Affiliation: Northwestern University
Au Yeung N, Horvath C. Transcriptional and chromatin regulation in interferon and innate antiviral gene expression. Cytokine Growth Factor Rev. 2018;44:11-17 pubmed publisher
..Here, gene-specific and genome-wide investigations of the chromatin landscape at IFN and ISGs is discussed in parallel with IRF- and STAT- dependent regulation of Pol II transcription. ..
Mandhana R, Horvath C. Sendai Virus Infection Induces Expression of Novel RNAs in Human Cells. Sci Rep. 2018;8:16815 pubmed publisher
Au Yeung N, Horvath C. Histone H2A.Z Suppression of Interferon-Stimulated Transcription and Antiviral Immunity Is Modulated by GCN5 and BRD2. iScience. 2018;6:68-82 pubmed publisher
..This indicates that H2A.Z nucleosomes at ISG promoters restrict optimal ISGF3 engagement and modulate the biological response to IFN. ..
Horvath C. Weapons of STAT destruction. Interferon evasion by paramyxovirus V protein. Eur J Biochem. 2004;271:4621-8 pubmed
..Exposure of the viral weapons of STAT destruction may also be instructive for application to STAT-directed therapeutics for diseases characterized by STAT hyperactivity. ..
Horvath C. A serpin takes a bite out of the flu. Cell Host Microbe. 2015;17:283-284 pubmed publisher
..2015) designed to reveal immune strategies against the flu has uncovered an Achilles' heel for influenza replication based on its requirement for host proteolytic machinery to enable efficient spread. ..
Parisien J, Lenoir J, Mandhana R, Rodriguez K, Qian K, Bruns A, et al
. RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling. EMBO Rep. 2018;19: pubmed publisher
Rodriguez K, Horvath C. Paramyxovirus V protein interaction with the antiviral sensor LGP2 disrupts MDA5 signaling enhancement but is not relevant to LGP2-mediated RLR signaling inhibition. J Virol. 2014;88:8180-8 pubmed publisher
..These findings clarify the functions of LGP2 as a positive regulator of MDA5 signaling, demonstrate the basis for V-mediated LGP2 targeting, and broaden our understanding of paramyxovirus-host interactions. ..
Bruns A, Leser G, Lamb R, Horvath C. The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. Mol Cell. 2014;55:771-81 pubmed publisher
..These findings provide a mechanism for LGP2 coactivation of MDA5 and a biological context for MDA5-RNA filaments in antiviral responses. ..
Neapolitan R, Horvath C, Jiang X. Pan-cancer analysis of TCGA data reveals notable signaling pathways. BMC Cancer. 2015;15:516 pubmed publisher
..We conclude that our results will prove to be valuable to cancer researchers because they provide many opportunities for laboratory and clinical follow-up studies. ..