JAY GOTTFRIED

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Odor quality coding and categorization in human posterior piriform cortex
    James D Howard
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 12:932-8. 2009
  2. doi request reprint The value of identity: olfactory notes on orbitofrontal cortex function
    Jay A Gottfried
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Ann N Y Acad Sci 1239:138-48. 2011
  3. pmc Function follows form: ecological constraints on odor codes and olfactory percepts
    Jay A Gottfried
    Northwestern University Feinberg School of Medicine, Department of Neurology, Cognitive Neurology and Alzheimer s Disease Center, 320 E Superior St, Searle 11 453, Chicago, IL 60611, USA
    Curr Opin Neurobiol 19:422-9. 2009
  4. ncbi request reprint What can an orbitofrontal cortex-endowed animal do with smells?
    Jay A Gottfried
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Ann N Y Acad Sci 1121:102-20. 2007
  5. pmc Perceptual and neural pliability of odor objects
    Jay A Gottfried
    Department of Neurology, Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Ann N Y Acad Sci 1170:324-32. 2009
  6. ncbi request reprint Smell: central nervous processing
    Jay A Gottfried
    Northwestern University Feinberg School of Medicine, Cognitive Neurology and Alzheimer s Disease Center, Chicago, IL 60611, USA
    Adv Otorhinolaryngol 63:44-69. 2006
  7. ncbi request reprint Dissociable codes of odor quality and odorant structure in human piriform cortex
    Jay A Gottfried
    Cognitive Neurology and Alzheimer s Disease Center, Department of Neurology, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, Illinois 60611, USA
    Neuron 49:467-79. 2006
  8. ncbi request reprint On the scent of human olfactory orbitofrontal cortex: meta-analysis and comparison to non-human primates
    Jay A Gottfried
    Department of Neurology and the Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, 320 E Superior St, Searle 11 453, Chicago, IL 60611, USA
    Brain Res Brain Res Rev 50:287-304. 2005
  9. pmc Olfaction: when nostrils compete
    Jay A Gottfried
    Northwestern University Feinberg School of Medicine, Cognitive Neurology and Alzheimer s Disease Center and the Department of Neurology, 320 E Superior St, Searle 11 453, Chicago, IL 60611, USA
    Curr Biol 19:R862-4. 2009
  10. pmc Central mechanisms of odour object perception
    Jay A Gottfried
    Department of Neurology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 10 150, Chicago, Illinois 60611, USA
    Nat Rev Neurosci 11:628-41. 2010

