Research Topics
| M G IsonSummaryAffiliation: Northwestern University Country: USA Publications
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Detail Information
Publications
Clinical use of approved influenza antivirals: therapy and prophylaxisMichael G Ison
Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL 60654, USA
Influenza Other Respi Viruses 7:7-13. 2013..This article reviews the pharmacokinetics and clinical data available relative to the use of commercially available antiviral agents for the prevention of and treatment for influenza...
Preventable errors in organ transplantation: an emerging patient safety issue?M G Ison
Divisions of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Am J Transplant 12:2307-12. 2012..Further, the transplant community needs to embrace the implementation of evidence-based system and process improvements that will mitigate existing safety vulnerabilities...- Efficacy and safety of oral oseltamivir for influenza prophylaxis in transplant recipientsMichael G Ison
Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Antivir Ther 17:955-64. 2012..Haematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients are at high risk for severe influenza and its complications, and may not be adequately protected by vaccination... - Antivirals and resistance: influenza virusMichael G Ison
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States
Curr Opin Virol 1:563-73. 2011..In this paper, we will review the currently approved and investigational antiviral agents and the mechanisms of resistance that impact their activity... - Antiviral therapies for respiratory viral infections in lung transplant patientsMichael G Ison
Divisions of Infectious Diseases and Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Antivir Ther 17:193-200. 2012..This paper will review the epidemiology and management strategies of respiratory viral infections in lung transplant recipients... - Outcome of influenza infection managed with oseltamivir in lung transplant recipientsMichael G Ison
Division of Infectious Diseases and Organ Transplantation, Transplant and Immunocompromised Host Infectious Diseases Service, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Heart Lung Transplant 27:282-8. 2008.... - End points for testing influenza antiviral treatments for patients at high risk of severe and life-threatening diseaseMichael G Ison
Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
J Infect Dis 201:1654-62. 2010.... - Influenza, including the novel H1N1, in organ transplant patientsMichael G Ison
Divisions of Infectious Diseases and Organ Transplantation, Comprehensive Transplant Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Curr Opin Infect Dis 23:365-73. 2010..This article will review the epidemiology, diagnosis, prevention and management of influenza in solid organ transplant recipients... - Transplantation of high-risk donor organs: a survey of US solid organ transplant center practices as reported by transplant infectious diseases physiciansMichael G Ison
Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Clin Transplant 23:866-73. 2009..There is significant variability in the acceptance and management of ROHRD in the US. Most TID experts do not feel that the current PHS guidelines accurately define high-risk donors... - The epidemiology and prevention of donor-derived infectionsMichael G Ison
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Adv Chronic Kidney Dis 16:234-41. 2009..The regulatory framework related to and the epidemiology, identification, and management of donor-derived infectious disease transmission shall be reviewed... - Respiratory syncytial virus and other respiratory viruses in the setting of bone marrow transplantationMichael G Ison
Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Curr Opin Oncol 21:171-6. 2009..Several epidemiologic studies have enhanced our understanding of the impact of respiratory viruses on bone marrow transplant recipients... - Donor-derived disease transmission events in the United States: data reviewed by the OPTN/UNOS Disease Transmission Advisory CommitteeM G Ison
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Am J Transplant 9:1929-35. 2009..96% of deceased donor donations overall. Improved reporting, through enhanced recognition and communication, will be critical to better estimate the transmission risk of infection and malignancy through organ transplantation... - Influenza 2010-2011: lessons from the 2009 pandemicMichael G Ison
Divisions of Infectious Diseases and Organ Transplantation, Departments of Medicine and Surgery, Northwestern University Feinberg School of Medicine, 645 North Michigan Avenue Suite 900, Chicago, IL 60611, USA
Cleve Clin J Med 77:812-20. 2010..Much was learned about the diagnosis, management, and pathogenesis of influenza from the 2009 pandemic of influenza A (H1N1). This knowledge can be applied to the management of people affected by seasonal infection and to future pandemics... 
