Paul J Grippo

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice
    Paul J Grippo
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Gut 61:1454-64. 2012
  2. ncbi A high omega-3 fatty acid diet mitigates murine pancreatic precancer development
    Matthew J Strouch
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Surg Res 165:75-81. 2011
  3. ncbi Deploying mouse models of pancreatic cancer for chemoprevention studies
    Paul J Grippo
    Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Chicago, IL 60611, USA
    Cancer Prev Res (Phila) 3:1382-7. 2010
  4. ncbi Visualization of mouse pancreas architecture using MR microscopy
    Paul J Grippo
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Pathol 179:610-8. 2011
  5. ncbi Alteration of strain background and a high omega-6 fat diet induces earlier onset of pancreatic neoplasia in EL-Kras transgenic mice
    Eric C Cheon
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Int J Cancer 128:2783-92. 2011
  6. ncbi MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling
    Seth B Krantz
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Cancer Res 9:1294-304. 2011
  7. ncbi Apigenin down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells
    Laleh G Melstrom
    Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Surg Res 167:173-81. 2011
  8. ncbi Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2
    Surabhi Dangi-Garimella
    Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 71:1019-28. 2011
  9. ncbi Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer
    Kevin Adrian
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Cancer Res 69:9169-74. 2009
  10. ncbi Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid apigenin in pancreatic cancer cell lines
    Mohammad R Salabat
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Carcinog 47:835-44. 2008

Research Grants

  1. Pancreatic Development in Modeling Pancreatic Disease
    Paul Grippo; Fiscal Year: 2003
  2. Omega-6 Fat Promotion of Mutant Kras-Induced Pancreatic Neoplasia
    Paul Grippo; Fiscal Year: 2007

Collaborators

Detail Information

Publications12

  1. ncbi Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice
    Paul J Grippo
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Gut 61:1454-64. 2012
    ..Oncogenic Ras, the most common mutation in pancreatic ductal adenocarcinoma (PDAC), has similarly been shown to promote adipogenesis and premalignant lesions...
  2. ncbi A high omega-3 fatty acid diet mitigates murine pancreatic precancer development
    Matthew J Strouch
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Surg Res 165:75-81. 2011
    ..We assessed the effects of a diet rich in ω-3 fat on the development of pancreatic precancer in elastase (EL)-Kras transgenic mice and examined the effect of an ω-3 fatty acid on pancreatic cancer cells in vitro...
  3. ncbi Deploying mouse models of pancreatic cancer for chemoprevention studies
    Paul J Grippo
    Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Chicago, IL 60611, USA
    Cancer Prev Res (Phila) 3:1382-7. 2010
    ..Yet, arming the community of cancer investigators with a repertoire of models and the guidance to select relevant models that fit their research themes promises to produce findings that will have clinical relevance...
  4. ncbi Visualization of mouse pancreas architecture using MR microscopy
    Paul J Grippo
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Pathol 179:610-8. 2011
    ....
  5. ncbi Alteration of strain background and a high omega-6 fat diet induces earlier onset of pancreatic neoplasia in EL-Kras transgenic mice
    Eric C Cheon
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Int J Cancer 128:2783-92. 2011
    ..We herein introduce the EL-Kras B6 mouse model which presents with increased frequency of pancreatic neoplasia compared to EL-Kras F1 mice. The phenotype in EL-Kras F1 and FVB mice is promoted by a diet rich in ω-6 fatty acid...
  6. ncbi MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling
    Seth B Krantz
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Cancer Res 9:1294-304. 2011
    ..Overall, we show that the bona fide collagenase MT1-MMP paradoxically contributes to fibrosis by increasing TGF-β signaling and that targeting MT1-MMP may thus help to mitigate fibrosis...
  7. ncbi Apigenin down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells
    Laleh G Melstrom
    Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Surg Res 167:173-81. 2011
    ..The flavonoid apigenin exhibits anti-proliferative and anti-angiogenic activities. Our objective was to evaluate the effect of apigenin on hypoxia responsive genes important in pancreatic cancer cell proliferation...
  8. ncbi Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2
    Surabhi Dangi-Garimella
    Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 71:1019-28. 2011
    ....
  9. ncbi Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer
    Kevin Adrian
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Cancer Res 69:9169-74. 2009
    ..We conclude that Tgfbr1 signaling promotes the development of precancerous lesions in mice. These findings suggest that individuals with constitutively decreased TGFBR1 expression may have a decreased risk of pancreatic cancer...
  10. ncbi Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid apigenin in pancreatic cancer cell lines
    Mohammad R Salabat
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Carcinog 47:835-44. 2008
    ..In conclusion, our studies demonstrated that geminin is overexpressed in human pancreatic cancer and downregulated by apigenin which may contribute to the antitumor effect of this natural flavonoid...
  11. ncbi Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents
    Paul J Grippo
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Int J Cancer 131:1243-8. 2012
    ..Finally, focal ductal elements develop in some acinar cell carcinomas in Ela-c-myc transgenic rats, indicating that myc-associated acinar-to-ductal metaplasia is not restricted to the mouse...
  12. ncbi Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice
    Eric C Cheon
    Department of Surgery, Mount Sinai Hospital, University of Illinois College of Medicine, Chicago, Illinois, USA
    Cancer Res 71:1627-36. 2011
    ..Together, our results establish a pro-tumorigenic role of hematopoietic 5LO in the immune microenvironment and suggest 5LO inhibition as an avenue for future investigation in treatment of colorectal polyposis and cancer...

Research Grants3

  1. Pancreatic Development in Modeling Pancreatic Disease
    Paul Grippo; Fiscal Year: 2003
    ..Targeting pancreatic progenitor cells with various genetic alterations will provide valuable information for the developmental biologist and clinical pathologist alike. ..
  2. Omega-6 Fat Promotion of Mutant Kras-Induced Pancreatic Neoplasia
    Paul Grippo; Fiscal Year: 2007
    ..Results from this work will establish potential pathways that, when altered by drugs or changes in the diet, may prevent or retard the development of pancreatic cancer. ..