Paul J Grippo

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. doi request reprint Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice
    Paul J Grippo
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Gut 61:1454-64. 2012
  2. pmc A high omega-3 fatty acid diet mitigates murine pancreatic precancer development
    Matthew J Strouch
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Surg Res 165:75-81. 2011
  3. pmc Visualization of mouse pancreas architecture using MR microscopy
    Paul J Grippo
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Pathol 179:610-8. 2011
  4. pmc Deploying mouse models of pancreatic cancer for chemoprevention studies
    Paul J Grippo
    Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Chicago, IL 60611, USA
    Cancer Prev Res (Phila) 3:1382-7. 2010
  5. pmc Alteration of strain background and a high omega-6 fat diet induces earlier onset of pancreatic neoplasia in EL-Kras transgenic mice
    Eric C Cheon
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Int J Cancer 128:2783-92. 2011
  6. pmc MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling
    Seth B Krantz
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Cancer Res 9:1294-304. 2011
  7. doi request reprint Apigenin down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells
    Laleh G Melstrom
    Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Surg Res 167:173-81. 2011
  8. pmc Snail cooperates with KrasG12D to promote pancreatic fibrosis
    Mario A Shields
    Northwestern University Feinberg School of Medicine, Lurie Building, Room 3 117, 303 E Superior Street, Chicago, IL 60611
    Mol Cancer Res 11:1078-87. 2013
  9. pmc Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2
    Surabhi Dangi-Garimella
    Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 71:1019-28. 2011
  10. doi request reprint Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer
    Kevin Adrian
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Cancer Res 69:9169-74. 2009