Epidemiology, prevention, and management of influenza in patients with hematologic malignancyMichael G Ison
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Infect Disord Drug Targets 11:34-9. 2011..Available evidence suggests that prolonged course are frequently needed. Patients who fail to response or have relapsed infections should be tested for emergence of antiviral resistance and alternative diagnoses should be investigated...- Respiratory viral infections in transplant recipientsMichael G Ison
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Antivir Ther 12:627-38. 2007..In addition to epidemiological data, recent studies have also advanced our understanding of management of influenza, adenovirus, and RSV infections among transplant recipients... - An update on donor-derived disease transmission in organ transplantationM G Ison
Divisions of Infectious Diseases and Organ Transplantation, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Am J Transplant 11:1123-30. 2011..As the epidemiology of donor-derived disease transmission has become better understood, several groups have been working on methods to further mitigate this risk... - Screening and treatment of chagas disease in organ transplant recipients in the United States: recommendations from the chagas in transplant working groupP V Chin-Hong
Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA
Am J Transplant 11:672-80. 2011..Data on management and outcomes of all cases should be collected to inform future guidelines and to assist in coordination with public health authorities... - Diagnosis and management of tuberculosis in transplant donors: a donor-derived infections consensus conference reportM I Morris
Division of Infectious Diseases, University of Miami Miller School of Medicine, FL, USA
Am J Transplant 12:2288-300. 2012..This working group reviewed the currently available data to formulate consensus recommendations for screening and management of TB in organ donors... - Organ donor screening practices for Trypanosoma cruzi infection among US Organ Procurement OrganizationsB S Schwartz
Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA
Am J Transplant 11:848-51. 2011..Further research is needed to identify the risk of donor-derived T. cruzi infections to help inform the best screening strategy... - Use of the QuantiFERON-TB Gold interferon-gamma release assay for screening transplant candidates: a single-center retrospective studyN Theodoropoulos
Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Transpl Infect Dis 14:1-8. 2012.... - Opportunities for shared decision making in kidney transplantationE J Gordon
Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL Northwestern University Comprehensive Transplant Center, Chicago, IL Northwestern University Transplant Outcomes Research Collaborative, Chicago, IL Chicago Transplant Ethics Consortium, Chicago, IL Division of Transplantation, Department of Surgery, Northwestern University, Chicago, IL
Am J Transplant 13:1149-58. 2013..We propose strategies to promote and overcome obstacles to SDM in kidney transplantation. We contend that engagement in SDM can be facilitated by re-organization of clinical care, communication and education of providers and patients... - Transmission of human immunodeficiency virus and hepatitis C virus from an organ donor to four transplant recipientsM G Ison
Division of Infectious Diseases Division of Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Am J Transplant 11:1218-25. 2011..Routine posttransplant HIV and HCV serological testing and NAT of recipients of organs from donors with suspected risk factors should be considered as routine practice... - Carbapenem-resistant Acinetobacter baumannii infections after organ transplantationP Reddy
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Transpl Infect Dis 12:87-93. 2010..The current study suggests that SOT patients with CRAB suffer from prolonged hospitalization, infection with other MDR organisms, allograft dysfunction and loss, and high overall infection-related mortality... - Detection and diagnosis of herpes simplex virus infection in adults with acute liver failureJosh Levitsky
Northwestern Memorial Hospital Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Liver Transpl 14:1498-504. 2008.... - Viral infections in immunocompromised patients: what's new with respiratory viruses?Michael G Ison
Division of Infectious Diseases, University of Virginia, Charlottesville, Virginia 22908, USA
Curr Opin Infect Dis 15:355-67. 2002..The respiratory viruses, particularly respiratory syncytial virus, influenza, parainfluenza, adenovirus, and picornaviruses, are increasingly recognized as significant pathogens in these populations... - Alemtuzumab induction in non-hepatitis C positive liver transplant recipientsJosh Levitsky
Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Liver Transpl 17:32-7. 2011..In conclusion, a steroid-free AL induction regimen was associated with less hypertension and rejection but with more infectious complications; thus, the overall benefit of AL induction in LT recipients is called into question... - Expanded infectious diseases screening program for Hispanic transplant candidatesM A Fitzpatrick
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Transpl Infect Dis 12:336-41. 2010..Expanded screening identifies endemic infections in the Hispanic immigrant population that can be treated before transplant, thereby minimizing post-transplant infectious complications... - BK virus replication and nephropathy after alemtuzumab-induced kidney transplantationN Theodoropoulos
Division of Infectious Diseases, The Ohio State University College of Medicine, Columbus, USA
Am J Transplant 13:197-206. 2013..The incidence of BK viruria, viremia and nephropathy was not significantly different among kidney transplant recipients who received alemtuzumab induction compared to patients receiving less potent induction... - Therapeutic options for the management of influenzaM G Ison
