LINDA A HICKE

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi Protein regulation by monoubiquitin
    L Hicke
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University Evanston, Illinois 60208, USA
    Nat Rev Mol Cell Biol 2:195-201. 2001
  2. ncbi Ubiquitin-binding domains
    Linda Hicke
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500, USA
    Nat Rev Mol Cell Biol 6:610-21. 2005
  3. ncbi Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins
    Linda Hicke
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500, USA
    Annu Rev Cell Dev Biol 19:141-72. 2003
  4. ncbi The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo
    Rebecca Dunn
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Hogan 2 100, 2205 Tech Dr, Evanston, IL 60208 3500, USA
    J Cell Biol 165:135-44. 2004
  5. ncbi The Rsp5 ubiquitin ligase binds to and ubiquitinates members of the yeast CIN85-endophilin complex, Sla1-Rvs167
    Svetoslava D Stamenova
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500, USA
    J Biol Chem 279:16017-25. 2004
  6. ncbi Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis
    Susan C Shih
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL, 60208 3500, USA
    Nat Cell Biol 4:389-93. 2002
  7. ncbi Non-traditional functions of ubiquitin and ubiquitin-binding proteins
    Joshua D Schnell
    Department of Biochemistry, Northwestern University, Evanston, Illinois 60208-3500, USA
    J Biol Chem 278:35857-60. 2003
  8. ncbi Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding
    Richard S Kang
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Cell 113:621-30. 2003
  9. ncbi Ubiquitin binds to and regulates a subset of SH3 domains
    Svetoslava D Stamenova
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Mol Cell 25:273-84. 2007
  10. ncbi A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain
    Susan C Shih
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    EMBO J 22:1273-81. 2003

Research Grants

  1. Ubiquitin and Cellular Regulation
    Linda Hicke; Fiscal Year: 2006
  2. UBIQUITIN-DEPENDENT ENDOCYTOSIS OF SIGNALING RECEPTORS
    Linda Hicke; Fiscal Year: 2007
  3. Roles of ubiquitin protein ligases in endocytosis
    Linda Hicke; Fiscal Year: 2005
  4. UBIQUITIN-DEPENDENT ENDOCYTOSIS OF SIGNALING RECEPTORS
    Linda Hicke; Fiscal Year: 2003
  5. REGULATION OF M2 MUSCARINIC RECEPTORS
    Linda Hicke; Fiscal Year: 2001
  6. Regulation of endocytosis by ubiquitin and ubiquitin-binding proteins
    LINDA A HICKE; Fiscal Year: 2010

Collaborators

  • Heidi L Schubert
  • David Katzmann
  • James H Hurley
  • BEVERLY R WENDLAND
  • S D Emr
  • Joshua D Schnell
  • Susan C Shih
  • Svetoslava D Stamenova
  • Ishwar Radhakrishnan
  • Kurt A Swanson
  • Michael E French
  • Yuan He
  • Amy K A deHart
  • Adam S Adler
  • Smitha A Francis
  • Rebecca Dunn
  • Michael R Dores
  • Richard S Kang
  • Deborah A Klos Dehring
  • Michael French
  • Damian A Allen
  • Lymarie Maldonado-Baez
  • Benjamin R Kretzmann
  • Ava Hosseini
  • Zachary B Kramer
  • Kurt Swanson
  • Deborah A Klos
  • William J Salerno
  • Myra A Sutanto
  • Ju-Yun Tsai
  • Cynthia M Daniels
  • Gali Prag
  • Ju Yun Tsai
  • Myra Sutanto

