...
  74. ncbi request reprint AGA technical review on the clinical use of esophageal manometry
    John E Pandolfino
    Northwestern University, Chicago, Illinois, USA
    Gastroenterology 128:209-24. 2005
  75. ncbi request reprint American Gastroenterological Association medical position statement: Clinical use of esophageal manometry
    John E Pandolfino
    Northwestern University, Chicago, Illinois, USA
    Gastroenterology 128:207-8. 2005
  76. ncbi request reprint GERD pathophysiology: the importance of acid control
    Peter J Kahrilas
    Northwestern University, Chicago IL, USA
    Rev Gastroenterol Mex 68:14-9. 2003
    ..Patients on effective maintenance therapy may opt to have elective antireflux surgery after a thorough discussion of the associated risks and benefits...
  77. ncbi request reprint Effectiveness of esophageal dilation for symptomatic cricopharyngeal bar
    Andrew Y Wang
    Divison of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 3008, USA
    Gastrointest Endosc 61:148-52. 2005
    ..The effectiveness of esophageal dilation for patients with symptoms caused by a CP bar is not well studied...
  78. doi request reprint American Gastroenterological Association Medical Position Statement on the management of gastroesophageal reflux disease
    Peter J Kahrilas
    Department of Medicine, Gastroenterology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1383-1391, 1391.e1-5. 2008
  79. doi request reprint American Gastroenterological Association Institute technical review on the management of gastroesophageal reflux disease
    Peter J Kahrilas
    Department of Medicine, Gastroenterology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1392-1413, 1413.e1-5. 2008
  80. ncbi request reprint Endoscopic appraisal of the gastroesophageal valve after antireflux surgery
    Blair A Jobe
    Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA
    Am J Gastroenterol 99:233-43. 2004
    ..The purpose of this report is to characterize the gastroesophageal valve appearance unique to each type of antireflux procedure and to introduce an endoscopic lexicon by which to describe this anatomic region...
  81. ncbi request reprint Patterns of esophageal inhibition during swallowing, pharyngeal stimulation, and transient LES relaxation. Lower esophageal sphincter
    Philippe Pouderoux
    Service d Hépato Gastroentérologie et Alcoologie, Hopital Caremeau, Centre Hospitalier et Universitaire de Nimes, 30900 France
    Am J Physiol Gastrointest Liver Physiol 284:G242-7. 2003
    ..We conclude that LES relaxation is a necessary but not sufficient condition for reflux. LES relaxation and esophageal body inhibition are independent events that may be concurrent (swallowing) or dissociated (tLESR)...
  82. ncbi request reprint Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis
    Donald O Castell
    Department of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston 29425, USA
    Am J Gastroenterol 97:575-83. 2002
    ..This study compared esomeprazole with lansoprazole for the healing of erosive esophagitis and resolution of heartburn...
  83. pmc Magnetic enhancement of the lower esophageal sphincter
    Peter J Kahrilas
    Gastrointest Endosc 67:295-6. 2008
  84. doi request reprint A randomized, comparative trial of a potassium-competitive acid blocker (AZD0865) and esomeprazole for the treatment of patients with nonerosive reflux disease
    John Dent
    Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, Australia
    Am J Gastroenterol 103:20-6. 2008
    ..This double-blind, randomized, multicenter study investigated the efficacy and safety of AZD0865 in the treatment of patients with nonerosive reflux disease (NERD)...
  85. pmc When proton pump inhibitors fail
    Peter J Kahrilas
    Clin Gastroenterol Hepatol 6:482-3. 2008
  86. ncbi request reprint The mechanical basis of impaired esophageal emptying postfundoplication
    Sudip K Ghosh
    Department of Mechanical Engineering, The Pennsylvania State University, University Park, Pennsylvania, University Park, PA 16802, USA
    Am J Physiol Gastrointest Liver Physiol 289:G21-35. 2005
    ..Immobilization of the intrinsic sphincter by the surgical procedure may contribute to this deficiency, impaired emptying, and possibly, dysphagia...
  87. ncbi request reprint Endoscopic measurement of cardia circumference as an indicator of GERD
    Ann K Seltman
    Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA
    Gastrointest Endosc 63:22-31. 2006
    ..Our aims were to validate the software and to quantify cardia circumference along the spectrum of GERD...
  88. ncbi request reprint EUS characteristics of Nissen fundoplication: normal appearance and mechanisms of failure
    Deepak V Gopal
    Section of Gastroenterology and Hepatology, University of Wisconsin Hospitals and Clinics, Madison, Wisconsin, USA
    Gastrointest Endosc 63:35-44. 2006
    ..This observational study establishes that EUS can determine fundoplication integrity and hiatal anatomic relationships after Nissen fundoplication...
  89. ncbi request reprint Dilated intercellular spaces: extending the reach of the endoscope
    Peter J Kahrilas
    Am J Gastroenterol 100:549-50. 2005
    ..The other study demonstrated that DIS resolved with effective GERD therapy in essentially every instance. Both studies suggest that DIS are an objective structural marker of endoscopy-negative reflux disease...
  90. ncbi request reprint Ineffective esophageal motility does not equate to GERD
    Peter J Kahrilas
    Am J Gastroenterol 98:715-7. 2003
  91. ncbi request reprint Radiofrequency energy treatment of GERD
    Peter J Kahrilas
    Gastroenterology 125:970-3. 2003
  92. ncbi request reprint Canadian Consensus Conference on the management of gastroesophageal reflux disease in adults - update 2004
    David Armstrong
    Division of Gastroenterology, McMaster University, Hamilton
    Can J Gastroenterol 19:15-35. 2005
    ..Since the last Canadian Consensus Conference in 1996, GERD management has evolved substantially...

Research Grants10

  1. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter Kahrilas; Fiscal Year: 2007
    ..A future direction for this research group will be to devise and test a "corrective intervention" based on those physiological objectives. ..
  2. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter Kahrilas; Fiscal Year: 2009
    ..A future direction for this research group will be to devise and test a "corrective intervention" based on those physiological objectives. ..
  3. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter Kahrilas; Fiscal Year: 2005
    ..abstract_text> ..
  4. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter James Kahrilas; Fiscal Year: 2010
    ..A future direction for this research group will be to devise and test a "corrective intervention" based on those physiological objectives. ..