M Geoffrey Hayes

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies
    M Geoffrey Hayes
    Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Diabetes 62:3282-91. 2013
  2. pmc Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs
    Boris Pasche
    Division of Hematology Oncology, The University of Alabama at Birmingham and UAB Comprehensive Cancer Center, Birmingham, AL 35203, USA
    J Exp Clin Cancer Res 29:57. 2010
  3. pmc The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy
    Margrit Urbanek
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 7:e32958. 2012
  4. pmc The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study
    Margrit Urbanek
    Division on Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 22:3583-96. 2013
  5. pmc Genetic variation associated with circulating monocyte count in the eMERGE Network
    David R Crosslin
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA
    Hum Mol Genet 22:2119-27. 2013
  6. doi request reprint A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q
    Jayant M Pinto
    Section of Otolaryngology Head and Neck Surgery, Department of Surgery, The University of Chicago, Chicago, Illinois 60637, USA
    Laryngoscope 118:2067-72. 2008
  7. pmc Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome
    Toshihide Kawai
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Diabetes Res Clin Pract 86:186-92. 2009
  8. pmc Genetics of chronic rhinosinusitis: state of the field and directions forward
    Joy Hsu
    Division of Allergy Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60637, USA
    J Allergy Clin Immunol 131:977-93, 993.e1-5. 2013
  9. pmc Ethnic variation in allele distribution of the androgen receptor (AR) (CAG)n repeat
    Christine M Ackerman
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL 60611, USA
    J Androl 33:210-5. 2012
  10. pmc Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the I
    Rachel M Freathy
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Diabetes 59:2682-9. 2010

Collaborators

Detail Information

Publications16

  1. pmc Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies
    M Geoffrey Hayes
    Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Diabetes 62:3282-91. 2013
    ..These results suggest that the genetic architecture underlying glucose metabolism may differ, in part, in pregnancy. ..
  2. pmc Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs
    Boris Pasche
    Division of Hematology Oncology, The University of Alabama at Birmingham and UAB Comprehensive Cancer Center, Birmingham, AL 35203, USA
    J Exp Clin Cancer Res 29:57. 2010
    ..This phenotype was first observed in mice, then in lymphoblastoid cell lines from patients with microsatellite stable colorectal tumors...
  3. pmc The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy
    Margrit Urbanek
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 7:e32958. 2012
    ....
  4. pmc The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study
    Margrit Urbanek
    Division on Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 22:3583-96. 2013
    ..This region has previously been shown to be associated with birth weight in Europeans. The current study suggests that association of this locus with birth weight is secondary to an effect on fat as opposed to lean body mass...
  5. pmc Genetic variation associated with circulating monocyte count in the eMERGE Network
    David R Crosslin
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA
    Hum Mol Genet 22:2119-27. 2013
    ..68×10(-17), β = -0.23) at the integrin, alpha 4 gene on chromosome 2. The novel IRF8 results and further replications provide supporting evidence of genetic regions associated with monocyte count...
  6. doi request reprint A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q
    Jayant M Pinto
    Section of Otolaryngology Head and Neck Surgery, Department of Surgery, The University of Chicago, Chicago, Illinois 60637, USA
    Laryngoscope 118:2067-72. 2008
    ..Chronic rhinosinusitis (CRS) is an important public health problem with substantial impact on patient quality of life and health care costs. We hypothesized that genetic variation may be one factor that affects this disease...
  7. pmc Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome
    Toshihide Kawai
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Diabetes Res Clin Pract 86:186-92. 2009
    ..59], P=0.022). It was also associated with increased LDL (P=0.007) and total cholesterol levels (P=0.042). These results suggest that genetic variation in PLIN may affect glucose and lipid metabolism in women both with and without PCOS...
  8. pmc Genetics of chronic rhinosinusitis: state of the field and directions forward
    Joy Hsu
    Division of Allergy Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60637, USA
    J Allergy Clin Immunol 131:977-93, 993.e1-5. 2013
    ....
  9. pmc Ethnic variation in allele distribution of the androgen receptor (AR) (CAG)n repeat
    Christine M Ackerman
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL 60611, USA
    J Androl 33:210-5. 2012
    ..Significant interethnic differences in the allele frequencies of the AR exon 1 (CAG)(n) polymorphism exist. Our results suggest that there may be potential ethnic differences in androgenic pathway activity and androgen sensitivity...
  10. pmc Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the I
    Rachel M Freathy
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Diabetes 59:2682-9. 2010
    ..We hypothesized that these variants are associated with quantitative measures of glycemia in pregnancy...
  11. pmc Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study
    Abel N Kho
    Northwestern University, Chicago, Illinois, USA
    J Am Med Inform Assoc 19:212-8. 2012
    ..The aim of this study was to identify type 2 diabetes (T2D) cases and controls for a GWAS, using data captured through routine clinical care across five institutions using different electronic medical record (EMR) systems...
  12. pmc Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network
    David R Crosslin
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Hum Genet 131:639-52. 2012
    ..Variants in this region have been reported to be associated with WBC, neutrophil count, and inflammatory diseases including asthma and Crohn's disease...
  13. doi request reprint Practical challenges in integrating genomic data into the electronic health record
    Abel N Kho
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Genet Med 15:772-8. 2013
    ..Successful integration of genomic data may require significant redesign of existing electronic health record systems...
  14. doi request reprint A genome-wide screen for hyposmia susceptibility Loci
    Jayant M Pinto
    Section of Otolaryngology Head and Neck Surgery, The University of Chicago, 5841 S Maryland Avenue, MC 1035, Chicago, IL 60637, USA
    Chem Senses 33:319-29. 2008
    ..0013). Although this signal meets the criteria for suggestive linkage only and will require replication, these results offer the strongest data to date on the effects of genetic variation on olfactory dysfunction...
  15. pmc Insulin gene mutations as a cause of permanent neonatal diabetes
    Julie Støy
    Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 104:15040-4. 2007
    ..One of the human mutations we report here is identical to that in the Akita mouse. The identification of insulin mutations as a cause of neonatal diabetes will facilitate the diagnosis and possibly, in time, treatment of this disorder...
  16. ncbi request reprint Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies
    M Geoffrey Hayes
    Department of Medicine, University of Chicago, 5841 S Maryland Ave, MC6091, Chicago, IL 60637, USA
    Diabetes 56:3033-44. 2007
    ..The objective of this study was to identify DNA polymorphisms associated with type 2 diabetes in a Mexican-American population...