University of Virginia Health Sciences Center, Division of Infectious Diseases, Charlottesville 22908, USA
Curr Opin Pharmacol 1:482-90. 2001..Studies are also needed to address other groups at increased risk for influenza complications, such as pregnant women and children below one year of age... - The challenge of informed consent for increased risk living donation and transplantationE J Gordon
Institute for Healthcare Studies, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Am J Transplant 11:2569-74. 2011..Optimizing a recipient's informed consent is essential to protecting patient safety and autonomy... - Prevention and early treatment of opportunistic viral infections in patients with leukemia and allogeneic stem cell transplantation recipientsMichael Angarone
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
J Natl Compr Canc Netw 6:191-201. 2008..Fortunately, a growing armamentarium is allowing more effective prophylaxis of these pathogens. This article reviews the epidemiology and prophylactic strategies available for these common opportunistic viral pathogens... - Infections transmitted by transplantationMichele I Morris
Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, USA
Infect Dis Clin North Am 24:497-514. 2010..Issues related to the epidemiology of, screening for, and management of proven or probable donor-derived infections are reviewed in this article... - A survey of CMV prevention strategies after liver transplantationJ Levitsky
Department of Medicine, Division of Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Am J Transplant 8:158-61. 2008..In conclusion, the majority of LT centers utilize CMV prophylaxis over other strategies. Valganciclovir is the most commonly used agent for both antiviral prophylaxis and treatment of CMV viremia in the preemptive approach... - Donor screening for human T-cell lymphotrophic virus 1/2: changing paradigms for changing testing capacityD R Kaul
Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, MI, USA
Am J Transplant 10:207-13. 2010.... - Fatal adenovirus pneumonia in a person with AIDS and Burkitt lymphoma: a case report and review of the literatureOluwadamilola A Adeyemi
Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
AIDS Read 18:196-8, 201-2, 206-7. 2008.... - Development of BK nephropathy in recipients of simultaneous pancreas-kidney transplantationMichael G Ison
Division of Infectious Disease, Department of Medicine, Feinberg School of Medicine, Northwestern University Chicago, Chicago, IL, USA
Transplantation 87:525-30. 2009..The presence of dual organs limits the ability to reduce maintenance immunosuppression, typically the first intervention in the management of BKVN... - Adenovirus infections in transplant recipientsMichael G Ison
Division of Infectious Diseases, Transplant Infectious Diseases Service, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Clin Infect Dis 43:331-9. 2006..Prospective studies are needed to better understand the pathogenesis of and therapeutic options for adenoviral infections in this patient population... - Current research on respiratory viral infections: Fourth International SymposiumMichael G Ison
University of Virginia School of Medicine, Charlottesville, VA, USA
Antiviral Res 55:227-78. 2002 - Rhinovirus infections in hematopoietic stem cell transplant recipients with pneumoniaMichael G Ison
Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA
Clin Infect Dis 36:1139-43. 2003..Whether the poor prognosis is due to HRV or the copathogen is not clear... - Safety and efficacy of nebulized zanamivir in hospitalized patients with serious influenzaMichael G Ison
University of Virginia, Charlottesville, VA, USA
Antivir Ther 8:183-90. 2003..Two rimantadine-resistant viruses emerged during rimantadine monotherapy; no ZNV resistance was observed. Nebulized ZNV appears to be well tolerated in this hospitalized population but further studies are needed to assess its efficacy... - Cardiac findings during uncomplicated acute influenza in ambulatory adultsMichael G Ison
Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, USA
Clin Infect Dis 40:415-22. 2005..These abnormalities resolve promptly and are not associated with changes in cardiac markers or echocardiogram findings... - Cytomegalovirus pneumonia in transplant recipientsMichael G Ison
Transplant Infectious Disease and Compromised Host Program, Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA
Clin Chest Med 26:691-705, viii. 2005..Invasive procedures are often required for the optimal management of such infections. The use of sensitive and quantitative assays have greatly improved the outcomes of CMV infection... - Recovery of drug-resistant influenza virus from immunocompromised patients: a case seriesMichael G Ison
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
J Infect Dis 193:760-4. 2006..We describe a novel Asp198Asn NA mutation in an influenza B virus and its decreased susceptibility to both oseltamivir and zanamivir... - Prevention and treatment of cancer-related infectionsBrahm H Segal
Roswell Park Cancer Institute, USA
J Natl Compr Canc Netw 6:122-74. 2008 - Current research on respiratory viral infections: Fifth International SymposiumMichael G Ison
University of Virginia School of Medicine, Charlottesville, USA
Antiviral Res 62:75-110. 2004 - Comparative activities of oseltamivir and A-322278 in immunocompetent and immunocompromised murine models of influenza virus infectionMichael G Ison
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
J Infect Dis 193:765-72. 2006..This model would be useful for elucidation of the molecular mechanisms of resistance to NA inhibitors and for testing of anti-influenza therapy options that might prevent the emergence of resistant variants...