Detail Information

Publications20

  1. ncbi Protein regulation by monoubiquitin
    L Hicke
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University Evanston, Illinois 60208, USA
    Nat Rev Mol Cell Biol 2:195-201. 2001
    ..Instead of sending proteins to their death through the proteasome, monoubiquitylation regulates processes that range from membrane transport to transcriptional regulation...
  2. ncbi Ubiquitin-binding domains
    Linda Hicke
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500, USA
    Nat Rev Mol Cell Biol 6:610-21. 2005
    ..Such knowledge will be key to our understanding of how ubiquitin regulates cellular proteins and processes...
  3. ncbi Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins
    Linda Hicke
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500, USA
    Annu Rev Cell Dev Biol 19:141-72. 2003
    ....
  4. ncbi The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo
    Rebecca Dunn
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Hogan 2 100, 2205 Tech Dr, Evanston, IL 60208 3500, USA
    J Cell Biol 165:135-44. 2004
    ..These results demonstrate that the C2 domain specifies Rsp5-dependent ubiquitination of endosomal cargo and suggest that Rsp5 function is regulated by membrane phosphoinositides...
  5. ncbi The Rsp5 ubiquitin ligase binds to and ubiquitinates members of the yeast CIN85-endophilin complex, Sla1-Rvs167
    Svetoslava D Stamenova
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500, USA
    J Biol Chem 279:16017-25. 2004
    ..Rvs167 ubiquitination is not required for general function of Rvs167, but may control specific Rvs167 SH3 domain-protein interactions or negatively regulate SH3 domain activity...
  6. ncbi Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis
    Susan C Shih
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL, 60208 3500, USA
    Nat Cell Biol 4:389-93. 2002
    ..UIM domains are found in a broad spectrum of proteins, consistent with the idea that mono-ubiquitin can function as a regulatory signal to control diverse biological activities...
  7. ncbi Non-traditional functions of ubiquitin and ubiquitin-binding proteins
    Joshua D Schnell
    Department of Biochemistry, Northwestern University, Evanston, Illinois 60208-3500, USA
    J Biol Chem 278:35857-60. 2003
  8. ncbi Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding
    Richard S Kang
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Cell 113:621-30. 2003
    ..Comparative modeling suggests that the UBA domain interacts analogously with ubiquitin. The structure of the CUE-ubiquitin complex may thus serve as a paradigm for ubiquitin recognition and signaling by ubiquitin binding proteins...
  9. ncbi Ubiquitin binds to and regulates a subset of SH3 domains
    Svetoslava D Stamenova
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Mol Cell 25:273-84. 2007
    ..We conclude that a subset of SH3 domains constitutes a distinct type of ubiquitin-binding domain and that ubiquitin binding can negatively regulate interaction of SH3 domains with canonical proline-rich ligands...
  10. ncbi A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain
    Susan C Shih
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    EMBO J 22:1273-81. 2003
    ..Thus, we conclude that the CUE motif is an evolutionarily conserved monoubiquitin-binding domain that mediates intramolecular monoubiquitylation...
  11. ncbi Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site
    Michael E French
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 284:12071-9. 2009
    ..We propose that a subset of HECT E3s are regulated by a conserved ubiquitin-binding site that functions to restrict the length of polyubiquitin chains synthesized by the HECT domain...
  12. ncbi A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase
    Deborah A Klos Dehring
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 283:34188-96. 2008
    ..These observations identify a new functional region within the Sec7/BIG family of Arf GEFs that is required for trans-Golgi network localization...
  13. ncbi Structural basis for monoubiquitin recognition by the Ede1 UBA domain
    Kurt A Swanson
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, 2 100 Hogan Bldg, Evanston, IL 60208 3500, USA
    J Mol Biol 358:713-24. 2006
    ....
  14. ncbi The function of yeast epsin and Ede1 ubiquitin-binding domains during receptor internalization
    Michael R Dores
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Campus Drive, Evanston, IL 60208, USA
    Traffic 11:151-60. 2010
    ..Together, our results suggest that the ubiquitin-binding domains within the yeast epsin Ent2 and Ede1 are involved in the formation and regulation of the endocytic network...
  15. ncbi PtdIns(3,5)P2 finds a partner
    Linda Hicke
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Dev Cell 5:363-4. 2003
    ..New work by in this issue of Developmental Cell describes the identification of a yeast epsin-like protein that binds PtdIns(3,5)P(2) and functions in the transport of proteins through late endosomes to the lysosome-like vacuole...
  16. ncbi Structural basis for ubiquitin recognition by SH3 domains
    Yuan He
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    J Mol Biol 373:190-6. 2007
    ..The structure of the SH3-ubiquitin complex explains how a subset of SH3 domains has acquired this non-traditional function...
  17. ncbi Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulation
    Kurt A Swanson
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    EMBO J 22:4597-606. 2003
    ....
  18. ncbi The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast
    Amy K A deHart
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    J Cell Biol 156:241-8. 2002
    ..These observations demonstrate that Ypk1 acts downstream of the Pkh kinases to control endocytosis by phosphorylating components of the endocytic machinery...
  19. ncbi Identification and characterization of modular domains that bind ubiquitin
    Michael French
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois, USA
    Methods Enzymol 399:135-57. 2005
    ..Here, we discuss the strategies and tools that have been most successful in the identification and characterization of ubiquitin-binding domains...
  20. ncbi Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway
    Amy K A deHart
    Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, Illinois 60208, USA
    Mol Biol Cell 14:4676-84. 2003
    ..These findings reveal a novel function for the Tor2-Rho1 pathway in controlling endocytosis in yeast, a function that is mediated in part through the plasma membrane protein Fks1...

Research Grants18

  1. Ubiquitin and Cellular Regulation
    Linda Hicke; Fiscal Year: 2006
    ..Based on past years, the conference will be oversubscribed; however, to foster strong interactions between participants the conference is limited to 180 participants. ..
  2. UBIQUITIN-DEPENDENT ENDOCYTOSIS OF SIGNALING RECEPTORS
    Linda Hicke; Fiscal Year: 2007
    ..abstract_text> ..
  3. Roles of ubiquitin protein ligases in endocytosis
    Linda Hicke; Fiscal Year: 2005
    ....
  4. UBIQUITIN-DEPENDENT ENDOCYTOSIS OF SIGNALING RECEPTORS
    Linda Hicke; Fiscal Year: 2003
    ..Lastly, the relationship of ubiquitin-mediated endocytosis and degradation to pathways involving other endocytosis signals will be studied by indirect immunofluorescence. ..
  5. REGULATION OF M2 MUSCARINIC RECEPTORS
    Linda Hicke; Fiscal Year: 2001
    ..The results will provide new insights into novel events involved in turning off the signals from mAChRs. ..
  6. Regulation of endocytosis by ubiquitin and ubiquitin-binding proteins
    LINDA A HICKE; Fiscal Year: 2010
    ..abstract_text> ..