Detail Information

Publications24

  1. pmc Odor quality coding and categorization in human posterior piriform cortex
    James D Howard
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 12:932-8. 2009
    ..These findings substantiate theoretical models emphasizing the importance of distributed piriform templates for the perceptual reconstruction of odor object quality...
  2. doi request reprint The value of identity: olfactory notes on orbitofrontal cortex function
    Jay A Gottfried
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Ann N Y Acad Sci 1239:138-48. 2011
    ....
  3. pmc Function follows form: ecological constraints on odor codes and olfactory percepts
    Jay A Gottfried
    Northwestern University Feinberg School of Medicine, Department of Neurology, Cognitive Neurology and Alzheimer s Disease Center, 320 E Superior St, Searle 11 453, Chicago, IL 60611, USA
    Curr Opin Neurobiol 19:422-9. 2009
    ....
  4. ncbi request reprint What can an orbitofrontal cortex-endowed animal do with smells?
    Jay A Gottfried
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Ann N Y Acad Sci 1121:102-20. 2007
    ....
  5. pmc Perceptual and neural pliability of odor objects
    Jay A Gottfried
    Department of Neurology, Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Ann N Y Acad Sci 1170:324-32. 2009
    ..The findings presented here highlight the important role of experience in shaping odor object perception and in ensuring the human sense of smell achieves its full perceptual potential...
  6. ncbi request reprint Smell: central nervous processing
    Jay A Gottfried
    Northwestern University Feinberg School of Medicine, Cognitive Neurology and Alzheimer s Disease Center, Chicago, IL 60611, USA
    Adv Otorhinolaryngol 63:44-69. 2006
    ....
  7. ncbi request reprint Dissociable codes of odor quality and odorant structure in human piriform cortex
    Jay A Gottfried
    Cognitive Neurology and Alzheimer s Disease Center, Department of Neurology, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, Illinois 60611, USA
    Neuron 49:467-79. 2006
    ..In turn, quality-based codes are independent of any simple structural configuration, implying that synthetic mechanisms may underlie our experience of smell...
  8. ncbi request reprint On the scent of human olfactory orbitofrontal cortex: meta-analysis and comparison to non-human primates
    Jay A Gottfried
    Department of Neurology and the Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, 320 E Superior St, Searle 11 453, Chicago, IL 60611, USA
    Brain Res Brain Res Rev 50:287-304. 2005
    ....
  9. pmc Olfaction: when nostrils compete
    Jay A Gottfried
    Northwestern University Feinberg School of Medicine, Cognitive Neurology and Alzheimer s Disease Center and the Department of Neurology, 320 E Superior St, Searle 11 453, Chicago, IL 60611, USA
    Curr Biol 19:R862-4. 2009
    ..By analogy, simultaneous presentation of two different odorants separately to the two nostrils has now been shown to cause alternating odor percepts, an effect termed 'binaral rivalry'...
  10. pmc Central mechanisms of odour object perception
    Jay A Gottfried
    Department of Neurology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 10 150, Chicago, Illinois 60611, USA
    Nat Rev Neurosci 11:628-41. 2010
    ..Convergent findings from human and rodent models suggest that distributed piriform ensemble patterns of olfactory qualities and categories are crucial for maintaining the perceptual constancy of ecologically inconstant stimuli...
  11. ncbi request reprint Human orbitofrontal cortex mediates extinction learning while accessing conditioned representations of value
    Jay A Gottfried
    Wellcome Department of Imaging Neuroscience, Functional Imaging Laboratory, 12 Queen Square, London, WC1N 3BG, UK
    Nat Neurosci 7:1144-52. 2004
    ..Moreover, by manipulating UCS aversiveness via reinforcer inflation, we showed that a CS+ retains access to representations of UCS value in distinct regions of ventral prefrontal cortex, even as extinction proceeds...
  12. ncbi request reprint The nose smells what the eye sees: crossmodal visual facilitation of human olfactory perception
    Jay A Gottfried
    Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, United Kingdom
    Neuron 39:375-86. 2003
    ..We suggest these findings can be interpreted as indicating that human hippocampus mediates reactivation of crossmodal semantic associations, even in the absence of explicit memory processing...
  13. ncbi request reprint Remembrance of odors past: human olfactory cortex in cross-modal recognition memory
    Jay A Gottfried
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, United Kingdom
    Neuron 42:687-95. 2004
    ..We suggest that reactivation of memory traces distributed across modality-specific brain areas underpins the sensory qualities of episodic memories...
  14. ncbi request reprint Encoding predictive reward value in human amygdala and orbitofrontal cortex
    Jay A Gottfried
    Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Science 301:1104-7. 2003
    ..Thus, differential activity in amygdala and orbitofrontal cortex encodes the current value of reward representations accessible to predictive cues...
  15. ncbi request reprint Appetitive and aversive olfactory learning in humans studied using event-related functional magnetic resonance imaging
    Jay A Gottfried
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, WC1N 3BG, United Kingdom
    J Neurosci 22:10829-37. 2002
    ..Moreover, the findings suggest that the role of human primary (piriform) and secondary olfactory cortices transcends their function as mere intermediaries of chemosensory information processing...
  16. ncbi request reprint Functional heterogeneity in human olfactory cortex: an event-related functional magnetic resonance imaging study
    Jay A Gottfried
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, WC1N 3BG, United Kingdom
    J Neurosci 22:10819-28. 2002
    ..They also show that brain regions mediating emotional processing are differentially activated by odor valence, providing evidence for a close anatomical coupling between olfactory and emotional processes...
  17. pmc Attention to odor modulates thalamocortical connectivity in the human brain
    Jane Plailly
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 28:5257-67. 2008
    ..The results imply that olfaction, like all other sensory modalities, requires a thalamic relay, if only to consciously analyze a smell...
  18. pmc Aversive learning enhances perceptual and cortical discrimination of indiscriminable odor cues
    Wen Li
    Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Science 319:1842-5. 2008
    ..That completely indiscriminable sensations can be transformed into discriminable percepts further accentuates the potency of associative learning to enhance sensory cue perception and support adaptive behavior...
  19. ncbi request reprint Subliminal smells can guide social preferences
    Wen Li
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Psychol Sci 18:1044-9. 2007
    ..These results indicate that social preferences are subject to influences from odors that escape awareness, whereas the availability of conscious odor information may disrupt such effects...
  20. pmc Learning to smell the roses: experience-dependent neural plasticity in human piriform and orbitofrontal cortices
    Wen Li
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Neuron 52:1097-108. 2006
    ..Our findings suggest that neural representations of odor quality can be rapidly updated through mere perceptual experience, a mechanism that may underlie the development of odor perception...
  21. ncbi request reprint A truffle in the mouth is worth two in the bush: odor localization in the human brain
    Jay A Gottfried
    Cognitive Neurology and Alzheimer s Disease Center, Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 47:473-6. 2005
    ..or to the inside or outside of the mouth (Small et al.). Together, these studies validate the idea that the human brain is equipped with the apparatus necessary to pinpoint the location of an odor source...
  22. ncbi request reprint Acquired mirror writing and reading: evidence for reflected graphemic representations
    Jay A Gottfried
    Department of Neurology, Center for Cognitive Neuroscience, The Hospital of the University of Pennsylvania, 3 West Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neuropsychologia 41:96-107. 2003
    ..Furthermore, because she seemed better able to read irregular words in mirrored than in normal formats, we suggest that mirrored representations may exist at the whole word level and not simply at the letter level...
  23. ncbi request reprint Integrated neural representations of odor intensity and affective valence in human amygdala
    Joel S Winston
    Wellcome Department of Imaging Neuroscience, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 25:8903-7. 2005
    ..This implies that the amygdala codes neither intensity nor valence per se, but a combination that we suggest reflects the overall emotional value of a stimulus...
  24. ncbi request reprint Linking affect to action: critical contributions of the orbitofrontal cortex. Preface
    Geoffrey Schoenbaum
    Ann N Y Acad Sci 1121:xi-xiii. 2007

Research Grants5

  1. Neural organization of odor coding in human piriform cortex
    JAY GOTTFRIED; Fiscal Year: 2007
    ..By helping to clarify how smells are represented in the intact human brain, the proposed research may have important utility in enlightening our understanding of Alzheimer's disease and other neurological disorders. ..
  2. Perceptual Coding and Modulation of Odor Objects in the Human Brain
    Jay A Gottfried; Fiscal Year: 2010
    ....
  3. Perceptual Coding and Modulation of Odor Objects in the Human Brain
    JAY GOTTFRIED; Fiscal Year: 2009
    ....