Adrian Gross

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi Identification of protein side chains near the membrane-aqueous interface: a site-directed spin labeling study of KcsA
    Adrian Gross
    Jules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
    Biochemistry 41:1123-8. 2002
  2. ncbi Potassium channel gating observed with site-directed mass tagging
    Brent L Kelly
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nat Struct Biol 10:280-4. 2003
  3. ncbi Structural basis of TEA blockade in a model potassium channel
    Michael J Lenaeus
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nat Struct Mol Biol 12:454-9. 2005
  4. pmc The structure of the lipid-embedded potassium channel voltage sensor determined by double-electron-electron resonance spectroscopy
    Magdalini Vamvouka
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Protein Sci 17:506-17. 2008

Research Grants

Collaborators

Detail Information

Publications4

  1. ncbi Identification of protein side chains near the membrane-aqueous interface: a site-directed spin labeling study of KcsA
    Adrian Gross
    Jules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
    Biochemistry 41:1123-8. 2002
    ..The results indicate that residues near the interface can be identified on the basis of their high rates of collision with the headgroup region of the bilayer...
  2. ncbi Potassium channel gating observed with site-directed mass tagging
    Brent L Kelly
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nat Struct Biol 10:280-4. 2003
    ..The results indicate that KcsA is a dynamically modular molecule; the extracellular half of the membrane-spanning region is held rigid during gating, while the intracellular half undergoes a significant conformational change...
  3. ncbi Structural basis of TEA blockade in a model potassium channel
    Michael J Lenaeus
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nat Struct Mol Biol 12:454-9. 2005
    ..We propose that TEA blocks potassium channels by acting as a potassium analog at the dehydration transition step during permeation...
  4. pmc The structure of the lipid-embedded potassium channel voltage sensor determined by double-electron-electron resonance spectroscopy
    Magdalini Vamvouka
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Protein Sci 17:506-17. 2008
    ....

Research Grants10

  1. STRUCTURAL STUDIES ON PROKARYOTIC POTASSIUM CHANNELS
    Adrian Gross; Fiscal Year: 2011
    ..Determining the precise structure and mechanism of action of these channels will allow for the development of safer and more effective drugs. ..
  2. STRUCTURAL STUDIES ON PROKARYOTIC POTASSIUM CHANNELS
    Adrian Gross; Fiscal Year: 2009
    ..The long term goal of this proposal is to understand functional properties of ion channels at a structural level. ..
  3. STRUCTURAL STUDIES ON PROKARYOTIC POTASSIUM CHANNELS
    Adrian Gross; Fiscal Year: 2003
    ..The long-term goal of this proposal is to understand functional properties of ion channels at a structural level. ..
  4. Mass spectrometric studies on potassium channels
    Adrian Gross; Fiscal Year: 2003
    ..It is anticipated that results from this study will provide new insight into the general structural layout of Shaker. ..