Affiliation: Northwestern University
- Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitalsS Johnson
Department of Medicine, Veterans Affairs Chicago Health Care System, Lakeside Division, and Northwestern University Medical School, IL 60611, USA
N Engl J Med 341:1645-51. 1999..Since frequent use of clindamycin was associated with the outbreak in one of the hospitals, we examined the resistance genes of the epidemic-strain isolates and studied the role of clindamycin use in these outbreaks...
- Infection of hamsters with epidemiologically important strains of Clostridium difficileS P Sambol
Infectious Disease Section, Department of Medicine, Veterans Affairs Chicago Health Care System, Lakeside Division, and Northwestern University Medical School, Chicago, Illinois 60611, USA
J Infect Dis 183:1760-6. 2001..01) colonization and 30% mortality (P= .0003). The hamster model demonstrated pathogenicity differences between a toxin variant strain and standard toxigenic strains but no significant differences among the standard strains...
- Fatal pseudomembranous colitis associated with a variant clostridium difficile strain not detected by toxin A immunoassayS Johnson
Medical Service, Veterans Affairs Chicago Health Care System-Lakeside, 333 East Huron Street, Chicago, IL 60611, USA
Ann Intern Med 135:434-8. 2001..CONCLUSIONS: Toxin A variant strains of C. difficile cause serious disease and are undetectable in clinical laboratories that use only toxin A immunoassays for C. difficile testing...