Collaborators

Detail Information

Publications15

  1. doi request reprint Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice
    Paul J Grippo
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Gut 61:1454-64. 2012
    ..Oncogenic Ras, the most common mutation in pancreatic ductal adenocarcinoma (PDAC), has similarly been shown to promote adipogenesis and premalignant lesions...
  2. pmc A high omega-3 fatty acid diet mitigates murine pancreatic precancer development
    Matthew J Strouch
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Surg Res 165:75-81. 2011
    ..We assessed the effects of a diet rich in ω-3 fat on the development of pancreatic precancer in elastase (EL)-Kras transgenic mice and examined the effect of an ω-3 fatty acid on pancreatic cancer cells in vitro...
  3. pmc Visualization of mouse pancreas architecture using MR microscopy
    Paul J Grippo
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Pathol 179:610-8. 2011
    ....
  4. pmc Deploying mouse models of pancreatic cancer for chemoprevention studies
    Paul J Grippo
    Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Chicago, IL 60611, USA
    Cancer Prev Res (Phila) 3:1382-7. 2010
    ..Yet, arming the community of cancer investigators with a repertoire of models and the guidance to select relevant models that fit their research themes promises to produce findings that will have clinical relevance...
  5. pmc Alteration of strain background and a high omega-6 fat diet induces earlier onset of pancreatic neoplasia in EL-Kras transgenic mice
    Eric C Cheon
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Int J Cancer 128:2783-92. 2011
    ..We herein introduce the EL-Kras B6 mouse model which presents with increased frequency of pancreatic neoplasia compared to EL-Kras F1 mice. The phenotype in EL-Kras F1 and FVB mice is promoted by a diet rich in ω-6 fatty acid...
  6. pmc MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling
    Seth B Krantz
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Cancer Res 9:1294-304. 2011
    ..Overall, we show that the bona fide collagenase MT1-MMP paradoxically contributes to fibrosis by increasing TGF-β signaling and that targeting MT1-MMP may thus help to mitigate fibrosis...
  7. doi request reprint Apigenin down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells
    Laleh G Melstrom
    Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Surg Res 167:173-81. 2011
    ..The flavonoid apigenin exhibits anti-proliferative and anti-angiogenic activities. Our objective was to evaluate the effect of apigenin on hypoxia responsive genes important in pancreatic cancer cell proliferation...
  8. pmc Snail cooperates with KrasG12D to promote pancreatic fibrosis
    Mario A Shields
    Northwestern University Feinberg School of Medicine, Lurie Building, Room 3 117, 303 E Superior Street, Chicago, IL 60611
    Mol Cancer Res 11:1078-87. 2013
    ..Together, these results suggest that Snail contributes to pancreatic tumor development by promoting fibrotic reaction through increased TGF-β signaling...
  9. pmc Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2
    Surabhi Dangi-Garimella
    Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 71:1019-28. 2011
    ....
  10. doi request reprint Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer
    Kevin Adrian
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Cancer Res 69:9169-74. 2009
    ..We conclude that Tgfbr1 signaling promotes the development of precancerous lesions in mice. These findings suggest that individuals with constitutively decreased TGFBR1 expression may have a decreased risk of pancreatic cancer...
  11. doi request reprint TGF-β: duality of function between tumor prevention and carcinogenesis
    Daniel R Principe
    Affiliations of authors Department of Medicine, Division of Gastroenterology DRP, JB, BJ and Division of Hematology Oncology HGM, Department of Surgery, Division of GI Surgical Oncology DRP, PJG, and Department of Urology CL, Northwestern University Feinberg School of Medicine, Chicago, IL Department of Biomedical Engineering McCormick School of Engineering, Northwestern University, Evanston, IL DRP Department of Biomedical Sciences, University of Wisconsin Milwaukee, Milwaukee, WI JAD UMR INSERM U1052, CNRS 5286, Universite Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France LB Division of Hematology Oncology, Department of Medicine, University of Alabama Birmingham, Birmingham, AL BP Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA CL
    J Natl Cancer Inst 106:djt369. 2014
    ..Understanding the mechanisms of TGF-β dysregulation will likely reveal novel points of convergence between TGF-β and other pathways that can be specifically targeted for therapy. ..
  12. doi request reprint Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid apigenin in pancreatic cancer cell lines
    Mohammad R Salabat
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Carcinog 47:835-44. 2008
    ..In conclusion, our studies demonstrated that geminin is overexpressed in human pancreatic cancer and downregulated by apigenin which may contribute to the antitumor effect of this natural flavonoid...
  13. doi request reprint Evaluating dietary compounds in pancreatic cancer modeling systems
    Emman Mascariñas
    Department of Surgery, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Methods Mol Biol 980:225-48. 2013
    ..Thus, both approaches are considered in this chapter as each can provide unique strengths to determining the effectiveness of various dietary compounds or supplements on pancreatic neoplasia and cancer...
  14. doi request reprint Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents
    Paul J Grippo
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Int J Cancer 131:1243-8. 2012
    ..Finally, focal ductal elements develop in some acinar cell carcinomas in Ela-c-myc transgenic rats, indicating that myc-associated acinar-to-ductal metaplasia is not restricted to the mouse...
  15. doi request reprint Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice
    Eric C Cheon
    Department of Surgery, Mount Sinai Hospital, University of Illinois College of Medicine, Chicago, Illinois, USA
    Cancer Res 71:1627-36. 2011
    ..Together, our results establish a pro-tumorigenic role of hematopoietic 5LO in the immune microenvironment and suggest 5LO inhibition as an avenue for future investigation in treatment of colorectal polyposis and cancer...

Research Grants3

  1. Pancreatic Development in Modeling Pancreatic Disease
    Paul Grippo; Fiscal Year: 2003
    ..Targeting pancreatic progenitor cells with various genetic alterations will provide valuable information for the developmental biologist and clinical pathologist alike. ..
  2. Omega-6 Fat Promotion of Mutant Kras-Induced Pancreatic Neoplasia
    Paul Grippo; Fiscal Year: 2007
    ..Results from this work will establish potential pathways that, when altered by drugs or changes in the diet, may prevent or retard the development of pancreatic cancer. ..